基于BP神经网络的半夏泻心汤及其类方配伍模型研究

半夏泻心汤为<伤寒论>调和脾胃的代表方.由半夏、干姜、黄芩、黄连、人参、甘草及大枣7味药组成,用于治疗小柴胡汤证误下所致的心下痞证.半夏泻心汤类方生姜泻心汤为该方加生姜,减干姜用量;甘草泻心汤为在此基础上重用甘草.     

半夏泻心汤的临床运用

半夏泻心汤出自《伤寒论》。由半夏、黄芩、干姜、人参、黄连、甘草、大枣组成。半夏泻心汤即小柴胡汤去柴胡加干姜、黄连,主治脾胃虚弱而寒热互结,升降失调而以呕吐为主的痞证。笔者用本方治疗多种疾病,取得了满意的疗效。现举验案数则如下。     

半夏泻心汤加减在临床中的运用

半夏泻心汤出自《伤寒论》第149条:“伤寒五六日,呕而发热者,柴胡汤证具……但满而不痛者,此为痞,柴胡不中与之,宜半夏泻心汤。”半夏泻心汤是一首治疗寒热错杂证的主方,由半夏、黄芩、黄连、人参、甘草、干姜、大枣组成。此证气机升降不利,中焦痞塞,胃气不降而生热,处方用芩、     

半夏泻心汤临证应用体会

<正> 半夏泻心汤出自张仲景《伤寒论》一书。本方由三大类药物组成:一类为苦寒药如黄连、黄芩;一类为辛温药如干姜、半夏;一类为益气补中药如人参、甘草、大枣。属于调和剂范畴,原治因小柴胡汤误下形成的痞证。所谓痞证即胃脘痞满、堵塞不适之感。《伤寒论》中治疗痞证的方剂计5个,其中寒热互结而致心下痞的有3个,即半夏泻心汤、生姜泻心汤、甘草泻心汤,虽然三方在病因病机及适应证方面同中有异,但均以本方为基础而进行化裁。方中以半夏辛开散结、降逆止呕;干姜辛温散寒;黄芩、黄连苦寒降逆以清中焦之     

半夏泻心汤的临症运用

《伤寒论》半夏泻心汤,由半夏、黄芩、干姜、人参、甘草、黄连、大枣七药组成,具有辛开苦降,寒热同治,补中益气的功能。主治邪滞中焦,寒热虚实错杂的病证。笔者临床常用此方治疗痞满     

《伤寒论》五泻心汤类方证探析

五泻心汤类方出自《伤寒论》,为治疗痞证而设,千百年来一直应用于临床,疗效昭彰,是著名的系列古方。五泻心汤类方在组成上都有黄连,其中半夏泻心汤、生姜泻心汤、甘草泻心汤组方用药大同小异,均有生姜(或干姜)、黄连、黄芩、半夏、人参、甘草、大枣;而大黄黄连泻心汤、附子泻心     

半夏泻心汤临床应用近况

半夏泻心汤始由半夏、黄连、黄芩、甘草、人参、干姜、大枣组成,寒热平调,消痞散结,健运脾胃,旺盛气血,补气,清热,和中。该方药简意深,配伍精当,寒温并用,攻补兼施,原治少阳证误下、少阳邪热内陷、寒热郁结中焦等引起的"但满而不痛","呕而肠鸣、心下痞"等症。今人应用半夏泻心汤治疗功能性消化不良、复发性口腔溃疡、慢性胃炎、糖尿病性胃轻瘫、消化性溃疡等疾病效果显著     

浅谈半夏泻心汤的异病同治

半夏泻心汤,出自于东汉著名医家张仲景的名著《伤寒论》。是他在长期临床实践中反复验证的经典名方。最初始自于小柴胡汤证误下而导致的心下痞证。小柴胡汤证误用下法后,误伤中阳,外邪乘机而入,寒热互结于中焦,由半夏、黄芩、黄连、干姜、人参、大枣、炙甘草组成。本方用黄芩、黄连苦寒之性清其中焦之热,干姜、半夏之辛温散其寒,人参、炙甘草、大枣甘温益气补其虚。在临床中应用于湿热中阻,损伤脾胃的胃肠疾病,以及湿热下注于下焦而引起的妇科带下病等。同病异治、异病同治是中医辨证论治的精髓之一。     

半夏泻心汤对幽门螺杆菌相关性胃炎小鼠血清IL-2、IL-8影响的实验研究

目的:探讨半夏泻心汤治疗幽门螺杆菌相关性胃炎的机制。方法:将90只小鼠随机分成10组,除正常组外,其余小鼠灌胃造模后分别给予相应药物灌胃治疗。半夏泻心汤组(由半夏、黄连、黄芩、人参、干姜、炙甘草、大枣组成),半夏组(单味半夏),甘温组(由人参、甘草、生姜、大枣组成),苦寒组(由黄连、黄芩组成),半夏加苦寒组(由半夏、黄连、黄芩组成),半夏加甘温组(由半夏、人参、甘草、干姜、大枣组成),苦寒加甘温组(由黄连、黄芩、人参、甘草、干姜、大枣组成),阳性对照组(给予氨苄西林胶囊),模型组和正常组(给予等量白开水灌胃)。主要观察各组小鼠血清中自细胞介素-2(IL-2)、白细胞介素-8(IL-8)的含量。结果:各组小鼠IL-2含量:正常组、半夏泻心汤组、阳性对照组分别与模型组比较,差异均有非常显著性意义(P<0.01);苦寒加甘温组与模型组比较,差异有显著性意义(P<0.05)。各组小鼠IL-8含量:正常组、半夏泻心汤组、苦寒组、半夏加苦寒组、苦寒加甘温组、阳性对照组分别与模型组比较,差异均有非常显著性意义(P<0.01)。结论:半夏泻心汤通过降低血清中IL-8、升高IL-2的含量而减轻炎症反应,提高机体免疫力而发挥其治疗作用。     

半夏泻心汤在消化系统疾病中的应用

半夏泻心汤方出自张仲景《伤寒杂病论》一书,原方由半夏、黄芩、干姜、人参、甘草、黄连、大枣组成,其类方包括生姜泻心汤、甘草泻心汤等,张仲景用其治疗痞证。半夏泻心汤类证注家一般称为“寒热错杂痞证”,其症多兼呕、利,实即脾胃湿热证(或兼脾虚)。其产生原因,张仲景责之于“攻下过早”,即湿     

《温病条辨》药物性味配伍规律探讨

探讨《温病条辨》所载方剂的性味配伍规律。认为其"辛苦咸寒以清热、苦辛寒温以祛湿、酸甘咸寒以滋阴、苦酸甘咸调水火",并分别以银翘散、白虎汤、清营汤、茵陈汤、清燥救肺汤等举例说明。     

脾阳虚证用药规律浅析

目的:通过对近现代临床应用于脾阳虚证的方剂进行统计分析,探讨脾阳虚证用药规律。方法:运用SPSS 19.0统计软件,对脾阳虚证方剂中的中药进行频次分析,并对所用中药的性味、功效进行统计分析。结果:共收集方剂83首,涉及药物86味。药物使用频次显示甘草、干姜、人参、白术、陈皮、附子、木香、肉桂、茯苓、丁香等为常用药物,以补气药、温里药、理气药为主。性味分布情况显示治疗脾阳虚证以温、热、平性及辛、甘、苦味药为主,以辛热、辛温、甘平、辛苦温药居多。结论:脾阳虚证的遣方用药规律为药性上以温药、热药为主,药味上以辛、甘味为主,药物选择以补气药(甘草、人参、白术)和温里药(干姜、附子)为主,为临床脾阳虚证的治疗提供了理论依据。     

谈半夏泻心汤之演化方半芥泻心汤

半芥泻心汤系半夏泻心汤加白芥子而成。如此配伍有两个特点,一是增强本方豁痰开结之力,弥补因半夏毒性而用量受限的缺憾;二是增加本方疏肝气之功效。经临床应用,取得了较为满意的效果。本文阐述如此配伍的理论依据,并附临床验案3则。希望通过优化方剂配伍,实现其增效减毒的目的。     

论麻杏石甘汤证无表证

仲景麻黄与石膏同用,若要保留方中解表功能,一是麻黄用量大于石膏用量(可因表证轻重配伍辛温解表之品);二是在麻黄用量小于(或等于)石膏用量时,必定配伍辛温解表之品,或是解表之方(如桂枝汤等)。麻杏石甘汤中麻黄虽用4两,生石膏则用至半斤,麻黄与石膏之比是1∶2。此时,由于方中石膏用量大于麻黄用量一倍,也无辛温解表之品,或是解表之方,则本方实无表证。     

Towards a scientific rationale for traditional properties of Chinese medicinal plants: a€?naturesa€? and a€?flavorsa€?

Objective According to theory of Chinese medicine property, the ecological environment shapes properties (natures and flavors) of Chinese materia medica (CMM) and there are close relationships between certain natures and flavors. However, to date these observations have not been validated scientifically in the context of the whole flora of a region. The present study aims to address this gap. Methods We collected geographical distributions of 3637 vascular plant species native to the Xinjiang region of northwest China, of which around 812 are medicinal plants. The CMM property characters of these medicinal plants were also collected. All medicinal plants were then analyzed in the occurrence of their natures (cold, cool, neutral, warm, and hot) and flavors (sweet, bitter, sour, salty, and pungent). Possible correlations between these properties and environmental factors, notably climate, as well as correlations with plant species richness of the wider native flora of Xinjiang were then investigated using permutation test and regression. Results Cold species (38.5%) were more numerous than warm (21.0%) and neutral (22.3%), while bitter species (43.3%) were more numerous than pungent (25.6%), sweet (22.4%) and sour (6.7%) ones. Species with bitter flavor were most commonly also cold (48.6%) in nature, sour flavor usually coincided with cold (44.2%) or cool nature (26.0%), whereas pungent or sweet species tended to be warm (34.4%, 28.4%) or neutral (27.8%, 28.4%). The percentages of species of cold/cool nature, bitter flavor were higher in mountainous regions, and the percentages of warm/neutral and pungent/sweet/sour were higher in basins. The percentages of species of bitter, cold/cool, bitter were positively correlated with actual evapotranspiration (AET), plant species richness andbut had a bell-shaped relationship with potential evapotranspiration (PET), whereas the inverse situation was shown for warm/neutral and pungent/sweet/sour species. Conclusion Analysis of the data in Xinjiang region of China supports the qualitative observations concerning natures and flavors in traditional theory of Chinese medicine property. Specifically, (i) certain natures and flavors co-occur more frequently than if randomly distributed; (ii) correlations between proportions of natures and flavors and climatic variables suggest a role for the environment in shaping the properties of CMM.     

Towards a scientific rationale for traditional properties of Chinese medicinal plants: “natures” and “flavors”

Objective: According to theory of Chinese medicine property, the ecological environment shapes properties(natures and flavors) of Chinese materia medica(CMM) and there are close relationships between certain natures and flavors. However, to date these observations have not been validated scientifically in the context of the whole flora of a region. The present study aims to address this gap.Methods: We collected geographical distributions of 3637 vascular plant species native to the Xinjiang region of northwest China, of which around 812 are medicinal plants. The CMM property characters of these medicinal plants were also collected. All medicinal plants were then analyzed in the occurrence of their natures(cold, cool, neutral, warm, and hot) and flavors(sweet, bitter, sour, salty, and pungent). Possible correlations between these properties and environmental factors, notably climate, as well as correlations with plant species richness of the wider native flora of Xinjiang were then investigated using permutation test and regression.Results: Cold species(38.5%) were more numerous than warm(21.0%) and neutral(22.3%), while bitter species(43.3%) were more numerous than pungent(25.6%), sweet(22.4%) and sour(6.7%) ones. Species with bitter flavor were most commonly also cold(48.6%) in nature, sour flavor usually coincided with cold(44.2%) or cool nature(26.0%), whereas pungent or sweet species tended to be warm(34.4%, 28.4%) or neutral(27.8%, 28.4%). The percentages of species of cold/cool nature, bitter flavor were higher in mountainous regions, and the percentages of warm/neutral and pungent/sweet/sour were higher in basins. The percentages of species of cold/cool, bitter were positively correlated with actual evapotranspiration(AET),and also plant species richness but had a bell-shaped relationship with potential evapotranspiration(PET),whereas the inverse situation was shown for warm/neutral and pungent/sweet/sour species.Conclusion: Analysis of the data in Xinjiang region of China supports the qualitative observations concerning natures and flavors in traditional theory of Chinese medicine property. Specifically,(i) certain natures and flavors co-occur more frequently than if randomly distributed;(ii) correlations between proportions of natures and flavors and climatic variables suggest a role for the environment in shaping the properties of CMM.     

《伤寒论》治呕方药统计

目的:探讨《伤寒论》治疗呕吐的遣方用药特点,为学习研究和临床治疗提供参考。方法:整理《伤寒论》中治疗呕吐的方剂,对"呕吐"关键词的出现频数,治呕方药使用频数、频率,以及四气五味、脏腑归经进行统计分析。结果:《伤寒论》中含"呕吐"相关字词的条文达87条,治呕方剂共31首,药味精简,最多不超过10味,除去瓜蒂散及重复的药物后,一共运用了45种药物。结论:《伤寒论》治呕善用辛甘温热之品,从脾胃论治为主,八法之中尤重和法。     

从半夏、生姜、甘草“泻心汤”论寒热错杂痞证

试从半夏、生姜、甘草三“泻心汤”的角度,分析原文,结合实践,探讨《伤寒论》中寒热错杂痞证的病名、成因、治疗及用药规律,感悟经典之魅力,启发思维,指导临床.     

青龙白虎汤方解(二)——从陶氏生化角度看《五脏用药法要》青龙白虎汤

经方青龙、白虎^[1],效力无与伦比,释者说法各异。用小补汤实化脏功能;再用兼味药实化下级脏功能,以虚生本级脏体。经两步放大,使本脏功能持久而强劲地显示,从而驱散病邪,恢复机体健康。作者认为这是陶弘景五味生化方剂的本来面目。在今天看来,这种重开视窗,纯用陶弘景的兼味学说,查看方剂结构,解释方剂原理,应该也有现实意义。     

从肠道菌群论半夏泻心汤证治

半夏泻心汤证由虚、寒、热三证组成.虚主要为脾胃运化水湿能力减弱,气属阳,脾气虚,则脾阳不足,寒从内生,形成中焦虚寒证.肠道菌群紊乱,线粒体能量代谢障碍,则细胞因缺乏能量致功能受损,表现为脾气虚.另外,肠道菌群紊乱,有益菌减少,影响肠道消化、吸收、代谢功能,导致脾胃功能低下.热证是半夏泻心汤证最明显特征,其形成机制是肠道...