脑卒中患者血清脂蛋白(a)的变化及临床意义

目的 :探讨脑卒中患者血清脂蛋白 (a) [LP(a) ]含量的变化 ,以阐明LP(a)与脑卒中的关系及作用机制。方法 :采用酶联免疫吸附试验 (ELISA)双抗体夹心法检测 10 0例患者和 6 0例正常对照LP(a)的含量。结果 :脑卒中组LP(a)水平高于对照组 (P <0 0 1)。脑卒中合并糖尿病患者LP(a)水平明显高于不合并糖尿病患者 (P <0 0 1)。结论 :LP(a)是脑卒中患者相对独立的危险因素 ,它的水平可作为判断脑卒中患者的预后指标之一。     

60例成年癫(癎)患者生活质量的调查

目的:评价成年癫(癎)患者的生活质量.方法:用癫(癎)患者生活质量量表-31 (QOLIE-31)对湖南省岳阳市60例确诊的成年癫(癎)患者和60名对照组进行评定.结果:癫(癎)组较对照组生活质量降低[得分分别为(58.71±16.78)分和(62.16±11.99)分],表现在惧怕发作以对日常生活不满意,认知功能下降和社交受限等.结论:湖南省岳阳地区成年癫(癎)患者生活质量降低,应控制癫(癎)发作以提高患者的生活质量.     

狼疮性肾炎患者凝血纤溶指标的检测分析

目的:检测分析狼疮性肾炎患者凝血纤溶指标的变化及临床意义。方法:选择已确诊的狼疮性肾炎患者(狼疮性肾炎组)及原发性肾小球肾炎患者(肾小球肾炎组)各30例,平行检测两组凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(FIB)及D二聚体(DD)水平以及不同病程狼疮性肾炎患者上述指标变化。结果:狼疮性肾炎组FIB、DD水平均高于肾小球肾炎组(P0.05),但PT、APTT差异无统计学意义(P0.05)。病程5年的狼疮性肾炎患者较病程≤5年的患者PT、APTT缩短,FIB增高,差异均有统计学意义(P0.05)。结论:狼疮性肾炎患者存在高凝状态,且病程延长,高凝加重。     

胃癌患者性激素水平测定及临床意义

目的:探讨胃癌患者性激素水平变化及临床意义。方法:采用化学发光免疫分析法,测定134例胃癌患者血清睾酮(T)、雌二醇(E2)、催乳素(PRL)、黄体生成素(LH)及卵泡刺激素(FSH)水平,根据TNM分期对各期胃癌患者E2及T含量进行分析。结果:男性及女性胃癌患者E2、T含量明显低于对照组(P<0.05),女性患者E2水平较对照组下降更为明显(P<0.01);女性患者PLR水平显著性升高(P<0.01)、TNM各期胃癌患者E2、T水平变化为低分化者明显高于高分化者(P<0.01)。结论:了解胃癌患者血清性激素水平,对分析胃癌与性激素的关系有重要意义。     

急性期脑梗死患者血浆纤溶指标水平变化

目的:检测分析急性期脑梗死患者纤溶指标的血浆水平变化。方法:测定40例急性期脑梗死患者(病例组)血浆纤维蛋白原(FIB)、纤维蛋白降解产物(FDP)、D-二聚体(D-Dimer)、纤溶酶原活性(PLG:A)等指标水平,并与30例健康人群(对照组)进行统计学比较。结果:病例组FIB、FDP和D-Dimer水平明显高于对照组(P0.01);PLG:A活性明显降低于对照组(P0.05)。结论:急性期脑梗死患者呈现高凝及纤溶激活状态。     

精神分裂症、抑郁症、双相障碍患者自杀风险比较及相关因素

目的:描述和分析精神分裂症、抑郁症、双相障碍患者的自杀风险。方法:选取符合精神障碍诊断与统计手册第5版诊断标准,来自住院、门诊或社区的精神分裂症患者2 016例、抑郁症患者903例和双相障碍患者381例,使用简明国际神经精神访谈诊断精神障碍并评估自杀风险,精神症状维度评定量表(CRDPSS)评估症状,采用多因素logistic回归分析探讨3类精神障碍患者自杀风险的差异及相关因素。结果:37例(1.8%)精神分裂症患者、516例(57.1%)抑郁症患者、102例(26.8%)双相障碍患者近1个月有自杀风险。与精神分裂症患者相比,抑郁症(OR=36.50)和双相障碍患者(OR=20.10)自杀风险增加。女性(OR=1.87)、目前吸烟(OR=1.76)、有自杀家族史(OR=5.09)、CRDPSS幻觉条目得分高(OR=1.80)、CRDPSS抑郁条目得分高(OR=1.54)是患者有自杀风险的危险因素。结论:抑郁症和双相障碍患者的自杀风险高于精神分裂症患者,临床上应定期评估患者的自杀风险,重点关注存在幻觉和抑郁症状的患者。     

慢性鼻-鼻窦炎患者嗅觉功能与鼻内镜评分、鼻窦CT评分的相关性

目的:研究慢性鼻-鼻窦炎(chronic rhinosinusitis,CRS)患者嗅觉功能与Lund-Kennedy鼻内镜评分、Lund-Mackay鼻窦CT评分的相关性研究分析.方法:选择CRS住院患者200例.其中CRS(不伴鼻息肉)患者:95例;CRS(伴有鼻息肉)患者:105例,每组患者均进行病史采集,嗅觉功能检测、鼻内镜评分以及鼻窦CT评分.应用SPSS 13.0统计软件,对以上两个评分结果与嗅觉功能进行相关性分析.结果:CRS(不伴鼻息肉)或(伴有鼻息肉)患者中,Lund-Mackay鼻窦CT评分结果和Lund-Kennedy鼻内镜评分结果均是:随着嗅觉功能的下降,分数逐渐增加(P<0.01).结论:CRS患者与Kennedy鼻内镜评分和Lund-Mackay鼻窦CT评分均具有相关性;与CRS(不伴鼻息肉)患者的嗅觉功能最密切相关的是Lund-Mackay鼻窦CT评分;与CRS(伴有鼻息肉)患者的嗅觉功能最密切相关的是与Lund-Kennedy鼻内镜评分.     

PCR法检测不孕症妇女二种病原体(CT,UU)结果分析

目的 :探讨不孕症患者沙眼衣原体 (CT)和解脲支原体 (UU)感染的相关性。方法 :采用聚合酶链反应 (PCR)技术对 1 31 6例不孕症患者及 1 84例正常对照者进行宫颈沙眼衣原体 (CT)和解脲支原体 (UU)检测。结果 :不孕组宫颈分泌物的CTDNA和UUDNA阳性检出率显著高于对照组 (p <0 0 1 )。 结论 :对不孕症患者 ,尤其对原因不明的不孕症、继发性不孕症患者 ,应将生殖道CT及UU检测列为常规     

CHD患者血清可溶性CD40L检测的临床意义

目的:探讨冠心病(CHD)患者血清可溶性CD40L(sCD40L)水平变化的临床意义.方法:应用酶联免疫吸附法(ELISA)对入选的90例CHD患者[急性心梗(AMI)患者28例,不稳定型心绞痛(UAP)患者35例,稳定型心绞痛(SAP)患者27例]的外周血sCD40L进行检测,并与30例正常对照者血清sCD40L的浓...     

儿童期受虐与肠易激综合征关系的临床研究

目的:探讨儿童期受虐在肠易激综合征(IBS)发生及患者精神心理状态、生活质量中所起的作用。方法:72例IBS患者(患者组)评定儿童期虐待问卷(CTQ),评估儿童期受虐情况,并与92例正常健康人(对照组)进行对照。IBS患者同时还评定抑郁自评量表(SDS)、焦虑自评量表(SAS)、肠易激综合征患者生活质量表(IBSQOL)。结果:1患者组CTQ评分显著高于对照组,差异有统计学意义(t=3.590,P0.001);患者组儿童期受虐发生率为44.4%,高于对照组的27.2%,差异有统计学意义(χ~2=5.313,P0.05);2与无儿童期受虐的IBS患者(40例)比较,有儿童期受虐的IBS患者(32例)SAS评分显著较高,差异有统计学意义(t=2.099,P0.05);3有儿童期受虐的IBS患者QOL评分显著高于无儿童期受虐的IBS患者,差异有统计学意义(t=-2.223,P0.05)。结论:儿童期受虐可能是IBS发生的社会心理学因素之一,并可能对IBS患者的心理状况、生活质量产生不良的影响。     

Rates of oxygen consumption and of anaerobic glycolysis in renal cortex and medulla of adult and new-born rats and guinea-pigs

1. Rates of oxygen uptake and of anaerobic glycolysis were estimated in slices from the renal cortex and medulla (a) of adult rats and guinea-pigs, (b) of new-born (1-, 5- and 21-day-old) rats and of guinea-pigs of 1, 12, 21, 24 and 120 hr age.2. In the adult rat, Q(O2) values for the cortex were 12.55 +/- 0.20 (22) and for the medulla: 8.56 +/- 0.17 (22) mul./hr.mg dry weight, while in the new-born rat (24 hr old) they were 10.99 +/- 0.46 (12) and 9.33 +/- 0.18 (9) mul./hr.mg dry weight respectively.3. Values for Q(CO2) (N2) (anaerobic glycolysis) in the 14 hr old new-born rat were in the renal cortex 9.65 +/- 0.35 (5) and in the medulla 7.39 +/- 0.43 (5) mul./hr.mg dry weight; while in the adult they were 2.25 +/- 0.08 (16) and 5.76 +/- 0.14 (16) mul./hr.mg dry weight, respectively.4. In the adult guinea-pig values for Q(CO2) (N2) were of the same order as in the adult rat, though the rate of O(2) uptake was for the cortex 8.12 +/- 0.22 (12) and for the medulla 5.02 +/- 0.23 (11) mul./hr.mg dry weight.5. Though the Q(O2) values in the renal cortex and medulla were smaller in the 1 hr old new-born guinea-pig, they were already increasing in the 12 hr old neonate.6. The results are discussed in the light of enzyme changes occurring during the process of maturation of the nephron as indicated by histochemical observations.     

Modes of reinforcement and gender and culture of experimenter and subject: effects of "alien" and external reinforcement for Japanese and American men and women

In this study, we examined external and "alien" reinforcement (ER and AR. respectively) as a factor in social learning, and studied the combined effects of culture and reinforcement mode. A female (Experiment 1) and a male (Experiment 2) experimenters conducted experimental sessions. Both men and women, who grew up in the same culture as the experimenter, participated and performed the experimental task. A three-way interaction effect of experimenter gender, culture, and reinforcement mode was found on task performance. And the effect was more pronounced for a Japanese experimenter. A female and a male experimenters conducted Experiments 3 and 4, respectively; however participants this time were men and women who grew up in different cultures than the experimenter. Results indicated that the pattern of the subject gender and reinforcement mode interaction effect, when the experimenter was Japanese with American subjects, was exactly opposite to that when the experimenter was American. These experiments showed that AR was as effective for social learning as ER, and that the cultural backgrounds of experimenter and subject influenced AR and ER effectiveness.     

Timing and intensity of early fevers and the development of allergies and asthma

BACKGROUND: Early childhood fevers appear to protect against later allergies and asthma. What is not known is the time in which fevers exert this effect and whether the degree of temperature increase is important. OBJECTIVE: We sought to examine the relationship between the time and degree of early fevers and later allergies and asthma. METHODS: Eight hundred thirty-five children from southeast Michigan were enrolled at birth. Clinic records from their first 2 years were abstracted for episodes of fever. At age 6 to 7 years, children underwent allergy testing. We examined fevers occurring within 6-month intervals in the first 2 years of life and outcomes at age 6 to 7 years. The primary outcome measures were allergic sensitization, asthma, asthma with allergic sensitization, and asthma without allergic sensitization. RESULTS: In the unadjusted analysis each episode of fever between 7 and 12 months of age was associated with a lower odds of allergic sensitization (odds ratio [OR], 0.71; 95% CI, 0.54-0.93) and asthma with allergic sensitization (OR, 0.43; 95% CI, 0.21-0.90) at age 6 to 7 years. Likewise, every 1 degrees C increase in the maximum temperature between 7 and 12 months was associated with a lower odds of allergic sensitization (OR, 0.77; 95% CI, 0.61-0.96) and asthma with allergic sensitization (OR, 0.62; 95% CI, 0.40-0.94). After adjusting for potential confounders, each episode of fever between 7 and 12 months was associated with a lower likelihood of asthma with allergic sensitization (adjusted OR, 0.33; 95% CI, 0.11-0.94) at age 6 to 7 years. CONCLUSIONS: Both the timing and intensity of childhood fevers appear to be important factors in the development of allergies and asthma.     

纳米水平分子成像与诊疗一体化研究进展与挑战

分子成像能以非侵入性的方式重现活体细胞的生理功能和生物学过程,提高疾病的早期和特异性诊断水平。纳米颗粒/材料具有物理性质可控性高、易于表面修饰、血液循环时间长和可功能化等优点,在疾病诊断与治疗中显示出巨大潜力。但如何阐明纳米材料多功能间的内在联系、解决其代谢及安全性等关键机制难题、实现纳米颗粒/材料多功能性到临床多功能...