肝脏巨大海绵状血管瘤的介入治疗(附20例分析)

目的：探讨肝脏巨大海绵状血管瘤(HHCH)的介入治疗方法与疗效。方法：20例肝海绵状血管瘤患者经导管肝动脉注入平阳霉素和超液化碘油混合乳剂，然后用明胶海绵或PVA适量栓塞肿瘤供血动脉。结果：所有病例术前肝动脉造影均显示“爆米花样染色”“早出晚归”的异常血管湖样改变。术后20例肿瘤血供中断，瘤体缩小及碘油在肿瘤内均匀沉积。结论：采用超液化碘油和平阳霉素加适量明胶海绵微粒联合栓塞是一种微创、安全简便、切实可行且疗效显著的治疗方法。     

介入治疗肝脏巨大海绵状血管瘤

目的 探讨肝脏巨大海绵状血管瘤（HHCH）的介入治疗方法与疗效。材料与方法 治疗肝巨大绵状血管瘤14例,经导管注入超液化碘油和平阳霉素（PYM）混合乳剂,最后用明胶海绵颗粒适量栓塞肿瘤周围小血管。结果 所有病例术前肝动脉造影均显示“枝上挂果,早出晚归”的异常血管湖样改变。术后8例肿瘤明显缩小,异常血管湖消失。结论 采用超液化碘油和PYM混合剂加适量明胶海绵微粒联合栓塞是治疗肝巨大海绵状血管瘤较好的方法之一。     

双途径注药术治疗肝海绵状血管瘤的疗效评价

目的探讨经肝动脉栓塞结合经皮瘤体内直接注射治疗肝血管瘤的疗效和价值。资料与方法采用Seldinger技术行肝动脉插管至血管瘤供血动脉,对32例肝海绵状血管瘤注入平阳霉素碘油乳剂(PLE)至血管瘤体大部分充填,用明胶海绵颗粒栓塞供血动脉;对碘油空虚区域再行经皮瘤体内直接注射PLE。定期观察瘤体碘油充填情况,瘤体大小和并发症。结果经肝动脉栓塞结合经皮瘤体内直接注射治疗肝血管瘤后,碘油沉积好,血管瘤体积明显缩小,无严重并发症。结论经肝动脉栓塞结合经皮瘤体内直接注射治疗肝血管瘤具有疗效好,并发症少等优点。     

平阳霉素+碘油乳剂栓塞治疗肝海绵状血管瘤的疗效观察

目的 评价平阳霉素碘油乳剂栓塞肝海绵状血管瘤的临床疗效。方法 对18例患者采用Seldinger技术股动脉插管,将导管超选择至肿瘤供血动脉,缓慢注入利多卡因5-10 m1及平阳霉素碘油乳剂5-20 ml。栓塞前常规肌内注射杜冷丁50-100 mg;病变巨大、多支血供、病人年龄>60岁者,分次介入治疗。术后3-48个月CT、B超随访观察栓塞前后肿瘤直径大小变化、临床症状缓解情况及并发症。结果 18例肝海绵状血管瘤均见平阳霉素碘油完全充填。病灶完全消失9例,缩小50％以上7例,病灶缩小25％-50％2例。其中6例血管造影复查见病灶血管完全消失,载瘤动脉闭塞。临床症状好转率89％,无严重并发症。结论 平阳霉素碘油乳剂动脉栓塞肝海绵状血管瘤疗效良好,微创、安全、副作用少,可作为首选的治疗方法。     

肝小血管瘤的肝段动脉栓塞治疗

肝海绵状血管瘤(cavernoushemangiomaoftheliver,CHL)是肝脏最常见的良性肿瘤,肝动脉栓塞已成为肝海绵状血管瘤有效治疗方法之一,以往多用于对巨大肝海绵状血管瘤(>10cm或>5cm)栓塞治疗。笔者1998-10～2004-12间采用平阳霉素碘油乳剂加明胶海绵栓塞治疗肝小血管瘤6例,取得良好疗效,报告如下。1材料与方法1.1临床资料1998-10～2004-12间,使用平阳霉素碘油乳剂加明胶海绵肝段动脉栓塞治疗小CHL6例。6例中,5例为US、CT、MRI初诊肝血管瘤,1例US、CT、MRI初诊HCC或CHL,后1～2月复查CT,显示瘤体有增大,平均14mm,患者要求做介入治疗,造…     

不同栓塞剂介入治疗肝海绵状血管瘤的疗效

目的: 评价经肝动脉插管不同栓塞剂治疗肝海绵状血管瘤的疗效.材料和方法: 56例肝海绵状血管瘤患者分为3组,A组15人,栓塞剂鱼肝油酸钠 碘化油;B组18人,栓塞剂为8mg平阳霉素 碘化油乳化液栓塞组,C组23人,栓塞剂为8mg平阳霉素 碘化油乳化液 明胶海绵颗粒.全部患者于栓塞后3及6个月行CT复查,评价瘤体萎缩情况.结果: A组和B组疗效无差异,C组比A,B组疗效好(P<0.01).结论: 应用平阳霉素作为血管内皮损伤剂和碘化油栓塞海绵状血管瘤,再以明胶海绵阻断供载瘤供血动脉干为最佳安全有效治疗方法.     

巨大肝海绵状血管瘤介入治疗的疗效评价

目的：评价平阳霉素碘化油乳剂经选择性肝动脉栓塞治疗巨大肝海绵状血管瘤的临床应用和疗效。方法：对32例有症状的巨大肝海绵状血管瘤患者采用Seldinger技术,经皮股动脉穿刺行肝动脉插管注入平阳霉素碘化油乳剂栓塞硬化肝血管瘤体,并用明胶海绵颗粒栓塞瘤体供血动脉。栓塞术后3、6、12和18个月的随访观察肿瘤大小变化、临床症状缓解和并发症发生情况。结果：栓塞治疗后肿瘤进行性缩小,术后第3、6、12、18个月复查,肿瘤平均缩小程度分别为29.6%、43.7%、56.3%、64.8%;其中3例肝血管瘤分别于第12个月和第18个月复查时CT或MRI提示消失;所有患者临床症状明显减轻或消失,无严重并发症发生。结论：介入栓塞治疗巨大肝海绵状血管瘤安全有效、并发症少,具有重要的临床应用价值。     

肝海绵状血管瘤合并动静脉短路的介入治疗

目的 :评价平阳霉素碘化油乳剂合用PVA微粒肝动脉双重栓塞治疗合并有门静脉短路的肝海绵状血管瘤的可行性和临床疗效。方法 :对 6例肝海绵状血管瘤合并门静脉短路 ,应用微导管行肝动脉超选择插管 ,局部平阳霉素碘化油乳剂合用PVA微粒双重栓塞 ,观察动静脉短路闭塞情况肿瘤染色变化情况、术后患者临床症状的缓解和并发症及随访瘤体缩小程度。结果 :6例肝血管瘤患者行平阳霉素碘化油合用PVA微粒肝动脉超选择双重栓塞后 ,动静脉短路均闭塞 ,肿瘤染色消失 ,术后随访瘤体直径明显缩小 (P <0 .0 5 ) ,临床症状基本缓解 ,无严重并发症出现。结论 :平阳霉素碘化油乳剂合用PVA微粒肝动脉双重栓塞治疗 ,合并门静脉短路的肝海绵状血管瘤疗效及安全性良好。     

肝海绵状血管瘤动脉栓塞术后胆管损伤原因分析与对策

目的：探讨肝动脉栓塞术治疗肝血管瘤后胆管损伤的原因与对策。方法：46例肝海绵状血管瘤患者,用5F导管超选择插管至肝血管瘤的供血支,经导管注入平阳霉素-碘油乳剂（PLE）进行栓塞。结果：超选择性插管成功率100%,术后共有2例出现胆管损伤并发症,总发生率4.4%,经对症等处理后分别于3、8个月后肝功能恢复正常。结论：明确CHL血供类型、控制碘油乳剂用量及高水平的操作技术可以减少和避免胆管损伤并发症的发生。     

肝脏巨大血管瘤的动脉栓塞治疗

目的分析和探讨肝动脉栓塞治疗对肝巨大血管瘤(直径大于5cm)的治疗效果。方法运用超液态碘化油 明胶海绵颗粒和平阳霉素碘化油混合乳剂 明胶海绵颗粒对我院36例肝脏巨大血管瘤患者进行动脉栓塞治疗。结果所有病例术前肝动脉造影显示“枝上挂果”、“早出晚归”的异常血管湖样改变,栓塞后肿瘤内碘油沉积良好;术后除1例出现严重并发症,除4例栓塞后无明显效果外,其他患者肿瘤均缩小,18例患者肿瘤缩小大于50%。结论动脉介入栓塞治疗对肝巨大血管瘤患者是一种疗效肯定、相对安全较为理想的治疗方法。     

Knee injury and Osteoarthritis Outcome Score (KOOS) - validation of a Swedish version

The Knee injury and Osteoarthritis Outcome Score (KOOS) is a self-administered instrument measuring outcome after knee injury at impairment, disability, and handicap level in five subscales. Reliability, validity, and responsiveness of a Swedish version was assessed in 142 patients who underwent arthroscopy because of injury to the menisci, anterior cruciate ligament, or cartilage of the knee. The clinimetric properties were found to be good and comparable to the American version of the KOOS. Comparison to the Short Form-36 and the Lysholm knee scoring scale revealed expected correlations and construct validity. Item by item, symptoms and functional limitations were compared between diagnostic groups. High responsiveness was found three months after arthroscopic partial meniscectomy for all subscales but Activities of Daily Living.     

Endovascular management of carotid-cavernous fistulas

Objective To investigate endovascular treatment of traumatic direct carotid-cavernous fistulas （CCF） and their complications such as pseudoaneurysms. Methods： Over a five-year period, 22 patients with traumatic direct CCFs were treated endovascularly in our institution. Thirteen patients were treated once with the result of CCF occluded, 8 twice and 1 three times. Treatment modalities included balloon occlusion of the CCF, sacrifice of the ipsilateral internal carotid artery with detachable balloon, coll embolization of the cavernous sinus and secondary pseudoaneurysms, and covered-stem management of the pseudoaneurysms. Results All the direct CCFs were successfully managed endovascularly. Four patients developed a pseudoaneurysm after the occlusion of the CCF with an incidence of pseudoaneurysm formation of 18.2% （4/22）. A total number of 8 patients experienced permanent occlusion of the ICA with a rate of ICA occlusion reaching 36.4% （8/22）. Followed up through telephone consultation from 6 months to 5 years, all did well with no recurrence of CCF symptoms and signs. Conclusion Traumatic direct CCFs can be successfully managed with endovascular means. The pseudoaneurysms secondary to the occlusion of the CCFs can be occluded with stent-assisted coiling and implantation of covered stents.     

The acutely limping child

Acute limping may be the result of multiple pathologies in children. The differential diagnosis varies based on the age of the child. Irrespective of age, the initial imaging work-up includes AP and frog leg radiographs of the pelvis and ultrasound; MRI may sometimes be helpful. In children less than 3 years, infections and trauma are most frequent. MRI is the imaging modality of choice when osteomyelitis is clinically suspected. Between the ages of 3 and 10 years, transient synovitis of the hip and Legg-Calvé-Perthes disease are main considerations but infection, inflammation and focal bony lesions are also considered. In children over 10 years, slipped capital femoral epiphysis also is considered.     

Do Balance Board Training Programs Reduce the Risk of Ankle Sprains in Athletes?

Introduction Ankle sprains are the most common musculo-skeletal injury that occurs in athletes,particularly in sports that require jumping and landing on one foot such as soccer,and basketball(1-4).These injuries often result in significant time loss from participation,long-term disability,and have a major impact on health care costs and resources(5-8).     

High Intensity Interval Training:New Insights

KEY POINTS ·High-intensity interval training(HIT)is characterized by repeated sessions of relatively brief，intermittent exercise.often performed with an“a11 out”effort or at an intensity close to that which elicits peak oxygen uptake(i.e.，≥90%of VO2 peak).     

Developmental validation of the PowerPlex(®) ESI 16 and PowerPlex(®) ESI 17 Systems: STR multiplexes for the new European standard

In response to the ENFSI and EDNAP groups’ call for new STR multiplexes for Europe, Promega^® developed a suite of four new DNA profiling kits. This paper describes the developmental validation study performed on the PowerPlex^® ESI 16 (European Standard Investigator 16) and the PowerPlex^® ESI 17 Systems. The PowerPlex^® ESI 16 System combines the 11 loci compatible with the UK National DNA Database^®, contained within the AmpFlSTR^® SGM Plus^® PCR Amplification Kit, with five additional loci: D2S441, D10S1248, D22S1045, D1S1656 and D12S391. The multiplex was designed to reduce the amplicon size of the loci found in the AmpFlSTR^® SGM Plus^® kit. This design facilitates increased robustness and amplification success for the loci used in the national DNA databases created in many countries, when analyzing degraded DNA samples. The PowerPlex^® ESI 17 System amplifies the same loci as the PowerPlex^® ESI 16 System, but with the addition of a primer pair for the SE33 locus. Tests were designed to address the developmental validation guidelines issued by the Scientific Working Group on DNA Analysis Methods (SWGDAM), and those of the DNA Advisory Board (DAB). Samples processed include DNA mixtures, PCR reactions spiked with inhibitors, a sensitivity series, and 306 United Kingdom donor samples to determine concordance with data generated with the AmpFlSTR^® SGM Plus^® kit. Allele frequencies from 242 white Caucasian samples collected in the United Kingdom are also presented. The PowerPlex^® ESI 16 and ESI 17 Systems are robust and sensitive tools, suitable for the analysis of forensic DNA samples. Full profiles were routinely observed with 62.5 pg of a fully heterozygous single source DNA template. This high level of sensitivity was found to impact on mixture analyses, where 54–86% of unique minor contributor alleles were routinely observed in a 1:19 mixture ratio. Improved sensitivity combined with the robustness afforded by smaller amplicons has substantially improved the quantity of data obtained from degraded samples, and the improved chemistry confers exceptional tolerance to high levels of laboratory prepared inhibitors.