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本文报道了药物不良反应监测报告的内容设 计及计算机处理。以所输入病历为例,显示了计算 机检索系统操作方便、提供信息准确和及时的特 点。本系统可从药名、不良反应名以及病人职业等 多方面进行检索,需要时还可提供病例的全部内 容,弥补了人工查阅资料的不足。 相似文献
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随着中药注射剂在临床的广泛应用 ,其临床不良反应 (ADR)的报道也在逐年增加。笔者收集了1991~ 2 0 0 1年 9种临床常用中药注射液不良反应报告 86 5例进行汇总分析 ,旨在了解中药注射液临床不良反应的特点和表现形式 ,用以指导临床合理用药 ,减少不良反应的发生。1 资料来源中国生物医学文献光盘数据库检索系统[1](CBM ) ,该数据库收录了 1983至今的 6 0 0多种期刊、汇编、论文题录约 6 0万条。本文重点检索 1991~ 2 0 0 1年双黄连等 9种中药注射液临床不良反应文献报告共计病例 86 5例。按设定标准对涉及到的不良反应资料进行分类统… 相似文献
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中国生物医学文献数据库(CBMdisc)和中国生物医学期刊目次数据库(CMCC),分别由中国医学科学院医学信息研究所CBMdisc和解放军医学图书馆数据库研究部研制的面向生物医学领域的光盘数据库检索系统,两者既相互联系又有所区别,形成了相对独立的统一体。结合文献检索工作实践,就其收录范围、检索途径、数据库界面内容进行对比分析。1收录范围CBMdisc数据库收录1978年以来1000余种中文文献期刊、以及汇编、会议论文的文献题录及90%的文献摘要,总计250余万条。CMCC收录了自1994年以来1300余种中文生物医学期刊约200万条文献记录,并以每年30… 相似文献
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郭燕华 《临床合理用药杂志》2014,(19):92-93
目的:分析硫普罗宁所致不良反应特点及相关因素。方法检索2003年6月-2013年6月清华同方期刊题录及全文数据库中有关硫普罗宁不良反应的报道,并收集国家药品不良反应监测中心病例数据库中有关硫普罗宁不良反应的报告,统计分析上述文献及报告所涉及的患者性别、有无过敏史、给药途径及剂量、不良反应发生时间、不良反应累积系统及临床表现等。结果硫普罗宁所致不良反应男性明显高于女性,伴有过敏史患者更易出现不良反应,不良反应大多出现在静脉给药30min内,累积系统以呼吸系统最为常见。结论予以硫普罗宁治疗期间应密切关注患者是否出现不良反应,避免不良反应的不利影响,进而提高临床疗效。 相似文献
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《中国新药与临床杂志》1985,(6)
我国卫生部药典委员会于1984年组织编订了《英汉、汉英药名词典》由化学工业出版社发行。所有4100多种药名是根据中外药名相互对应的原则,采取音译、意译与音意合译方法译成中文药名,注明药理作用类别。《新药与临床》决定自1986年开始全面采用该书的中文药名,但在括号中仍注有以前常用的中文药名作为过渡,并防止误解。今先在本期中以本刊创刊四年来所用药品列成下表提供参考,希读者、作者注意。下表第一行是英文药名,第二行是卫生部药典委员会核定中文药名,括号中是本刊曾用中文药名。 相似文献
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《中国生物医学文献数据库》应用体会 总被引:2,自引:0,他引:2
《中国生物医学文献光盘数据库》(简称CBMdisc)是由中国医学科学院医学信息研究所开发研制的大型综合性医学文献题录文摘型数据库。内容涵盖了《中文科技资料目录(医药卫生)》、《中文生物医学期刊数据库》(简称CMCC)收录的所有文献题录。该数据库自1979年以来收录了1000多种中国生物医学期刊、资料汇编、会议论文的文献题录,总计约230余万条,年增加量约20余万条。 相似文献
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本文介绍的信息是由各国药政管理部提供的,详细资料可向世界卫生组织(WHO)索取。某些特殊类别的产品如造影剂和放射药品删略。顺序是按照国际非专有药名排列,后附商品名称及生产药厂名称。选登的药物只供参考,并无推荐之意。 相似文献
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关注药名纠纷现象与安全用药 总被引:9,自引:0,他引:9
李立安 《中国医院药学杂志》2004,24(1):58-59
目的:对药名纠纷现象进行归纳、综合,为临床安全用药提供参考.方法:根据工作经验,结合考查有关药学文献,对一药多名、药名一字之差及同名异药情况进行整理、综述,并分析药名纠纷带来的危害,提出安全用药建议.结果:一药多名主要见于西药,普遍存在的药名纠纷现象,药名一字之差有75种之多,同名异药8种.结论:医药卫生工作者应加强安全用药意识及区分药名纠纷的健康宣教. 相似文献
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Little information exists regarding the use of nesiritide for treatment of right-sided heart failure. Similarly, little information is available regarding routine use of combination nesiritide and diuretics as initial therapy to relieve edema due to heart failure. Nesiritide may be beneficial in combination with diuretics because it reduces activity of the renin-angiotensin-aldosterone system. It is unclear how potent nesiritide is as a diuretic. Patients exhibit wide variability in clinical response from the diuretic effects of the drug. Two patients were given a combination of nesiritide and diuretics as initial treatment of right-sided heart failure; both experienced significant diuresis and weight loss. Further literature is needed to clarify the role of nesiritide in the treatment of right-sided heart failure. 相似文献
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从网络环境的角度,阐述图书馆文献信息资源保障体系建设的必要性,指出网络环境对图书馆文献信息资源保障体系建设的影响,并对文献信息资源保障体系建设中所面临的问题和障碍进行了深入分析,最后提出创新发展图书馆文献信息资源保障体系应采取的措施和对策。 相似文献
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Objectives. To assess the impact of using “grey literature” (information internally produced in print or electronic format by agencies such as hospitals, government, businesses, etc) rather than a textbook in a course on healthcare delivery systems on students’ perception of the relevance of healthcare delivery system topics and their ability to identify credible sources of this information.Design. A reading from the grey literature was identified and assigned to the students for each topic in the course.Assessment. Pre- and post-course survey instruments were used for the assessment. Students reported healthcare delivery systems topics to be moderately relevant to the profession of pharmacy on both the pre- and post-course survey instruments. Students’ knowledge of current and credible sources of information on healthcare delivery system topics significantly improved based on self-reports and scores on objective assessments (p<0.05).Conclusions. Assignment of grey literature in a course on healthcare delivery systems can be used to ensure that information in the pharmacy school curriculum is the most current and credible information available. 相似文献
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目的加强医院数字图书馆文献资源整合,促进实现信息集成化的应用开发,并设计出一种资源整合系统。方法采用实体与虚拟相结合的方法,基于ASP和SQL数据库实现图书馆资源整合,将ILASII系统纸质图书信息与电子图书信息进行文献信息资源整合,基本满足了图书馆各项业务及广大临床科研教学对信息服务的需求。结果通过对医院图书馆文献信息资源整合,建成了以ILASII系统为核心的文献信息资源整合系统。结论该系统的设计,使得医院图书馆文献信息有效组织、管理与开发利用具有现实意义。 相似文献
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Kristine Kongsbak Niels Hadrup Karine Audouze Anne Marie Vinggaard 《Basic & clinical pharmacology & toxicology》2014,115(1):45-49
Systems biology as a research field has emerged within the last few decades. Systems biology, often defined as the antithesis of the reductionist approach, integrates information about individual components of a biological system. In integrative systems biology, large data sets from various sources and databases are used to model and predict effects of chemicals on, for instance, human health. In toxicology, computational systems biology enables identification of important pathways and molecules from large data sets; tasks that can be extremely laborious when performed by a classical literature search. However, computational systems biology offers more advantages than providing a high‐throughput literature search; it may form the basis for establishment of hypotheses on potential links between environmental chemicals and human diseases, which would be very difficult to establish experimentally. This is possible due to the existence of comprehensive databases containing information on networks of human protein–protein interactions and protein–disease associations. Experimentally determined targets of the specific chemical of interest can be fed into these networks to obtain additional information that can be used to establish hypotheses on links between the chemical and human diseases. Such information can also be applied for designing more intelligent animal/cell experiments that can test the established hypotheses. Here, we describe how and why to apply an integrative systems biology method in the hypothesis‐generating phase of toxicological research. 相似文献
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A review of literature on pre-eclampsia/eclampsia indicates that this is one of the commonest causes of high maternal and infant mortality and morbidity rates. Current information on the condition indicates that use of aspirin, phenytoin and magnesium sulphate are on the increase. However, in Malawi lytic cocktail and use of antihypertensives such as Hydralazine and, anticonvulsants such as Valium are currently in use. Even with this type of management, Malawi experiences high morbidity and mortality rates. This literature review was done to identify baseline data for a study to be carried out in some of the hospitals in Malawi to establish a protocol for effective management of pre-eclampsia and eclampsia in Malawi. It is hoped that after using low dose aspirin and magnesium sulphate, the morbidity and mortality caused by the disease will be reversed with time. 相似文献
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目的: 对脑心通胶囊有关临床安全性的文献进行研究,获取临床安全性信息,为临床安全用药提供参考。方法: 对脑心通胶囊临床安全性相关文献进行收集、筛选、标化及整合,形成脑心通胶囊不良事件(adverse drug event,ADE)/不良反应(adverse drug reaction,ADR)文献数据库,采用描述性分析方法对ADR发生特点进行梳理分析。结果: 共计纳入58篇符合标准的文献,其中临床研究54篇,个案报告2篇,不良事件监测2篇;报告不良反应共计213例,其中ADR的临床表现31个,累及9个器官/系统损害,以胃肠系统损害(67.21%)、中枢及外周神经系统损害(15.79%)和全身性损害(7.69%)为主;有记录的ADR转归及预后情况(141例,66.2%)均良好。结论: 通过文献研究可获取脑心通胶囊的ADR临床表现、累及器官/系统损害情况,ADR转归及预后情况;但整体ADR发生情况的描述不够详细,对ADR的发生时间等信息缺失较多,不良反应发生率受文献中临床研究样本量的限制而差别较大;有待规范临床研究文献中对ADE/ADR发生情况描述的内容,提高安全性有效信息的获取;目前描述性文献研究在获取药品临床安全性有效信息中可起到一定的补充作用。 相似文献