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1.
Kameyama R Yamamoto Y Izuishi K Takebayashi R Hagiike M Murota M Kaji M Haba R Nishiyama Y 《European journal of nuclear medicine and molecular imaging》2009,36(3):382-388
Purpose We prospectively investigated the feasibility of 3′-deoxy-3′-18F-fluorothymidine (FLT) positron emission tomography (PET) for the detection of gastric cancer, in comparison with 2-deoxy-2-18F-fluoro-d-glucose (FDG) PET, and determined the degree of correlation between the two radiotracers and proliferative activity as indicated
by Ki-67 index.
Methods A total of 21 patients with newly diagnosed advanced gastric cancer were examined with FLT PET and FDG PET. Tumour lesions
were identified as areas of focally increased uptake, exceeding that of surrounding normal tissue. For semiquantitative analysis,
the maximal standardized uptake value (SUV) was calculated.
Results For detection of advanced gastric cancer, the sensitivities of FLT PET and FDG PET were 95.2% and 95.0%, respectively. The
mean (±SD) SUV for FLT (7.0 ± 3.3) was significantly lower than that for FDG (9.4 ± 6.3 p < 0.05). The mean FLT SUV and FDG SUV in nonintestinal tumours were higher than in intestinal tumours, although the difference
was not statistically significant. The mean (±SD) FLT SUV in poorly differentiated tumours (8.5 ± 3.5) was significantly higher
than that in well and moderately differentiated tumours (5.3 ± 2.1; p < 0.04). The mean FDG SUV in poorly differentiated tumours was higher than in well and moderately differentiated tumours,
although the difference was not statistically significant. There was no significant correlation between Ki-67 index and either
FLT SUV or FDG SUV.
Conclusion FLT PET showed as high a sensitivity as FDG PET for the detection of gastric cancer, although uptake of FLT in gastric cancer
was significantly lower than that of FDG. 相似文献
2.
Efficiency of 18F-FDG and 99mTc-depreotide SPECT in the diagnosis of malignancy of solitary pulmonary nodules 总被引:4,自引:0,他引:4
Halley A Hugentobler A Icard P Porret E Sobrio F Lerochais JP Bouvard G Zalcman G Agostini D 《European journal of nuclear medicine and molecular imaging》2005,32(9):1026-1032
Purpose The purpose of the study was to compare 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and 99mTc-depreotide single-photon emission computed tomography (SPECT) in the diagnosis of malignancy of solitary pulmonary nodules (SPNs).Methods Twenty-eight patients without any history of cancer and presenting an SPN (0.8–3 cm in size) underwent FDG PET and depreotide SPECT. Depreotide SPECT and FDG PET were performed on a double-head gamma camera and a dedicated PET scanner respectively. Twenty-five out of 28 lesions were removed by thoracotomy or assessed by biopsy (n=1) and histologically examined. A strategy of serial CT scanning was adopted in the three remaining patients.Results Histological findings revealed 18 malignant nodules and seven benign lesions. Stability over a 2-year period indicated a benign process in the remaining three cases. Both techniques yielded true positive results in 15 of the 18 cancers. FDG PET identified two additional adenocarcinomas not detected by depreotide SPECT. A carcinoid tumour not visualised on FDG PET was identified by depreotide SPECT. Seven of the ten benign lesions did not reveal tracer uptake on either depreotide SPECT or FDG PET. Both techniques showed false positive results for the same two lesions. One more false positive was seen on FDG PET. FDG PET and depreotide SPECT had a sensitivity of 94.4% and 88.9% respectively; this difference was not significant. In our experience, depreotide SPECT and FDG PET are equally sensitive (92.3%) for large (>1.5 cm) and equally specific (85.7%) for small (up to 1.5 cm) SPNs suspicious for malignancy.Conclusion This study showed 18F-FDG PET to be more sensitive than 99mTc-depreotide SPECT in the diagnosis of malignancy of SPNs. However, the combination of both techniques may provide additional accuracy. 相似文献
3.
Yukihiro Umeda Yoshiki Demura Takeshi Ishizaki Shingo Ameshima Isamu Miyamori Yuji Saito Tatsuro Tsuchida Yasuhisa Fujibayashi Hidehiko Okazawa 《European journal of nuclear medicine and molecular imaging》2009,36(7):1121-1130
Purpose Individual clinical courses of idiopathic interstitial pneumonia (IIP) are variable and difficult to predict because the pathology
and disease activity are contingent, and chest computed tomography (CT) provides little information about disease activity.
In this study, we applied dual-time-point [18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET), commonly used for diagnosis of malignant tumours, to the differential diagnosis
and prediction of disease progression in IIP patients.
Methods Fifty patients with IIP, including idiopathic pulmonary fibrosis (IPF, n = 21), non-specific interstitial pneumonia (NSIP, n = 18) and cryptogenic organizing pneumonia (COP, n = 11), underwent 18F-FDG PET examinations at two time points: scan 1 at 60 min (early imaging) and scan 2 at 180 min (delayed imaging) after
18F-FDG injection. The standardized uptake values (SUV) at the two points and the retention index (RI-SUV) calculated from them
were evaluated and compared with chest CT findings, disease progression and disease types. To evaluate short-term disease
progression, all patients were examined by pulmonary function test every 3 months for 1 year after 18F-FDG PET scanning.
Results The early SUV for COP (2.47 ± 0.74) was significantly higher than that for IPF (0.99 ± 0.29, p = 0.0002) or NSIP (1.22 ± 0.44, p= 0.0025). When an early SUV cut-off value of 1.5 and greater was used to distinguish COP from IPF and NSIP, the sensitivity,
specificity and accuracy were 90.9, 94.3 and 93.5%, respectively. The RI-SUV for IPF and NSIP lesions was significantly greater
in patients with deteriorated pulmonary function after 1 year of follow-up (progressive group, 13.0 ± 8.9%) than in cases
without deterioration during the 1-year observation period (stable group, −16.8 ± 5.9%, p < 0.0001). However, the early SUV for all IIP types provided no additional information of disease progression. When an RI-SUV
cut-off value of 0% and greater was used to distinguish progressive IIPs from stable IIPs, the sensitivity, specificity and
accuracy were 95.5, 100 and 97.8%, respectively.
Conclusion Early SUV and RI-SUV obtained from dual-time-point 18F-FDG PET are useful parameters for the differential diagnosis and prediction of disease progression in patients with IIP. 相似文献
4.
Kitajima K Nakamoto Y Senda M Onishi Y Okizuka H Sugimura K 《Annals of nuclear medicine》2007,21(7):405-410
Objective The aim of this study was to assess the physiological uptake of 18F-fluoro-2-deoxyglucose (FDG) by an apparently normal testis with combined positron emission tomography–computed tomography
(PET/CT) and its correlation with age, blood glucose level, and testicular volume.
Methods The testicular uptake of 18F-FDG, expressed as the standardized uptake value (SUV), was measured on PET/CT images in 203 men. The correlation between
SUV and age, blood glucose level, and testicular volume was assessed.
Results The SUV in the total of 406 testes was 2.44 ± 0.45 (range 1.23–3.85). The SUV was 2.81 ± 0.43 (2.28–3.85) for 30–39 years
(n = 12), 2.63 ± 0.45 (1.77–3.75) for 40–49 years (n = 64), 2.46 ± 0.35 (1.44–3.15) for 50–59 years (n = 82), 2.51 ± 0.41 (1.50–3.46) for 60–69 years (n = 86), 2.43 ± 0.47 (1.42–3.29) for 70–79 years (n = 86), and 2.18 ± 0.45 (1.23–3.03) for 80–89 years (n = 76). When we calculated the mean SUV of bilateral testes in each patient, there were significant statistical differences
between those in the age group of 30–39 years and 80–89 years, 40–49 years and 80–89 years, and 50–60 years and 80–89 years,
when using an unpaired test with Bonferroni correction. The laterality index (|L − R|/(L + R) × 2) in 203 men was 0.066 ±
0.067 (0–0.522). There was a mild correlation between the mean SUV and age (r = −0.284, P < 0.001) as well as between the mean SUV and mean volume (r = +0.368, P < 0.001). There was no correlation between the mean SUV and glucose blood level (r = −0.065, P = 0.358).
Conclusions Some uptake of FDG is observed in the normal testis and declines slightly with age. Physiological FDG uptake in the testis
should not be confused with pathological accumulation. 相似文献
5.
Higashi K Ueda Y Matsunari I Kodama Y Ikeda R Miura K Taki S Higuchi T Tonami H Yamamoto I 《European journal of nuclear medicine and molecular imaging》2004,31(1):13-21
Recently carbon-11 acetate (AC) positron emission tomography (PET) has been reported to be of clinical value for the diagnosis of cancer that is negative on fluorine-18 fluorodeoxyglucoce (FDG) PET. We investigated the uptake of AC in lung cancer to determine whether this tracer is of potential value for tumour detection and characterisation, and to compare AC PET imaging with FDG PET and technetium-99m sestamibi (MIBI) single-photon emission tomography (SPET). Twenty-three patients with 25 lung cancers underwent AC and FDG PET. Twenty of 23 patients were also investigated with MIBI SPET. Dynamic images were acquired for 26 min after the injection of 555 MBq of AC. Standardised uptake values (SUVs) and/or tumour to non-tumour activity ratios (T/N) for each tumour were investigated at 10–20 min after AC administration, 40–60 min after administration of 185 MBq FDG and 15–45 min after administration of 555 MBq MIBI. Twenty lung cancers were resected surgically, and the degree of tracer uptake in the primary lesion was correlated with histopathological features (cell dedifferentiation and aggressiveness) and prognosis. Rapid uptake of AC followed by extremely slow clearance was observed. For the purpose of tumour identification, AC PET was inferior to FDG PET in 8 of 25 (32%) lung cancers, and the T/N of AC was lower than that of FDG. However, AC PET was superior to FDG PET in the identification of a slow-growing tumour (bronchiolo-alveolar carcinoma). There was a positive correlation between AC uptake (T/N) and MIBI uptake (T/N) (r=0.799, P<0.0001). A positive correlation was not observed between either AC or MIBI uptake and the degree of cell dedifferentiation in lung adenocarcinomas, whereas FDG uptake did correlate with the degree of cell dedifferentiation. In lung adenocarcinoma, there was a weak correlation between aggressiveness and FDG uptake, but no correlation was evident for AC and MIBI. In addition, a positive correlation was not observed between AC or MIBI uptake and postoperative recurrence in lung adenocarcinoma, whereas FDG uptake did correlate with postoperative recurrence. Thus, the greater the FDG uptake, the higher the malignant grade. In conclusion, for the purpose of tumour identification, AC PET was inferior to FDG PET but superior to MIBI SPET. Neither AC nor MIBI uptake reflects the malignant grade in lung adenocarcinoma, whereas FDG uptake does. AC PET is less diagnostically informative than FDG PET in patients with lung cancer. However, AC PET may play a complementary role in the identification of low-grade malignancies that are not FDG avid. 相似文献
6.
Optimal dose of <Superscript>18</Superscript>F-FDG required for whole-body PET using an LSO PET camera 总被引:2,自引:0,他引:2
Everaert H Vanhove C Lahoutte T Muylle K Caveliers V Bossuyt A Franken PR 《European journal of nuclear medicine and molecular imaging》2003,30(12):1615-1619
Reducing the acquisition time of whole-body fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) (corrected for attenuation) is of major importance in clinical practice. With the introduction of lutetium oxyorthosilicate (LSO), the acquisition time can be dramatically reduced, provided that patients are injected with larger amounts of tracer and/or the system is operated in 3D mode. The aim of this study was to determine the optimal dose of 18F-FDG required in order to achieve good-to-excellent image quality when a "3-min emission, 2-min transmission/bed position" protocol is used for an LSO PET camera. A total of 218 consecutive whole-body 18F-FDG PET studies were evaluated retrospectively. After excluding patients with liver metastases, hyperglycaemia and paravenous injections, the final study population consisted of 186 subjects (112 men, 74 women, age 59±15 years). Patients were injected with an activity of 18F-FDG ranging from 2.23 to 15.21 MBq/kg. Whole-body images corrected for attenuation (3 min emission, 2 min transmission/bed position) were acquired with an LSO PET camera (Ecat Accel,Siemens) 60 min after tracer administration. Patients were positioned with their arms along the body. Image reconstruction was done iteratively and a post-reconstruction filter was applied. Image quality was scored visually by two independent observers using a five-point scoring scale (poor, reasonable, good, very good, excellent). In addition, the coefficient of variability (COV) was measured in a region of interest over the liver in order to quantify noise. Of the images obtained in 118 patients injected with 8 MBq/kg 18F-FDG, 92% and 90% were classified as good, very good or excellent by observer 1 and observer 2, respectively. The COV averaged 10.63%±3.19% for doses 8 MBq/kg and 16.46%±5.14% for doses <8 MBq/kg. Administration of an 18F-FDG dose of 8 MBq/kg results in images of good to excellent quality in the vast majority of patients when using an LSO PET camera and applying a 3-min emission, 2-min transmission/bed position acquisition protocol. At lower doses, a rapid decline in image quality and increasing noise are observed. Alternative protocols should be adopted in order to compensate for the loss in image quality when doses <8 MBq/kg are used. 相似文献
7.
Yoshiki Demura Tatsuro Tsuchida Daisuke Uesaka Yukihiro Umeda Miwa Morikawa Shingo Ameshima Takeshi Ishizaki Yasuhisa Fujibayashi Hidehiko Okazawa 《European journal of nuclear medicine and molecular imaging》2009,36(4):632-639
Purpose To evaluate the usefulness of 18F-FDG PET in the imaging of pulmonary lesions related to disease activity and in monitoring responses to treatment in patients
with pulmonary mycobacteriosis (PM).
Materials and methods We used high-resolution computed tomography (HRCT) and 18F-FDG PET to evaluate 47 consecutive untreated patients with PM, 25 with tuberculosis (TB) and 22 with Mycobacterium avium-intracellulare complex (MAC), who presented with small peripheral pulmonary nodules ≤3 cm, and compared the findings. The diagnosis of mycobacteriosis
was confirmed by bacteriological examinations of bronchoscopic or surgically resected specimens. PET scans were visually and
quantitatively analysed using SUVmax. In addition, 14 patients with PM underwent repeat PET scanning during antimycobacterial
therapy, and changes in 18F-FDG uptake were clinically evaluated (6 during treatment and 12 after treatment).
Results Of all the lesions, 87.2% had SUVmax levels ranging from 3 to 7 (5.05 ± 1.56, range 2.5–7.6, n = 47). Further, SUV levels in patients with PM reflected disease activity as estimated by HRCT, but did not differ significantly
between those with TB (4.96 ± 1.61, n = 25) and MAC (5.15 ± 1.53, n = 22). 18F-FDG uptake was significantly decreased in all 14 patients who received chemotherapy, indicating a positive response to treatment.
Conclusion
18F-FDG PET is considered to be useful for the diagnosis and evaluation of disease activity along with HRCT findings, and in
monitoring response to chemotherapy in patients with PM. 相似文献
8.
Yamamoto Y Nishiyama Y Ishikawa S Nakano J Chang SS Bandoh S Kanaji N Haba R Kushida Y Ohkawa M 《European journal of nuclear medicine and molecular imaging》2007,34(10):1610-1616
Purpose The nucleoside analogue 3′-deoxy-3′-18F-fluorothymidine (FLT) has recently been introduced for imaging cell proliferation with positron emission tomography (PET).
We prospectively evaluated whether FLT uptake reflects proliferative activity as indicated by the Ki-67 index in non-small
cell lung cancer (NSCLC), in comparison with 2-deoxy-2-18F-fluoro-D-glucose (FDG).
Methods A total of 18 patients with newly diagnosed NSCLC were examined with both FLT PET and FDG PET. PET imaging was performed at
60 min after each radiotracer injection. Tumour lesions were identified as areas of focally increased uptake, exceeding background
uptake in the lungs. For semi-quantitative analysis, the maximum standardised uptake value (SUV) was calculated. Proliferative
activity as indicated by the Ki-67 index was estimated in tissue specimens. Immunohistochemical findings were correlated with
SUVs.
Results The sensitivity of FLT and FDG PET for the detection of lung cancer was 72% and 89%, respectively. Four of the five false-negative
FLT PET findings occurred in bronchiolo-alveolar carcinoma. The mean FLT SUV was significantly lower than the mean FDG SUV.
A significant correlation was observed between FLT SUV and Ki-67 index (r = 0.77; p < 0.0002) and for FDG SUV (r = 0.81; p < 0.0001).
Conclusion The results of this preliminary study suggest that, compared with FDG, FLT may be less sensitive for primary staging in patients
with NSCLC. Although FLT uptake correlated significantly with proliferative activity in NSCLC, the correlation was not better
than that for FDG uptake. 相似文献
9.
The role of <Superscript>18</Superscript>F-FDG PET in characterising disease activity in Takayasu arteritis 总被引:2,自引:0,他引:2
Webb M Chambers A AL-Nahhas A Mason JC Maudlin L Rahman L Frank J 《European journal of nuclear medicine and molecular imaging》2004,31(5):627-634
Takayasu arteritis (TA) is a rare, sporadic and chronic inflammatory arteritis, which predominantly affects the aorta and its branches. Diagnosis can be difficult and there are limitations to the current diagnostic work-up. By detecting areas of active glucose metabolism present in active vasculitis, imaging with fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) could potentially have a role in the management of TA. Our aim was to assess this role by reviewing 28 18F-FDG PET scans performed on 18 patients suspected of having TA. All patients had full clinical and laboratory assessment, cross-sectional imaging and angiography, and 16/18 satisfied the American College of Rheumatologists criteria for TA. 18F-FDG PET achieved a sensitivity of 92%, a specificity of 100%, and negative and positive predictive values of 85% and 100% respectively in the initial assessment of active vasculitis in TA. We conclude that 18F-FDG PET can be used to diagnose early disease, to detect active disease (even within chronic changes) and to monitor the effectiveness of treatment. 相似文献
10.
The performance of<Superscript> 18</Superscript>F-fluorodeoxyglucose positron emission tomography in small solitary pulmonary nodules 总被引:3,自引:0,他引:3
Herder GJ Golding RP Hoekstra OS Comans EF Teule GJ Postmus PE Smit EF 《European journal of nuclear medicine and molecular imaging》2004,31(9):1231-1236
Solitary pulmonary nodule (SPN, intraparenchymal lung mass <3 cm) is often a diagnostic challenge. This study was performed to evaluate the diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography (FDG PET) in radiologically indeterminate SPN 10 mm on spiral CT. Between August 1997 and March 2001, we identified all patients with radiologically indeterminate SPNs 10 mm who were referred for FDG PET imaging at the VU University Medical Centre. All PET scans were retrospectively reviewed by an experienced nuclear medicine physician. PET was considered positive in cases with at least moderately enhanced focal uptake, and otherwise as negative. Lesions were considered benign on the basis of histology, no growth during 1.5 years or disappearance within at least 6 months. Thirty-five patients with 36 SPNs 10 mm in diameter at clinical presentation were identified (one patient had two metachronous lesions). In 13 of 14 malignant nodules and in two of 22 benign nodules, diagnosis was confirmed by histology. Prevalence of malignancy was 39%. PET imaging correctly identified 30 of 36 small lesions. One lesion proved to be false negative on PET (CT: 10 mm), and in five lesions, PET scans proved to be false positive. Specificity was 77% (17/22; 95% CI: 0.55–0.92), sensitivity 93% (13/14; 95% CI: 0.66–1.0), positive predictive value 72% (13/18; 95% CI: 0.46–0.90) and negative predictive value 94% (17/18; 95% CI: 0.73–1.0). This retrospective study suggests that FDG PET imaging could be a useful tool in differentiating benign from malignant SPNs 10 mm in diameter at clinical presentation. Such results may help in the design of larger prospective trials with structured clinical work-up. 相似文献
11.
Ruth G. Keijsers Fred J. Verzijlbergen Wim J. Oyen Jules M. van den Bosch Henk J. Ruven Heleen van Velzen-Blad Jan C. Grutters 《European journal of nuclear medicine and molecular imaging》2009,36(7):1131-1137
Purpose Angiotensin-converting enzyme (ACE) and soluble interleukin-2 receptor (sIL-2R) are serological markers, widely used for determining
sarcoidosis activity. 18F-FDG PET has proven to be a sensitive technique in the imaging of sarcoidosis. The aim of this study was to determine sensitivity
of 18F-FDG PET, genotype-corrected ACE and sIL-2R in active sarcoidosis as well as their correlation.
Methods This retrospective study included 36 newly diagnosed, symptomatic sarcoidosis patients. ACE and sIL-2R levels were simultaneously
obtained within 4 weeks of 18F-FDG PET. ACE was corrected for genotype and expressed as Z-score. 18F-FDG PET was visually evaluated and scored as positive or negative. Maximum and average standardized uptake values (SUVmax and SUVavg) were compared with ACE and sIL-2R.
Results
18F-FDG PET was found positive in 34 of 36 patients (94%). Thirteen patients (36%) showed an increased ACE with the highest
sensitivity found in patients with the I/I genotype (67%). Seventeen patients (47%) showed an increased sIL-2R. No correlation
was found between SUV and ACE or sIL-2R. Increased ACE and sIL-2R correlated with a positive 18F-FDG PET in 12 patients (92%) and 16 patients (94%), respectively.
Conclusion
18F-FDG PET is a very sensitive technique to assess active sarcoidosis, in contrast with ACE and sIL-2R, suggesting a pivotal
role for 18F-FDG PET in future sarcoidosis assessment. 相似文献
12.
Braun JJ Kessler R Constantinesco A Imperiale A 《European journal of nuclear medicine and molecular imaging》2008,35(8):1537-1543
PURPOSE: To evaluate the interest of (18)F-fluoro-2-deoxy-D: -glucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) for diagnosis and therapeutic follow-up of patients with sarcoidosis. METHODS: Twenty consecutive patients with biopsy-proven sarcoidosis were retrospectively included, in particular, 13 and seven cases of thoracic and extra-thoracic sarcoidosis, respectively. All patients underwent (18)F-FDG PET/CT, and 12 of them also (67)Ga scintigraphy. Five patients were re-examined by (18)F-FDG PET/CT to assess response to corticosteroid (CS) treatment. RESULTS: Sensitivity of (18)F-FDG PET/CT in detecting active sarcoidosis localizations was determined considering only biopsy-proven sites. For thoracic, sinonasal, and pharyngo-laryngeal localizations, (18)F-FDG PET/CT sensitivity was 100%, 100%, and 80%, respectively. Overall sensitivity for all 36 biopsy-proven localizations improved from 78% to 87% after excluding skin involvement. Considering only the 12 patients who underwent both scintigraphic examinations, overall sensitivity of (67)Ga scintigraphy and (18)F-FDG PET/CT was 58% and 79%, respectively and improved to 67% and 86% after excluding all sites of skin involvement. To evaluate the efficacy of CS treatment, five enrolled patients underwent second (18)F-FDG PET/CT. Complete regression of all foci of pathological tracer uptake was showed in two cases, permitting CS withdrawal after 2 and 6 months. Improvement but incomplete regression of mediastino-pulmonary disease occurred in two patients treated with CS for 19 and 21 months. Disease progression was assessed in one patient treated with decreasing doses of CS during 16 months. CONCLUSION: (18)F-FDG PET/CT allows to obtain a complete morpho-functional cartography of inflammatory active localizations and to follow treatment efficacy in patients with sarcoidosis, particularly in atypical, complex, and multisystemic forms. 相似文献
13.
Nakagawa M Kuwabara Y Sasaki M Koga H Chen T Kaneko O Hayashi K Morioka T Masuda K 《Annals of nuclear medicine》2002,16(3):207-211
OBJECTIVES: Carbon-11-L-methyl-methionine (11C-methionine) has been reported to be useful for evaluating brain tumors, but several other brain disorders have also shown signs of high methionine uptake. We retrospectively evaluated the significance of 11C-methionine uptake in cerebrovascular diseases, and also compared our results with those for 18F-FDG PET and 99mTc-HMPAO SPECT. METHODS: Seven patients, including 3 patients with a cerebral hematoma and 4 patients with a cerebral infarction, were examined. All 7 patients underwent both 11C-methionine PET and 99mTc-HMPAO SPECT, and 6 of them underwent 18F-FDG PET. RESULTS: A high 11C-methionine uptake was observed in all 3 patients with cerebral hematoma. Increased 99mTc-HMPAO uptake was observed in 2 out of 3 patients, and all 3 patients had decreased 18F-FDG uptake. Of 4 patients with a cerebral infarction, high 11C-methionine uptake was observed in 3. Increased 99mTc-HMPAO uptake was also observed in one patient, whereas 3 patients had decreased 18F-FDG uptake. CONCLUSIONS: We should keep in mind that high 11C-methionine uptake is frequently observed in cerebrovascular diseases. CVD should therefore be included in the differential diagnosis when encounting patients with a high 11C-methionine uptake. 相似文献
14.
目的探讨18F-FDG双时相显影在肺结节性病灶诊断与鉴别诊断的临床应用价值。方法回顾性分析43例18F-FDG双时相显影且经病理证实的肺结节性病例。其中男性31例,女性12例,年龄38~84岁。使用18F-FDG行全身或肺部PET/CT及双时相病灶扫描,依据PET图像、CT图像、PET/CT融合图像进行综合性分析。结果 43例肺结节性病灶的病例中,双时相显影诊断肺癌26例,病理证实23例;诊断可疑肺癌8例,病理证实5例;诊断良性病变9例,病理证实8例。结论对于肺结节性病灶,应用18F-FDG双时相显影可提高诊断的准确性。 相似文献
15.
Hartmann A Eid K Dora C Trentz O von Schulthess GK Stumpe KD 《European journal of nuclear medicine and molecular imaging》2007,34(5):704-714
Purpose To retrospectively evaluate the diagnostic value of 18F-FDG PET/CT in trauma patients with suspected chronic osteomyelitis.
Methods Thirty-three partial body 18F-FDG PET/CT scans were performed in 33 patients with trauma suspected of having chronic osteomyelitis. In 10 and 23 patients,
infection was suspected in the axial and appendicular skeleton, respectively. In 18 patients, PET/CT was performed in the
presence of metallic implants. Histopathology or bacteriological culture was used as the standard of reference. For statistical
analysis, sensitivity, specificity and accuracy were calculated in relation to findings of the reference standard.
Results Of 33 PET/CT scans, 17 were true positive, 13 true negative, two false positive and one false negative. Eighteen patients
had chronic osteomyelitis and 15 had no osseous infection according to the reference standard. Sensitivity, specificity and
accuracy for 18F-FDG PET/CT was 94%, 87% and 91% for the whole group, 88%, 100% and 90% for the axial skeleton and 100%, 85% and 91% for
the appendicular skeleton, respectively.
Conclusion
18F-FDG PET/CT is a highly sensitive and specific method for the evaluation of chronic infection in the axial and appendicular
skeleton in patients with trauma. PET/CT allows precise anatomical localisation and characterisation of the infectious focus
and demonstrates the extent of chronic osteomyelitis with a high degree of accuracy. 相似文献
16.
Gontier E Fourme E Wartski M Blondet C Bonardel G Le Stanc E Mantzarides M Foehrenbach H Pecking AP Alberini JL 《European journal of nuclear medicine and molecular imaging》2008,35(1):95-99
Purpose This prospective and bi-centric study was conducted in order to determine the impact of antidiabetic treatments (AD) on 18F-FDG bowel uptake in type 2 diabetic patients.
Methods Fifty-five patients with previously diagnosed and treated type 2 diabetes mellitus (group 1) were divided in two subgroups:
AD treatment including metformin (n=32; group 1a) and AD treatment excluding metformin (n=23; group 1b). The 95 patients without
diabetes mellitus made up controls (group 2). 18F-FDG uptake in small intestine and colon was visually graded and semi-quantitatively measured using the maximum standardized
uptake value.
Results
18F-FDG bowel uptake was significantly increased in AD patients (group 1) as compared to controls (group 2) (p<0.001). Bowel
uptake was significantly higher in AD patients including metformin (group 1a) as compared to AD patients excluding metformin
(group 1b) (p<0.01), whose bowel uptake was not significantly different from controls (group 2). A metformin treatment was
predictive of an increased bowel uptake in the small intestine (odds ratio OR=16.9, p<0.0001) and in the colon (OR=95.3, p<0.0001),
independently of the other factors considered in the multivariate analysis. Bowel uptake pattern in the patients treated with
metformin was typically intense, diffuse and continuous along the bowel, strongly predominant in the colon, in both the digestive
wall and lumen.
Conclusion This study emphasizes that metformin significantly increases 18F-FDG uptake in colon and, to a lesser extent, in small intestine. It raises the question of stopping metformin treatment
before an 18F-FDG PET/CT scan is performed for intra-abdominal neoplasic lesion assessment. 相似文献
17.
Hyo Jung Seo Byung Wook Min Jae Seon Eo Sun Il Lee Sang Hee Kang Sung Yup Jung Sang Chul Oh Jae Gol Choe 《Nuclear Medicine and Molecular Imaging》2016,50(1):85-89
Metastatic mucinous adenocarcinoma in an inguinal hernia is a rare disease and the image findings of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) are little known. Here, we introduce a 57-year-old man with metastatic mucinous adenocarcinoma in an inguinal hernia. On initial 18F-FDG PET/CT, hypermetabolism was observed in mucinous adenocarcinoma of the cecum, and adenocarcinomas of the transverse and ascending colon, respectively. Follow-up 18F-FDG PET/CT revealed newly developed multiple hypermetabolism in peritoneal seeding masses and nodules in the pelvic cavity and scrotum. Peritoneal carcinomatosis in the right pelvic side wall was extended to the incarcerated peritoneum and mesentery in the right inguinoscrotal hernia.18F-FDG PET/CT was useful to reveal unexpected peritoneal seeding within the inguinal hernia. Also, this case demonstrated that metastatic mucinous adenocarcinomas had variably intense FDG uptake. 相似文献
18.
Soyeon Park Eunsub Lee Seunghong Rhee Jaehyuk Cho Sunju Choi Sinae Lee Jae Seon Eo Kisoo Pahk Jae Gol Choe Sungeun Kim 《Nuclear Medicine and Molecular Imaging》2016,50(1):24-30
Purpose
The aim of this study was to evaluate the relationship between semiquantitative parameters on 18F-FDG PET/CT including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and the expression level of Ki-67 in small-cell lung cancer (SCLC).Methods
Ninety-four consecutive patients with SCLC were enrolled in this study. They underwent 18F-FDG PET/CT for initial evaluation of SCLC, and we measured SUVmax, avgSUVmean, MTVsum, and TLGtotal on 18F-FDG PET/CT images. The protein expression of Ki-67 was examined by immunohistochemical staining.Results
Significant correlations were found between the MTVsum and Ki-67 labeling index (r = 0.254, p = 0.014) and the TLGtotal and Ki-67 labeling index (r = 0.239, p = 0.020). No correlation was found between the SUVmax and Ki-67 labeling index (r = 0.116, p = 0.264) and the avgSUVmean and Ki-67 labeling index (r = 0.031, p = 0.770). Dividing the Ki-67 expression level into three categories, it was suggested that increasing Ki-67 expression level caused a stepwise increase in the MTVsum and TLGtotal. (p = 0.028 and 0.039, respectively), but not the SUVmax and avgSUVmean (p = 0.526 and 0.729, respectively).Conclusion
In conclusion, the volume-based parameters of 18F-FDG PET/CT correlate with immunohistochemical staining of Ki-67 in SCLC. Measurement of the MTVsum and TLGtotal by 18F-FDG PET/CT might be a simple, noninvasive, and useful method to determine the proliferative potential of cancer cells. 相似文献19.
Watanabe N Kato H Shimizu M Noguchi K Kamisaki Y Fuse H Matsunari I Hisada K Seto H 《Annals of nuclear medicine》2004,18(2):161-163
18F fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging is a useful modality in detecting various tumors, including renal cell carcinoma. We evaluated a patient with renal pelvic tumor (transitional cell carcinoma) with multiple metastases using 18F-FDG PET imaging and detected abnormal increased uptake of a right renal pelvic tumor extending to the renal cortex with liver metastasis and paraaortic lymph node metastases. These results suggest that 18F-FDG PET imaging may be useful in detecting primary and metastatic lesions of renal pelvic tumor (transitional cell carcinoma). 相似文献
20.
腺癌性孤立性肺结节的^18F—FDG PET/CT表现 总被引:1,自引:0,他引:1
目的探讨腺癌性孤立性肺结节(ASPN)的^18F—FDG PET/CT显像特点。方法回顾分析35例ASPN的^18F-FDG PET/CT显像形态学和代谢特点,计算SUVmax,以公式[(延迟显像SUVmax-早期显像SUVmax)/早期SUVmax×100%]计算△SUVmax。以SPSS11.5软件对数据分别行t检验、方差分析和Fisher确切概率法检验。结果(1)42.86%(15/35)ASPN呈典型的癌性肺结节表现(结节状FDG摄取增高),另有57.14%(20/35)ASPN FDG摄取呈片状、云雾状、肉眼无法辨认;结节状、云雾状、片状、肉眼无法辨认ASPN的SUVmax大小顺序递减,不同FDG摄取形态的ASPN早期和晚期SUVmax差异均有统计学意义,F=30.696和24.758,P均〈0.001。(2)54.29%(19/35)ASPN SUVmax≥2.5,45.71%(16/35)ASPN SUVmax〈2.5。(3)68.57%(24/35)ASPN呈实性密度结节,31.43%(11/35)ASPN呈“磨玻璃”密度结节;早期SUVmax分别为4.54±2.69、1.30±0.87,t=-5.234,P〈0.001。(4)延迟显像ASPN的SUVmax为422±3.52,高于早期显像的3.49±2.72(t=-4021,P〈0.1301);延迟显像SUVmax是否增高与早期显像SUVmax的高低相关:94.74%(18/19)SUVmax≥2.5ASPN的△SUVmax为正值,仅56.25%(9/16)SUVmax〈2.5ASPN的△SUVmax为正值,P=0.013。(5)高分化ASPN SUVmax为1.70±1.51,低于中低分化ASPN的4.91±2.69,t=-3.951,P〈0.001,且△SUVmax〉0的比例(10/17)也低于中低分化ASPN(13/14),P=0.045。结论ASPNFDG摄取形态、代谢活性差异大,SUVmax〈2.5ASPN比例较高,△SUVmax对这类结节良恶性的鉴别有一定帮助。 相似文献