共查询到20条相似文献,搜索用时 15 毫秒
1.
Nadia El Fakhar Zoubida Charrouf Bernadette Coddeville Yves Leroy Jean Claude Michalski Dominique Guillaume 《Journal of natural medicines》2007,61(4):375-380
Five new triterpene saponins, arganine L (1), O (2), P (3), Q (4) and R (5), were isolated from the barks of Argania spinosa (L.) Skeels. Arganines L-P and R are bidesmosidic saponins. The structures of 1–5 were elucidated as 3-O-[β-d-xylopyranosyl-(1–4)-β-d-glucuronopyranosyl]-28-O-[β-d-apiofuranosyl-(1–3)-β-d-xylopyranosyl-(1–4)-α-l-rhamnopyranosyl-(1–2)-α-l-arabinopyranosyl] bayogenin, 3-O-[β-d-xylopyranosyl-(1–4)-β-d-glucuronopyranosyl]-28-O-[β-d-xylopyranosyl-(1–4)-α-l-arabinopyranosyl] bayogenin, 3-O-[β-d-xylopyranosyl-(1–4)-β-d-glucuronopyranosyl]-28-O-[α-l-arabinopyranosyl] bayogenin, 3-O-[β-d-xylopyranosyl-(1–4)-β-d-glucuronopyranosyl] bayogenin, and 3-O-[β-d-apiofuranosyl-(1–4)-β-d-glucuronopyranosyl]-28-O-[β-d-xylopyranosyl-(1–4)-α-l-rhamnopyranosyl-(1–2)-α-l-arabinopyranosyl] bayogenin, respectively, mainly on the basis of their spectroscopic data. 相似文献
2.
Pawadee Noiarsa Qian Yu Katsuyoshi Matsunami Hideaki Otsuka Somsak Ruchirawat Tripetch Kanchanapoom 《Journal of natural medicines》2007,61(4):406-409
A new (Z)-3-hexenyl O-β-d-glucopyranosyl-(1→6)-β-d-glucopyranoside was isolated from the aerial part of Spermacoce
laevis, along with 17 known compounds: (6S,9R)-roseoside, (Z)-3-hexenyl O-β-d-glucopyranoside, (Z)-3-hexenyl O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside, (Z)-3-hexenyl O-α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside, phenyethyl O-β-d-glucopyranoside, phenyethyl O-α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside, phenyethyl O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside, benzyl O-α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside, benzyl O-β-d-xylopyranosyl-(1→6)-β-d-glucopyranoside, asperuloside, 6α-hydroxyadoxoside, asperulosidic acid, kaempferol 3-O-β-d-glucopyranoside, kaempferol 3-O-rutinoside, quercetin 3-O-β-d-galactopyranoside, quercetin 3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside, and rutin. The structure determinations were based on physical data and spectroscopic evidence. 相似文献
3.
Hardik S. Bodiwala Gaganmeet Singh Ranvir Singh Chinmoy Sankar Dey Shyam Sundar Sharma Kamlesh Kumar Bhutani Inder Pal Singh 《Journal of natural medicines》2007,61(4):418-421
The n-hexane, ethyl acetate, methanol, and acetone extracts of Piper cubeba Linn. and P. retrofractum Vahl. (Piperaceae) were evaluated in vitro against promastigotes of Leishmania donovani, and all exhibited significant in vitro activity at 100 μg/ml. Two lignans, cubebin and hinokinin, were isolated from the
hexane extract of P. cubeba; and one bis-epoxy lignan, (−)-sesamin, and two amides, pellitorine and piplartine, were isolated from the hexane and methanol
extracts of P. retrofractum. Cubebin and piplartine showed significant antileishmanial activity in vitro at 100 μM and were further tested in vivo in
a hamster model of visceral leishmaniasis. Piplartine showed activity at 30 mg/kg dose. This is the first report of antileishmanial
activity of these two plants and their isolated constituents.
NIPER Communication No. 395. 相似文献
4.
Hitomi Sakai Rie Kakuda Yasunori Yaoita Masao Kikuchi 《Journal of natural medicines》2007,61(2):226-228
Seven secoiridoid glycosides, secologanin dimethyl acetal (1), n-butyl vogeloside (2), n-butyl epi-vogeloside (3), (7R)-n-butyl morroniside (4), hydrangenoside A (5), hydrangenoside C (6), and hydrangenoside A dimethyl acetal (7), have been isolated from the leaves of Hydrangea macrophylla subsp. serrata (Thunb.) Makino (Saxifragaceae). The structures were elucidated on the basis of spectral data. 相似文献
5.
Yumi Nishiyama Masataka Moriyasu Momoyo Ichimaru Maki Sonoda Kinuko Iwasa Atsushi Kato Francis D. Juma Simon G. Mathenge Patrick B. Chalo Mutiso 《Journal of natural medicines》2007,61(1):56-58
A tropane alkaloid, anhydroecgonine methyl ester N-oxide (2), was isolated for the first time as a naturally occurring compound, with anhydroecgonine methyl ester (1) from the bark of Erythroxylum emarginatum. Compound 1 was also isolated from the twigs. Their structures were elucidated mainly by spectroscopic methods. 相似文献
6.
Bohang Sun Bailing Hou Jian Huang Lijun Wu Masonori Kuroyanagi Huiyuan Gao 《Archives of pharmacal research》2008,31(12):1530-1533
Further chemical study led to two new A-seco-rearranged lanostane triterpenoid derivatives (1–2) and one known compound Abiesanolide C (3) from the ethyl acetate (EtOAc) soluble fraction of the MeOH extract of Abies sachalinensis needles. The new compounds were identified as 3,4-seco-8-(14→13R)abeo-17,13-friedo-9β-lanosta-4(28), 7, 14, 24-tetraen-26,23-olide-23-hydroxy-3-oic acid and methyl-3,4-seco-8-(14→13R) abeo-17,13-friedo-9β-lanosta-4(28), 7, 14, 24-tetraen-26,23-olide-23-hydroxy-3-oate, respectively. Structural determination of these compounds
were carried out by the spectral studies especially by the two digital (2D)-NMR and high-resolution (HR)-MS experiences. 相似文献
7.
Mariko Kitajima 《Journal of natural medicines》2007,61(1):14-23
We have proved that the plant of origin of “Yakatsu”, one of the ancient medicines stored in Shosoin Repository, is Gelsemium elegans (Loganiaceae). Exhaustive investigation of the alkaloids in this plant as well as its closely related plant, G. sempervirens, resulted in the isolation of more than 50 compounds, including new gelsedine-, sarpagine-, and yohimbane-type alkaloids. Pharmacological study of representative and new Gelsemium alkaloids revealed that the gelsedine-type alkaloids exhibit potent cytotoxic activity against the A431 human epidermoid carcinoma cell line. It was found that Ophiorrhiza pumila (Rubiaceae) produces a remarkable anti-tumor alkaloid, camptothecin, and its related alkaloids, including new compounds that might be the biogenetic precursors of camptothecin. Chemical investigation of callus cultures, regenerated plants, and hairy roots of O. pumila revealed that the regenerated plants and the hairy roots produce almost the same alkaloids, including camptothecin, as do the wild-type plants. 相似文献
8.
A new kaempferol trioside [kaempferol 3-O-rutinoside 7-O-β-d-apiofuranoside, (1)] was isolated together with nine phenolic compounds, trans-tiliroside (2), caffeic acid (3), chlorogenic acid (4), 3-O-caffeoylquinic acid (5), 4-O-caffeoylquinic acid (6), 3-O-coumaroylquinic acid (7), 4-O-coumaroylquinic acid (8), 3,5-di-O-caffeoylquinic acid (9) and 4,5-dicaffeoylquinic acid (10) from the leaves of Solidago altissima L. The structure elucidations of the compounds were based on the analyses of spectroscopic data. 相似文献
9.
Toru Yamasaki Chikako Masuoka Toshihiro Nohara Masateru Ono 《Journal of natural medicines》2007,61(3):318-322
A new phenylethanoid glycoside, named acetyl forsythoside B (1), was isolated from the fruits of Callicarpa japonica Thunb. var. luxurians Rehd. (Verbenaceae) along with forsythoside B (2), brandioside (3), poliumoside (4), actioside (5), and apigenin 7-galacturonide (6). The structures of 1–6 were determined on the basis of spectroscopic data. In addition, the antioxidative activity of 1–4 and 6 was evaluated by the ferric thiocyanate method. All of the tested compounds except 6 exhibited almost the same activity as 3-tert-butyl-4-hydroxyanisole. The radical-scavenging effect of 1–6 on the stable free radical 1,1-diphenyl-2-picrylhydrazyl was also examined. Compounds 1–5 showed almost twice the activity compared to α-tocopherol. 相似文献
10.
Tripetch Kanchanapoom Mohamed S. Kamel Chayan Picheansoonthon Prathan Luecha Ryoji Kasai Kazuo Yamasaki 《Journal of natural medicines》2007,61(4):478-479
Four hydrolyzable tannins, 1,2,4,6-tetra-O-galloyl-β-d-glucopyranoside, 1,2,6-tri-O-galloyl-β-d-glucopyranoside, 1,4,6-tri-O-galloyl-β-d-glucopyranoside; and 1,2,4-tri-O-galloyl-β-d-glucopyranoside, along with a phenylpropanoid glucoside, syringin, were isolated from the flowers of Rafflesia kerrii. The structure elucidations were based on physical data and spectroscopic evidence. 相似文献
11.
Bidyut K. Datta M. Mukhlesur Rahman Alexander I. Gray Lutfun Nahar Syed A. Hossein Abdurazag A. Auzi Satyajit D. Sarker 《Journal of natural medicines》2007,61(4):391-396
Three new sesquiterpenes, 6-hydroxy-7-(1-methylethyl)-3,3a,6,7,8,8a-hexahydroazulene-1,4-dicarboxylic acid methyl ester (1, named viscozulenic acid methyl ester), 7-(1-methylethyl)-3,3a,6,7,8,8a-hexahydroazulene-1,4-dicarboxylic acid 1-methyl ester
(2, named viscoazucinic acid) and 3-oxo-1-epi-sclerosporin (3, named polygosumic acid), have been isolated from the chloroform extract of the aerial parts of Polygonum viscosum by reversed-phase preparative high performance liquid chromatography (HPLC). The structures of these compounds were established
conclusively by ultraviolet (UV), mass spectrometry (MS) and a series of 1D and 2D nuclear magnetic resonance (NMR) analyses.
The anti-bacterial properties of 1–3 against 12 pathogenic bacterial strains have also been assessed by the rapid and robust microtitre-plate-based serial dilution
method incorporating resazurin as an indicator of cell growth. Polygosumic acid was the most active among the sesquiterpenes
and inhibited the growth of penicillin-resistant Escherichia coli (minimum inhibitory concentration, MIC=0.05 mg/ml) and methicillin-resistant Staphylococcus aureus (MRSA) (MIC=0.10 mg/ml). 相似文献
12.
The dichloromethane extract of air-dried leaves of Blumea lacera (Asteraceae) afforded α-pinene-7β-O-β-d-2,6-diacetylglucopyranoside (1), 5,4′-dihydroxy-6,7,3′-trimethoxyflavone (2), and 3,5,4′-trihydroxy-6,7,3′-trimethoxyflavone (3). Compounds 1–3 showed moderate activity against Candida albicans, low activity against Trichophyton mentagrophytes, and were inactive against Aspergillus niger. Compounds 1 and 3 indicated low activity against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus and were inactive against Bacillus subtilis, while 2 was inactive against all four bacteria tested. 相似文献
13.
Three new prenylated xanthones, 1,3,5-trihydroxy-6,7-[2′-(1-methylethenyl)-dihydrofurano]-xanthone (1), 1,3,5-trihydroxy-6,7-[2′-(1-hydroxy-1-methylethyl)-dihydrofurano]-xanthone (2), and 1,3,5-trihydroxy-6-O-prenyl-xanthone (3), together with eight known compounds were isolated from the leaves of Hypericum ascyron. Compound 3 has an O-prenyl moiety, and therefore represents the first reported xanthone to have an O-prenyl moiety from genus Hypericum. The structures of the isolated compounds were established based on spectroscopic data and on a comparison with values for
previously identified analogues. 相似文献
14.
Sumei Huang Toshihiro Fujioka Miyako Yoshida Kanji Ishimaru 《Journal of natural medicines》2007,61(3):339-341
A new chalcone glycoside, having an allenic ester moiety, was isolated together with chalcononaringenin 2′-O-β-D-glucopyranoside from the catkin of Sapium sebiferum. The structure elucidations of chalcone glycosides were based on the analyses of spectroscopic data. 相似文献
15.
Jun Li Makoto Tanaka Katsuki Kurasawa Tsuyoshi Ikeda Toshihiro Nohara 《Journal of natural medicines》2007,61(2):222-223
The constituents of the flower buds of Magnolia kobus DC. and M. salicifolia MAXIM. have been investigated. We isolated and identified six bis-tetrahydrofuran-type and three tetrahydrofuran-type lignan
derivatives from M. kobus, and one bis-tetrahydrofuran-type lignan and eight phenylpropanoid-type derivatives from M. salicifolia. The structures of these compounds were elucidated on the basis of chemical and spectroscopic evidence. 相似文献
16.
Etsuko Sueyoshi Hui Liu Katsuyoshi Matsunami Hideaki Otsuka Takakazu Shinzato Mitsunori Aramoto Yoshio Takeda 《Journal of natural medicines》2007,61(4):468-471
A new lignan glycoside, bridelioside, has been isolated from Bridelia glauca f. balansae. The structure of bridelioside was elucidated be (+)-isolariciresinol 2a-O-α-l-arabinopyranoside on the basis of spectral data. 相似文献
17.
A new ceramide, (2S,2′R,3R,4E,8E)-N-2′-hydroxyoctadecanoyl-2-amino-9-methyl-4,8-heptadecadiene-1,3-diol (1), was isolated together with four known sterols, 5α,6α-epoxy-3β-hydroxy-(22E)-ergosta-8(14),22-dien-7-one (2), ergosterol peroxide (3), cerevisterol (4) and 9α-hydroxycerevisterol (5), from the fruiting bodies of Ramaria botrytis (Pers.) Ricken (Ramariaceae). The structure of the new compound was elucidated based on spectral data. 相似文献
18.
Won Keun Oh Chul- Ho Lee Jee Hee Seo Mi Yeon Chung Long Cui Z. Tanee Fomum Jong Seong Kang Hyun Sun Lee 《Archives of pharmacal research》2009,32(1):43-47
Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) is proposed to be a drug target for the treatment of obesity
and type 2 diabetes. Bioassay-guided fractionation of the CH2Cl2-soluble extract of the stem bark of Erythrina senegalensis, using an in vitro DGAT enzyme assay, resulted in the isolation of eight known prenylflavonoids, 8-prenylleutone (1), auriculatin (2), erysenegalensein O (3), erysenegalensein D (4), erysenegalensein N (5), derrone (6), alpinumisoflavone (7), and 6,8-diprenylgenistein (8). Compounds 1, 2–4, 6, and 8 inhibited DGAT activity, with IC50 values ranging from 1.1 ± 0.3 to 15.1 ± 1.1 μg/mL. On the basis of the data obtained, we propose isoflavonoids with isoprenyl
groups as a novel class of DGAT inhibitors. 相似文献
19.
Nobukazu Ryu Hiroki Tanabe Toshiaki Makino Hajime Mizukami Makoto Inoue 《Journal of natural medicines》2007,61(3):342-348
A large number of infectious or inflammatory agents are well known to reduce cytochrome P450-catalyzed drug metabolism in
the liver. Changes in the levels of hepatic P450s in infectious or inflammatory diseases can lead to alteration in physiology,
therapeutic failure, and disease development. This study was therefore designed to examine the effect of shosaikoto, a Kampo
medicine used for treatment of chronic hepatitis and acute flu, on the changes in P450 activity and protein levels following
intravenous injection of Mycobacterium butyricum. Intravenous injection of M. butyricum into rats reduced hepatic P450: CYP1A1, 1A2, 2B, and 3A activities and CYP2E1 and 3A2 protein levels. When administered orally
to rats for 2 weeks since 1 week before M. butyricum injection, shosaikoto prevented the reduction in CYP1A1, 1A2, 2B, and 3A activities dose dependently and further abrogated
the repression of CYP3A2 protein but not CYP2E1 protein. Serum C-reactive protein levels in this rat model were not highly
elevated, and neither were significantly influenced by shosaikoto treatment. Taken together, these results suggest that shosaikoto
would be capable of modulating the change in hepatic P450 caused by M. butyricum injection and the effect, which might not be brought about by its anti-inflammatory activity but by translational or posttranslational
regulation, appears to differ in each P450 isoform. 相似文献
20.
Noriyuki Kogure Ayumi Someya Akiko Urano Mariko Kitajima Hiromitsu Takayama 《Journal of natural medicines》2007,61(2):208-212
A yohimbane-type indole alkaloid, ourouparine, was found in Gelsemium sempervirens, and its structure was elucidated by spectroscopic analysis and total synthesis. 相似文献