生物活性多肽修饰的碳磷酸钙骨水泥修复牙周骨缺损的实验研究

目的　探讨生物活性多肽处理的碳磷酸钙骨水泥 (carbonatedcalciumphosphatebonecement,CCPBC)修复牙周骨缺损的可能性与效果。方法　 4只健康家犬牙周用手术方法去骨 ,缺损约1cm× 1cm ,每只犬分别用羟基磷灰石 (hydroxyapatite ,HA)、倍骼生、CCPBC以及用多肽处理的CCPBC直接修复缺损 ,术后 1～ 3个月进行X线片检查及组织形态学观察。结果　实验条件下 ,HA组和倍骼生组均有不同程度的材料丢失 ,HA组缺损处为软组织修复 ,倍骼生组牙槽骨侧残余材料周围有少量新生骨组织 ;CCPBC组能有效维持牙周骨缺损间隙 ;CCPBC经多肽处理组 ,材料周围有较多的新骨形成 ,修复效果优于其他组。结论　CCPBC经过生物活性多肽修饰后具有一定的成骨活性 ,其在牙周骨缺损修复中的应用前景 ,值得关注。     

骨修复材料生物活性玻璃矿化性能影响因素的研究进展

生物活性玻璃材料(Bioactive glass,BG)因有出色的骨结合能力、骨诱导能力、骨传导特性,且生物相容性好,甚至在一定条件下能与结缔组织结合,是拥有很大潜力的骨修复材料.但当前生物活性玻璃产品的性能尚不能达到理想的骨组织修复材料所要求的标准.为使其能更好的治疗骨组织缺损,学者们通过改进制备工艺、改变成分、制备复合支架的方法改善生物活性玻璃材料的矿化性能.本文就以上三个方面对生物活性玻璃矿化性能的研究进展作一综述.     

骨修复材料生物活性玻璃矿化性能影响因素的研究进展

生物活性玻璃材料(Bioactive glass,BG)因有出色的骨结合能力、骨诱导能力、骨传导特性,且生物相容性好,甚至在一定条件下能与结缔组织结合,是拥有很大潜力的骨修复材料.但当前生物活性玻璃产品的性能尚不能达到理想的骨组织修复材料所要求的标准.为使其能更好的治疗骨组织缺损,学者们通过改进制备工艺、改变成分、制备复合支架的方法改善生物活性玻璃材料的矿化性能.本文就以上三个方面对生物活性玻璃矿化性能的研究进展作一综述.     

骨修复材料生物活性玻璃矿化性能影响因素的研究进展

生物活性玻璃材料(Bioactive glass,BG)因有出色的骨结合能力、骨诱导能力、骨传导特性,且生物相容性好,甚至在一定条件下能与结缔组织结合,是拥有很大潜力的骨修复材料.但当前生物活性玻璃产品的性能尚不能达到理想的骨组织修复材料所要求的标准.为使其能更好的治疗骨组织缺损,学者们通过改进制备工艺、改变成分、制备复合支架的方法改善生物活性玻璃材料的矿化性能.本文就以上三个方面对生物活性玻璃矿化性能的研究进展作一综述.     

骨结合种植体骨界面组织学三维重建研究进展

种植与骨界面的骨结合被认为是骨内种植体成功的标志,而骨界面组织学的研究多为二维图像,计算机三维重建技术可以从立体角度多层次,多方位地进行研究,可以得到直观的种植与体骨界面各部位形态的计算机图像,同时获得种植周转各部位的骨结合楷。     

生物活性陶瓷骨修复材料的改性研究进展

生物活性陶瓷的研制成功为骨缺损与畸形的修复提供了良好的骨替代物,但随着研究的深入及临床应用的扩大,人们也发现此材料的一些缺陷,目前正进行相关研究以改善材料的性能,提高修复的功效。 一、生物活性陶瓷骨修复材料的缺陷 (一)缺乏骨诱导性。虽然不少学者报道在骨环境中他具有促进骨组织生长与沉积的作用,但要证明其具有骨诱导能力尚缺乏依据,他不能像其他骨诱导物质一样具有肌内成骨作用。然而早期骨与材料的结合,新生骨在材料中生长与沉积,是种植成功的关键。 (二)在体内可发生生物降解及吸收。主要指磷酸三钙(TCP)类生物陶瓷材料,他在体内仅能作为一种暂时性支架。如果一种骨替代材料能随骨组织的生长而被逐渐吸收,     

钛网成型自体颗粒骨复合骨修复材料修复兔下颌骨缺损的实验研究

目的:评价钛网成型自体颗粒骨复合骨修复材料移植重建兔下颌骨节段性缺损的成骨效果.方法:18只新西兰家兔,均建立单侧下颌骨节段性缺损模型,随机分为3组,用钛网成型重建下颌骨外形后,分别移植自体颗粒骨、骨修复材料和自体颗粒骨复合骨修复材料.术后12周取移植骨做组织学检查及Micro-CT检查.应用SPSS 14.0软件包对...     

用于评价骨修复材料的临界性骨缺损

本文介绍了临界性骨缺损的定义、病理机制,并以大鼠为重点,对以往文献中研究骨修复材料时所用的不同动物不同部位的骨缺损的大小作一综述。     

牙本质作为骨修复材料的研究进展

各种原因造成的口腔硬组织缺损给口腔修复带来了极大的困难.寻找一种具有良好骨传导性、骨诱导性、生物相容性和可吸收性的新型骨修复材料是近年来的研究热点.牙本质是一种新型骨修复材料,来源广泛,可取自临床中拔除的废用牙或阻生齿.牙本质与牙槽骨有相同的组织学来源,理化性质相似,且含有大量的骨活性因子,用作骨修复材料具有其他材料无...     

含氨基结构骨修复材料的实验研究

本文采用低温等离子体表面活化处理技术方法获得含有氨基结构的生物活性骨修复材料．通过不同时期动态的材料—骨界面扫描电镜观察和微量元素分析，结果表明经活化处理的具有生物活性的骨修复材料对新骨的早期形成具有明显的促进作用．     

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口腔颌面部骨组织结构是支撑面型的重要基础,发生在口腔颌面部的外伤、肿瘤、先天畸形是引发患者口腔颌面部骨组织缺损的主要原因,而如何在一期对患者面型及骨组织缺损进行修复也是口腔颌面外科手术中亟待解决的重点和难点问题。本文主要总结了口腔颌面部骨组织缺损修复材料的发展。     

2种修复膜材料用于牙种植引导骨再生的临床效果比较

目的：比较2种修复膜材料用于牙种植引导骨再生的临床效果。方法：选择上海市静安区牙病防治所2017年9月—2018年9月行牙种植引导骨再生治疗的患者139例,按随机表法分为对照组（68例）和试验组（71例）,对照组应用博特医用胶原修复膜引导骨再生,试验组应用海奥口腔修复膜引导骨再生,术后6个月随访记录修复情况,分别比较2组修复成功率和并发症发生率,并评价成骨厚度和高度、植骨厚度和高度,以及水平和垂直骨生长情况。采用SPSS 20.0软件包对数据进行统计学分析。结果：术后6个月,对照组修复成功率为85.29%（58/68）,试验组为95.77%（68/71）,差异有统计学意义(P<0.05);2组植骨厚度和植骨高度无显著差异(P>0.05),试验组成骨厚度、成骨高度、水平骨生长和垂直骨生长均显著高于对照组(P<0.05);对照组并发症发生率为25.00%,显著高于试验组的12.67%(P<0.05)。结论：海奥口腔修复膜引导骨再生的修复成功率优于博特医用胶原修复膜,可更好促进骨和植骨生长,疗效显著,安全性更高,更适合用于牙种植引导骨再生。     

含硅磷酸钙类骨水泥研究进展

磷酸钙骨水泥（calcium phosphate cement,CPC）作为骨修复材料已广泛用于临床,而硅元素作为生物活性离子,有良好的成骨活性和改善骨水泥理化性能的潜力,因此近年来通过各种方式将硅元素引入磷酸钙类骨水泥的研究逐渐成为热点。本文就含硅磷酸钙类骨水泥的研究进展作一综述。     

3D printing restorative materials using a stereolithographic technique: a systematic review

ObjectiveTo present through a systematic review a qualitative analysis of studies published on stereolithography-based 3D printing of restorative materials and their clinical applicability.MethodsThe literature search was conducted based on the question: “What is the state-of-the-art of available restorative materials for 3D printing based on stereolithography?" Online search was conducted in three databases (MEDLINE/PubMed, Scopus and Web of Science) with no restriction for year of publication. Data are reported based on PRISMA, including publication details such as authors and their countries, year and journal of publication, and study design. The synthesis is focused on describing the dental restorative materials and properties evaluated, applied methods, 3D printers used and clinical applicability.ResultsStudies that fit the inclusion criteria were performed in Asia (21), Europe (16) and USA (10), mostly using polymer-based restorative materials (38) for 3D printing constructs. Stereolithographic-printed ceramic-based restorative structures were evaluated by 9 studies. Many studies reported on dimensional accuracy (14), strength (11) and surface morphology (9) of the printed structures. Antibacterial response, cytotoxicity, internal and marginal fit, fracture and wear resistance, density, viscosity, elastic modulus, hardness, structural shrinkage and reliability, degree of conversion, layer cure depth, fatigue, and color were also evaluated by the included studies. Many of them (11) published a proof of concept as an attempt to demonstrate the clinical feasibility and applicability of the technology to print restorative materials, but only 5 studies actually applied the 3D printed restorative structures in patients, which highlights an increasing interest but limited early-stage translation.SignificanceThe fast expansion of stereolithographic-based 3D printing has been impressive and represents a great technological progress with significant disruptive potential. Dentistry has demonstrated an incredible willingness to adapt materials, methods and workflows to this promising digital technology. However, esthetic appearance, wear resistance, wet strength and dimensional accuracy are the main current clinical limitations restricting the progression to functional part production with 3D printing, which may explain the absence of clinical trials and reports on permanent/definitive dental restorative materials and structures.     

髓室底穿孔的修复方法和材料研究进展

髓腔穿孔,特别是髓室底穿孔是牙体牙髓治疗的难点。该文对临床常用的髓室底穿孔修复方法的研究现状及进展进行了综述,并对穿孔修复新方法屏障法和新材料MTA等作重点介绍。     

Methods to evaluate and strategies to improve the biocompatibility of dental materials and operative techniques

Objective

The general aim of this article is to describe the state-of-the-art of biocompatibility testing for dental materials, and present new strategies for improving operative dentistry techniques and the biocompatibility of dental materials as they relate to their interaction with the dentin–pulp complex.

Methods

The literature was reviewed focusing on articles related to biocompatibilty testing, the dentin–pulp complex and new strategies and materials for operative dentistry. For this purpose, the PubMed database as well as 118 articles published in English from 1939 to 2014 were searched. Data concerning types of biological tests and standardization of in vitro and in vivo protocols employed to evaluate the cytotoxicity and biocompatibility of dental materials were also searched from the US Food and Drug Administration (FDA), International Standards Organization (ISO) and American National Standards Institute (ANSI).

Results

While there is an ongoing search for feasible strategies in the molecular approach to direct the repair or regeneration of structures that form the oral tissues, it is necessary for professionals to master the clinical therapies available at present. In turn, these techniques must be applied based on knowledge of the morphological and physiological characteristics of the tissues involved, as well as the physical, mechanical and biologic properties of the biomaterials recommended for each specific situation. Thus, particularly within modern esthetic restorative dentistry, the use of minimally invasive operative techniques associated with the use of dental materials with excellent properties and scientifically proved by means of clinical and laboratory studies must be a routine for dentists. This professional and responsible attitude will certainly result in greater possibility of achieving clinical success, benefiting patients and dentists themselves.

Significance

This article provides a general and critical view of the relations that permeate the interaction between dental materials and the dentin–pulp complex, and establish real possibilities and strategies that favor biocompatibility of the present and new products used in Dentistry, which will certainly benefit clinicians and their patients.     

应用齿贝骨粉及矿化胶原膜修复小型猪拔牙创骨缺损的效果观察

目的：比较 Bio-Oss骨粉和齿贝骨粉修复拔牙窝骨缺损的成骨效果,评估齿贝牙科骨粉在拔牙窝骨缺损修复中的可靠性。方法：以引导骨再生术（GBR）为基本原理,在小型猪拔牙区制造骨缺损,分别植入齿贝牙科骨粉及Bio-Oss骨粉。术后12周进行肉眼观察、影像学检查及组织学染色。影像学检查测量骨缺损的成骨密度,采用SPSS 22.0软件包进行配对t检验,观察骨缺损修复情况。分析组织切片中新生骨在骨缺损区域所占面积的百分比,得出新生骨百分率,比较2种不同材料骨粉修复拔牙窝骨缺损的效果。结果：术后12周,CT显示不同组的拔牙窝骨缺损完全被新生骨填充,2种骨粉修复骨缺损效果无显著差异。组织学切片显示,与Bio-Oss骨粉相比,齿贝骨粉填充骨缺损区成骨量略有减少,但两者差异不显著。结论：齿贝牙科骨粉在拔牙窝骨缺损修复中具有可靠性,有必要做进一步临床研究。     

四环素骨诱导活性材料整复牙槽缺损的实验研究

目的将盐酸四环素处理的人离体非功能牙块用于诱导骨再生技术中,观察和比较其对牙槽骨再生修复的影响。方法拔除大鼠第一磨牙近中根做人工牙槽缺损。置入盐酸四环素处理的离体人牙块,以盐酸处理的离体人牙块为阳性对照,未做任何处理的离体人牙块为阴性对照。不同时期取材做组织观察和评价。结果四环素处理组炎症反应小,早期成骨明显。中晚期成骨量明显高于对照组。结论盐酸四环素处理的人离体非功能牙块有抑制骨吸收,诱导、促进牙槽骨再生等作用。