共查询到20条相似文献,搜索用时 15 毫秒
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Rocco Damiano Marco De Sio Giuseppe Quarto Giuseppe Di Lorenzo Sisto Perdonà Italo M. Palumbo Giuseppina Azzarito Francesco Giugliano Riccardo Autorino 《BJU international》2009,104(5):633-639
OBJECTIVE
To determine whether the new fluoroquinolone prulifloxacin might improve tolerance to Bacillus Calmette‐Guérin (BCG) intravesical therapy in patients with bladder cancer.PATIENTS AND METHODS
A series of 72 patients with intermediate‐ or high‐risk nonmuscle‐invasive bladder cancer were enrolled in this prospective, randomized, open‐label, controlled clinical trial performed at a single tertiary care institution. After complete transurethral resection, patients were randomized to receive induction treatment with BCG and three capsules of prulifloxacin 600 mg or no prophylactic treatment (control group). Adverse events (AEs) were self‐recorded by the patients after each instillation and classified by the investigator according to a classification grid considering account duration and intensity. Cystoscopy findings at 3 and 6 months were also recorded.RESULTS
There was no significant difference in baseline symptoms between the groups. Overall, there was a significant decrease in the percentage of patients with at least one AE between instillations in prulifloxacin‐treated group. The proportion of patients with moderate to severe AEs after the fourth instillation was significantly less in the prulifloxacin‐treated group. There was a significant effect of prulifloxacin on the need for anti‐tuberculosis treatment. More patients in the control group stopped or delayed the full induction course of BCG instillations (34% vs 19%, P = 0.04). Recurrence rates were not affected by prulifloxacin treatment.CONCLUSION
Prulifloxacin reduces the incidence of moderate to severe AEs from BCG intravesical therapy in patients with nonmuscle‐invasive bladder cancer, improving compliance to the induction BCG course. These preliminary findings warrant further clinical research. 相似文献3.
《Journal of cystic fibrosis》2014,13(6):712-715
BackgroundDisease progression in cystic fibrosis (CF) is marked by worsening exercise tolerance. Further, maximal exercise capacity (VO2 peak) correlates with survival in CF, but maximal tests are uncomfortable and resource-intensive. A three-minute step test (STEP) has been validated in CF. Heart rate (HR) recovery after exercise correlates with all-cause mortality in adult non-CF populations. We compared HR recovery after the three-minute step test with VO2 peak in children with CF.Methods: Twenty-four children with CF performed STEP and a maximal exercise test. Correlation between the tests was assessed.Results: Maximum HR on STEP was lower than on the maximal test (140 vs. 190, p < 0.01). Peak HR during STEP correlated inversely with VO2 peak. In subjects with mild lung disease, faster HR recovery after STEP correlated with higher VO2 peak.Conclusions: The three-minute step test is a feasible submaximal test in this patient population. HR during and after a three-minute step test may reflect VO2 peak in children with CF. 相似文献
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BACKGROUND: Baroreceptor control of beat-to-beat blood pressure in heart and heart-lung-transplanted children is impaired. Time-related trends of baroreceptor function recovery are studied and a possible correlation of baroreflex impairment and systolic hypertension may give evidence for supplemental medical treatment of hypertension. METHODS: Seventeen patients (six female) 6.1 +/- 3.7 years (range 0.8-13.0 years) after heart (n = 14) and heart-lung (n = 3) transplantation (TX) were studied. Twelve healthy children and 10 children after liver and bone marrow TX taking cyclosporine A (CyA) served as control groups 1 and 2, respectively. Baroreceptor sensitivity (BRS) was calculated from noninvasive systolic beat-to-beat blood pressure (sBP) measurement during a resting phase and a tilt-table test. RESULTS: BRS was significantly impaired in the study group at rest and during tilting; mean sBP was slightly elevated. Significant difference between patients on CyA and healthy controls was not observed. Discrete recovery of BRS occurred after 4 years postTX with decreased sBP (n = 12 pts, BRS 6.78 +/- 7.44 msec/mmHg, sBP 116.2 +/- 12.4 mmHg) when compared to a postTX time course of less than 4 years (n = 5 pts, BRS 4.02 +/- 4.21 msec/mmHg, sBP 122.0 +/- 6.7 mmHg, P = NS). CONCLUSION: BRS is disturbed after TX in children; four years postTX, a minimal recovery of BRS and a discrete reduction of sBP seem to occur. Those patients with a persistent low BRS and elevated sBP may profit from pharmacological influence in sympathovagal imbalance. 相似文献
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OBJECTIVE: To determine the need for an estimate of glomerular filtration rate (GFR) in the follow-up of children undergoing unilateral nephrectomy for benign renal disease. PATIENTS AND METHODS: Forty-four children (21 girls and 23 boys) undergoing unilateral nephrectomy for benign renal disease over a 3-year period were reviewed for the underlying diagnosis and indication for nephrectomy, imaging before and after surgery, postoperative GFR and final outcome. The follow-up included ultrasonography (US) of the contralateral kidney at 3 and 12 months and an estimate of GFR before discharge at > or = 1 year. All children were aged > 2 years when the GFR was measured. The criteria for discharge were normal imaging of the contralateral kidney before and after surgery and a normal GFR afterward. Spearman's correlation coefficient was used to determine the relationship between age, GFR and contralateral renal length after surgery. RESULTS: The median (range) age at surgery was 2.5 (0.67-16) years. The indications for nephrectomy included reflux nephropathy in 18, multicystic dysplastic kidney in 12, a congenital obstructive uropathy in eight, congenital renal dysplasia in four and miscellaneous in two. All patients had a normal contralateral kidney before surgery on US and functional imaging, and normal US at the follow-up, with evidence of compensatory hypertrophy in all. The median (range) corrected GFR for the 44 children was 109 (81-140) mL/min/1.73 m2, with no correlation between age and GFR, or between renal length and GFR. CONCLUSION: After unilateral nephrectomy for benign renal disease, provided there is a structurally and functionally normal contralateral kidney before surgery, with no abnormality on US, a routine estimate of GFR is unnecessary before discharge from follow-up. There was no correlation between GFR and age or renal length. 相似文献
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VA‐ECMO for cardiogenic shock in the contemporary era of heart transplantation: Which patients should be urgently transplanted? 下载免费PDF全文
Marlena V. Habal Lauren Truby Masahiko Ando Hirohisa Ikegami Arthur R. Garan Veli K. Topkara Paolo Colombo Koji Takeda Hiroo Takayama Yoshifumi Naka Maryjane A. Farr 《Clinical transplantation》2018,32(9)
With the impending United Network for Organ Sharing (UNOS) heart allocation policy giving VA‐ECMO supported heart transplant (HT) candidates highest priority status (Tier 1), identifying patients in cardiogenic shock (CS) with severe and irreversible heart failure (HF) appropriate for urgent HT is critically important. In a center where wait times currently preclude this approach, we retrospectively reviewed 119 patients (ages 18‐72) with CS from 1/2014 to 12/2016 who required VA‐ECMO for >24 hours. Underlying aetiologies included postcardiotomy shock (45), acute coronary syndromes (33), and acute‐on‐chronic HF (16). Eighty‐four percent of patients (100) had ≥1 contraindication to HT with 61.3% (73) having preexisting contraindications (eg, multiorgan dysfunction and substance abuse), and 68.1% (81) experienced preclusive complications (eg, renal failure, coagulopathy, and infection). Potential HT candidates were significantly more likely to survive to discharge (potential HT candidates 84.2% vs preexisting contraindications 43.8% vs contraindications developing on VA‐ECMO 33.3%, P = 0.001). Among potential HT candidates, 11 (68.8%) were discharged without advanced therapies and 4 received durable left ventricular assist device (25.0%). Importantly, 1‐year survival was 100% for the 11 patients with follow‐up. Thus, further work is critical to define appropriate candidates for HT from VA‐ECMO while avoiding preemptive transplantation in those with otherwise favorable outcomes. 相似文献
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Laparoscopic repair of incisional hernia in solid organ‐transplanted patients: the method of choice?
Jan R. Lambrecht Morten Skauby Erik Trondsen Arild Vaktskjold Ole M. Øyen 《Transplant international》2014,27(7):712-720
Due to immunosuppressive (IS) therapy, incisional hernias are overrepresented in the organ‐transplanted (Tx) population with larger defects, a high rate of recurrence, and a tendency toward more seromas and infectious problems. Thirty‐one Tx/IS patients with a control group of 70 non‐IS patients with incisional hernia (6/7 recurrences) were included in a prospective interventional study. Both cohorts were treated with laparoscopic ventral hernia repair (LVHR). Follow‐up time and rate was 37 months and 95%. One hundred LVHR's were completed as there was one conversion in the Tx/IS group. No late infections or mesh removals occurred. Recurrence rates were 9.7% vs. 4.2% (P = 0.37) and the overall complication rates were 19% vs. 27% (P = 0.80). The Tx/IS group had a higher mesh‐protrusion rate (29% vs. 13%, P = 0.09), but also larger hernias. Polycystic kidney disease was overrepresented in the Tx cohort (44% of kidney‐Tx). Incisional hernias in Tx/IS patients may be treated by LVHR with the same low complication rate and recurrence rate as non‐IS patients. By LVHR, the highly problematic seroma/infection problems encountered in Tx/IS patients treated by conventional open technique seem almost eliminated. The minimally invasive procedure seems particularly rational in the Tx/Is population and should be the method of choice. (ClinicalTrials.gov number: NCT00455299, date: 5 May 2006). 相似文献
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David Prieto Pedro Correia Pedro Antunes Manuel Batista Manuel J. Antunes 《Brazilian Journal Of Cardiovascular Surgery》2014,29(3):379-387
Objective
To evaluate immediate and long-term results of cardiac transplantation at two different levels of urgency.Methods
From November 2003 to December 2012, 228 patients underwent cardiac transplantation. Children and patients in cardiogenic shock were excluded from the study. From the final group (n=212), 58 patients (27%) were hospitalized under inotropic support (Group A), while 154 (73%) were awaiting transplantation at home (Group B). Patients in Group A were younger (52.0±11.3 vs. 55.2±10.4 years, P=0.050) and had shorter waiting times (29.4±43.8 vs. 48.8±45.2 days; P=0.006). No difference was found for sex or other comorbidities. Haemoglobin was lower and creatinine higher in Group A. The characteristics of the donors were similar. Follow-up was 4.5±2.7 years.Results
No differences were found in time of ischemia (89.1±37.0 vs. 91.5±34.5 min, P=0.660) or inotropic support (13.8% vs. 11.0%, P=0.579), neither in the incidence of cellular or humoral rejection and of cardiac allograft vasculopathy. De novo diabetes de novo in the first year was slightly higher in Group A (15.5% vs. 11.7%, P=0.456), and these patients were at increased risk of serious infection (22.4% vs. 12.3%, P=0.068). Hospital mortality was similar (3.4% vs. 4.5%, P=0.724), as well as long-term survival (7.8±0.5 vs. 7.4±0.3 years).Conclusions
The results obtained in patients hospitalized under inotropic support were similar to those of patients awaiting transplantation at home. Allocation of donors to the first group does not seem to compromise the benefit of transplantation. These results may not be extensible to more critical patients. 相似文献11.
DeBattista C Cochran M Barry JJ Brock-Utne JG 《Acta anaesthesiologica Scandinavica》2003,47(1):101-103
Electroconvulsive therapy (ECT) is sometimes indicated during pregnancy and may offer advantages over pharmacotherapy for the patient and the fetus (1,2). However, very little data is available on the impact of epileptic or ECT-induced seizures on the fetus. We report a case of brief fetal heart rate decelerations in a fetus associated with maternal ECT-induced convulsions. 相似文献
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Background: Removal of an LMA without producing untoward complications has remained a matter of concern to all anesthesiologists; more so in pediatric practice where the margin of safety is narrow. Most work on LMA in adults supports its removal following return of airway reflexes. The situation regarding its removal in children is, however, less clear.
Methods: We conducted a randomized, prospective study to compare incidence of airway complications after removal of the LMA at deep or awake planes in 120 children, ASA I or II, aged 1–8 years and to objectively determine the most appropriate Bispectral index (BIS) to allow safe removal of an LMA in children. They were studied in two groups of 60 and depth of anesthesia (whether awake-Gp A or deep-Gp D) for LMA removal was decided by random distribution from sealed envelopes. BIS was recorded continuously for all the patients until 2 min after removal of LMA.
Results: Mean SpO2 after removal of LMA was 93% Gp A and 98% in Gp D. The mean duration of surgery in Gp A was 53.9 ± 10 and in Gp D 46.7 ± 4 min. PE Sev at removal in Gp A was 0.20 ± 0.16 and in Gp D was 0.59 ± 0.1. BIS median in Gp A was 79 with a maximum of 86 and minimum of 66. In Gp D BIS, median was 60 with maximum of 76 and minimum of 58. The number of patients with airway complications in awake removal group was 21 (35%) and in deep removal group was 4 (6.6%).
Conclusions: Bispectral index scoring should prove a useful adjunct to the present monitoring and can be used to achieve smoother emergence conditions. We suggest that LMA removal should be attempted in children when a BIS value of approximately 60 is reached. 相似文献
Methods: We conducted a randomized, prospective study to compare incidence of airway complications after removal of the LMA at deep or awake planes in 120 children, ASA I or II, aged 1–8 years and to objectively determine the most appropriate Bispectral index (BIS) to allow safe removal of an LMA in children. They were studied in two groups of 60 and depth of anesthesia (whether awake-Gp A or deep-Gp D) for LMA removal was decided by random distribution from sealed envelopes. BIS was recorded continuously for all the patients until 2 min after removal of LMA.
Results: Mean SpO
Conclusions: Bispectral index scoring should prove a useful adjunct to the present monitoring and can be used to achieve smoother emergence conditions. We suggest that LMA removal should be attempted in children when a BIS value of approximately 60 is reached. 相似文献
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The reported incidence of venous thromboembolism (VTE) in children has increased dramatically over the past decade, and the primary risk factor for VTE in neonates and infants is the presence of a central venous catheter (CVC). Although the associated morbidity and mortality are significant, very few trials have been conducted in children to guide clinicians in the prophylaxis, diagnosis, and treatment of CVC‐related VTE. Furthermore, pediatric guidelines for prophylaxis and management of VTE are largely extrapolated from adult data. How then should the anesthesiologist approach central access in children of different ages to lessen the risk of CVC‐related VTE or in children with prior thrombosis and vessel occlusion? A comprehensive review of the pediatric and adult literature is presented with the goal of assisting anesthesiologists with point‐of‐care decision‐making regarding the risk factors, diagnosis, and treatment of CVC‐related VTE. Illustrative cases are also provided to highlight decision‐making in varying situations. The only risk factor strongly associated with CVC‐related VTE formation in children is the duration of the indwelling CVC. Several other factors show a trend toward altering the incidence of CVC‐related VTE formation and may be under the control of the anesthesiologist placing and managing the catheter. In particular, because children with VTE may live decades with its sequelae and chronic vein thrombosis, careful consideration of lessening the risk of VTE is warranted in every child. Further studies are needed to form a clearer understanding of the risk factors, prophylaxis, and management of CVC‐related VTE in children and to guide the anesthesiologist in lessening the risk of VTE. 相似文献
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According to recent trends to develop implantable nonpulsatile blood pumps for different function modes and times, our intention was and still is to build a Mini-Spindle-Pump for a pumping duration of about 14 days. Initial conception for this plan was the premise that the device in a mock circuit should move 4 L of water/min at a speed of 12,000 to 15,000 rpm against a pressure difference of 90 mm Hg between pump inlet and outlet. Despite the development of 6 different prototypes, this project was not realized. Under the above-mentioned conditions, the main problem of this type of blood pump, the blood trauma, could not be reduced to an adequate level, i.e., the Mini-Spindle-Pump is not a high speed pump. Therefore, a revision of the conception was necessary. The device in a mock circuit should transport 5 L of water/min at a speed of about 9,000 rpm against a pressure difference of 90 mm Hg between its inlet and outlet. Considering the implantability of the blood pump, the following measurements for its components were arrived at. The U-shaped blockformed plexiglas housing was enlarged to 120 x 40 x 40 mm (length of blood chamber 86 mm, inner diameter 27 mm), and the rotor with 5 windings was redesigned at a length of 64 mm (outer diameter 25 mm, inner diameter 6.7 mm). In a mock circuit, this 7th prototype transported with a speed of 9,000 rpm about 10 L of water/min at an afterload of 80 mm Hg. In acute animal experiments with calves up to 15 h of pumping duration, the device showed the expected efficiency. Experiments with a longer pumping duration are necessary to confirm that this prototype will fulfill the criteria of a short-term pump according to Dr. Y. Nosé's advice. 相似文献
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Kurklu M Komurcu M Başbozkurt M 《Journal of pediatric orthopedics》2008,28(5):597; author reply 597-597; author reply 598
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PURPOSE: Complications arising from limb-lengthening procedures are often severe leading to long-term residuals. The aim of this study was to determine whether the complication rate and complexity could be predicted using a distraction index for bone lengthening in children. STUDY DESIGN: This study retrospectively reviewed a series of 116 lower limbs lengthening in 88 consecutive patients (mean age 13.5). Mean follow-up 3.8 years. Lengthening percentage, lengthening index, distraction regenerate length, additional surgeries, and complications rate were used to evaluate the results of limb lengthening. The correlation between lengthening percentage and complication rate was particularly analyzed and its practicability illustrated. Scatter plots of complication rate (%) against lengthening percentage were constructed, and linear regression was used to investigate mathematical relationship between the variables. RESULTS: The lengthening index was 33 +/- 12.1 days/cm. The length of distraction regenerate was 6 +/- 3.2 cm. The lengthening percentage was 21 +/- 16.5. The scatter plots of neurological complication rate, residual deformities rate, broken pins rate, joint contractures rate, and hypertension rate against lengthening percentage showed a positive linear relationship with r = 0.8. CONCLUSIONS: The number of complications increased considerably with the increase in lengthening percentage. The lengthening percentage correlates very well with the complication rate and can be used to predict the complication rate. CLINICAL RELEVANCE: During planning a lengthening procedure, the lengthening percentage should be a useful tool to predict the complications rate and to discuss the risks and benefits with patients and their families. The knowledge about predictable complications should help prevent and early detect expected complications. 相似文献
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Patient Compliance in the Setting of BI‐RADS Category 3: What Factors Impact Compliance With Short‐Term Follow‐Up Recommendations? 下载免费PDF全文
Marisa H. Borders MD Lucy Cheng MD Kimberly A. Fitzpatrick MD Elizabeth A. Krupinski PhD 《The breast journal》2017,23(1):77-82
The study aims to define how imaging findings, patient demographics, patient–provider interactions, and health care practices may affect a woman's decision to follow‐up in the setting of a BI‐RADS Category 3. A total of 398 women from the University of Arizona Breast Imaging Center with a BI‐RADS Category 3 assessment for mammography and/or ultrasound findings were evaluated between February 2012 and June 2014. Demographic information was analyzed for all patients, regardless of follow‐up. Women who returned for follow‐up within the recommended time period were given one survey at the time of their follow‐up appointment, and women who returned for follow‐up, but later than recommended, were given a separate survey to complete. Age, palpability of a lesion, and menopause status were related to follow‐up. Self‐rated general health was the only factor found to be associated with the decision to follow‐up on time. The majority of patients who followed up on time reported that mailed reminder cards were the primary practice that prompted follow‐up. Of patients who followed up later than recommended, the major reason was “no time.” The findings suggest that additional counseling regarding the benefits of short‐interval imaging follow‐up might be advantageous for patients. 相似文献