葛根素对缺氧性肺动脉高压大鼠的保护作用

目的:研究葛根素对缺氧性肺动脉高压的治疗作用及作用机制。方法:采用常压低氧培养箱建立大鼠的缺氧性肺动脉高压模型;60只清洁级SD大鼠,随机分成正常对照组、模型组、葛根素组,各组造模前30 min进行腹腔注射,葛根素组注射葛根素注射液20 mg/kg,正常对照组、模型组注射等体积0.9%Na Cl溶液。正常对照组于实验室正常环境下培养,模型组、葛根素组于缺氧环境下培养3 d、7 d、14 d、21 d后进行检测。测定包括肺动脉平均压力(mPAP)、右心室肥厚指数(RVHI)及肺组织中超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量。结果:在常压低氧培养箱中进行大鼠的缺氧性肺动脉高压模型成功建立;模型组mPAP、RVHI、MDA含量显著高于正常对照组,SOD活性明显低于正常对照组(P0.05,P0.01)。与模型组比较,14 d、21 d时葛根素组mPAP、RVHI、MDA含量明显降低,SOD活性明显升高(P0.05,P0.01)。结论:葛根素能有效抑制缺氧导致的肺动脉平均压力增加及氧自由基增加,减轻其肺血管重构的程度,对缺氧性肺动脉高压具有一定的防治作用。     

Study on effect of different dosages of ligustrazine on level of plasminogen activator inhibitor-1 activity in type 2 diabetes mellitus patients

Objective: To observe the effect of different dosages of ligustrazine (LG) on the level of plasminogen activator inhibitor-1 (PAI-1) activity in patients with type 2 diabetes mellitus.Methods: Ninety cases of type 2 diabetes mellitus inpatients were selected, and randomly divided into LG small dosage group (SDG), LG large dosage group (LDG) and control group. The 120 mg LG, 400 mg LG and normal saline 250 ml were given through intravenous dripping respectively, once daily, 20 days as one treatment course. Before and after treatment, all the patients had their fasting blood taken for PAI-1 and tissue plasminogen activator (t-PA) assessment test to perform the comparative study.Results: Seventythree out of the 90 patients completed the observation course, the PAI-1 activity of three groups after treatment all lowered compared with that before treatment, and the difference between groups was also significant (allP < 0.01). After treatment the PAI-1 level of SDG and LDG of LG were all markedly lowered (allP < 0.01), the LDG’s lowering was more evident than that of SDG, and comparison between these two groups of patients showed significant difference (P < 0.01). Although in the control group there was some difference between before and after treatment, it was not so significant like the above-mentioned two groups (P = 0. 0140). No adverse reaction occurred in the 3 groups during the observation period.Conclusion: LG could safely and effectively lower type 2 diabetes mellitus patient’s plasma PAI-1 activity level, and LDG of LG proved to be particularly effective.     

Clinical study on Zhuyu Tongfu Serial Recipe combined with acupuncture and massotherapy in treating hypertensive cerebral hemorrhage

Objective: To observe the clinical efficacy and mechanism of Zhuyu Tongfu (ZYTF) Serial Recipe combined with acupuncture and massotherapy in treating hypertensive cerebral hemorrhage (HCH).Methods: One hundred and eighteen patients with hypertensive cerebral hemorrhage, on the basis of conventional Western medicine treatment, were randomly divided into ZYTF combined with acupuncture and massotherapy group (treated group) and simple Western medicine group (control group); the clinical efficacy, neurofunction deficit scoring (NDS) alterations and hematoma absorption rate of both groups were observed, and also the plasma Superoxide dismutase (SOD) activity, plasma lipid peroxidase (LPO) content, erythrocyte glutathion peroxidase (GSH-Px) activity, hematocrit (Ht) and the whole blood viscosity (Va) change were also observed.Results: In the treated group, the clinical efficacy, NDS improvement and hematoma absorption rate were superior to that of the control group; comparison between the two groups after treatment showed that plasma SOD activity and GSH-Px activity got more elevated and plasma LPO content, Ht and Va more lowered in the the treated group than those in the control group.Conclusion: ZYTF combined with acupuncture and massotherapy has better effect, its therapeutic mechanism was possibly correlated to the elevation of plasma SOD activity, GSH-Px activity and lowering of plasma LPO content, Ht and Va. Supported by the Programs Foundation of Cerebrovascular Disease Treated by Integrative Traditional Chinese and Western Medicine of the Key Subject of TCM of Zhejiang Province (No. 2001-18)     

葛根素注射液治疗糖尿病性冠心病的初步观察

目的探讨葛根素对糖尿病性冠心病的疗效。方法45例糖尿病性冠心病人随机分为治疗组与对照组。对照组用常规方法治疗;治疗组在常规治疗的基础上加用葛根素注射液。以临床症状、血糖、心电图、SOD、LPO作为疗效标准。结果治疗组的疗效明显优于对照组(P<001)。结论葛根素注射液对糖尿病性冠心病有明显的治疗效果。     

Effect of Yiqi Huoxue herbs on vascular endothelial cells and platelets in patients with chronic cor pulmonale

Objective: To observe the clinical effect of Yiqi Huoxue, YQHX) herbs in treating the patients with chronic cor pulmonale and to explore its mechanism by determining the relationship of oxidation/antioxidation system and how such herbs change on the function of endothelial cells and platelets.Methods: Fifty-eight patients were divided into two groups: conventional therapy group (control group, 28 patients) and convention plus YQHX herbs group (treated group, 30 patients). The control group received conventional management. The treated group were treated with YQHX 150 ml, twice a day, plus the conventional treatment, and the clinical efficacy was recorded. The lipid peroxidation (LPO), Superoxide dismutase (SOD), α-granule membrane protein (GMP140), partial pressure of arterial oxygen (PaO₂), partial pressure of carbon dioxide in artery (PaCO₂) and circulating endothelial cells (CEO were measured respectively before and after treatment, and the relationship between various parameters were analyzed. The results were compared with those of 10 healthy subjects got at the same period.Results: (1) The effective rate and PaO₂ of the treated group was higher than that of the control group and there were no difference in PaCO₂ between the two groups. (2) The levels of LPO, GMP140, CEC in all the patients before therapy were significantly higher than those of the healthy group, and there were marked decrease in the levels of those after treatment (all P<0.01). On the contrary, the levels of SOD in all the patients before therapy were markedly lower than those in the healthy subjects and increased after treatment, P<0.01. (3) The increase of SOD in the treated group was significantly more obvious than that of the control group. In the treated group, the decrease of LPO, GMP140, CEC were markedly more obvious than those in the control group (all P<0. 01). (4) The number of CEC, as well as GMP140, was negatively correlated to PaO₂ (P<0.01) and SOD (P< 0.01), which was positively correlated to LPO (P<0.01). There was a positive correlation between CEC and GMP140 (P<0.05).Conclusion: YQHX herbs in treating chronic cor pulmonale proved to be effective by balancing the oxidation and antioxidation, protecting the pulmonary endothelial cells and activated platelets and helpful in treating respiratory failure.     

Effects of Xuezhikang capsule on blood lipids, platelet activation and coagulation-fibrinolysis activity in patients with hyperlipidemia

Objective: To investigate the effects of Xuezhikang capsule (XZK) on blood lipids level, platelet activation and coagulation-fibrinolysis activity in patients with hyerlipidemia.Methods: Seventy-six patients of hyperlipidemia were randomly divided into two groups, the XZK group (n = 38) treated with XZK 600mg, taken two times per day and the Simvastatin (SIM) group (n = 38) treated with SIM 20mg per day, with the treatment lasting 8 weeks for both groups. Levels of fasting serum lipids, including total cholesterol (TC), triglyceride (TG), high and low density lipoprotein cholesterol (HDL-C and LDL-C), plasma GMP-140, fibrinogen (FIB), tissue plasminogen activator (t-PA), plasminogen activator inhibitor type-1 (PAI-) and prothrombin time (PT) were all measured before and 8 weeks after treatment. Data were compared before and after treatment and also compared with those measured in 20 healthy subjects of control.Results: Before treantment the levels of TC, TG and LDL-C were obviously higher and HDL-C level was significantly lower in hyperlipidemia patients than those in healthy subjects (P<0.05 orP<0.01). After 4–8 weeks of XZK treatment, the levels of TC, TG, LDL-C and FIB and activities of GMP-140 and PAI-1 were obviously lowered (P<0.05 orP<0.01). But in the SIM group there was no obvious change in FIB (P>0.05), instead it showed obvious increase of HDL-C and decrease of TC and LDL-C after treatment (P<0.05 orP<0.01).Conclusion: XZK could inhibit platelet activity and improve coagulation-fibrinolysis function, besides its lipids lowering effect.     

血浆uPA、PAI-1和其4G/5G多态性与鼻咽癌临床分期关系

目的 探讨尿激酶型纤溶酶原激活物（uPA）、纤溶酶原激活物抑制剂1（PAI-1）的血浆浓度和PAI-1基因启动子区4G/5G多态性与鼻咽癌临床分期的相关性。方法 收集86例鼻咽癌患者血液标本,35例健康人血液标本作对照。所有标本均采用用酶联免疫吸附法（ELISA法）检测uPA和PAI-1的血浆浓度,微量法提取DNA,采用等位基因特异性引物PCR分析PAI-1基因启动子4G/5G多态性。结果 与正常对照组相比,鼻咽癌组血浆uPA浓度明显升高（P<0.05）,而血浆PAI-1浓度显著降低（P<0.05）,上述效应和临床分期具有显著相关性;PAI-1启动子区4G和5G基因频率与对照组相比差异无统计学意义（P>0.05）。结论 鼻咽癌的临床分期和恶性程度和血浆uPA浓度呈正相关,与PAI-1浓度呈负相关;PAI-1基因4G/5G多态性与鼻咽癌没有相关性。     

Effect of Weikangfu Granule on the physiopathologic figure of precancerosis of gastric mucosa in patients of chronic gastritis with Pi-Deficiency syndrome

Objective: To study the physiopathologic basis of Weikangfu Granule (WKFG) in treating precancerosis of gastric mucosa in patients of chronic gastritis with Pi-deficiency syndrome (CG-PDS).Methods: One hundred and fifteen patients of CG-PDS who suffered from intestinal metaplasia (IM) and atypical hyperplasia (ATHP) of gastric mucosa, were divided into two groups. The treated group (n = 61) was treated by WKFG with its ingredients modified according to the syndrome type of patients. The control group(n= 54) was treated with Weishu granule. The histopathological and subcellular ultrastructural changes were detected by optical microscope, screening electronic microscope, transmission electronic microscope and histochemical staining; the nuclear and mitochondrial ultrastructure of gastric mucosa were analyzed with energy dispersion X-ray analyser and image analysis system. And the changes of cAMP, lipid peroxide (LPO), Superoxide dismutase (SOD) before and after treatment in the treated group were measured and compared with those of the health control group consisting of 15 volunteers.Results: The symptomatic and pathological therapeutic effect in the treated group were significantly superior to those in the control group (P< 0.05). The contents of Zn, Cu, cAMP, SOD and³H-TdR LCT in gastric mucosa of the treated group before treatment were all lower than those of the healthy control group, yet all these indexes markedly increased after treatment, while serum LPO level, which increased before treatment was lowered after treatment. All the changes showed statistical significance (P<0.05 orP<0.01).Conclusion: WKFG can reverse IM and ATHP in patients of CG-PDS, and the effect may be realized by way of increasing the level of Zn, Cu, cAMP and SOD in gastric mucosa, promoting cell differentiation, enhancing cellular immunity and reducing oxygen free radicals and lipid peroxidation.     

RP-HPLC法测定左卡尼汀片中左卡尼汀杂质A

目的 探讨聚乙二醇（PEG）化葛根素对大鼠心肌缺血再灌注损伤（MIRI）的保护作用。方法 将SD大鼠随机分为6组（每组10只）： 假手术组,MIRI模型组,葛根素注射剂（20 mg/kg）对照组,PEG化葛根素低、中、高剂量（244、488、976 mg/kg）组。阻断大鼠升主动脉造成心肌缺血30 min,再灌注120 min,造成大鼠MIRI模型,在结扎后5 min各给药组尾iv给药。心电图监测心律失常情况,再灌注结束后腹主动脉采血,测定血清肌酸激酶（CK）、乳酸脱氢酶（LDH）、天冬氨酸转氨酶（AST）和丙二醛（MDA）水平,并测量心肌梗死面积。结果 葛根素注射剂和PEG化葛根素均具有抗心律失常,降低血清中CK、LDH、AST和MDA水平的作用,减少心肌梗死面积;其中PEG化葛根素中、高剂量组的药效明显强于葛根素注射剂组。结论 PEG化葛根素对大鼠MIRI引起的损伤具有保护作用。     

聚乙二醇化葛根素对大鼠心肌缺血再灌注损伤的保护作用

目的 探讨聚乙二醇（PEG）化葛根素对大鼠心肌缺血再灌注损伤（MIRI）的保护作用。方法 将SD大鼠随机分为6组（每组10只）： 假手术组,MIRI模型组,葛根素注射剂（20 mg/kg）对照组,PEG化葛根素低、中、高剂量（244、488、976 mg/kg）组。阻断大鼠升主动脉造成心肌缺血30 min,再灌注120 min,造成大鼠MIRI模型,在结扎后5 min各给药组尾iv给药。心电图监测心律失常情况,再灌注结束后腹主动脉采血,测定血清肌酸激酶（CK）、乳酸脱氢酶（LDH）、天冬氨酸转氨酶（AST）和丙二醛（MDA）水平,并测量心肌梗死面积。结果 葛根素注射剂和PEG化葛根素均具有抗心律失常,降低血清中CK、LDH、AST和MDA水平的作用,减少心肌梗死面积;其中PEG化葛根素中、高剂量组的药效明显强于葛根素注射剂组。结论 PEG化葛根素对大鼠MIRI引起的损伤具有保护作用。     

Effects of compound Salvia Injection on lipid peroxidation antioxidant enzymes activity in patients with chronic cor pulmonale

The effects of Compound Salvia Injection (CSI) on plasma lipid peroxidation (LPO), RBC superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activity in patients with chronic cor pulmonale were studied. Thirty patients were randomly divided into two groups: the group treated with routine therapy (routine group) and the group treated with routine therapy plus CSI (CSI group). The 4 parameters mentioned above have been measured in patients of the two groups and in 22 healthy subjects for control. The results showed: (1) Before treatment, both the treatment groups had significantly higher LPO and SOD and markedly lower GSH-Px and CAT level than those of the healthy control (P<0.001). (2) After treatment the 4 parameters have been normalized in CSI group. (3) In the routine group, the parameters were still abnormal, that is, the increased levels of GSH-Px and CAT and the decreased LPO were singificantly greater in CSI group than that in routine group. These results indicated that CSI could obviously lower the enhanced lipid peroxidation and adjust the imbalance of antioxidant enzymes.     

氯沙坦对高糖诱导大鼠肾近端小管上皮细胞纤溶酶原激活物及其抑制物表达的影响

目的 研究高糖对正常大鼠肾近端小管上皮细胞纤溶酶原激活物(tPA和uPA)及其抑制物-1(PAI-1)表达的影响,并探讨血管紧张素Ⅱ受体阻滞剂氯沙坦对其改善作用.方法 培养大鼠肾近端小管上皮细胞,并分组为正常对照组、甘露醇组(5 mmol/L D-葡萄糖 25 mmol/L 甘露醇)、高糖组(30 mmol/L D-葡萄糖)、氯沙坦组(10-3 mmol/L氯沙坦)、高糖 氯沙坦组(30 mmol/L D-葡萄糖 10-3 mmol/L氯沙坦).RT-PCR法检测各组细胞tPA、uPA及PAI-1 mRNA表达. 结果与正常对照组比较,高糖组肾小管上皮细胞tPA和uPA mRNA表达下降(P＜0.01), PAI-1 mRNA表达增加(P＜0.01);氯沙坦可部分逆转高糖的作用,高糖加氯沙坦组tPA、uPA表达分别是高糖组的2.06倍、1.69倍(P＜0.01),PAI-1表达为高糖组的44% (P＜0.01). 结论高糖可使肾近端小管上皮细胞PA/PAI-1 mRNA异常表达, 氯沙坦可以在肾小管中通过维持PA/ PAI-1的平衡,对糖尿病肾病防治起一定的作用.     

水蛭对肺纤维化大鼠PAI-1的影响

目的:观察水蛭对肺纤维化大鼠纤溶酶原激活物抑制因子-1(Plasminogen activator inhibitor-1,PAI-1)的作用,并探讨其机制。方法:采用气管内注入博莱霉素(BLM)制作大鼠肺纤维化模型,造模后随机分为模型组(MD组,生理盐水6 ml/d灌胃),水蛭组[HD组,水蛭粉4 g/(kg.d)灌胃],另设鼠龄、体重相匹配的正常对照组(NC组),每组8只;28 d后ELISA法测定血浆PAI-1含量及活性,同时检测肺组织羟脯氨酸(HYP)含量。结果:NC组PAI-1含量(0.469 2±0.081 3)μg/L,活性(0.363 4±0.047 0)Au/ml,明显低于MD组和HD组(P<0.01);MD组PAI-1含量(8.920 5±1.094 8)μg/L,活性(2.066 7±0.598 6)Au/ml,高于HD组(3.479 8±0.487 2)μg/L、(1.225 3±0.199 4)Au/ml(P<0.01);NC组、HD组HYP低于MD组(P<0.01)。结论:水蛭可能通过减少凝血酶在肺内的表达,抑制PAI-1生成及活性,使重组尿激酶型纤溶酶原激活物(Urokinase plasmino-gen activator,uPA)活性升高,减少纤维蛋白沉积,对肺纤维化大鼠肺组织具有保护作用。     

Study on Effect of Different Dosages of Ligustrazine on Level of Plasminogen Activator Inhibitor-1 Activity in Type 2 Diabetes Mellitus Patients

Objective:To observe the effect of different dosages of ligustrazine(LG)on the level ofplasminogen activator inhibitor-1(PAI-1)activity in patients with type 2 diabetes mellitus.Methods:Ninety cases of type 2 diabetes mellitus inpatients were selected,and randomly divided into LG small dos-age group(SDG),LG large dosage group(LDG)and control group.The 120 mg LG,400 mg LG andnormal saline 250 ml were given through intravenous dripping respectively,once daily,20 days as onetreatment course. Before and after treatment,all the patients had their fasting blood taken for PAI-1 andtissue plasminogen activator(t-PA)assessment test to perform the comparative study.Results:Seventy-three out of the 90 patients completed the observation course,the PAI-1 activity of three groups aftertreatment all lowered compared with that before treatment,and the difference between groups was alsosignificant(all P<0.01).After treatment the PAI-1 level of SDG and LDG of LG were all markedly low-ered(all P<0.01),the LDG’s lowering     

丹参对视网膜静脉阻塞患者脂质过氧化物及超氧化物歧化酶的影响

目的：探讨丹参对视网膜静脉阻塞（ＲＶＯ）患者血浆脂质过氧化物（ＬＰＯ）含量及红细胞超氧化物歧化酶（ＳＯＤ）活性的影响。方法：静脉滴注丹参注射液治疗３６例ＲＶＯ患者,测定治疗前后ＲＶＯ患者ＬＰＯ含量及ＳＯＤ活性,选取３０例健康人作为对照。结果：与健康人相比,ＲＶＯ患者血浆ＬＰＯ含量明显升高,红细胞ＳＯＤ活性明显下降（Ｐ＜０．００１）;ＲＶＯ患者使用丹参治疗后血浆ＬＰＯ含量较治疗前下降（Ｐ＜０．０５）,红细胞ＳＯＤ活性较治疗前明显升高（Ｐ＜０．０１）;ＲＶＯ患者使用丹参治疗后血浆ＬＰＯ含量及红细胞ＳＯＤ活性与健康人相比,均无明显变化（Ｐ＞０．０５）。结论：丹参作为一种外源性自由基清除剂,可有效地增加ＲＶＯ患者红细胞ＳＯＤ活性,降低ＬＰＯ含量,对ＲＶＯ的防治有重要意义     

玛咖提取物对体育运动的抗疲劳作用

目的 探讨玛咖提取物对体育运动的抗疲劳作用。方法 50只雄性Wistar大鼠随机分为,①对照组：正常饲养,不游泳,灌胃等量蒸馏水;②单纯游泳组：游泳,灌胃等量蒸馏水;③游泳+给药组：游泳,并分别灌胃玛咖提取物4.0、8.0和16.0 g/（kg·bw）。每组10只动物。采用循环水流自由游泳,给予大鼠4.0、8.0和16.0 g/（kg·bw）玛咖提取物,连续给药15 d,第16天采样测定肝过氧化脂质（LPO）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）和肝糖元水平。结果 与单纯游泳组动物比较,给予玛咖提取物4.0、8.0和16.0 g/（kg·bw）15 d后,大鼠下沉次数分别减少了27.44%、42.86%、64.11%（P<0.01）,下沉前游泳时间和游泳总时间分别延长了18.99%、64.46%、90.69%和37.12%、56.23%、94.72%（P<0.01）,LPO水平分别降低了31.31%、42.00%、56.95%（P<0.01）,SOD、GSH-Px和肝糖原水平分别升高了25.92%,31.82%、62.09%,12.33%,23.01%、46.36%和17.83%、44.69%、62.99%（P<0.01）。结论 玛咖提取物具有降低肝LPO水平,增加肝糖原水平,提高SOD、GSH-Px活性,增强运动耐力和抗疲劳作用。     

Clinical studies on treatment of acute cerebral infarction with Xueshuantong injection

Objective: To observe the effect of Xueshuantong injection (XST, with its ingredient as Notoginseng saponin, on acute cerebral infarction (ACI) and on blood coagulation and fibrinolysis, so as to comprehensively analyse the mechanism of XST.Methods: Fifty ACI patients were randomly divided into 2 groups, and XST group (30 patients) was treated with XST, and the control group (20 patients) given low molecular dextrose, as well as low molecular heparin calcium. The course of treatment for both groups was 15 days. The changes of effective rate, score of neurologic impairment, tissuetype plasminogen activator (tPA), inhibitor of plasminogen activator (PAI), D-D dimmer, antithrombinIII (AT-III), and fibrinogen (Fbg) were all observed.Results: The total effective rate of XST group was 73.33%, that of the control group 65. 00%. After the therapy, plasma level of tPA, ratio of tPA/PAI, and AT-III content were increased obviously, while the plasma level of PAI and D-D dimmer were decreased significantly (all P<0.01). But there was only insignificant difference between the 2 groups (P> 0.05).Conclusion: XST injection could be effective to ACI, the mechanism of which is probably related to improving the balance between plasminogen activator and its inhibitory factor, increasing the activity of fibrinolysin, inactivating thrombin, inhibiting platelet aggregation induced by thrombin, and decreasing blood coagulation.     

Study on blood coagulant/fibrinolytic activity at plasma and monocytic levels in coronary heart disease patients with blood-stasis syndrome of traditional chinese medicine

Study on Blood Coagulant/Fibrinolytic Activity at Plasma and Monocytic Levels in Coronary Heart Disease Patients with Blood-Stasis Syndrome of Traditional Chinese Medicine@吕 中 @施赛珠     

阻塞性睡眠呼吸暂停综合征患者纤溶活性、血粘度及红细胞变形性的研究

目的：探讨阻塞性睡眠呼吸暂停综合征(OSAS)思者纤溶活性、血粘度及红细胞变形性的变化情况。方法：选取经多导睡眠图(PSG)确诊的OSAS患者32例为试验组，30例PSG检查正常者为对照组，分别测定两组血浆组织型纤溶酶原激活物(t—PA)、纤溶酶原激活抑制物—1(PAI-l)水平，全血及血浆粘度，血浆纤维蛋白原(Fg)含量及红细胞变形性。结果：OSAS患者(轻、中、重度)与对照组相比PAI-l活性、低切全血粘度及血浆粘度明显增高，红细胞变形性明显下降(P＜0．05)，且OSAS越严重上述变化越明显；中、重度OSAS患者t-pA活性、高切全血粘度及Fg含量较对照组明显增高(P＜0．05)。结论：OSAS患者存在纤溶活性及红细胞变形性降低，血浆纤维蛋白原含量及血粘度增高，有形成血栓的倾向。     

竹节人参提取物对胃缺血再灌注损伤的防护

目的 观察竹节人参提取物对胃缺血再灌注损伤的防护作用。方法 采用腹腔动脉结扎法，造成胃缺血20min，解除结扎，再灌注60min后，取出胃粘膜，观察正常对照组，病理模型组和用药各组中胃粘膜之氧自由基，脂质过氧化物及清除酶系诸指标的变化。结果 大鼠胃缺血后再灌注，胃粘膜脂质过氧化物（LPO）含量比正常对照组明显增加，超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GSH－Px)含量则明显降低（P＜0．01）；术前口服竹节人参提取物组，胃粘膜LPO含量明显低于病理组，SOD，GSH－Px水平则明显高于病理组（P＜0．01）。结论 竹节人参提取物通过消除和抑制胃缺血再灌注时氧自由基产生，提高组织抗氧化能力，对胃缺血再灌注损伤起到保护作用。