胃肠道间质瘤合并消化道癌17例临床诊治分析

目的：探讨胃肠道间质瘤合并消化道癌的临床特点、诊疗及预后。方法收集2010年7月-2015年6月湖北省荆州市中心医院收治的289例胃肠道间质瘤患者的病例资料,男性170例,女性119例,其中272例(94.1%)为单发胃肠道间质瘤(单发组),17例(5.9%)并发消化道癌(合并组)。采用t检验或Fisher确切概率法比较两组患者的年龄、性别、发病部位、肿瘤直径、有丝分裂指数和风险评估,并采用Kaplaln-Meier方法和Log-rank方法分析其预后。结果单发组和合并组在性别、年龄及肿瘤位置等方面无统计学差异。与单发组相比,合并组在肿瘤直径(P<0.001)、有丝分裂指数(P<0.05)和NIH危险分级(P<0.05)有统计学差异。合并组的中位随访时间分别为30个月(8~50个月),单发组为36个月(12~60个月),两组间的预后差异有统计学意义(P=0.008)。结论胃肠道间质瘤合并消化道癌发病率低,较单发胃肠道间质瘤患者预后差,根治性手术切除是GIST合并消化道癌的一种有效方法。     

胃癌合并胃间质瘤6例分析

胃癌同时合并胃间质瘤的病例少见,我院自2004-2010年共收治6例,现报道如下.临床资料回顾分析2004-2010年胃癌手术病例1246例,发现胃癌同时合并胃间质瘤6例,占胃癌切除病例的0.48％.其中男5例,女1例;中位年龄63岁(44 ～ 86岁).临床症状为上腹部隐痛不适,乏力,消瘦等,胃镜检查可见溃疡或肿瘤病变,病理活检确诊为胃癌.术前检查发现并发胃间质瘤2例(图1,2),未发现者4例.     

胃肠管间质瘤23例临床诊治分析

目的 探讨胃肠管间质瘤的诊断和治疗.方法 对2000年7月～2005年10月外科治疗的胃肠管间质瘤病例进行回顾性分析.结果 23例均行手术治疗,其中手术切除21例,未行手术切除2例.病理诊断良性7例,潜在恶性6例,恶性10例.随访时间10个月至6年,3例出现远处转移或局部复发,5例死亡.结论 胃肠管间质瘤术前确诊率低,超声内镜和影像学检查是发现胃肠管间质瘤病变的主要手段,其确诊依赖病理结果,手术切除是治疗的主要方法.     

十二指肠胃肠间质瘤22例诊治分析

目的探讨十二指肠胃肠间质瘤的临床特征、诊断与治疗。方法回顾分析2005年1月至2010年9月诊治的22例十二指肠胃肠间质瘤患者的临床病例资料。本组患者均行手术切除治疗,包括肿瘤局部切除12例,其中1例合并远端胃大部切除及右肾切除;十二指肠节段切除6例;胰十二指肠切除术4例,其中1例合并右半结肠切除。结果危险度分级为极低危组4例,低危组5例,中危组8例,高危组5例。CD117阳性率95．5％（21／22）,CD34阳性率86．4％（19／22）,SMA阳性率54．5％（12／22）,S-100阳性率9．1％（2／22）。术后随访10—66个月,平均随访30．9个月,其中20例获得完整随访,2例死于肿瘤复发或转移,余均无瘤生存。结论内镜超声和CT是术前诊断十二指肠胃肠间质瘤的有效方法,确诊需依靠病理及免疫组化。外科手术仍是当前十二指肠胃肠间质瘤最主要的治疗方法,需依据肿瘤的大小及部位采取不同的手术方式。高危患者术后联合靶向治疗可改善预后。     

腹部胃肠道外间质瘤六例分析

胃肠间质瘤是指胃肠道除平滑肌肿瘤、神经鞘瘤及神经纤维瘤以外,富于表达CD117的梭形、上皮样或多形性细胞的间叶源性肿瘤.该肿瘤不仅可以发生在消化道,也可以发生在消化道外的软组织,后者又被称为胃肠道外间质瘤(extragastrointestinal stromal tumor,EGIST).现回顺性分析我院从2005年2月1日至2008年7月30日期间收住院的6例EGIST患者的临床资料.     

小肠间质瘤41例的预后分析

目的 探讨影响小肠间质瘤预后的因素.方法 回顾性分析2005年1月至2010年12月河南省肿瘤医院普外科手术治疗的41例小肠间质瘤患者的临床及随访资料,进行NIH恶性危险度分级,采用Kaplan-Meier法比较不同因素对生存率的影响,并用COX多因素回归分析对该组病例进行预后分析.结果 本组41例小肠间质瘤患者位于十二指肠12例,空回肠29例,其中有消化道出血16例.有消化道出血史患者术后3年生存率为22％,而无出血史者为65％,两者相比差异有统计学意义(x2=6.613,P=0.012).COX多因素回归分析表明肿瘤原发部位、复发转移及消化道出血是小肠间质瘤预后的有效预测指标.结论 消化道出血是小肠间质瘤最常见的临床症状,肿瘤原发部位、复发转移及消化道出血是影响小肠间质瘤预后的独立影响因素.     

胃肠间质瘤12例诊治分析

目的探讨胃肠间质瘤的诊治方法。方法回顾性分析我院1998年1月~2006年1月收治的胃肠间质瘤12例的临床资料。结果本组12例均行手术治疗。术后病理免疫组化CD34阳性6例,CD117阳性7例。术后1年随访12例,3年随访10例,5年随访7例。结论对于反复消化道出血的中老年病人,如胃结肠内窥镜无阳性发现应高度怀疑本病。CT扫描对术前确诊帮助较大。完整的局部切除是最有效的治疗手段。     

胃肠道间质瘤的诊断和治疗

目的 总结胃肠道间质瘤的诊断与治疗经验。方法 回顾性总结分析27例胃肠道间质瘤的临床和病理资料。结果 本组胃间质瘤21例,十二指肠间质瘤4例,小肠间质瘤2例。临床表现为消化道出血者16例(59.3％),其中腹痛伴消化道出血者7例;腹痛13例(48.1％),其中上腹部疼痛者6例;以腹部肿块就诊者5例(18.5％)。25例行胃镜检查,确诊为间质瘤2例,发现病变部位22例。2例伴消化道大出血者急诊数字式减法血管造影(DSA)发现病变部位。病理诊断为良性间质瘤12例、交界性13例、恶性2例;良性间质瘤核分裂像和肿瘤直径均显著小于交界性和恶性者(P<0.05)。本组均行手术局部切除治疗,术后发生肺部感染2例,胃排空障碍1例。21例患者术后随访3～24个月,除1例小肠恶性间质瘤患者术后20个月腹壁切口复发外,其余20例均无肿瘤转移复发。结论 内镜和影像学检查对胃肠道间质瘤病变定位有重要作用,胃肠道间质瘤的确诊依靠病理学检查。手术局部切除是治疗胃肠道间质瘤的有效手段。     

直肠间质瘤12例诊治分析

直肠间质瘤是一种起于直肠间质细胞的消化道间叶性肿瘤,由未分化或多能的梭形或上皮细胞组成。临床少见,约占胃肠间质瘤的5％。直肠间质瘤早期临床症状较为隐匿,对其诊断和治疗,缺乏统一的共识。近年来文献报道越来越多,自2001年9月～2008年3月,鲁西南十个医院共收治直肠间质瘤患者12例,现报告如下。     

胃肠间质瘤9例临床诊治分析

目的 探讨胃肠间质瘤诊治方法及预后.方法 采用病例序列报道结合文献回顾分析的方法,评价和分析9例胃肠间质瘤患者临床资料及随访结果.结果 所有患者均采取手术治疗,5例复发均已死亡.4例未复发.手术后有2例患者口服甲磺酸伊马替尼(400 mg/d).结论 胃镜、B超、CT等检查对胃肠道间质瘤定位有较大作用,CD117是胃肠...     

胃癌合并胃间质瘤的诊治体会

目的 探讨胃癌合并胃间质瘤的诊断与治疗.方法 回顾性分析1996年1月至2009年12月18例胃癌合并胃间质瘤患者的临床资料.结果 本组18例患者均无特异性临床表现,术前确诊1例,术中确诊3例,术后确诊14例.胃癌病灶大小平均为(3.3±2.3)cm,胃间质瘤病灶大小平均为(0.9±0.5)cm.胃间质瘤病灶处于低度危险性16例,中度危险性2例.所有病例手术顺利,术后1、3、5年总体生存率分别为88%、63%和36%.结论 胃癌合并胃间质瘤的临床表现无特异性,其中胃间质瘤多为早期病灶,恶性程度低,采取以手术为主的综合治疗,预后主要取决于胃癌病灶.

Abstract：

Objective To study the diagnosis and treatment of synchronous gastric cancer and gastric stromal tumor in 18 cases. Methods Clinical data of 18 cases of synchronous occurrence of gastric cancer and gastric stromal tumor from January 1996 to December 2009 were analyzed retrospectively.Results Clinical features of all cases were atypical. There was 1 case diagnosed preoperatively, 3 cases diagnosed intraoperatively and 14 cases diagnosed postoperatively. The mean size of gastric cancer and gastric stromal tumor was (3.3±2.3) cm and (0.9 ±0.5) cm respectively. There were 16 cases of gastric stromal tumor in low risk of malignance and 2 cases in moderate risk of malignance. All cases were operated without complications and the 1-year, 3-year and 5-year overall survival rate was 88.2%, 63.2% and 36. 1% respectively. Conclusions Clinical features of synchronous occurrence of gastric cancer and gastric stromal tumor are atypical, in this series most gastric stromal tumors are in early stage and of low risk of malignance. The prognosis of patients with synchronous occurrence of gastric cancer and gastric stromal tumor mainly depends on gastric cancer.     

Synchronous gastrointestinal stromal tumor (GIST) and multiple digestive neoplasms, benign and malignant

Gastrointestinal stromal tumors (GIST) are a broad category of mesenchymal, non-epithelial primary tumors of the digestive tract, located in the wall of hollow viscera, from the esophagus to the anus and often in adjacent mesentery and omentum. They are clinically unpredictable (may be discovered incidentally during an imagistic investigation or during surgery for other pathological entity, or at necropsy) and also have an unpredictable behavior (GISTs with very low risk, with low or moderate malignancy, which have benign histopathologic features but can recurr or can metastasize). The case we present here represents a rare association between a synchronous gastrointestinal stromal tumor (GIST) and multiple gastric benign and malignant tumors.     

Risk factors for malignant evolution of gastrointestinal stromal tumors

Gastrointestinal stromal tumors are the most frequent non-epithelial digestive tumors, being classified in the group of primitive mesenchymal tumors of the digestive tract. These tumors have a non predictable evolution and where stratified regarding the risk for malignant behavior in 4 categories: very low risk, low risk, intermediate risk and high risk. We performed a retrospective non randomised study including the patients with gastrointestinal stromal tumors treated in the Department of General Surgery and Liver Transplantation of Fundeni Clinical Institute in the period January 2002 - June 2007, to define the epidemiological, clinico-paraclinical, histological and especially evolutive features of the gastrointestinal stromal tumors from this group, with a special regard to the risk factors for their malignant behavior. The most important risk factors in gastrointestinal stromal tumors are the tumor size and the mitotic index, based on them being realised the classification of Fletcher in the 4 risk categories mentioned above. In our group all the local advanced or metastatic gastrointestinal stromal tumors, regardless of their location, were classified in the group of high risk for the malignant behavior. The gastric location and the epithelioid type were positive prognostic factors, and the complete resection of the tumor, an other important positive prognostic feature, was possible in about 80% of the cases, probably because the gastrointestinal stromal tumors in our study were diagnosed in less advanced evolutive situations, only about one third being metastatic and about 14% being locally advanced at the time of diagnose. The association with other neoplasias was in our cases insignificant, only 5% of the patients presenting concomitant malignant digestive tumors and 7.6% intraabdominal benign tumors. Gastrointestinal stromal tumors remain a challenge for the medical staff, regarding their diagnose and therapeutical management, the stratification of the risk for their malignant behavior being essential for the evolution of these patients.     

Adenocarcinoma and gastro-intestinal stromal tumor: fortuitous association or a single carcinogenic agent? A report of 2 cases

The synchronous development of epithelial and stromal tumors of the digestive tract was rarely reported in the literature. Two such cases are described in this article. One is of a 44-year-old man presenting a high grade gastric stromal tumor associated with an adenocarcinoma of the large bowel. The other is of a 68-year-old man presenting an adenocarcinoma of the head of the pancreas associated with a low grade gastric stromal tumor. The hypothesis that the association is due to a simple coincidence particularly in areas with high rates of digestive cancer is proposed. A possibility of a genetic mutation or a single carcinogenic agent interacting with two tissues in the digestive tract and inducing the development of tumors of different histotype cannot be discarded.     

合并其他消化道恶性肿瘤的胃肠间质瘤临床病理特征及其诊治

目的探讨合并其他消化道恶性肿瘤的胃肠间质瘤（GIST）患者的临床病理特征及诊治方法。方法回顾性分析2004年9月至2012年11月间在上海仁济医院接受手术治疗的525例原发性GIST的临床资料,其中合并其他消化道恶性肿瘤者46例．未合并其他消化道恶性肿瘤者479例。结果合并其他消化道恶性肿瘤的46例GIST患者术前诊断率仅为2．2％（1／46）,按NIH术后危险度分级,极低危患者36例（78-3％）,低危患者9例（19．6％）,高危患者1例（2．2％）。与未合并其他消化道肿瘤的GIST患者相比,合并者多见于老年患者（P=0．001）,多发生于胃（P=0．000）,肿瘤直径更小（P=0．000）,核分裂像更少（P=0．000）,危险度更低（P=0．000）。46例患者5年生存率为36．1％,显著低于未合并者的82．2％（P=0．000）。结论合并其他消化道恶性肿瘤的GIST大多为低危或极低危险度,对预后影响较小,其预后主要取决于合并的消化道恶性肿瘤,故对其治疗主要针对合并的恶性肿瘤,同时在不明显增加手术风险和术后并发症的情况下可考虑一并切除GIST。     

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目的 总结肝脏与胃肠道同时存在甩块的处理原则。方法 分析１２例肝脏与胃肠道同时有肿块而术中或术后病理检查证实并非癌肿转移关系者的临床资料。结果 ７例为同时性双重癌,３例为肝脏癌肿并胃肠道良性疾病,１例为结肠癌伴套迭而肝脏病灶来自胰腺囊实性氏度恶性）,另１例肝脏与胃肠道均为良性疾病。结论 肝脏与胃肠道同时存在的肿块并不一定是癌肿转移,可能为同时性双重癌或伴发良性肿物,非团长 变的治疗与转移性癌截然不     

胃肠道间质瘤的诊治现状与进展

目的总结胃肠道间质瘤（GIST）的发病机制及流行病学特点,探讨其诊断及治疗并分析其预后。方法复习与GIST的发病机制、流行病学、诊断、治疗及预后方面有关的文献并对其进行综述。结果 GIST为非上皮源性肿瘤,起源于Cajal间叶细胞,是消化道最常见的间叶性肿瘤,约占消化道肿瘤的1%～3%,中位发病年龄为40～60岁,胃为最好发部位。目前认为,GIST的发病机制与原癌基因c-kit或血小板源性生长因子受体α（PDGFRα）基因突变有密切关系,但PDGFRα和c-kit基因突变不会同时出现在同一患者中。GIST的临床表现缺乏特异性,临床诊断主要依靠内镜及影像学技术,最终确诊依靠病理学检查。目前对GIST的治疗以手术与分子靶向药物治疗为主,其预后与肿瘤危险度分级及治疗干预密切相关。结论 GIST是具有恶性潜能的肿瘤,其危险度分级是指导临床治疗及预后评估的重要指标,GIST的预防、诊断、治疗及复发的预防有待进一步研究。