骨性安氏Ⅲ类错(牙合)正畸矫治前后下前牙牙槽骨密度的临床研究

目的比较骨性安氏Ⅲ类错（牙合）正畸矫治前后下前牙牙槽骨密度的变化。方法选择恒牙期骨性安氏Ⅲ类错（牙合）患者及替牙期骨性安氏Ⅲ类错（牙合）儿童各15例,治疗前后拍摄头影测量片,测定骨性参数SNA、SNB和ANB的数值;运用螺旋CT测量正畸矫治前后下前牙区牙槽的骨密度。结果恒牙期骨性安氏Ⅲ类错（牙合）及替牙期骨性安氏Ⅲ类错（牙合）正畸治疗前后,下前牙区的SNA、SNB和ANB的数值发生改变,（P〉0.05）,差异无统计学意义,但骨密度差异有统计学意义（P〈0.05）,且替牙期正畸治疗前后骨密度的变化更明显。结论骨性安氏Ⅲ类错（牙合）正畸矫治前后,下前牙区牙槽骨密度发生改变,与头部摄片骨性参数的改变相一致,并能较好的反映矫治前后骨组织代偿的过程,值得临床     

改良箭头卡联合前牵矫治替牙期Angle Ⅲ类骨性错合15例临床报告

目的 探讨一种活动性矫治器联合前牵矫治替牙期Angle Ⅲ类骨性前牙反合的临床效果及矫治器的评价.方法 应用改良箭头卡合垫口内固位、联合前牵引矫治替牙期骨性前牙反合15例,对治疗前后临床表现及头颅侧位片测量进行分析.结果 15例患者矫治5～12个月,前牙反覆合、反覆盖纠正、侧貌改善.结论 改良箭头卡合垫联合前牵是简便、有效的安氏Ⅲ类骨性错合治疗装置,值得临床推广应用.     

多曲方丝弓技术矫治骨性Ⅲ类错

多曲方丝弓 (Ｍｕｌｔｉｌｏｏｐ ｅｄｇｅｑｗｉｓｅａｒｃｈ ｗｉｒｅ ,简称ＭＥＡＷ )技术是由Ｙｏｎｇ Ｈ．Ｋｉｍ医师于７０年代在方丝弓的基础上始创并发展起来的一种新型正畸固定矫治技术 ,最初应用于前牙开牙合的治疗取得了正畸界公认的良好疗效。９０年代经左藤贞雄等学者的研究发展证实其在骨性安氏Ⅲ类错牙合矫治方面也有着非常显著的疗效 ［１］。近年来国内也有报道将ＭＥＡＷ技术应用于骨性安氏Ⅲ类错牙合的矫治 ,取得了明显的效果［２］。笔者报告了通过ＭＥＡＷ技术矫治骨性前牙反牙合的几例病例。１资料和方法１．１病例选…     

轻中度上颌发育不足骨性安氏Ⅲ类错殆的矫治

目的评价应用固定矫治技术垂直开大曲复合牙合垫在轻至中度上颌发育不足骨性安氏Ⅲ类错牙合伴上前牙区拥挤矫治的可行性。方法应用上述方法对25例处于生长发育期，诊断为轻至中度上颌发育不足为主伴前牙萌出问腺不足骨性安氏Ⅲ类错牙合患者进行矫治。结果经过6．8～12．6个月，平均9个月的治疗后，25例患者的磨牙关系均达到安氏Ⅰ类，侧貌改善，阻生萌出间隙不足的前牙均能顺利萌出或经牵引至正常牙列位置，前后牙覆牙he覆盖关系正常。结论固定矫治技术垂直开大曲复合he垫能有效矫正轻中度上颌发育不足伴发前牙区萌出间腺不足骨性安氏Ⅲ类错he。     

MEAW技术矫治严重开合及严重反合的临床应用体会

目的运用MEAW技术矫治严重开合及严重反合,探索骨性安氏Ⅲ类错合的临床矫治方法。方法选择恒牙期骨性安氏Ⅲ类错合严重开合及严重反合23例,男9例,女性14例,年龄13～18岁,平均16岁,用多曲方丝弓技术矫治,矫治结束时至前牙反合及开合解除,尖牙磨牙为中性关系。治疗前后拍摄头颅侧位定位片,进行x线头影测量分析。结果矫治后上前牙唇倾度加大,上后牙近中移动,下前牙代偿性舌向移动,下后牙远中直立平面变平,颌骨变化较小。结论多曲方丝弓矫治技术可以通过牙的三维移动矫治骨性前牙开合及反合,拓宽了正畸矫治范围。     

上颌前方牵引矫治骨性安氏Ⅲ类错殆畸形25例疗效观察

采用上颌前方牵引矫治器牵引上颌骨向前移动，矫治25例处于生长发育期的骨性安氏Ⅲ类错牙合畸形患儿。结果所有患儿前牙反牙合解除，磨牙关系中性，面形得到明显改善。疗程5～9个月，平均7．6个月。颌骨矢状方向A点明显前移，SNA角增大，ANB角增大，上颌骨明显前移，上颌骨长度增加。下颌稍有顺时针旋转。提示上颌前方牵引是矫治儿童骨性安氏Ⅲ类错（牙合）畸形行之有效的方法。     

上颌前牵引矫治器矫治安氏Ⅲ类错(牙合)畸形的应用体会(附24例报告)

安氏Ⅲ类错牙合畸形是临床上最常见的错牙合畸形 ,它对口腔功能及颜面的美观有严重的影响 ,是否在儿童期进行矫形治疗一直是争论的热点。早期矫治方法很多 ,如替牙期常用的有头帽颏兜 ,ＦＲ Ⅲ ,上颌前方牵引等 ,这些方法均可使颅面结构发生显著变化 ,但其适应证及疗效各不相同[1] 。本文目的在于探讨上颌前牵引对青春发育期安氏Ⅲ类错牙合畸形矫治原理及临床应用体会。1　材料与方法1.1　病历选择 :2 4例替牙期安氏Ⅲ类错牙合畸形患者 ,男性 9例 ,女性 15例 ;年龄 8.5～ 12岁 ,平均10 .5岁。病历选择标准 :①安氏Ⅲ类错牙合前牙反牙合 ;②…     

成人骨性Ⅲ类错的正畸掩饰性矫治

20 0 0年 2月我科收治 1例 18岁以上骨性Ⅲ类错牙合畸形患者 ,采用正畸掩饰性矫治方法 ,取得满意的效果。1　病例摘要患者男 ,19岁。Ⅲ类面型即面部侧貌为轻度凹面型 ,磨牙为近中关系 ,前牙反牙合 ,下前牙不能后退至前牙对刃关系 :3|3唇侧向错位。X线头影示 :SNA 78° ,SNB 81° ,ANB- 3°,反复牙合Ⅱ°,反覆盖Ⅰ°。诊断 :安氏Ⅲ类错牙合 ,骨性Ⅲ类错牙合。治疗目标 :(1)内收下牙列开展上前牙 ,矫治前牙反牙合。(2 )促后牙齿槽骨长高 ,使下颌骨产生向下、向后旋转 ,从而达到矫正下颌前突的效果 ,促成安氏Ⅰ类关系。 (3)保持治疗后咬合…     

前方牵引器矫治骨性Ⅲ类错

骨性安氏Ⅲ类错牙合是临床中较为常见的一种错牙合畸形。据最近的研究显示 ,在骨性安氏Ⅲ类错牙合中有 42 %～ 6 3 %的患者含有不同程度的上颌骨发育不足因素[1 ] 。在应用前方牵引器、颏兜、ＦｒａｎｋⅢ等矫治骨性安氏Ⅲ类错牙合的方法中 ,普遍认为前牵引可以早期矫治上颌骨发育不足产生的骨性Ⅲ类错牙合 ,从而改善上颌骨的发育不足 ,使患者获得较理想的面型[2 5] 。目前 ,口外前方牵引已成为正畸临床治疗上颌后缩畸形的主要方法之一。本文应用前方牵引矫治器矫治 1 3例替牙期骨性安氏Ⅲ类错牙合患者 ,取得了满意效果 ,现报告如下。1　材…     

骨性前牙反前方牵引治疗的疗效观察

安氏Ⅲ类前牙反牙合是一种发育性畸形 ,随儿童的生长发育而发生、发展 ,影响功能和美观。早期的功能矫形治疗对大多数Ⅲ类畸形有明显的治疗作用 ,可促进上颌骨生长 ,改变下颌骨生长方向 ,引导牙颌面正常发育 ,是Ⅲ类畸形早期矫治的有效手段。但对较严重的骨性Ⅲ类错牙合，用一般的功能矫治器难以达到满意效果。作者对生长发育高峰前期的较严重的安氏Ⅲ类错牙合采用前方牵引治疗１２例 ,取得满意效果。１资料与方法患者１２例 ,男４例 ,女８例 ,年龄最大１１岁 ,最小７．５岁 ,平均９岁。前牙反覆盖大于４ｍｍ ,ＡＮＢ角小于 -５°，第一磨牙…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.