Effect of treatment of rosacea in females by Chibixiao Recipe (赤鼻消方) in combination with minocycline and spironolactone

To observe the clinical efficacy of Chibixiao Recipe （赤鼻消方, CBX） in combination with minocycline and spironolactone in treating rosacea in females. Methods： Sixty-eight women with rosacea were randomly assigned to the treated group （48 cases） and the control group （20 cases）, both of which were treated with minocycline and spironolactone taken orally, but to the treated group, the Chinese herbal recipe, CBX was given additionally. Besides, cryotherapy with liquid nitrogen was applied to those with apparent capillary dilatation. The therapeutic course for both groups was 8 weeks. The levels of serum testosterone before and after treatment were determined by radioimmunoassay （RIA）, and a 4-month followup was conducted. Results： In the treated group the cure-markedly effective rate was 87.5% and the recurrent rate was 6.5 %, while in the control group, they were 45.0 % and 41.2 % respectively. Comparisons in the indexes between the two groups all showed significant difference （both P〈0. 01 ）, with the cure-markedly effective rate higher, and the recurrent rate lower in the treated group. The serum level of testosterone got lowered in both groups （ P〈0. 05 and P〈0. 01 ）, but the lowering in the treated group was more significant, showing significance when compared with that in the control group （ P〈0. 01 ）. Conclusion： CBX in combination with Western medicine has effect in treating rosacea superior to that of Western medicine alone, and could effectively reduce recurrent rate and the serum level of testosterone.     

贝伐株单抗与阿帕替尼分别联合替莫唑胺治疗复发性高级别脑胶质瘤的近期及远期疗效分析

目的 探究贝伐株单抗与阿帕替尼分别联合替莫唑胺（TMZ）治疗复发性高级别脑胶质瘤的近期及远期疗效。方法 选取2018年3月—2020年3月武汉市第一医院107例复发性高级别脑胶质瘤患者作为研究对象,按照随机数字表法分为贝伐株单抗组（53例）和阿帕替尼组（54例）。贝伐珠单抗组予以贝伐珠单抗联合TMZ治疗;阿帕替尼组予以阿帕替尼联合TMZ治疗。评估两组治疗3个周期后的临床疗效,比较两组血清VEGF、EGFR水平,分析给药期间两组的药物毒性反应,并随访记录两组总生存期（OS）和2年生存率。结果 阿帕替尼组治疗后客观缓解率和疾病控制率高于贝伐珠单抗组（P <0.05）;贝伐珠单抗组治疗前后血清VEGF和EGFR的差值高于阿帕替尼组（P <0.05）;贝伐珠单抗组治疗后血小板降低率高于阿帕替尼组（P <0.05）;贝伐珠单抗组治疗后高血压发生率低于阿帕替尼组（P <0.05）;截止随访时间,贝伐珠单抗组OS为13.5个月,2年生存率22.64%,阿帕替尼组OS为17个月,2年生存率44.44%,Kaplan-Meier生存曲线显示,阿帕替尼组生存率高于贝伐珠单抗组（P <0.05）。结论 相对于贝伐珠单抗联合TMZ治疗方案,阿帕替尼联合TMZ治疗复发性高级别脑胶质瘤疗效更为优越,且可延长患者生存期。     

Clinical observation on treatment of hyperplasia of mammary gland by Lirukang Granule (利乳康颗粒)

Objective:To explore the effi cacy and mechanism of Lirukang Granule(利乳康颗粒,LRKG) in treating hyperplasia of mammary gland(HMG).Methods:One hundred patients with HMG were randomly assigned to two groups,50 in each group.The patients in the treated group were orally administered with LRKG thrice a day,one package each time,and those in the control group were given orally Rukuaixiao Tablet(乳块消,RKX) thrice a day,4 tablets each time.The therapeutic course for both groups was 4 months.The clinical eff icacy,pain alleviating rate,as well as changes of local sign and symptom scores were observed before and after treatment.The changes of serum estradiol(E2),progesterone(P),testosterone(T),follicle stimulating hormone(FSH),luteinizing hormone(LH) and prolactin(PRL) in some randomly selected patients(24 patients in the treated group and 24 in the control group) before and after treatment were measured with radioimmunoassay.Results:The total clinical effi cacy in the treated group was superior to that in the control group,signifi cant difference was shown between the two groups(P<0.01).The cure-effective rate and total effective rate in the treated group were 70.0%and 88.0% respectively,signif icantly higher than those in the control group(38.0% and 64.0%) respectively(P<0.01),and the pain alleviating rate in the treated group was also significantly higher in the former than that in the latter(88.0% vs 64.0%,P<0.05).Moreover,the treated group showed obvious superiority in improving the patients' symptom and sign scores(P<0.01),and abnormalities of gonadal hormone as compared with the respective items in the control group(P<0.01).Conclusion:LRKG has good effi cacy in the treatment of HMG,and its mechanism may be related to the regulation on endocrine and immune function.     

Safety and efficacy of Qingre Buyi Decoction (清热补益煎剂) in the treatment of acute radiation proctitis: A prospective, randomized and controlled trial

Objective:To investigate the efficiency,safety,and possible mechanisms of Qingre Buyi Decoction(清热补益煎剂,QBD)in the treatment of acute radiation proctitis(ARP).Methods:This study was a single center,prospective,single blind,randomized,and placebo-controlled clinical trial.A total of 60 patients with ARP was equally and randomly distributed into the control group(conventional treatment)and the combination group(conventional treatment plus QBD).The changes of main Chinese medicine clinical symptoms and signs...     

Analysis of the therapeutic effect of sodium copper chlorophyllin tablet in treating 60 cases of leukopenia

Leukopenia is frequently encounteredinclinical practice . But at present no satisfac-tory agents have been found in its manage-ment .It was reported that sodium copperchlorophyllin (commercially named Yebaikeand abbreviated as YBK,叶拜克) ,a deriva-tive of chlorophyllin extracted from silk-worm faeces ( which has been traditionallyused as a drugin TCM) ,possesses multiplebiological actions and could be used in trea-ting leukopenia . However ,it is regrettablethat literature regardingits rol…     

Clinical observation on the efficacy of Xiaoshui decoction (消水方) combined with intrapleural perfusion of cisplatin in treating malignant pleural effusion

Objective： To observe the clinical efficacy of Xiaoshui decoction （XSD,消水方） combined with intrapleural perfusion of cisplatin in the treatment of malignant pleural effusion. Methods： Fifty-one patients with malignant pleural effusion were randomly assigned to two groups. The treated group patients） received oral administration of XSD combined with intrapleural perfusion of cisplatin, and control group （25 patients） was only treated with intrapleural perfusion of cisplatin. The effects of 26 he he short-term efficacy, quality of life scores and clinical symptom scores of malignant pleural effusion were evaluated. Results： The short-term efficacy in the treated group and the control group was 72.0% and 58.3%, respectively, and no significant difference was found （P〉0.05）. In contrast, the quality of life in the treated group was significantly improved compared to that of the control group （P〈0.05）, and so was the symptom remission （P〈0.05）. Conclusions： The combined therapy of XSD and intrapleural perfusion of cisplatin did not show obvious improvement in short-term efficacy, but the therapy remarkably alleviated the symptoms and improved the quality of life of patients.     

Clinical observation on the treatment of male neoplastic anemia with Yixuesheng capsule (益血生胶囊) combined with recombination human erythropoietin

Objective:To explore the efficacy and mechanism of Yixuesheng capsule(益血生胶囊,YXS) combined with recombination human erythropoietin(RHE) in treating male neoplastic anemia(NA).Methods: Sixty-five patients were randomized into two groups,the 33 patients in the treated group treated with a combined therapy of YXS and RHE,and the 32 in the control group treated with RHE alone,all for 12 weeks.Related clinical indexes,including hemoglobin(Hgb),red blood cell(RBC),hematocrit(HMC),testosterone(T),estradiol (E_2)...     

Clinical study on effect of Astragalus Injection (黄芪注射液) and its immuno-regulation action in treating chronic aplastic anemia

Objective:To observe the clinical effect of Astragalus Injection(黄芪注射液,AI) and its immuno-regulatory action in treating chronic aplastic anemia(CAA).Methods:Sixty patients with CAA were randomly assigned to two groups equally,both were treated with Stanozolol three times a day,2 mg each time through oral intake,but AI was given additionally to the patients in the treated group once a day via intravenous dripping.All were treated for 15 days as one therapeutic course and the whole medication lasted for more than 4 months totally,with follow-up adopted.The clinical effi cacy was estimated and the changes of T-lymphocyte subsets in peripheral blood as well as the serum levels of tumor necrosis factor-α(TNF-α) and interleukin-2(IL-2) were observed.Results:The total effective rate in the treated group was 83.3%(25/30),which was higher than that in the control group 66.7%(20/30),showing significant difference between them(P<0.05).Levels of hemoglobin,WBC,reticular cell and platelet were elevated in both groups after treatment,but the improvement was signif icantly better in the treated group than that in the control group with respect to the former three indexes(P<0.05).The level of CD4 increased and that of CD8 decreased signifi cantly after treatment in the treated group(P<0.05),which showed significant difference as compared with those in the control group(P<0.05).Levels of serum TNF-α and IL-2 lowered after treatment in both groups,but signifi cance only showed in the treated group(P<0.05).The degree of proliferation in bone marrow got raised signifi cantly and the percentage of non-hemopoietic cells reduced signifi cantly in the treated group after treatment,also showing significant difference to those in the control group(P<0.05).Conclusion:AI could promote the recovery of hemopoietic function,which might be through improving T-lymphocyte subsets and reducing the release of negative regulatory factors such as TNF-α and IL-2 to alleviate the inhibition on hemopoietic function.     

Effect and prognostic analysis of treatment for acute myeloid leukemia using Chinese drugs combined with chemotherapy

Objective:To observe the clinical efficacy of Chinese drugs combined with chemotherapy in the treatment of acute myeloid leukemia(AML) and to investigate the prognostic relevance of the main parameters in AML treated with integrative medicine.Methods:Forty AML patients hospitalized at the authors' hospital were treated with Chinese drugs and chemotherapy.The routine examination,immunophenotype and karyotype analyses were carried out.The clinical efficacy was observed and the prognostic factors were analy...     

Clinical study on treatment of primary hepatocellular carcinoma by Shenqi mixture combined with microwave coagulation

Objective: To observe the short-term efficacy and safety of Shenqi mixture (SQM) combined with microwave coagulation in treating primary hepatocellular carcinoma (HCC).Methods: Seventy-two patients with primary HCC of stage II – III, Karnofsky scoring ⩾50 scores and predicted survival period ⩾3 months were selected and randomly assigned into two groups, the treated group and the control group, 36 in each. Microwave therapy was applied to both groups by double leads, 60 W, 800 sec once a week for two weeks. To the treated group, SQM was given additionally through oral intake of 20 ml, three times a day for 1 month. The changes in tumor size, main symptoms, serum level of alpha-fetoprotein (AFP), immune function and adverse reaction were observed after treatment and the immune parameters of the patients were compared with 30 healthy persons in the normal control group.Results: (1) In the SQM treated group, after treatment 3 patients got completely remitted (CR), 24 partial remitted (PR), 4 unchanged (NC) and 5 progressively deteriorated (PD), the effective rate being 75.00%; while in the control group, 1 got CR, 19 PR, 9 NC and 7 PD, the effective rate being 55.56%. Comparison of the effective rate between the two groups showed significant difference (P<0.05). (2) AFP level decreased after treatment in both groups, but the decrement in the treated group was significantly higher than that in the control group (P<0.01). (3) After treatment, in the treated group, CD3⁺, CD4⁺, CD4⁺/CD8⁺ and NK activity were improved, Karnofsky scores increased and liver function bettered, with these improvements significantly superior to those in the control group (P<0. 01). (4) The improvement in symptoms such as hepatic region pain, fever, weakness, poor appetite and jaundice in the treated group after treatment was also superior to that in the control group (P<0.01). (5)The 12-month, 18-month and 24-month survival rates were higher and the recurrence rate was lower in the treated group than those in the control group, showing significant difference (P<0.05).Conclusion: Combined therapy with SQM and microwave coagulation could not only kill the tumor and residue tumor cells to prevent recurrence, but also enhance the cellular immunity of organism. It is one of the effective therapies for patients with middle-advanced hepatocarcinoma, who have lost the chance of surgical operation. It could improve clinical symptoms, elevate the quality of life, prolong the survival period of patients, but shows no evident adverse reaction. Supported by Fund for Young Researchers Set by Ministry of Health of Fujian Province(No. 2002-2-20)     

Study on Tongkuaixiao Babu plaster in treating cancer pain

Objective: To explore the efficacy of Tongkuaixiao Babu plaster (TKXBBP) in treating cancer pain.Methods: In the clinical observation, sixty-five patients with moderate or severe cancer pain were randomly divided into two groups: 32 in the treated group (TKXBBP group) and 33 in the control group (Bucinnazine group). The therapeutic effects in relieving pain, improving quality of life (QOL), and the rate of satisfaction the patients felt of the two groups were compared respectively. Results: TKXBBP was effective in treating cancer pain. There wasn’t any statistically significant difference in total effective rate (P>0.05), but the statistical difference was significant in obvious remission rate (P<0.05) between the treated and control group, and the effect on serious pain shown in the treated group was better than that of the control group (P<0. 05). The difference in the initiation time of relieving cancer pain was insignificant (P>0.05), while in the remission period, the treated group showed its treatment was obviously superior to that of the control group (P<0.05). TKXBBP showed better effect in the improvement of QOL (P<0.05) and satisfaction rate, with significant difference between the treated and the control groups (P<0.01).Conclusion: TKXBBPs effect in treating cancer pain was obvious, its application was safe and convenient. It was shown that the external treatment with this kind of Chinese medicine had great advantage in treating cancer pain.     

Effect of Xin’ anning Nasal Drop (心安宁滴鼻剂) in treating coronary heart disease with unstable angina pectoris

Objective： To observe the clinical efficacy of Xin＇anning Nasal Drop （XAND,心安宁滴鼻剂） in treating coronary heart disease with unstable angina pectoris （CHD-UAP）. Methods： Sixty patients with CHD-UAP were assigned, according to the randomizing number table, to two groups, the control group treated with conventional Western medicine, and the treated group treated with conventional Western medicine plus XAND. The clinical efficacy and the changes of S-T segment in resting EKG and total ischemia burden （TIB） in 24-h dynamic EKG were observed. Results： The clinical efficacy, including the effect of angina alleviation, its initiation, and the effect of TOM syndrome score reduction, were significantly superior in the treated group to those in the control group （ P〈0.05 or P〈0.01 ）. The degree and extent of myocardial ischemia were significantly improved in both groups （ P〈0.01 ）, but the improvement in the treated group was better than that in the control group （ P〈0.05）. Moreover, it was worth mentioning that the immediate effect in the treated group was better than that in the control group, and the reduction of TIB, the improvement in heart rate and myocardial oxygen consumption （ immediately after the first administration or by the end of the therapeutic course）, and systolic blood pressure after treatment in the former were all superior to those in the latter, showing significant difference （ P〈0.05 or P〈0.01 ）. Conclusion： XAND has a quick effect in alleviating angina in patients with CHD-UAP, and it is worthy of further studies and spreading in clinical practice.     

Evaluation by survival analysis on effect of traditional Chinese medicine in treating children with respiratory syncytial viral pneumonia of phlegm-heat blocking Fei syndrome

Objective:To objectively evaluate the clinical effect of traditional Chinese medicine in treating children's respiratory syncytial viral pneumonia(RSVP) of phlegm-heat blocking Fei(肺) syndrome(PHBFS). Methods:A single-blinded multi-center,blocked,randomized and parallel-controlled method was adopted.The clinical study was carried out on 206 children with RSVP-PHBFS who were assigned to two groups,108 in the test group treated through intravenous dripping of Qingkailing Injection(清开灵注射液) in combination of...     

Randomized controlled trial on treatment of bronchial asthma of qi-deficiency cold syndrome type by Pingchuan Yiqi Granule (平喘益气颗粒)

Objective： To evaluate the effect and safety of Pingchuan Yiqi Granule （平喘益气颗粒, PYG） in treating bronchial asthma of qi-deficiency cold syndrome type （BS-QDC）. Methods： With the randomized, positive agent parallel controlled design adopted, the 80 subjects enrolled were assigned in the ratio of 3：1 to two groups, the 60 patients in the trial group were treated with PYG and the 20 in the control group treated with Ruyi Dingchuan Pill （如意定喘丸,RDP）, with the therapeutic course consisting of 7 days for both groups. The clinical effects, effects on TCM syndrome and the changes of lung function after treatment were observed. Results： The effect of the treatment on asthma in the trial group： clinically controlled rate was 6.67%, markedly effective rate 51.67%, improved rate 33.33% and ineffective rate 8.33%; and the corresponding rates in the control group were 5.00%, 50.00%, 30.00%, and 15.00% respectively. Comparison between the two groups showed insignificant difference （P〉0.05）. The effect on TCM syndrome in the treated group： clinically controlled rate was 11.67%, markedly effective rate 58.33%, effective rate 21.67% and ineffective rate 8.33%; and those in the control group were 10.00%, 50.00%, 30.00% and 10.00% respectively, also showing insignificant difference between the two groups （P〉0.05）. Lung function test showed that the change on forced expiratory volume in 1 second （FEV1） after treatment in the trial group was of statistical significance （P〈0.05）, but no significant difference was shown in the change of peak expiratory flow （PEE P〉0.05）; while the changes in the control group were just the opposite, showing insignificance in FEV1 （P〉0.05） but significance in PEF （P〈0.05）. Comparison of the therapeutic effect on lung function between the two groups showed no significant difference （P〉0.05）. No adverse reaction was found in either group in the course of treatment. Conclusion： PYG used to treat BS-QDC is effective and safe, it＇s effect is similar to that of RDP.     

推拿联合行为干预治疗儿童原发性夜间遗尿症临床观察

目的:观察推拿联合行为干预治疗儿童原发性夜间遗尿症的临床疗效。方法:将60例原发性夜间遗尿症患儿随机分为对照组和治疗组,每组各30例。对照组采用行为干预治疗,治疗组采用推拿联合行为干预治疗,疗程均为3个月。观察两组临床疗效、中医证候积分的变化情况及复发率。结果:治疗组临床总有效率为90.0%,对照组临床总有效率为66.7%,治疗组临床疗效明显优于对照组(P0.05);治疗前两组中医证候积分比较差异无统计学意义(P0.05),治疗后两组中医证候积分均较治疗前明显降低(P0.05),且治疗组优于对照组(P0.05); 2个月后,治疗组的复发率为11.1%,对照组为60.0%,治疗组明显低于对照组(P0.01)。结论:推拿联合行为干预治疗儿童原发性夜间遗尿症临床疗效良好,复发率低。     

骨蚀汤加减联合塞来昔布胶囊治疗非创伤性股骨头坏死的临床疗效观察

目的 探讨骨蚀汤加减联合塞来昔布胶囊治疗非创伤性股骨头坏死的临床疗效。方法 选取2015年3月—2018年3月在深圳市宝安中医院（集团）治疗的非创伤性股骨头坏死患者120例,按就诊顺序分为对照组和观察组,每组60例。对照组采用西医常规结合塞来昔布胶囊治疗,观察组在对照组基础上联合骨蚀汤加减治疗,均连续治疗6个月,随访12个月。比较两组患者的Harris评分、健康调查简表（SF-36）评分、影像学评分,关节疼痛采用视觉模拟评分法（VAS）;比较两组患者的总有效率、复发率及不良反应总发生率。结果 研究期间对照组患者脱落4例,观察组患者脱落2例。观察组治疗后的Harris评分、SF-36评分及影像学评分高于对照组（P <0.05）;观察组治疗后关节疼痛VAS评分低于对照组（P <0.05）。观察组总有效率为94.83%,高于对照组的78.57%（P <0.05）;随访12个月观察组的复发率为8.62%,低于对照组的23.21%（P <0.05）。观察组不良反应发生率为10.34%,低于对照组的32.14%（P <0.05）。结论 骨蚀汤加减联合塞来昔布胶囊治疗非创伤性股骨头坏死临床疗效更优,复发率更低,更有利于减轻服药后带来的不良反应,值得临床推广应用。     

Clinical experience in treatment of Amanita mushroom poisoning with Glossy Ganoderma Decoction (灵芝煎剂) and routine Western medicines

Objective:To assess the effects of treatment of Amanita mushroom poisoning with Glossy anoderma Decoction(灵芝煎剂,GGD).Methods:Twelve patients with acute Amanita mushroom poisoning received conventional treatment(penicillin and reduced glutathione) combined with oral administration of GGD(treated group),which was prepared out of 200 g Glossy ganoderma decocted in water to 600 mL,and 200 ml was given once,three times a day for 7 successive days;while conventional treatment alone was given to the other 11 patients assigned to the control group.The therapeutic eff icacy and changes in serum levels of total bilirubin(TBil),bile acids(BA),alanine transaminase(ALT),and aspartate transaminase(AST) activities in the two groups were compared.Results:The cured-markedly effective rate in the treated group was more signif icant than that in the control group(P<0.01).Elevation in TBil,BA,ALT,and AST activities were observed in both groups 3 days after poisoning,which progressively increased thereafter in the control group.In the treated group,they reached their peak on the 3rd day and then declined gradually.The differences between pre-treatment and post-treatment in both groups were obviously signif icant(P<0.01),so were the differences between the two groups at corresponding time points(P<0.01).Conclusion:GGD shows excellent clinical eff icacy in the treatment of acute Amanita mushroom poisoning and can reduce mortality signif icantly.     

Effect of Shengmai injection (生脉注射液) on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus

Objective： To study the effect of Shengmai injection （生脉注射液, SMI） on vascular endothelial and heart functions in coronary heart disease patients complicated with diabetes mellitus （CHD-DM）. Methods： One hundred and twenty patients with CHD-DM, their diagnosis confirmed by coronary arteriography, were equally randomized into a control group treated with conventional treatment and a treated group treated with conventional treatment plus SMI. The changes in blood levels of nitric oxide （NO）, endothelin-1 （ET-1） and angiotensin Ⅱ （Ang Ⅱ）, as well as endothelium-dependent vascular dilating function and heart function in the patients were observed before treatment and after the 3-week treatment. Results： After being treated with SMI for 3 weeks, in the treated group, blood level of NO was raised significantly from 69.8±33.1 μmol/L to 120.1±50.8μmol/L, and ET-1 was lowered from 70.1±32.1 ng/L to 46.2±21.3 ng/L, respectively （P〈0.01）; that of Ang Ⅱ was lowered from 81.3±24.3 ng/L to 50.2±27.3 ng/L （P〈0.01）; brachial arterial post-congestion blood flow increasing rate was raised from 389.4±26.3% to 459.3±27.8% （P〈0.01）; and the improvement in heart function as seen through the ejection fraction （EF） was increased from 44±5% to 68±6% （P〈0.01）, all the changes being more significant than those in the control group （all P〈0.01）. Conclusion： SMI can improve not only the endothelial function in CHD-DM patients, but also heart contraction significantly.     

西格列汀联合门冬胰岛素治疗老年2型糖尿病患者的疗效及对脂代谢、炎症因子、同型半胱氨酸的影响

目的 探讨西格列汀联合门冬胰岛素治疗老年2型糖尿病（T2DM）患者的疗效,及其对患者脂代谢、炎症因子、同型半胱氨酸（Hcy）的影响。方法 选取2018年1月—2019年12月台州市中心医院和宁波大学医学院附属医院收治的老年T2DM患者60例,采用随机数字表法分为观察组和对照组,每组30例。观察组采用西格列汀联合门冬胰岛素治疗,对照组采用门冬胰岛素治疗,均治疗3个月。比较两组患者治疗3个月总有效率,治疗前与治疗3个月患者血脂、炎症因子［C反应蛋白（CRP）、白细胞介素-6（IL-6）和IL-18］和Hcy水平的变化。结果 观察组总有效率高于对照组（P <0.05）。观察组治疗前后低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、总胆固醇和甘油三酯的差值均大于对照组（P <0.05）。观察组治疗前后CRP、IL-6和IL-18的差值均大于对照组（P <0.05）。观察组治疗前后Hcy的差值大于对照组（P <0.05）。结论 西格列汀联合门冬胰岛素治疗老年T2DM患者疗效良好,且可改善血脂代谢,减轻炎症反应,降低Hcy水平。     

Evaluation of the clinical efficacy of Qingqiao Capsule in treating patients with secretory otitis media

Objective: To observe the clinical efficacy of Qingqiao Capsule (QQC) in treating patients with secretory otitis media (SOM).Methods: A total of 90 patients were randomly assigned into the treated group (n = 45) and the control group (n = 45). Patients in the treated group were administrated with QQC, 5 capsules each time, 3 times a day for totally 10–14 days, and those in the control group were given per os cefaclor capsules 0.5g each time for adult, 3 times a day, or 20mg/(kg.d) for children, for 10–14 days. The therapeutic efficacy of treatment on the patients was observed and compared after treatment and followed up for 3–6 months.Results: (1) The clinical efficacy in the treated group was superior to that in the control group with significant statistical difference (P< 0.01); (2) Comparison of the efficacies in patients of three different TCM syndrome types (the external pathogenic wind invasion caused auditory orifice stuffiness type, the Gan-Dan damp-heat steaming up auditory orifice type and the Pi-deficiency dysfunction induced dirty dampness blocking ear type) showed no statistically significant difference(P> 0. 05); (3) The vanishing rate and time needed of the main symptoms and signs in the treated group were superior to those in the control group on ear muffle, tinnitus, hearing impairment, hydrotypanum, pure tone threshold and abnormal tongue figure, and the difference was statistically significant (P< 0.05 or P< 0.01), only those of earache, otopiesis and abnornal pulse figure were insignificantly different between the two groups (P> 0.05).Conclusion: QQC is an effective Chinese composite medicine on patients with SOM, and shows no obvious adverse reaction.