Polymorphous low-grade adenocarcinoma at the base of the tongue: an unusual location

Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm of low aggressiveness that occurs almost exclusively in the minor salivary glands, primarily those in the palate. We report a case of PLGA that arose in the base of the tongue and subsequently metastasized to the neck. The tumor was resected through the oral cavity with wide margins and dissection. The neck metastasis was treated with radical neck dissection and radiotherapy. The patient recovered and remained disease-free at follow-up 30 months later. This case shows that PLGA, which has a variable morphologic appearance, can occur at sites other than the salivary glands.     

Polymorphous low-grade adenocarcinoma of the tongue

Polymorphous low-grade adenocarcinoma has been recently recognized as a distinct entity with a predilection for minor salivary glands. We present an unusual case of polymorphous low-grade adenocarcinoma of the tongue. Only a few cases located at the tongue have been reported in the English literature. Current literature concerning the histopathological and clinical features of this tumor was discussed.     

Polymorphous low-grade adenocarcinoma of the tongue

Primary adenocarcinoma of the oral cavity is an infrequently encountered problem. Adenocarcinomas are distinctive lesions which can be subclassified according to their tissue growth patterns or histomorphology. The polymorphous low-grade adenocarcinoma of the oral cavity is usually of minor salivary gland origin. We present an unusual case of polymorphous low-grade adenocarcinoma of the tongue and add this case to the existing two previous reports in the literature. A review of the current literature concerning this tumor is included. Treatment presently consists of complete local excision followed by radiation therapy.     

Polymorphous low-grade adenocarcinoma of the parotid gland

Polymorphous low-grade adenocarcinoma (PLGA) of the parotid gland is rare. We describe a new case in which the patient underwent parotidectomy only to experience an extensive recurrence 2 years later. The recurrence was treated with radical surgical excision and radiation therapy, and the patient remained disease-free at 5 years of follow-up. We also review the literature on primary parotid PLGA.     

耳多形性低度恶性腺癌一例

患者男,42岁,主因左耳堵6年,加重1个月于2010年2月收入院.6年前患者无明显诱因出现左耳堵,偶有耳痒,耳道无出血、流脓、流水,无疼痛,无发热.当地医院诊断为外耳道肿物,行外耳道肿物切除术,但未行组织病理学检查.术后1年,患者仍旧自觉有耳堵感,未予诊治,1个月前耳堵感加重,听力明显下降,遂就诊于我院,门诊以左侧外耳道肿物收人院.入院检查:患者一般情况好,心、肺、腹部未见明显异常,颌下、颈部末触及肿大淋巴结.腹部B超肝、胆、胰、脾、双肾未见异常.     

Polymorphous low-grade adenocarcinoma: A 17 patient case series

Polymorphous low-grade adenocarcinoma (PLGA) is a rare malignancy most commonly seen in the minor salivary glands. First described in 1983, this entity has been recognized to have an indolent course with rare metastases or deaths. We describe our experience with 17 patients treated at our institution for PLGA from 1984 to 2012. All tumors were located in the oral cavity or soft palate. All patients were treated surgically, with the exception of one patient who declined therapy. No deaths or metastases have been identified in subsequent follow-up. Three patients in this series had undergone prior surgery up to 20 years previously and were treated for recurrences at our institution; no other recurrences have been noted. In summary, PLGA is best treated with wide excision to negative margins with excellent prognosis, but long-term follow-up is recommended given the propensity for late recurrences.     

Polymorphous low-grade adenocarcinoma of the palate: report of cases

OBJECTIVE: Polymorphous low-grade adenocarcinoma (PLGA) is a rare tumor that mostly affects minor salivary glands. The purpose of this study is to report six new cases followed-up during a long period. We also review the literature concerning clinical, histological and immunohistochemical features, as well as the proper management. METHODS: Malignant tumors of the salivary glands diagnosed in our department from 1990 to 1999 were reviewed. A total of 66 cases were registered. Six of these cases were diagnosed as PLGA. All cases satisfied the histopathological criteria for this entity, and at least 3 years follow-up was available. RESULTS: In the six cases the primary location was the mucosa of the palate. Hard palate was affected in 83.3% of the cases. There were no cases of extraoral PLGA in our series. Tumors were ulcerated in a 16.6% of the cases, and exofitic in the other 86.4%. Histologically, it was observed a tumoral proliferation of round clusters of uniform cells with round-to-oval clear nuclei and small nucleoli. All the cases underwent surgical management with local excision with surgical margins, five of them with bone extirpation associated. No recurrence was observed in four cases, whereas the remaining two cases showed recurrence in the follow-up. In one of the patients, lococervical recurrence appeared 12 months after the surgery, and this patient died after a few months. The remaining patients have been followed-up for 11, 7, 4 and 3 years postoperatively, with no evidence of recurrence. CONCLUSION: Our results for a long follow-up period support the idea for a low grade of malignancy and good prognosis of this tumor, but the appearance of recurrences many years after the surgery must induce us to be very careful and systematic with the follow-up.     

Polymorphous low-grade adenocarcinoma of the tonsil: report of a case and review of the literature

Polymorphous low-grade adenocarcinoma (PLGA) is a relatively common malignancy of the oral cavity, representing 7% to 11% of all intraoral minor salivary gland tumors, and 19% to 26% of those that are malignant. However, it is a rare finding in the oropharynx, with only 6 cases reported in the medical literature. The clinical features of a case of PLGA of the tonsillar fossa in a 64-year-old gentleman are presented, only the second such case reported in the medical literature. A review and discussion of the literature pertaining to PLGA of the oral cavity and the oropharynx is provided. (Am J Otolaryngol 2002;23:297-299.     

Polymorphous low grade adenocarcinoma of the palate in a child

We report a case of polymorphous low grade adenocarcinoma involving the palate of a 12-year-old girl, the first example of this tumour occurring in the paediatric age group. The tumour displayed infiltrative growth, neural invasion, variegated histological patterns, and minimal cytological atypia. The patient remained disease-free four years after wide local excision of the tumour. The distinction of polymorphous low grade adenocarcinoma from pleomorphic adenoma and adenoid cystic carcinoma is also discussed.     

Recurrent polymorphous low-grade adenocarcinoma manifesting as a sinonasal mass: a case report

Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm that tends to follow a benign clinical course. Recurrences are uncommon. We report a case of recurrent PLGA of the paranasal sinuses that manifested as a large mass that filled the entire nasal cavity and left maxillary sinus. To our knowledge, this is the first reported case of a recurrent PLGA of the paranasal sinuses.     

The need for clinical awareness of polymorphous low-grade adenocarcinoma: a review.

Adenocarcinomas of the salivary glands are a heterogeneous group both in terms of histomorphology and clinical course. One recently described adenocarcinoma, polymorphous low-grade adenocarcinoma (solely of minor salivary gland occurrence), is appropriately named. This neoplasm has a wide spectrum of histology and can resemble tumors such as pleomorphic adenoma and adenoid cystic carcinoma; both aspects can lead to diagnostic problems for the pathologist. As well, despite an infiltrative growth pattern, which frequently results in perineural invasion, this tumor has a low local recurrence rate and a remarkable infrequency of local or distant metastasis. In order to provide appropriate therapy for polymorphous low-grade adenocarcinoma, oral and head and neck surgeons must be familiar with this neoplasm.     

Retrospective study and review of polymorphous low-grade adenocarcinoma

OBJECTIVES/HYPOTHESIS: We review a single institution's experience with polymorphous low-grade adenocarcinoma. To our knowledge, this is the largest patient series of polymorphous low-grade adenocarcinoma with clinical follow-up in the otolaryngology literature. STUDY DESIGN: We retrospectively identified 19 patients with polymorphous low-grade adenocarcinoma who had adequate clinical follow-up and pathologic specimens available for examination. METHODS: All pathologic materials were reviewed by one head and neck pathologist. RESULTS: The median follow-up was 9.6 years. The most frequently affected sites were the hard palate (12 patients) and soft palate (9 patients). Fifteen patients had their initial treatment at our institution, and four patients presented with a recurrent tumor. Five patients had a local recurrence after surgery; of those patients, two had initially presented with recurrent tumors. Local tumors recurred as late as 15 years after the initial surgery. One patient had regional nodal disease 20 years after the initial procedure, and another had lung metastasis. No patients received chemotherapy. The most common initial diagnoses were polymorphous low-grade adenocarcinoma, adenoid cystic carcinoma, and pleomorphic adenoma. CONCLUSIONS: Polymorphous low-grade adenocarcinoma is an increasingly recognized malignancy that originates predominantly in the minor salivary gland. Our experience confirms good local control after a wide local excision is performed, but local recurrences can occur despite having negative margins after surgery. The delayed local recurrences and regional nodal metastases noted in our series show that prolonged follow-up is needed. This series also reports one of the first pathologically confirmed cases of distant metastasis.     

Metastasis in the palatine tonsil as the first sign of a gastric adenocarcinoma

Gastric adenocarcinomas rarely give rise to metastases in the palatine tonsils; twelve such cases have been published. In two of them the tonsillar tumour was the first sign of the disease. We present a patient with a tumour of the palatine tonsil and cervical lymph node involvement who was diagnosed as having an adenocarcinoma of "signet ring" cells in the histopathology and cytology studies. Finding such cells directed us to the stomach in our search for the primary.     

鼻腔鼻窦低级别非肠型腺癌4例报道及文献复习

目的 探讨鼻腔鼻窦低级别非肠型腺癌的临床特点及治疗方式。方法 收集分析2013—2022年于青岛大学附属医院确诊的4例鼻腔鼻窦低级别非肠型腺癌患者的临床、影像学、病理学及随访预后资料。结果 4例患者中,男1例,女3例,发病年龄33～70岁。2例查体发现右侧鼻腔肿物,1例右侧鼻塞、流涕1年余,1例左侧面部疼痛4月余。3例患者行手术治疗,1例术后接受放疗。免疫组化结果：CK7阳性表达,CK20、CDX2和villin均阴性。3例手术患者随访至今,均无复发及转移。1例未行治疗,因并发中耳癌去世。结论 鼻腔鼻窦低级别非肠型腺癌临床罕见,发病隐匿,确诊需根据病理诊断,手术治疗有效。