可吸收缝线固定移位带角膜缘干细胞结膜瓣术治疗原发性翼状胬肉

目的:观察可吸收缝线固定移位带角膜缘干细胞结膜瓣术治疗原发性翼状胬肉临床疗效。方法:对52例52眼原发性翼状胬肉行可吸收缝线固定移位带角膜缘干细胞结膜瓣术。结果:随访6～36mo,2例复发,复发率为4%。结论:可吸收缝线固定移位带角膜缘干细胞结膜瓣术治疗原发性翼状胬肉,复发率低,疗效满意。     

无缝隙缝合带角膜缘干细胞结膜瓣术治疗翼状胬肉

目的 观察应用无缝隙缝合带角膜缘干细胞结膜瓣术治疗翼状胬肉的临床疗效.方法 对100例(120)眼原发性翼状胬肉行无缝隙缝合带角膜缘干细胞结膜瓣术.结果 随访6～24月,1例复发.结论 无缝隙缝合带角膜缘干细胞结膜瓣术治疗翼状胬肉,复发率低,疗效良好.     

单纯胬肉切除、角膜缘干细胞移植与带蒂结膜瓣移植治疗翼状胬肉疗效比较

目的比较单纯胬肉切除、角膜缘干细胞移植及带蒂结膜瓣移植术治疗翼状胬肉的疗效，探讨降低术后复发率的方法。方法667例（718眼）翼状胬肉，采用上述三种术式治疗，术后随访5～20个月观察胬肉复发情况。结果单纯胬肉切除术组62例（62眼），6眼胬肉复发，复发率为9．68％。联合角膜缘干细胞移植术组430例（462眼），3眼复发，复发率0．65％。联合带蒂结膜瓣移植术组175例（194眼），2眼复发，复发率1．03％。单纯切除组与其他两组复发率之间差异具有统计学意义（P〈0．01）。联合角膜缘干细胞移植组与联合带蒂结膜瓣移植组之间差异不具有统计学意义（P〉0．05）。结论胬肉切除联合角膜缘干细胞移植术治疗翼状胬肉其复发率与联合带蒂结膜瓣移植术相比无明显优势。两者术后复发率均明显低于单纯胬肉切除术。     

翼状胬肉切除联合带角膜缘上皮的自体结膜瓣移植术152例疗效观察

目的 探讨翼状胬肉切除联合带角膜缘上皮的自体结膜瓣移植术的疗效。方法 对152例(182只眼)翼状胬肉患者行翼状胬肉切除后联合带角膜缘上皮的自体结膜瓣移植术。术后随访观察6～12个月。结果 术后复发10只眼，复发率5．49％，其中3只眼为复发性翼状胬肉。结论翼状胬肉切除联合带角膜缘上皮的自体结膜瓣移植术方法简单、疗效可靠。     

翼状胬肉撕离联合不同角膜缘干细胞移植

目的比较翼状胬肉撕离联合自体游离结膜瓣角膜缘十细胞移植及带蒂结膜瓣角膜缘干细胞移植治疗翼状胬肉的临床疗效。方法91例（97眼）翼状胬肉随机分为A、B两组．A组45例（47眼）行翼状胬肉撕离联合白体游离结膜瓣角膜缘干细胞移植术;B组46例（50眼）行翼状胬肉撕离联合带蒂结膜瓣角膜缘干细胞移植术。术后随访6～30月,比较两组术后角膜缘干细胞植片存活及翼状胬肉复发情况。结果A组5眼移植片脱落,B组植片无脱落,（X2=5．31,P〈0．05）。A组6眼翼状胬肉复发,复发率为12．76％;B组巾1眼复发,复发率仅为2．00％;（X2=5．20,P〈0．05）。结论翼状胬肉撕离联合带蒂角膜缘干细胞移植术,植片存活率高,翼状胬肉复发率低。     

自体带结膜瓣的角膜缘移植治疗翼状胬肉

目的 观察采用巩膜隧道刀切取的自体带结膜瓣的角膜缘移植片治疗翼状胬肉的临床疗效.方法 对52例(60眼)采用翼状胬肉切除和自体带结膜瓣的角膜缘移植的翼状胬肉的资料进行回顾性研究.术后随访6～12月,观察术后角结膜植片生长情况,供区创面修复时间及翼状胬肉复发情况.结果 供区创面修复为7～10 d,角结膜植片生长良好.2眼复发,复发率3.33%.结论 采用巩膜隧道刀切取的自体带结膜瓣的角膜缘移植片能有效地降低翼状胬肉术后的复发率.     

自体带结膜瓣角膜缘干细胞移植治疗翼状胬肉

目的降低翼状胬肉术后复发率,减少术后并发症。方法采用自体带结膜瓣角膜缘干细胞移植治疗63例(68眼) 翼状胬肉患者。结果68眼中显效62眼,有效4眼,复发2眼,总有效率97％。结论采用自体带结膜瓣角膜缘干细胞移植, 可有效维持角膜上皮与结膜上皮之间的屏障作用,阻止异常结膜源性组织的再侵入,从而降低翼状胬肉术后复发率。     

不同术式治疗翼状胬肉的疗效分析

目的分析3种不同的手术方式治疗翼状胬肉的临床效果,探寻减少复发的最佳术式。方法第1组44例（46眼）行单纯翼状胬肉切除术;第2组44例（44眼）行带蒂结膜瓣移植联合丝裂霉素C湿贴术;第3组41例（41眼）行角膜缘干细胞移植术。结果术后随访观察6个月至2年。第1组有10眼复发、复发率为21.74%;第2组有2眼复发、复发率为4.54%;第3组有1眼复发、复发率为2.44%。结论带蒂结膜瓣移植联合应用丝裂霉素C湿贴治疗翼状胬肉,较单纯切除术的复发率低。自体角膜缘干细胞移植可有效降低翼状胬肉术后的复发率最低。     

自体角膜缘干细胞移植与结膜瓣转位治疗翼状胬肉的对比研究

目的 探讨自体角膜缘干细胞移植与结膜瓣转位治疗翼状胬肉的疗效.方法 将126例(214眼)翼状胬肉患者随机分为2组:角膜缘干细胞移植组58例92眼,结膜瓣转位组68例122眼,分别在手术显微镜下行胬肉切除联合自体角膜缘干细胞移植术和胬肉切除联合结膜瓣转位术,术后随访1 a,观察并比较2组复发率和并发症情况.结果 术后1 a,自体角膜缘干细胞移植组4眼复发,复发率为4.35%,结膜瓣转位组23眼复发,复发率为18.85%,2组术后复发率比较差异有显著统计学意义(P=0.002<0.01).角膜缘干细胞组无一眼发生睑球粘连,而结膜瓣转位组有9眼出现睑球粘连.结论 自体角膜缘干细胞移植是治疗翼状胬肉的一种有效方法 .     

翼状胬肉撕离联合带角膜缘结膜瓣转位术疗效观察

目的探讨翼状胬肉头部撕离方式切除联合自体带角膜缘结膜瓣转位术治疗翼状胬肉的临床效果。方法在手术显微镜下采取用有齿镊逆行撕离胬肉头部后用上方带角膜缘结膜瓣转位方式治疗翼状胬肉58例(61眼),术后随访3月~1年。结果随访期内有3眼复发(4.96%)。未发现睑球粘连。结论翼状胬肉逆行撕离联合上方带角膜缘结膜瓣转位术有利于重建角膜缘干细胞功能,可较大幅度地降低胬肉术后复发率。     

Strabisme Alternant - Etude clinique - traitement

The author defines motor and sensory alternation: the term alternation should not be used in isolation, it should always be accompanied by the name of the parameter concerned. Sensory alternation is always found together with motor alternation but the reverse is not true.The examining criteria for a diagnosis of sensory alternation are given, sensory alternation must not be confused with alternating inhibition. Working from clinical observations of cases of motor alternating strabismus, the author selects 2 types of binocular sensory relations which allow one to differentiate between:- cases of primary alternating strabismus- cases of secondary alternating strabismusThese forms will develop in different ways; in both cases a cure is possible providing that the right treatment is prescribed and once prescribed carefully followed, etc. It is always a case of serious forms of strabismus whose developmental period is spread over several years.According to the authors, the frequency of cases of true primary strabismus is from 1–3%, the frequency of cases of secondary alternating strabismus varies according to the type of therapy practised on cases of monocular strabismus with amblyopia. These latter will become cases of alternating strabismus under the influence of certain types of therapy carried out over several years (penalization, rocking, alternated occlusion, etc...).Experimental data on kittens confirm clinical data; kittens placed in abnormal environments during the sensitive period will show modification in the distribution of cortical cells and the absence of binocular cells (either because the excitation of the two eyes was not simultaneous, or not identical: artificial strabismus, occlusion, opaque glasses). This disturbances become irreversible after a certain period of exposure (a function of age, length of exposure, etc...).It is thus necessary to bear in mind: 1) the iatrogenic risks of certain orthoptic treatments, 2) the necessity for a binocular form of treatment as soon as possible, as once a certain stage is passed, cortical plasticity diminishes and the elaboration of normal binocular relations becomes impossible.

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Effects of Adenosine Agonists on Intraocular Pressure and Aqueous Humor Dynamics in Cynomolgus Monkeys

The effects of single or multiple topical doses of the relatively selective A₁adenosine receptor agonists (R)-phenylisopropyladenosine (R-PIA) and N⁶-cyclohexyladenosine (CHA) on intraocular pressure (IOP), aqueous humor flow (AHF) and outflow facility were investigated in ocular normotensive cynomolgus monkeys. IOP and AHF were determined, under ketamine anesthesia, by Goldmann applanation tonometry and fluorophotometry, respectively. Total outflow facility was determined by anterior chamber perfusion under pentobarbital anesthesia. A single unilateral topical application of R-PIA (20–250 μg) or CHA (20–500 μg) produced ocular hypertension (maximum rise=4.9 or 3.5 mmHg) within 30 min, followed by ocular hypotension (maximum fall=2.1 or 3.6 mmHg) from 2–6 hr. The relatively selective adenosine A₂antagonist 3,7-dimethyl-1-propargylxanthine (DMPX, 320 μg) inhibited the early hypertension, without influencing the hypotension. Neither 100 μg R-PIA nor 500 μg CHA clearly altered AHF. Total outflow facility was increased by 71% 3 hr after 100 μg R-PIA. In conclusion, the early ocular hypertension produced by topical adenosine agonists in cynomolgus monkeys is associated with the activation of adenosine A₂receptors, while the subsequent hypotension appears to be mediated by adenosine A₁receptors and results primarily from increased outflow facility.