Young apheresis platelet donors show significant and sustained growth over the last decade in the US, 2010–2019: A favorable sign of the resiliency of the platelet supply

Background

Platelet demand continues to rise and US hospitals frequently face shortages. The peak median age of apheresis platelet donors (APD) is believed to have increased over the last decade, raising concerns that the APD base is not being adequately replenished with young donors.

Study Design/Methods

American Red Cross (ARC) apheresis platelet collections were evaluated from calendar years 2010 through 2019. APD, products per procedure/split rate (PPP) and donation frequencies were stratified into age groups.

Results/Findings

The number of unique APD from calendar year 2010 through 2019 in the ARC donor pool increased from 87,573 to 115,372 donors, representing a 31.7% overall growth. Donors in the 16–40 year-old (y) age group increased by 78.8% overall, with the largest absolute increases seen in the 26–30 y (4852 donors, 99.9% growth), followed by the 31–35 y (3991, 94.1%) group. Donors aged 56+ increased by 50.4% overall, with the largest increase seen in the 66–70 y (5988 donors, 108.1% growth) group. Middle-aged donors, aged 41–55 y, demonstrated a decrease of 16.5%. Over the last decade, the youngest age groups (16–40 y) comprised 61.3% of first-time donors (FTD). Annual donation frequency increased with increasing age and PPP. The highest donation frequencies were seen in the oldest age groups.

Conclusion

Although the peak median age of APD increased over the study period, relative contribution of the 16–40 y APD base also increased. Older donors exhibited the highest donation frequencies and thus contributed the largest volume of apheresis platelet units. Platelet donor activity declined in the middle age (41–55 y) group.     

对无偿献血者未能成为固定献血者的原因分析和探讨

目的分析探讨无偿献血者未能成为固定献血者的原因。方法根据献血者登记资料的电话号码对一般献血者进行电话回访,询问其未能成为固定献血者的原因。结果电话回访2 801人,成功2 016人,没有时间、畏惧针刺疼痛、再次献血时未通过献血前筛查是阻碍无偿献血者未能成为固定献血者的主要原因。结论影响无偿献血者未能成为固定献血者的原因是多方面的,只有为无偿献血者提供更便利的条件、更好的服务、更多的尊重才能让更多的无偿献血者成为固定献血者。     

固安县献血(浆)者HCV和HBV感染的血清学追踪观察

1985年固安县献浆者中发生丙型肝炎流行。1986年初,调查了该县当年(1985年)献浆村、献浆5年村和基本无献血村的献浆者和献全血者HCV和HBV的感染状况,1990年又追踪观察。结果是1986年和1990年献浆者抗-HCV阳性率分别为64.7％和43.9％。在献浆者中ALT异常的抗-HCV阳性率分别为77.5％和81.1％;ALT正常的分别为51.3％和34.3％。献浆者抗-HCV阳性率均高于献全血者和非献血成人。提出在固安县供血单位增加抗-HCV筛选献血者势在必行。另外对91例抗-HCV阳性献浆者第5年又进行了追踪观察,阴转率为30.8％,约有70％的病例转为慢性。     

家属对亲属器官捐献决定的影响因素及对策研究

[目的]通过参与协调的潜在心脏死亡遗体器官捐献(DCD)案例,探讨影响家属决定亲属器官捐献的因素及解决对策.[方法]2010年3月至2011年3月,对51例潜在捐献者家属进行开放式访谈,探讨协调介入时间和环境、协调员的专业水平、家属对脑死亡及捐献流程信息的了解、家庭组成对家属捐献决定的影响.[结果]成功捐献的案例,协调...     

Reaction rates in allogeneic donors

In Canada and several other countries, there is an upper age limit for blood donation. In order to evaluate the safety of whole blood donation in elderly Canadian allogeneic donors, we analysed reaction rates following whole blood donation. Reactions rates in allogeneic whole blood donors who donated at Canadian Blood Services were reviewed retrospectively. Rates were analysed by age, donation frequency and by donation frequency for each age group. A total of 5478 reactions were available for analysis in 469 837 donors. The highest rate of mild reactions occurred in donors less than 20 years of age. Moderate and severe reactions decreased with increasing age and with donation frequency. Age-adjusted rates for mild reactions were less frequent in donors aged 66-77 years than in donors younger than 20 years. Although age-adjusted moderate reactions varied with donation frequency, after seven donations, rates were not increased for donors aged 60 years or older (0.61% for donors aged less than 20 years compared to 0.03% for donors aged 60-65 years compared to 0% for donors aged 66-71 years). Age-adjusted rates for severe reactions generally did not increase with donation frequency. These results confirm the safety of whole blood donation in regular donors who are 66-71 years of age.     

济南市无偿献血者献血前进行ALT快速检测可行性分析

目的探讨有无必要在街头无偿献血过程中进行丙氨酸氨基转移酶（ALT）快速检测。方法在街头无偿献血者献血前采用快速法检测ALT及对比分析街头用ALT快速检测法与实验室速率法的检测准确性。结果2010年4月、5月未采用ALT快速检测法检测ALT,采集全血后ALT阳性率分剐为1．86％、1．83％,使用快速法检测ALT,采集全血后ALT阳性率为0．35％。快速检测法与实验室速率法无显著,巨差异（P〉0．05）。结论快速法检测准确性另人满意,献血前进行ALT快速检测可有效地节约血液资源、降低血液成本。     

In the Mood for a Blood Donation? Pilot Study about Momentary Mood,Satisfaction, and Return Behavior in Deferred First-Time Donors

IntroductionTo maintain a sufficient donor pool, deferred first-time donors (FTD) should be motivated to return for blood donation. This pilot study investigates how deferral affects momentary mood, satisfaction with the donation process, and subsequent return behavior to examine their potential for motivating (deferred) FTD.MethodsAll of the subjects (n = 96) completed a first questionnaire (A1) before pre-donation assessment. Deferred FTD (n = 22) were asked to complete a second questionnaire (A2) immediately after deferral, while non-deferred FTD (n = 74) filled in the second questionnaire (A3) after blood donation. The impact of deferral, momentary mood, and satisfaction with the donation process on return behavior within 12 months was tested by calculating two path analyses, controlling for sex and age.ResultsMood (p < 0.001) and satisfaction with social aspects of the donation process (p = 0.01) were decreased after deferral. Deferred FTD were less likely than non-deferred FTD to return to the blood donation center within 12 months (60.8 vs. 36.4%; p = 0.043). However, path analyses revealed that deferral effects on mood and satisfaction were not connected to return behavior. Instead, age had a significant influence on return behavior (p < 0.05) such that, overall, non-returning FTD were older than returning FTD, regardless of their deferral status.ConclusionOur findings suggest that mood and satisfaction with the donation process are directly affected by deferral but not clearly responsible for low return rates. It seems promising to embed these variables in established health behavior models in further studies to increase the return rates of deferred FTD.     

上海地区献血人群隐匿性HBV感染状况

目的 了解HBsAg阴性、抗-HBc阳性的献血人群中HBV DNA感染情况.方法采用酶联免疫法(ELISA)检测5 121份HBsAg阴性的合格献血者血清抗-HBc和抗-HBc阳性反应滴度;对抗-HBc阳性样本采用ELISA法检测血清抗-HBs,采用巢式PCR三区段扩增法检测HBV DNA.结果HBsAg阴性的献血人群...     

How do I create a partnership between a blood bank and a milk bank to provide safe,pasteurized human milk to infants?

The now 5-year collaboration between the Indiana Blood Center, now Versiti Blood Center of Indiana, and The Milk Bank has increased the number of human milk donors, improved the collection and processing of donor milk, and improved awareness of this lifesaving resource. The Indiana Blood Center provides greater visibility for The Milk Bank, creating more opportunities to reach potential donors, and can provide the screening blood test for potential donors to become approved human milk donors. The resources of the multiple locations of the Indiana Blood Center permitted the formation of new milk depots in five different cities and quicker transportation of donated milk through their active courier system. This partnership most importantly has improved awareness for both lifesaving missions to the communities they serve.     

Alternative Medicines Toxicology: A Review of Selected Agents

Abstract

Experience with organ procurement from poisoned donors in brain death status is still limited in comparison with other etiologies. From 1963 to 1993, 2769 grafts (heart 141, kidney 1922, liver 623, pancreas 43) were performed in our Universitary Hospital. Since 1975, among 1174 patients admitted to the ICU for acute poisoning, 12 patients who developed brain death status were considered for organ donation. The toxics involved were: methaqualone (1), benzodiazepines (1), benzodiazepines plus tricyclic antidepressants(2), barbiturates (2), insulin (2), carbon monoxide (1), cyanide (I), methanol (1), and acetaminophen (1). Exclusion criteria for organ removal were applied according to the nature of the toxin and the general criteria used for organ donation. The organs removed were: heart 5, heart valves for graft bank 2, kidneys 22, liver 4, pancreas 2, pancrease islet cells 2. Pertinent follow-up was obtained in 23 of 32 recipients. Immediate outcome was favorable in 20/23 patients (85%). Three patients died either from stroke, heart failure or preexisting encephalopathy. Two patients died from either chronic hepatic or renal graft rejection. None of these events could be directly related to a toxic origin. The one year survival rate of 75% is similar to that observed in the population who received organs from nonpoisoned donors. Organ procurement can be considered in few selected cases of acute poisoning. The accuracy of the diagnosis of irreversible brain damage is essential in this setting.     

献血者血清过氧化氢酶活性测定

目的　探讨献血人群中血清过氧化氢酶 (catalase,CAT)的活性水平及其变化。方法　采用比色法测定血清CAT活性。结果　 2 77例体检合格的献血者血清 CAT活性测定结果为 (5 1.5± 16 .4 ) Ku/ L。经临床诊断的 2 5 0例甲、乙、丙型肝炎患者 ,与 2 77例体格合格组相比 ,血清 CAT活性明显升高 ,P<0 .0 1。对 2 77例不同 ABO血型献血者血清 CAT活性水平进行比较 ,结果差异无显著性 (P>0 .0 5 )。检测 2 77例具有不同献血史的献血者血清 CAT活性 ,结果差异亦无显著性 ,P>0 .0 5。结论　有规律、有计划和适度适量参与无偿献血 ,对献血者肝功能不会造成不良影响