A型肉毒毒素对眼睑痉挛的疗效观察

[背景 ]观察A型肉毒毒素对原发性眼睑痉挛和面肌痉挛的治疗效果 .[病例报告 ]多点局部注射A型肉毒毒素治疗原发性眼睑痉挛 2 6例及合并面肌痉挛的眼睑痉挛 13例 .结果 ,症状在 1～ 3d内缓解 ,5d内明显缓解 ,2个星期内缓解最明显 ,有效率为 10 0 % ,原发性眼睑痉挛的有效作用时间为 10～2 3周 ,平均 16周 .合并面肌痉挛的眼睑痉挛的平均有效作用时间为 14周 .[讨论 ]局部注射A型肉毒毒素是治疗原发性眼睑痉挛和面肌痉挛的一种方法     

A型肉毒杆菌毒素治疗面、睑肌痉挛临床研究

目的　探讨A型肉毒杆菌毒素对面、睑肌痉挛的疗效。方法　局部肌注A型肉毒杆菌毒素治疗面、睑肌痉挛 16 4例。结果　药效作用时间为 :面肌痉挛 18.92± 6 .12周 ,眼睑痉挛 12 .0 4± 6 .35周。副作用轻、可逆。结论　A型肉毒杆菌毒素局部注射治疗面、睑肌痉挛安全、有效。     

A型肉毒毒素治疗眼睑及面肌痉挛的临床研究

A型肉毒毒素治疗78例眼睑痉挛、面肌痉挛患者,均取得满意疗效。无全身反应,局部副作用轻微、短暂。药效作用时间:眼睑痉挛为4.0～16.0周,平均8.5周;面肌痉挛为8.0～32.0周,平均13.7周。可重复注射,无过敏反应。临床观察结果表明,A型肉毒毒素为一安全、有效、可靠的制剂,治疗方法简便易行,可作为治疗眼睑痉挛的首选药物。     

A型肉毒杆菌毒素治疗65例面肌痉挛的疗效观察

目的 探讨A型肉毒杆菌毒素治疗面肌痉挛的疗效及不良反应.方法 对65例面肌痉挛患者进行面肌多点注射A型肉毒杆菌毒素,对治疗前后的病情分级进行比较,并随访12～36周.结果 A型肉毒杆菌毒素治疗的总有效率为100%,无全身反应,局部不良反应主要为轻微短暂上睑下垂、鼻唇沟变浅、患侧眼流泪;6个月复发率为80%,药效作用时间平均为20周;重复注射仍然有效 .结论 局部注射A型肉毒杆菌毒素是治疗面肌痉挛的一种有效手段,方法 简便、易行,不良反应轻微,可作为治疗面肌痉挛的首选药物推广使用.     

A型肉毒杆菌毒素治疗眼睑及面肌痉挛的临床观察

目的：观察A型肉毒杆菌毒素治疗56例眼睑痉挛、面肌痉挛患的疗效。方法：用稀释后的A型肉毒素杆菌毒素行眼睑轮匝肌及面肌多点注射。结果：56例患均取得满意疗效。结论：A型肉毒杆菌毒素可用于治疗眼睑痉挛及面肌痉挛。安全、有效，方法简便易行。     

A型肉毒毒素治疗面肌、眼睑痉挛59例临床观察

目的探讨A型肉毒毒素治疗面肌、眼睑痉挛的疗效。方法采用A型肉毒毒素局部注射治疗偏侧面肌痉挛51例、眼睑痉挛8例,并使用Cohen和Albert量表进行评估。结果症状完全缓解占51.45%,明显改善占37.5%,部分改善占11.2%,疗效平均持续约3～6个月,复发者重复注射仍有效,出现眼睑闭合不全、面肌无力、眼睑下垂共18例,均恢复。结论局部注射A型肉毒毒素确为一种安全有效、简便易行的治疗面肌、眼睑痉挛的方法。     

A型肉毒毒素治疗面肌痉挛112例疗效观察

目的:探讨A型肉毒毒素治疗面肌痉挛的疗效及不良反应。方法:对112例面肌痉挛患者进行面肌多点注射A型肉毒杆菌毒素,对治疗前后的病情分级进行比较,并随访6～12月。结果:A型肉毒杆菌毒素治疗的总有效率为100%,不良反应轻微、短暂,药效作用时间平均为5月。结论:局部注射A型肉毒毒素治疗面肌痉挛安全,有效。     

A型肉毒杆菌毒素治疗面肌痉挛的临床研究

目的：观察A型肉毒杆菌毒素治疗面肌痉挛的临床疗效。方法：采用小剂量A型肉毒杆菌毒素局部多点注射治疗36例面肌痉挛患者。结果：36例面肌痉挛患者完全缓解32例,占88．89％;明显缓解3例,占8．33％;部分缓解1例,占2．78％。药效作用时间9周-32周．平均14．2周。无全身反应,局部并发症轻微、短暂。可重复注射。结论：局部注射A型肉毒杆菌毒素治疗面肌痉挛为一种安全、有效、简便易行的方法。     

A型肉毒杆菌毒素治疗眼睑及面肌痉挛临床疗效观察

目的 探讨A型肉毒杆菌毒素（BTX-A）治疗眼睑及面肌痉挛的临床疗效。方法 对22例眼睑及面肌痉挛患者局部注射BTX-A治疗，随诊观察其临床疗效3～6个月。结果 22例患者不同程度得到改善，其中一次完全治愈率50%，注射后药效作用时间：眼睑痉挛为8～16周，面肌痉挛为12～24周，局部应用无全身反应，局部副作用轻微。结论 BTX-A治疗眼睑及面肌痉挛疗效确切、安全，简便易行，不失为首选药物。     

A型肉毒杆菌毒素治疗眼睑及面肌痉挛临床分析

目的:探讨肉毒杆菌毒素治疗眼睑及面肌痉挛的效果。方法:对2000年8月～2004年12月收治的46例患者进行肉毒杆菌毒素治疗。结果:患者面肌及眼睑痉挛强度均下降,与治疗前比较,差异具有统计学意义(P<0.05)。6个月后随访有19例复发,无全身及局部过敏等不良反应。结论:A型肉毒杆菌毒素治疗眼睑及面肌痉挛是一种有效且安全的治疗方法。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.