Biological evaluation of chuangYuLing dressing—A multifunctional medicine carrying biomaterial

Summary The safety of Chuangyuling (CYL) dressing—a multifunctional medicine carrying biomaterial was evaluated in order to provide foundation for the application of CYL as material used in the wound healing. The traditional Chinese medicine (TCM) extract solution was compounded with scaffolds (gelatin and Bletilla hyacinthine gum), and then frozen and dried to form spongy and porous material CYL. According to the standard of biological evaluation of medical devices that was instituted by the ministry of health of China^[1], the biological evaluation of CYL dressing was conducted. The results showed that all the contents of biological evaluation test consisting of acute toxicity, skin irritation, sensitization and cytotoxicity met the requirement of standards. It was concluded that the biomaterial carrying TCM (CYL dressing) is safe for application of wound healing. PENG Rui, male, born in 1967, Associate Professor     

Biological Evaluation of ChuangYuLing Dressing-A Multifunctional Medicine Carrying Biomaterial

The safety of Chuangyuling (CYL) dressing-a multifunctional medicine carrying biomaterial was evaluated in order to provide foundation for the application of CYL as material used in the wound healing. The traditional Chinese medicine (TCM) extract solution was compounded with scaffolds (gelatin and Bletilla hyacinthine gum), and then frozen and dried to form spongy and porous material CYL. According to the standard of biological evaluation of medical devices that was instituted by the ministry of health of China, the biological evaluation of CYL dressing was conducted. The results showed that all the contents of biological evaluation test consisting of acute toxicity, skin irritation, sensitization and cytotoxicity met the requirement of standards. It was concluded that the biomaterial carrying TCM (CYL dressing) is safe for application of wound healing.     

应用中医护理技术干预慢性支气管炎

目的探讨应用中医护理技术干预慢性支气管炎的疗效和机制。方法采用冬病夏治、理疗、针灸、健康生活方式指导等综合护理措施。结果增强了患者的体质,改善了呼吸功能,减少了对住院的需求。结论应用中医护理技术干预慢性支气管炎,重在治病求本,提高机体的抗病能力,避免抗生素的副作用,可促进患者早日康复。     

中医药高等院校新型教师考核评价体系初探

当前,中医药高等院校迎来了自身跨越发展的历史机遇期,传统"德、能、勤、绩"的考核评价体系已不能满足学校发展的需要,建立一种综合评价、主动评价、自我评价、过程评价为特色的新型教师考核评价体系便显得尤为重要。文章探讨了中医药高等院校新型教师考核评价体系的特点、意义、内涵和实施,对中医药高等院校新型教师考核评价体系的理论和实践研究进行了初步探索。     

中医药干预糖尿病创面信号通路的研究进展

目的综述中医药调控糖尿病难愈性创面信号通路的研究进展,为中医药治疗糖尿病创面的整体优势提供坚实的理论依据。方法查阅近几年国内外相关的文献资料并总结中医药干预创面愈合信号通路的相关靶点。结果从中医药干预糖尿病创面的应用、效果评价等方面,可以看出中医药调控糖尿病创面信号通路具有多靶点、多层次的优势。结论中医药干预糖尿病创面具有其独特的优势,可更深一步探讨其作用的靶点和机制。     

中药外用制剂在慢性创面治疗中的应用与思考

慢性创面症状复杂,治愈难度大,是创面修复领域亟待解决的难题,中医药对其治疗具有独特优势。就慢性创面的中医认识、中药外用治疗机制、传统中药外用制剂和现代中药外用制剂4个方面综述了中药外用制剂治疗慢性创面的最新进展,以期为慢性创面治疗的中药制剂研究与开发提供依据。      

生物敷料治疗小儿深Ⅱ度烧伤的临床研究

目的探讨生物敷料治疗小儿深Ⅱ度烧伤的临床优势和提高治愈率的影响因素。方法采用辐照猪皮手术治疗小儿深Ⅱ度烧伤,分伤后48 h内手术和48 h外手术两组,每组分术后使用活血药物和不使用活血药物两组。对照组6例则采用传统保痂治疗。观察患者入院后高体温天数、创面疼痛时间天数、白细胞恢复正常天数、患者住院天数等指标。结果采用辐照猪皮治疗小儿深Ⅱ度烧伤48 h内手术患者各项指标均优于48 h外手术和对照组(P<0.05),使用活血药物可以明显缩短患者住院天数(P<0.05);伤后48 h外手术患者创面疼痛时间明显小于对照组(P<0.05)。结论生物敷料治疗小儿深Ⅱ度烧伤可以有效促进创面的康复,减少患者痛苦,同时使用活血药物可进一步促进创面的愈合。     

负压封闭引流技术在电击伤创面中的应用

目的：采用多种指标将传统换药和负压封闭引流（VSD）技术进行临床观察对比,比较两种方法在电击伤创面植皮术前准备方面的优缺点,探讨VSD技术在电击伤创面治疗中有无优势。方法收集某科室98例电击伤患者,共112处电击伤创面,根据处理方法的不同分为VSD组和传统换药组,进行回顾性分析。观察记录两组患者的疼痛程度评分、创面清洁时间、手术植皮成活率,将数据进行统计学检验。结果传统换药组和VSD组的患者疼痛程度评分平均值分别为5.9±2.5和2.4±1.3,两组数据的差异有统计学意义;传统换药组和VSD组的创面清洁时间平均值分别为（13.5±6.5）天和（9.25±2.5）天,两组数据的差异有统计学意义;传统换药组和VSD组的手术植皮成活率平均值分别为（65±15）％和（90±8）％,两组数据的差异有统计学意义上。结论与传统换药相比,在熟练掌握VSD技术的前提下,VSD技术在电击伤创面的临床治疗中,能够减轻患者疼痛程度,缩短创面清洁时间,缩短病程及住院时间,提高植皮成活率及治疗效果,值得推广应用。     

青黄珠口腔生物黏附贴片的制备

目的制备青黄珠口腔生物黏附贴片并考察其体外生物黏附性及释药性能。方法以青黛、黄连提取物、珍珠为药物,白芨胶、HPMC和卡波姆为黏附材料,通过生物黏附力和体外溶胀速率测定,优化青黄珠口腔黏附贴片处方。并对所制备的生物黏附贴片进行体外释放度和释药机制探讨。结果所筛选最优处方为白芨胶：Carbopol：HPMC=1．5：1：0．5,药粉所占比例为25％;体外释放度试验证明不同阶段存在着不同的释药机制。结论制备的口腔黏附片表现出一定的黏附性和缓释作用     

中医药期刊评价模型的建立

在对各相关期刊评价指标体系调研的基础上,初步建立了中医药期刊评价的模型,并通过对中西医结合类部分期刊的相关评价研究,为进一步系统地开展中医药期刊评价建立了相应的方式和方法。     

难愈性创面的中西医研究进展

创面愈合是目前临床研究的热点及难点问题之一,随着人们对创面愈合机制认识的不断进步,促创药物的研究及开发必将成为现代医学和传统医学研究的焦点。     

基于SOCS通路探讨糖尿病足溃疡治疗中中药“去腐生新”作用的研究进展

糖尿病足溃疡（DFUs）是糖尿病严重的并发症之一，发病率和截肢率高，目前具体发病机制仍未完全明确。相关研究表明，炎症、感染和营养障碍等多种因素共同影响DFUs的转归及预后。抑制相关炎症通路和细胞因子表达，可促使坏死组织脱落促进愈合。此外，细胞因子信号传导抑制因子家族蛋白（SOCS）可通过激活蛋白酪氨酸激酶（JAK）/信号转导和转录活化因子（STAT）信号通路参与细胞因子信号转导，参与DFUs创面炎症反应以及愈合过程。近年来，大量研究发现具有“去腐生新”功效的单味中药及其活性成分、中药复方对DFUs具有很好的疗效，研究中药治疗DFUs的具体机制已成为近些年来研究的热点之一。文章查阅近年文献，就SOCS通路与DFUs的关系及中医药治疗DFUs作用机制进行综述。     

论中医院校教师教学评价及其应用——以中医学专业本科医学教育标准的视角

高等院校教师教学评价是教学活动重要的环节,是深化高校教育改革的关键质点。如何合理分析教学评价的内涵以及如何将评价结果应用于教学活动,对衡量教师教学水平和提高教育教学质量有其重要的现实意义。该文以中医学专业本科医学教育标准的视角,探讨中医院校教师教学评价及其应用意义,为完善学校教学质量保障体系、发挥教学评价的积极作用提供参考。     

传统文化教育与高等中医人才培养

中国传统文化是中医学赖以生存和发展的土壤，是衡量中医学术定位和科学价值的文化坐标。坚持传统文化特色才能体悟中医学说之真谛，把握中医理论之精髓。传统文化教育的缺失，致使中医学与其母体文化出现断裂，严重影响了高素质中医药人才的培养。中医教育必须立足中医特色，培植中医传统文化土壤，注重中医特色思维模式的养成，以培养真正具备传统医学理论和技能的创新型人才为宗旨。     

中医药寒热本质的生物学基础研究进展

寒热是中医药理论中的核心问题。本文重点对长期以来在寒热体质、寒热证及寒热药性相关研究中,与寒热理论生物学基础有关的研究进行综述。相关临床和实验室研究从经典的生理生化指标、基因表达、蛋白表达和代谢差异等角度,观察到中医寒热体质和寒热证的生物学差异主要表现在神经递质、甲状腺功能、性激素、环核苷酸系统及能量代谢水平等方面,这些方面的差异又与机体相应基因、蛋白表达相关,并分析了相关指标在寒热体质一寒热证候一寒热中药干预的动态进展过程中的变化。对寒热本质的生物学基础研究已由单一指标向多指标、由分散研究向系统研究发展。     

Considerations on intervention goal and efficacy evaluation of traditional Chinese medicine in the treatment of neurological diseases

In the last several years,traditional Chinese medicine(TCM) has made much progress in the treatment of neurological diseases.The living space of TCM in neurological diseases lies in refractory diseases,aging and chronic diseases caused by multiple factors as well as sub-health state and chronic fatigue state.The effect model of TCM mainly consists of whole effect,self-organization,self-stable model,holographic effect and butter? y effect.The effective point of TCM in neurological diseases lies mainly in end-points and health-related events.Moreover,TCM has advantages in the evaluation of symptoms,syndrome and quality of life(QOL).Some key indexes should be included when evaluating the efficacy of TCM in neurological diseases.Meanwhile,the advantages of TCM such as end-points,health-related events and QOL should be highlighted.Multi-subject researching methods could be adopted to make a comprehensive evaluation of subjective and objective indexes.The clinical evidence on the TCM eff icacy evaluation may come from RCTs,and other types of designs can also be considered.     

Investigation of common symptoms of cancer and reliability analysis

Objective:To identify cancer distribution and treatment requirements,a questionnaire on cancer patients was conducted.It was our objective to validate a series of symptoms commonly used in traditional Chinese medicine (TCM).Methods:The M.D.Anderson Symptom Assessment Inventory (MDASI) was used with 10 more TCM items added.Questions regarding TCM application requested in cancer care were also asked.A multi-center,cross-sectional study was conducted in 340 patients from 4 hospitals in Beijing and Dalian.SPSS and Excel software were adopted for statistical analysis.The questionnaire was self-evaluated with the Cronbach's alpha score.Results:The most common symptoms were fatigue 89.4%,sleep disturbance 74.4%,dry mouth 72.9%,poor appetite 72.9%,and difficulty remembering 71.2%.These symptoms affected work (89.8%),mood (82.6%), and activity (76.8%),resulting in poor quality of life.Eighty percent of the patients wanted to regulate the body with TCM.Almost 100% of the patients were interested in acquiring knowledge regarding the integrated traditional Chinese medicine (TCM) and Western medicine (WM) in the treatment and rehabilitation of cancer.Cronbach's alpha score indicated that there was acceptable internal consistency within both the MDASI and TCM items,0.86 for MDASI,0.78 for TCM,and 0.90 for MDASI- TCM (23 items).Conclusions:Fatigue,sleep disturbance,dry mouth,poor appetite,and difficulty remembering are the most common symptoms in cancer patients.These greatly affect the quality of life for these patients.Patients expressed a strong desire for TCM holistic regulation.The MDASI and its TCM-adapted model could be a critical tool for the quantitative study of TCM symptoms.     

中医学在创新中求发展

创新是中医学发展的动力，中医不但需要继承，也需要创新，继承和创新是辩证的统一。创新只能以实践为判断标准，而不应设置禁区。理论创新是关键，需要解决过度依赖哲学和功能与结构不完全一致的两大难题。中医学必须借鉴所有学科知识为其发展之用。中医学是在发展中与现代学科体系逐步沟通，最终走向融合。这需要一个较长的历史时期才能完成，需要有更高层次理论的指导、人才的聚集和中医自身的有效发展等条件。     

中性粒细胞弹性蛋白酶在支气管扩张中的生物学功能及中药干预研究进展

中性粒细胞弹性蛋白酶（NE）是中性粒细胞原代颗粒中的一种主要蛋白酶,参与支气管扩张复杂病理的发生、发展,具有调节炎症反应、控制感染、增加黏液分泌、降解细胞外基质和细胞因子及损害免疫系统等多种生物学功能,与疾病预后有关,可作为临床治疗结果的预测因子和可能的治疗靶点。尚未有大量高级别临床研究证明内源性及外源性NE抑制剂对支气管扩张的疗效。中医药发挥其多靶点、多途径、精准施治等作用干预NE介导的支气管扩张,在改善临床症状、减少急性加重次数、减轻气道炎症反应等方面具有优势。该文综述NE在支气管扩张中的主要生物学功能,以及中医药干预NE介导的气道炎症的进展,期望为临床和科研提供有价值的参考依据。     

现代中医发展的取与舍

随着现代社会科学技术的发展,现代中医也在顺应着历史潮流不断发展。在此过程中,有符合历史发展规律之处,但亦出现一些问题。本文总结了中医发展中遭遇的突出问题,从中医经典与基础理论、传统医学与现代医学、临床与科研等矛盾冲突的几个方面进行论述,并探讨解决的办法。