异丙酚对阿曲库铵肌松效应及循环功能的影响

目的：探讨异丙酚对阿曲库铵的肌松效应及循环功能的影响，并与硫喷妥钠进行了比较。方法：择期全麻手术病人１６例随机分为异丙酚组和硫喷妥钠组，用加速度仪ＴＯＦ刺激模式监测拇内收肌肌张力，记录肌松起效时间、高峰时间、Ｔ１出现时间、Ｔ４／Ｔ１为２５％和７５％时间，同时监测ＢＰ和ＨＲ。结果：异丙酚组和硫喷妥钠组的工库铵肌松效应差异不大，仅异丙酚组Ｔ１出现时间先于硫喷妥钠组。异丙酚的降压作用较硫喷妥钠显著。结论     

不同麻醉诱导药对血钾浓度变化及肌颤和肌痛的影响

目的 观察硫喷妥钠、咪唑安定、依托咪酯以及异丙酚麻醉诱导对琥珀胆碱引起的血钾升高、肌颤和肌痛的影响。方法 ＡＳＡⅠ～Ⅱ级病人６０例,随机分为四组,分别采用硫喷妥钠、咪唑安定、依托咪酯或异丙酚静脉诱导,静注琥珀胆碱后行气管插管。于诱导前、气管插管前和插管后测定血清钾浓度,并观察诱导期病人肌颤及术后病人肌痛的发生率。结果 各组病人诱导前及气管插管前的血钾浓度组间及组内比较均无显著差异（Ｐ〉０．０５）,     

罗库溴铵与琥珀胆碱对脑血管血流动力学的影响及比较

研究罗库溴铵与琥珀胆碱对脑血管血流动力学的影响，以进一步证明作为全麻诱导用药，前者取代后者的合理性。方法：４６例择期病人随机分成两组，罗库溴铵组（Ｒ组）２１例，琥珀胆碱组（Ｓ组）２５例。全麻诱导应用芬太尼和硫喷妥钠后，Ｒ组静注罗库溴铵０．９ｍｇ／ｋｇ，Ｓ组静注琥珀胆碱１．５ｍｇ／ｋｇ。分别于全麻诱导前后，静注肌松药后１、５、１０分钟时检测ＣＶＤＩ。结果：（１）两组全麻醉诱导后平均，最小脑血流量（Ｑ     

全麻诱导气管插管时大脑皮层电活动与血流动力学的变化——比较异丙酚和硫喷妥钠的药理作用

目的：探讨数量化脑电图在反映麻醉诱导气管插管期间脑电的活动程度，以及ＥＥＧ和心血管反应相关性研究。方法：７０例ＡＳＡⅠ级病人，随机双盲分两组，组Ⅰ（ｎ＝３５）硫喷妥钠，组Ⅱ（ｎ＝３５）异丙酚。硫喷妥钠或异丙酚和琥珀胆碱行气管插管。分别于诱导前、诱导后、气管插管后１～２分和３～５分监测数量化脑电图、ＭＡＰ、ＨＲ、ＳｐＯ２的变化。结果：诱导前，两组病人的ＥＥＧ及血流动力学参数无差异。诱导后，ＥＥＧ抑制，ＳＥＦ、ＭＦ、ＢＩＳ下降，δＲ升高，但两组之间无区别；异丙酚组ＭＡＰ降低程度大于硫喷妥钠组（Ｐ＜０．０１），ＨＲ无差异。气管插管后，ＥＥＧ活化，ＳＥＦ、ＭＦ、ＢＩＳ升高（Ｐ＜０．０１），δＲ降低（Ｐ＜０．０１），异丙酚组ＥＥＧ各参数的变化程度轻于硫喷妥钠组（Ｐ＜０．０１）；异丙酚组ＭＡＰ和ＨＲ升高程度小于硫喷妥钠组（Ｐ＜０．０１）。结论：气管插管前，等效剂量的异丙酚和硫喷妥钠对中枢神经的抑制程度类似，气管插管后，异丙酚组的ＥＥＧ活化程度及血流动力学的变化明显轻于硫喷妥钠。     

双异丙酚或硫喷妥钠对琥珀胆碱引起肌痛的发生率和严重程度的比较

选择51例(ASAⅠ～Ⅱ级)16～45岁进行腹腔镜妇科手术或检查的病人,随机分为A组(n=25)用硫喷妥钠和B组(n=26)用双异丙酚。两组都不用术前用药,分别静注硫喷妥钠或双异丙酚后,均注琥珀胆碱1mg/kg,插气管导管,吸66％N_2O-O_2-异氟醚和静注芬太尼维持麻醉。术后24,48,72h询问非手术区的肌痛程度和特征,应用线性模拟记分法记录。     

异丙酚在全麻诱导插管期间对心血管系统影响的临床研究

本研究的目的主要是观察异丙酚在全麻诱导插管期间对心血管系统的影响，并与硫喷妥钠进行临床比较。择期手术病人２０例，随机分为二组，即异丙酚组（Ｐ组）和硫喷妥钠组（Ｔ组），每组各１０例。诱导方法为静注异丙酚２．５ｍｇ／ｋｇ或硫喷妥钠６～７ｍｇ／ｋｇ和琥珀酰胆碱１．５～２．０ｍｇ／ｋｇ后气管插管。应用ＢｏＭｅｄＮＣＣＯＭ３－Ｒ７无创心功能监测仪分别在诱导前、诱导后、插管后即刻及插管后１、５ｍｉｎ测定血流动力学参数的变化。结果表明，诱导后Ｐ组的血压和ＲＰＰ明显降低而ＨＲ稍减慢，其血压下降的幅度比Ｔ组显著，而静注硫喷妥钠后ＨＲ明显增快，ＲＰＰ反而增高，说明异丙酚可能减少心肌的耗氧量。在插管后即刻Ｐ组的血压、ＲＰＰ和ＨＲ上升幅度比Ｔ组小，说明应用异丙酚时插管刺激引起的高血压反应比硫喷妥钠弱。上述表明异丙酚不失为一种良好的全麻诱导药，在老年人和其他方面的应用仍有待研究。     

全麻诱导气管插管时大脑皮层电活动与血流动力学的变化

探讨数量化脑电图在反映麻醉诱导气管插管期间脑电的活动程度，以及ＥＥＧ和心血管反应相关性研究。方法：７０例ＡＳＡⅠ级病人，随机双盲分两组，组Ⅰ（ｎ＝３５）硫喷妥钠，组Ⅱ（ｎ＝３５）异丙酚。硫喷妥钠或异丙酚和琥珀胆碱行气管插管。分别于诱导前、诱导后，气导插管后１￣２分和３￣５分监测数量化脑电图，ＭＡＰ、ＨＲ、ＳｐＯ２的变化。结果：诱导前，两组病人的ＥＥＧ及血流动力学参数无差异。诱导后，ＥＥＧ抑制、ＳＥ     

不同药物用于全麻诱导对循环的影响

<正> 选择三组药物进行快速诱导气管插管,观察对循环功能的影响。现总结如下。 1 资料与方法 90例ASAⅠ～Ⅱ级的择期全麻手术病人:男58例,女32例,年龄55～75岁,体重44～95kg,随机分为三组:Ⅰ组用芬太尼、异丙酚、琥珀胆碱;Ⅱ组用芬太尼、硫喷妥钠、琥珀胆碱;Ⅲ组用安定、硫喷妥钠、琥珀胆碱。合并高血压病人28例,心电图     

异丙酚和硫喷妥钠静脉麻醉用于喉显微手术

本研究旨在对比观察在异丙酚和硫喷妥钠静脉麻醉下行喉显微手术的患者,在诱导、苏醒、血流动力学以及琥珀胆碱肌松效应等方面的变化。资料与方法一般资料　36例患者患声带息肉34例,喉内肿物2例,ＡＳＡⅠ～Ⅱ级,随机分为异丙酚(Ｐ)组和硫喷妥钠(Ｔ)组。Ｐ组20例,男6例、女14例,年龄438±104岁,体重628±78ｋｇ;Ｔ组16例,男6例、女10例,年龄449±94岁,体重611±92ｋｇ。麻醉方法　术前1小时肌注阿托品001ｍｇ/ｋｇ,术前30分钟内静滴平衡盐液6～8ｍｌ/ｋｇ和地塞米松10ｍｇ。麻醉开始先静注芬太尼3μｇ/ｋｇ,3分钟后Ｐ组于30秒内静注异丙酚2ｍ…     

异氟醚对阿库氯铵肌松效应的影响

吸入性麻醉药与非去极化肌松药伍用，能延长肌松药药效和减少非去极化肌松药药量。本文比较了吸入不同ＭＡＣ浓度异氟醚对阿库氯铵肌松效应的影响。资料和方法选择ＡＳＡⅠ～Ⅱ级，肝、肾功能正常，无神经肌肉传导障碍的患者５０例，平均年龄４９（２２～７０）岁。麻醉诱导为静脉注射安定２０ｍｇ、硫喷妥钠５ｍｇ／ｋｇ、琥珀胆碱１ｍｇ／ｋｇ，肌颤搐消失后气管插管，并吸入氧气和氧化亚氮１：１混合气体：吸入氧浓度维持在５０％。分三组，对照组术中麻醉维持为静脉注射芬太尼，另两组持续吸入异氟醚，其中一组呼气末异氟醚浓度维持在０…     

Endotracheale Intubation unter Propofol und Fentanyl

The routine use of succinylcholine for endotracheal intubation is being increasingly questioned. Initial studies have suggested that a combination of propofol and alfentanil without a muscle relaxant can provide good intubating conditions. However, most of these initial studies either did not have a double-blind design or did not include a control group with muscle relaxants. In this study, intubation conditions using fentanyl/propofol without a muscle relaxant were compared with the combinations of fentanyl/propofol/succinylcholine and sodium thiopental/succinylcholine. Material and methods. Following approval from the local ethics committee and written consent, 100 gynaecological patients (ASA I, II) were included in this study. The study was carried out in a double blind, randomized and prospective manner. Black perfusor syringes and extension sets were used, and the drugs administered were diluted to equal volumes. For induction, group 1 (n=25) received 0.1?mg fentanyl, 1?mg vecuronium, sodium thiopental (demand-adapted) and succinylcholine 1?mg/kg; group 2 (n=25) received 0.1?mg fentanyl and propofol (demand-adapted); group 3 (n=25) received 0.2?mg fentanyl and propofol (demand-adapted); group 4 (n=25) received 0.1?mg fentanyl, 1?mg vecuronium, propofol (demand-adapted) and succinylcholine 1?mg/kg. Each patient was assessed prior to induction with regard to visualization of the pharynx (grade I–IV). Following induction, jaw relaxation (grade I–IV) and the laryngoscopic visualization of the glottis (grade I-IV) were assessed. During the intubation, the position and movements of the vocal cords (grade I-IV) and patient movement during and 1?min following the intubation were assessed. The overall assessment of the intubation was graded (grade I–IV) by the anaesthetist and the anaesthetic nurse. Postoperatively the patients were questioned regarding muscle pain (grade I–IV). Before, during and after endotracheal intubation arterial haemoglobin oxygen saturation, heart rate and arterial blood pressure were monitored. Results. There were no intergroup differences with regard to age, height, weight and preanaesthetic visualization of the pharynx. In group 1 an average of 5.5±1.2?mg/kg sodium thiopental was required. There were no significant differences in group 2, 3 and 4 with respect to the dose of propofol (2.4, 2.2 and 2.2?mg/kg). No intergroup differences were noted with regard to jaw relaxation, laryngoscopic visualization of the glottis and patients' movements during intubation. Statistically significant intergroup differences occurred with regard to the position and movements of vocal cords during intubation (group 3 worse than groups 1, 2, 4) and the patients' movements 1?min after intubation (group 2 worse than group 3). Significant intergroup differences also occurred with regard to the overall assessment of the intubation by the anaesthetist (group 3 worse than groups 2, 4) and the anaesthetic nurse (group 3 wourse than group 4) and the postoperative muscle pain (group 1 worse than groups 2, 3). Conclusion. The use of 0.1?mg fentanyl/sodium thiopental/succinylcholine results in no better intubating conditions than 0.1?mg fentanyl plus propofol. Under these conditions, without the use of a muscle relaxant, it is possible to carry out safe endotracheal intubation in cases where no complications are anticipated.     

Quantitative evaluation of the neuroprotective effects of thiopental sodium, propofol, and halothane on brain ischemia in the gerbil: effects of the anesthetics on ischemic depolarization and extracellular glutamate concentration

Although propofol and thiopental are commonly used as neuroprotective agents, it has not been determined which is more neuroprotective. This study was designed to quantitatively evaluate the neuroprotective effects of thiopental, propofol, and halothane on brain ischemia by determining P50, ischemic time necessary for causing 50% neuronal damage. Gerbils were anesthetized with thiopental, propofol, or halothane and underwent 2-vessel occlusion (0, 3, 5 or 10 min). Direct current potentials were measured in bilateral CA1 regions, in which histologic evaluation was performed 5 days later. In some animals, extracellular glutamate concentrations (microdialysis) were measured during 7.5 minutes of ischemia. P50 in the thiopental, propofol, and halothane groups were estimated to be 8.4, 6.5 (P<0.05, vs. thiopental), and 5.1 (P<0.05) minutes, respectively. Durations of ischemic depolarization were equally reduced in the thiopental and propofol groups compared with that in the halothane group. Severity of neuronal damage with identical duration of ischemic depolarization was attenuated by thiopental compared with the effect of propofol. Maximum glutamate concentrations in the thiopental and propofol group were significantly reduced compared with that in the halothane groups but were comparable. By using P50, we found that the neuroprotective effect of thiopental was greater than that of propofol. Although duration of ischemic depolarization was equally reduced in thiopental and propofol groups, thiopental has a greater suppressive effect on neuronal injury during identical duration of ischemic depolarization than propofol does. Glutamate concentration during brain ischemia tended to be attenuated more by thiopental than by propofol, but it was not statistically significant.     

Drug use inefficiency: a hidden source of wasted health care dollars

A potential area for departmental savings is to minimize inefficient use of pharmaceuticals. We recorded drug waste data for multiple drugs for a fiscal year and surveyed providers' knowledge of departmental drug waste. Six large-cost or large-volume use drugs were chosen for study: thiopental, succinylcholine, rocuronium, atracurium, midazolam, and propofol. Amounts administered to patients were collected for one year by using a computerized anesthesia record keeper. Total drug distributed was the number of vials restocked by pharmacy for the year. An efficiency index, the percent administered to patients, was calculated for each drug. Drug administration to 25,481 patients was analyzed. Drug use efficiency indices were: atracurium 29%; thiopental, 31%; succinylcholine, 33%; propofol, 49%; midazolam, 53%; rocuronium, 61%. The total cost of unadministered study drugs was $165,667, 26% of the expenditure for all drugs. Most dollars wasted were for propofol, $80,863, and thiopental, $32,839. The reason most cited for drug waste was the disposal of full, or partially full, syringes. Drug wastage represents a significant portion of the entire anesthesia drug budget. Waste reduction strategies should allow a portion of the "avoidable" waste to be reduced. Implications: Unadministered drug amounts were measured for six study drugs over one fiscal year and found to be significant; the cost of unadministered drugs totaled $165,667. The reason most cited for waste was disposal of full, or partially full, syringes.     

四种常用静脉麻醉药对老年病人血液动力学影响的比较

目的 探讨脑电双频指数(BIS)为50时，硫喷妥钠、丙泊酚、咪唑安定、依托咪酯用于老年病人全麻诱导的剂量及其对血液动力学的影响。方法 65岁以上的老年病人48例，随机分为四组：硫喷妥钠组，丙泊酚组，咪唑安定组，依托咪酯组。四组均缓慢静注，并且用HXD-1型脑电监测仪测量每例病人的BIS。当BIS逐渐下降至50时停止静注，分别于注药前、注药后1、3、5、10min用Rheo Cardio Monitor连续非创伤性血液动力监测仪记录和计算出血液动力学有关参数。结果 BP下降以丙泊酚组为显著。丙泊酚组和硫喷妥钠组的PEP/LVEF比值明显增加，但丙泊酚组＞硫喷妥钠组。除依托咪酯组以外其他各组的每搏指数(SD、心脏指数(CI)、射血速率(EV)和每搏功(LVP)均有不同程度的降低，但以丙泊酚组为显著。依托咪酯组体循环血管阻力(SVR)无明显变化，硫喷妥钠组和咪唑安定组均有不同程度的升高，以咪唑安定组为显著，丙泊酚组明显下降。舒张末容量(EDV)咪唑安定组明显下降，其他各组无明显变化。结论 四种静脉麻醉药对老年病人血液动力学的影响由大到小依次为丙泊酚＞咪唑安定＞硫喷妥钠＞依托咪酯。BIS为50时，老年病人各静脉麻醉药的等效剂量为硫喷妥钠4mg／kg、丙泊酚1．2mg／kg、咪唑安定0．16mg／kg、依托咪酯0．34mg／kg。对于心功能较差和血容量不足的老年病人全麻诱导，依托咪酯是首选的静脉麻醉诱导药。     

Nitrous oxide potentiates succinylcholine neuromuscular blockade in humans.

Sixty ASA physical status I and II adults received 0.3 mg/kg succinylcholine to determine the effect of prolonged administration of thiopental and that of nitrous oxide on succinylcholine neuromuscular blockade. Succinylcholine was administered either 1 min (group 1) or 6 min (groups 2 and 3) after induction of anesthesia with thiopental. In group 2, anesthesia was maintained with thiopental and the patients' lungs were ventilated with oxygen. In group 3, anesthesia was maintained with only 70% nitrous oxide in oxygen. Train-of-four stimulation of the ulnar nerve was started 30 s before the administration of succinylcholine and repeated every 12 s. The force of contraction of the adductor pollicis muscle was measured. Maximum blockade (mean +/- SEM) did not vary significantly between group 1, where thiopental had been administered for 1 min, and group 2, where it had been administered for 6 min (group 1: 61% +/- 6%; group 2: 54% +/- 8%). However, the addition of nitrous oxide increased neuromuscular blockade (group 3: 80% +/- 6%; P less than 0.05 compared with group 2). The degree of twitch augmentation, i.e., greater than maximal response, and times to twitch augmentation and to maximum blockade did not vary significantly among the groups. It is concluded that nitrous oxide increases succinylcholine neuromuscular blockade and that this is manifest within 6 min. This effect is not due to the duration of the anesthetic because thiopental, administered over a similar time period, did not potentiate succinylcholine.     

Impact of the intubation model on the efficacy of rocuronium during rapid sequence intubation: systematic review of randomized trials

BACKGROUND: Propofol-rocuronium is thought to be superior to thiopental-rocuronium for rapid sequence intubation (RSI). The role of the intubation model per se has never been investigated. METHODS: Randomized comparisons of rocuronium with succinylcholine for true RSI (administration of muscle relaxant immediately after the hypnotic, intubation within 60 s) or modified RSI (delay between administration of the hypnotic and the muscle relaxant, intubation within 60 s) were sought. Good or excellent intubation conditions were expressed as relative risks (RR) with 95% confidence intervals (CI). RESULTS: Twelve trials (1,471 patients) used a true RSI. With propofol for induction, RR for good or excellent intubation conditions with conventional rocuronium doses (0.6-0.7 mg/kg) was 0.95 (95%CI, 0.90-1.00), with high doses (0.9-1.2 mg/kg) was 0.96 (0.92-1.01) compared with succinylcholine. With thiopental for induction, RR with conventional rocuronium doses was 0.69 (0.61-0.78) and with high doses was 0.99 (0.95-1.03). Nine trials (340 patients) used a modified RSI. With propofol for induction, RR with conventional rocuronium doses was 0.98 (0.91-1.06); data on high rocuronium doses were lacking. With thiopental for induction, RR with conventional rocuronium doses was 0.97 (0.92-1.02) and with high doses was 1.0. There was no evidence that concomitantly used opioids or the dose of the induction agent had an impact on intubation conditions, independent of the intubation model. CONCLUSION: The efficacy of rocuronium for RSI is influenced by both, the induction agent and the intubation model. To test the clinical usefulness of alternatives to succinylcholine for RSI, a true RSI model should be used.     

High-dose flumazenil potentiates the hypnotic activity of propofol, but not that of thiopental, in ddY mice

BACKGROUND: Flumazenil is a specific benzodiazepine agonist, which is reported to have a partial benzodiazepine agonist-like effect at a high dose. This study investigated the effects of flumazenil and midazolam on the hypnotic dose of propofol and thiopental in ddY mice, using a behavioral model. METHODS: Mice were given either propofol or thiopental intravenously to induce hypnosis, which was defined as a loss of the righting reflex. The mice were pre-treated with flumazenil (0.05, 0.1, or 0.2 mg kg(-1)) or midazolam (0.1 or 0.2 mg kg(-1)), and given propofol or thiopental after a 30-s delay. RESULTS: Pre-treatment with flumazenil (0.1 or 0.2 mg kg(-1)) significantly decreased the hypnotic dose of propofol compared to the control group (9.3+/-0.39 [8.5-10.0] or 9.0+/-0.28 [8.5-9.6] vs. 10.8+/-0.42 [9.9-11.6] mg kg(-1) (ED50+/-SEM and [95% confidence interval]) P<0.05), but not that of thiopental (9.1+/-0.30 [8.5-9.7] with 0.2 mg kg(-1) flumazenil vs. 9.3+/-0.42 [8.4-10.1] mg kg(-1) with saline). Midazolam reduced the hypnotic dose of both propofol and thiopental. Flumazenil antagonized the potentiating effect of midazolam (0.2 mg kg(-1)) on the hypnotic activity of propofol. CONCLUSIONS: These results suggest that the hypnotic activity of propofol is potentiated by the partial agonist activity of flumazenil in ddY mice.     

QT interval and QT dispersion during the induction of anaesthesia in patients with subarachnoid haemorrhage: a comparison of thiopental and propofol

BACKGROUND AND OBJECTIVE: Thiopental prolongs the QT interval more than propofol, and the two induction agents were compared in patients with subarachnoid haemorrhage predisposed to electrocardiographic abnormalities and cardiac dysrhythmias. METHODS: Twenty-nine patients were studied randomly. Anaesthesia was induced with either thiopental or propofol and fentanyl; vecuronium was used as a neuromuscular blocking agent. The electrocardiogram and arterial blood pressure were monitored from before the induction of anaesthesia to 2 min after endotracheal intubation. RESULTS: The median QT interval was at baseline 423 ms in the thiopental group and at 432 ms in the propofol group, and it increased in the thiopental group to 446 ms and decreased in the propofol group to 425 ms (P < 0.01 between groups). After induction and endotracheal intubation, the number of patients with increased QT dispersion was greater in the propofol group (P < 0.05). The incidence of cardiac dysrhythmias was similar in the study groups. CONCLUSIONS: Thiopental and propofol are equally suitable for the induction of anaesthesia in patients with subarachnoid haemorrhage.     

Onset time and haemodynamic response after thiopental vs. propofol in the elderly: a randomized trial

Background: The induction dose of hypnotic agents should be reduced in the elderly, but it is not well studied whether thiopental or propofol should be preferred in this group of patients. The aim of this study was to compare onset time, hypnosis level and the haemodynamic response after thiopental vs. propofol for induction of anaesthesia. Our primary hypothesis was that in the elderly, thiopental had a shorter onset time than propofol, defined as time to bispectral index (BIS) <50. Methods: In this randomized and double‐blinded study, we included 78 patients. Patients were eligible, if they were scheduled for elective surgery with general anaesthesia and aged 60 or older. Patients received alfentanil 10 μg/kg and either thiopental 2.5 mg/kg or propofol 1.0 mg/kg, and depth of anaesthesia was determined with BIS the following 120 s along with clinical assessment of anaesthetic depth. The primary endpoint was the time from start of injection of the hypnotic to a BIS value below 50. Results: Time to BIS <50 was significantly shorter in patients receiving thiopental, where onset time was 52 s (median value) compared with 65 s in the propofol group (P=0.01). Mean arterial pressure decreased 25.6 mmHg in the propofol group and 15.6 mmHg in the thiopental group (P=0.003) within 120 s. Heart rate decreased 9.1 b.p.m. within 120 s in the patients receiving propofol compared with a decrease of 5.1 b.p.m. in patients receiving thiopental (P=0.04). Conclusion: Thiopental was found to have a faster onset than propofol in elderly surgical patients.     

异丙酚和硫喷妥钠对心肌内游离Ca2+浓度的影响

目的　观察异丙酚和硫喷妥钠对心肌细胞内游离Ｃａ２＋ 浓度的影响,以探讨静脉麻醉药对心肌细胞内游离Ｃａ２＋ 的作用及其机制。方法　心肌细胞分离培养７～９ 天,以Ｆｕｒａ２／ＡＭ 荧光指示剂负载后,实验组Ａ 加入实验用药孵育１０ 分钟进行Ｃａ２＋ 测定;实验组Ｂ：加入实验用药１０ 分钟后,加ＫＣｌ４０ｍ ｍ ｏｌ／Ｌ,１ 分钟后进行Ｃａ２＋ 测定。结果　临床剂量的异丙酚和硫喷妥钠对静息心肌细胞内Ｃａ２＋ 浓度无明显影响,超临床剂量的异丙酚和硫喷妥钠使静息细胞内Ｃａ２＋ 明显降低。４０ｍ ｍ ｏｌ／Ｌ的ＫＣｌ可使心肌细胞内Ｃａ２＋ 浓度明显升高,异丙酚和硫喷妥钠对高浓度ＫＣｌ所激发Ｃａ２＋ 内流均有明显的抑制,并呈剂量依赖性。结论　异丙酚和硫喷妥钠降低心肌细胞内钙离子浓度。他们在完整心肌的负性肌力作用可能与其部分抑制兴奋收缩耦联过程中钙离子内流和抑制静息状态下的钙溢流有关