喜炎平注射液致过敏死亡

患者男,60岁,因不慎右足烫伤后感染,于2002年12月31日来医院治疗,给予喜炎平注射液6支(每支50mg)静滴,每日一次治疗。当日静滴后,患者出现右上肢肿胀疼痛,活动困难,未予注意。次日仍继续静滴喜炎平注射液治疗。静滴时,患者右上肢肿胀加重,约3h后,患者出现呼吸困难,且伴有晕厥,意识丧失约2~3min,二便失禁,无头痛、呕吐及抽搐。查体:T36.0℃,BP80/50mmHg(1mmHg=0.133kPa),呼吸急促,神志清楚,精神不振,面颊潮热,呈弥漫性肿胀,右眼睑浮肿明显,启目困难,右上肢肿胀疼痛,肘窝处皮肤可见4cm×4cm破损,上臂尺侧散在出血性疱疹,双肺未闻及干湿音,…     

帕博利珠单抗致致死性Stevens-Johnson综合征/中毒性表皮坏死松解症1例

1 临床资料患者,男,62岁,1月前无明显诱因下解黑色糊状便,伴纳差、乏力,腹胀明显.2020年7月6日胃镜病理示:(胃底近贲门)腺癌.2020年7月13日PET-CT示:纵隔、肝门区、网膜囊顶、胃小弯旁及肠系膜多发淋巴结转移;两肺多发转移;肝内广泛转移;全身多处骨转移.2020年7月17日予以XELOX方案:奥沙利...     

Synthesis of Aspartame by Thermolysin: An X-ray Structural Study

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电子肠镜定位下腹腔镜辅助结肠息肉切除10例临床分析

目的：探讨电子肠镜定位下施行腹腔镜辅助结肠息肉切除的手术方法及注意事项。方法：回顾分析10例电子肠镜定位下施行腹腔镜辅助结肠息肉切除患者的临床资料,对手术方法及注意事项进行探讨。结果：本组10例患者均痊愈出院。平均手术时间为（75.00±19.58） min;平均术中出血为（37.00±9.49） ml;平均首次肛门排气时间为（38.40±15.02） h;平均住院时间为（8.20±0.79） d。随访6～12个月未见复发。定位点与息肉基底部所在的肠管横断面距离最短0 cm,最长6 cm。镜下仅1例隐约有息肉影,其余9例均看不到息肉影。定位点有6例偏向息肉近侧,2例偏向远侧,2例在准确位置上。结论：电子肠镜定位腹腔镜辅助结肠息肉切除是安全可行的方法;但一般不能看到明确的息肉影,仅靠光感定位及器械触碰与肠镜观察配合定位,术中适当调整肠镜光强度和镜头角度并注意双镜配合,可获较准确的定位效果。     

Effect of interleukin-10 on pancreatic damage caused by organophosphate poisoning

Organophosphate poisoning is a common cause of severe morbidity and mortality in emergency departments. Acute pancreatitis is a frequently reported consequence of organophosphate poisoning, but preventing this potentially severe complication has not been the subject of much research. We tested whether interleukin-10, a cytoprotective agent, could prevent or diminish pathological signs of acute pancreatitis caused by organophosphate poisoning. Thirty rats were divided into three equal groups. Group 1 did not receive any agent during the experiment. Group 2 received 0.8 g/kg fenthion intraperitoneally, followed by 6 ml/kg intraperitoneal normal saline 30 min and 3 h later. Group 3 received 0.8 g/kg fenthion intraperitoneally, followed by 2 microg/kg of interleukin-10 intraperitoneally 30 min and 3 h later. All rats underwent laparotomy and thoracotomy while still under anesthesia at 6 h, and tissue samples were obtained from the pancreas. After blood samples were taken by cardiac puncture, the animals were sacrificed. Organophosphate poisoning resulted in significant elevations of serum amylase and glucose. Interleukin-10 significantly reduced pancreatic damage as determined by pathologic scoring, but not by enzyme elevations. Interleukin-10 should be considered for larger studies in other animal models to confirm its ability to decrease pancreatic damage after organophosphate poisoning treatment with interleukin-10.     

Effect of interleukin-10 on tissue damage caused by organophosphate poisoning

Organophosphate poisoning is a common cause of severe morbidity and mortality among patients admitted to emergency departments. Tissue damages as a consequence of organophosphate poisoning are frequently reported, but preventing this potentially severe complication has not been the subject of much research. We tested whether interleukin-10, a cytoprotective agent, could prevent or diminish pathological signs of tissue damages caused by organophosphate poisoning. Thirty rats were divided into three equal groups (n = 10). Group 1 (sham) did not receive any agent during the experiment. Group 2 (control) received 0.8 g/kg of fenthion intraperitoneally, followed by 6 ml/kg of intraperitoneal normal saline 30 min and 3 hr later. Group 3 (treatment) received 0.8 g/kg of fenthion intraperitoneally, followed by 2 microg/kg of interleukin-10 intraperitoneally 30 min and 3 hr later. All rats were killed under anaesthesia after 6 hr and tissue samples were obtained from liver, kidneys and lungs. Even organophosphate poisonings do not cause significant clinical problems; several degrees of damages could be observed in liver, kidneys and lungs. These damages could be reduced by interleukin-10 treatment.     

Synthesis of Novel Analogs of Cabergoline: Improving Cardiovascular Safety by Removing 5-HT2B Receptor Agonism

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