STD control in less developed countries: the time is now

This discussion of sexually transmitted diseases (STDs) in less developed countries covers incidence/prevalence, antimicrobial resistance, sequelae, future trends, and new opportunities for STD control -- technological changes, health service changes, and social and political changes. For most countries, current, population-based information on STD is lacking, yet STDs appear to be common problems in nearly all countries. The prevalence of gonococcal infection in non-STD clinic populations has been as high as 5-20%, and incidence estimates made in a few settings have ranged from 3-10% per annum. These observations may overrepresent the STD problem, yet they have been identified in countries in Asia, Africa, and the Americas. The prevalence of reactive serological tests for syphilis among antenatal clinic attendees has been as high as 10-15% in some countries of Africa and the Western Pacific. Chancroid infection is extremely common in many of the developing countries of Asia, Africa, and the Americas. Penicillinase-producing "N. gonorrhoeae" (PPNG) infections are a dramatic example of the emergence and worldwide dissemination of resistant gonococci since 1976. At this time PPNG isolates constitute over 10% of all gonococcal infections in nearly all southeast Asian and Africa settings where this problem has been explored. PPNG cause more than 50% of gonococcal infections in some settings. As a result of increasing PPNG prevalence, penicillin, previously the standard therapy for gonorrhea, has been replaced by alternative agents in many settings. A variety of antimicrobial agents are effective for PPNG infections, but these are too expensive or unavailable in many developing countries. Sequelae of STD produce enormous direct and indirect costs. Acute pelvic inflammatory disease (PID) caused by gonorrhea, chlamydia, and other STD agents is common throughout the world. In developing countries ectopic pregnancy is a common surgical emergency. Improved diagnostic tests, new approaches to treatment of STD, and development of vaccines provide opportunities for better STD control, as have changes in health care delivery. The promotion of the primary health care concept, a shift in emphasis of the international family planning programs, as well as a focus on support systems of health programs all are crucial to STD efforts, and their improvement enhances STD control possibilities. Also, greater discussion of the STD health problems has led to more serious consideration of these diseases and their control.     

The fight against sexually transmitted diseases in Ivory Coast: what strategies can we use in the face of HIV/AIDS?

In the AIDS era, sexually transmitted diseases (STDs) have become a major health problem in developing countries, particularly in Africa. Delays in the diagnosis and treatment of such infections may result in complications, many of which primarily affect women. Epidemiological studies in Abidjan have shown that more than 10% of the pregnant women attending antenatal clinics present STDs potentially serious for their own health or that of their infants (gonorrhea, chlamydia infection, genital ulcers or active syphilis). There is evidence that STDs increase the transmission of HIV and that improving the syndromic management of STDs reduces the incidence of HIV infection. This provides a strong argument in favor of controlling STDs in areas of high HIV prevalence. In Ivory Coast, as in other African countries, a STD control program has been integrated into the AIDS control program since 1992, as recommended by the World Health Organization. During the first six years of the STD program, considerable progress was made in some areas, but not without difficulty. Simple syndrome-based decision trees have been adopted for the management of STDs in primary health care. Clinical studies have shown these therapeutic algorithms to be effective. At the same time, effective and affordable drugs for treating STDs were added to the list of essential drugs in Ivory Coast, after an international invitation to tender. The entire staff of the public health sector in Abidjan has been trained in syndromic STD management. Training is now being extended to other parts of Ivory Coast, including the private health sector and, in particular, private nurses. The surveillance of syndromic STDs, mainly genital ulcers in both sexes and urethral discharge in men, facilitates monitoring and evaluation of the STD program, following health care activities and adapting orders for drugs for treating STDs to real needs. In the near future, some parts of the STD program will be strengthened, particularly the management of sexual partners of STD patients and reduction of the cost of STD treatment for pregnant women.     

Judging doctor supply--market or health criteria?

Large rural areas of developing countries show severe shortages of physicians, graduate nurses, and other trained health personnel. Countries have tried to alleviate this problem in several ways, including requiring all new medical graduates to 1st undertake periods of service in rural areas, the use of mobile clinic teams from small towns to visit outlying villages on a regular basis, and the use of air ambulances to transport seriously ill persons from isolated places to hospitals in cities. Perhaps the most significant strategy has been the use of trained community workers to provide primary health care for rural and low-income urban populations. Unfortunately, weak supervision of the community workers has often led to unsatisfactory performances. Surprisingly, a recent international congress claimed that many developing countries are training too many doctors, that some developing countries have, or will soon have, 1000s of unemployed physicians. However, comparison with developed countries shows that the "diagnosis" of a country's doctor supply situation may not depend on a universal standard, but on that job market's capacity for absorption of personnel. If specific public health goals are to be reached however, commercial criteria cannot be applied to the evaluation of a nation's health manpower; instead social need must be analyzed and strategies designed to meet them. Policy is shaped by the priority public authorities give to services. Of the 7 developing countries which reported a surplus of doctors, only Colombia and Mexico reported spending more on public health than on the military. In addition, in the other 5 countries, 40% or less of the overall public and private expenditures on health came from the government. When military expenditures absorb a high share of government funds, public support for health services is adversely affected, and individuals and families must depend on their own expenditures to obtain health services. Health services should be recognized as a basic human right, and, therefore, as an obligation of society. To meet this obligation necessary strategies are 1) increase public support, not only by increasing the health share of the general budget, but by other sources such as social security and community financing, 2) require 5-10 years of social service for all medical school graduates, 3) ensure that renumeration for doctors in public service is adequate to support a decent standard of living, 4) continue to train community health workers, but ensure physicians are qualified to supervise them, and, 5) health services and health manpower should be guided by principles of social justice, not by those of commercial market dynamics.     

Evidence-based public health: what does it offer developing countries?

The global burden of disease and illness is primarily situated in developing countries. As developing countries have limited resources, it is particularly important to invest in public health and health promotion strategies that are effective. Systematic reviews are central to evidence-based public health and health promotion practice and policy. This paper discusses issues surrounding the relevance of evidence-based public health and systematic reviews to the health of developing countries. It argues that there is a lack of systematic reviews relevant to the health priorities of developing countries; many interventions reviewed can not be implemented in resource-poor situations; and, a limited amount of primary research is conducted in developing countries. The paper further argues that improvements in public health are determined not only by effective health services and interventions, but through an approach that includes other sectors and influences broader structural and systematic barriers to health. Given the social complexity of human development, and the inter-sections amongst different development goals, there is no question that gains in developing country public health are unlikely to emerge from systematic reviews alone, but will require decisions about inter-sectoral collaboration and social policy initiatives. Nonetheless, evidence around intervention effectiveness has an important role to play in addressing health priorities in developing countries and resource-poor areas. The public health evidence base urgently needs strengthening, with dedicated effort towards increasing the relevance of primary evidence and systematic reviews.     

Surgical services for children in developing countries

There is growing evidence that childhood surgical conditions, especially injuries, are common in developing countries and that poor care results in significant numbers of deaths and cases of disability. Unfortunately, however, surgical care is not considered an essential component of most child health programmes. Strategies for improving paediatric surgical care should be evidence-based and cost-effective and should aim to benefit the largest possible number of children. The most likely way of achieving policy change is to demonstrate that childhood surgical conditions are a significant public health problem. For paediatric purposes, special attention should also be given to defining a cost-effective package of surgical services, improving surgical care at the community level, and strengthening surgical education. Surgical care should be an essential component of child health programmes in developing countries.     

Decreasing HIV / STD risk in relation to alcohol use: a research agenda

Alcohol consumption has been consistently associated with HIV-risk behaviors over time, with significantly higher rates of HIV infection generally found among samples of alcoholics and individuals who meet the criteria for alcohol dependence than in the general public. Research on HIV infection among alcoholics in treatment who use few other drugs has found 2.5-10% to be HIV-infected in cities where HIV is prevalent. Alcohol use and abuse may particularly compound the HIV-infection risk of those already in situations of high risk for HIV/STD infection in developing countries, such as women in households where alcohol abuse is common, prostitutes, runaway and homeless youth, and men in occupations which require them to travel long distances. HIV/STD prevention interventions should include alcohol harm reduction while alcohol treatment interventions should be bolstered with HIV/STD risk reduction measures. Harm reduction strategies and research opportunities are described.     

Effective screening programmes for cervical cancer in low- and middle-income developing countries.

Cervical cancer is an important public health problem among adult women in developing countries in South and Central America, sub-Saharan Africa, and south and south-east Asia. Frequently repeated cytology screening programmes--either organized or opportunistic--have led to a large decline in cervical cancer incidence and mortality in developed countries. In contrast, cervical cancer remains largely uncontrolled in high-risk developing countries because of ineffective or no screening. This article briefly reviews the experience from existing screening and research initiatives in developing countries. Substantial costs are involved in providing the infrastructure, manpower, consumables, follow-up and surveillance for both organized and opportunistic screening programmes for cervical cancer. Owing to their limited health care resources, developing countries cannot afford the models of frequently repeated screening of women over a wide age range that are used in developed countries. Many low-income developing countries, including most in sub-Saharan Africa, have neither the resources nor the capacity for their health services to organize and sustain any kind of screening programme. Middle-income developing countries, which currently provide inefficient screening, should reorganize their programmes in the light of experiences from other countries and lessons from their past failures. Middle-income countries intending to organize a new screening programme should start first in a limited geographical area, before considering any expansion. It is also more realistic and effective to target the screening on high-risk women once or twice in their lifetime using a highly sensitive test, with an emphasis on high coverage (>80%) of the targeted population. Efforts to organize an effective screening programme in these developing countries will have to find adequate financial resources, develop the infrastructure, train the needed manpower, and elaborate surveillance mechanisms for screening, investigating, treating, and following up the targeted women. The findings from the large body of research on various screening approaches carried out in developing countries and from the available managerial guidelines should be taken into account when reorganizing existing programmes and when considering new screening initiatives.     

What can developing economies learn from health system reforms of developed countries?

This paper outlines some general lessons developing nations can draw from the health system reform experiences of developed nations. Using the experiences of developed countries, developing countries should be better able to anticipate socio-economic changes and choose an optimal path for their health systems development to accompany those changes. Most developed countries have adopted rather common objectives and principles in their health systems because of market failure in health care; developing countries may start adopting those principles because they do not have market conditions in the first place. It is suggested that developing countries strengthen what is probably the most fundamental initial systemic asset they have: public finance. They should do so by attracting democratically, possibly through earmarked taxes, resources otherwise channelled through the private sector, competing with public finance for limited real resources. This effort can be promoted by giving consumers, mainly of high income groups and in urban areas, more say (through institutions performing the OMCC function) in the nature of care these groups have access to under auspices of public finance. Where feasible, private insurance as a major source of finance should be seen as a transitional phenomenon, giving way to the emergence of OMCC institutions which require similar financial and managerial market infrastructure. Private and competitive provision of care may be unrealistic in many developing areas because of both scarcity of real resources, mainly manpower, and health needs. The challenge of government is, as resources grow, to divest itself from the provision of care and stay involved in activities and facilities that are of 'public nature'--under specific circumstances--that foster private competitive provision. In general, the government should play an enabling role also by investing in health promotions and management skills for health systems.     

STD control: a key issue for reproductive health. An interview with Professor David Mabey

Treatable bacterial sexually transmitted diseases (STDs) are disappearing in many parts of North America and northern Europe, where single-dose antibiotic treatments are available; however, in many parts of Africa and other parts of the developing world, STDs are among the leading health problems. 20% of adults attending government clinics seek treatment for a STD. Many patients go to private clinics, traditional practitioners, pharmacists, and quacks. Government facilities treat 1 million cases of STD a year in Zimbabwe (population, 10 million). Professor David Mabey of the London School of Hygiene and Tropical Medicine states that STDs are more common in developing countries because: 1) young adults who are most at risk form a greater proportion of the population; 2) urban drift and the large migratory labor force create and use prostitutes; and 3) treatment, if available, is unaffordable. Since the effect of health education and condom promotion is, to date, unclear, and diagnostic tests for STDs are often unfeasible in Africa, Mabey suggests using syndromic treatment, in which patients are treated for all the common causes of their collection of symptoms. Although some believe an infection can be diagnosed based on clinical evidence alone, Mabey states highly experienced clinicians have been shown to be correct only 70% of the time in their diagnosis of genital ulcers. A Tanzanian study has shown that the introduction of a syndromic treatment program using nurses and medical assistants reduced the rate of increase of human immunodeficiency virus (HIV) by 42%, in comparison to nearby communities where no new treatment program was introduced. Mabey stresses the importance of screening for syphilis in pregnancy and notification of partners. Pressure should be brought on national governments and international donors to subsidize STD treatment. Attendance at STD clinics previously fell when fees were introduced.     

Health policies for controlling AIDS and STDs in developing countries

In developing countries the control and prevention of SexuallyTransmitted Diseases (STDs) and the ensuing complications hasreceived renewed attention since the emergence of the latestsexually transmitted disease, AIDS. Prevention via behaviouralchange has become more important than ever because of the currentlack of therapy or vaccination for HIV infections. Considerationsabout STD and AIDS control programmes are discussed, and theoption employed by the European Community to combine STD andAIDS control, is discussed. The strategies used for STD and AIDS control are health promotionand adequate management of patients with STDs. It is arguedthat health promotion should be targeted, and take into considerationpriority activities and groups; that condom promotion shouldbe an integral part of health promotion rather than being anautonomous activity; and that promotion of health seeking behaviouris an important part of the strategy. Adequate management of patients with STDs is effective for AIDSprevention because some STDs are associated with an increasedrisk of HIV transmission, but also because people coming spontaneouslyto a clinic can be considered a self-referred group, at an increasedrisk from HIV infection. The methodology used to implement thosestrategies is discussed, on three levels: the programming andmanagement level; the expertise unit; and implementation atperipheral levels. Experiences, obstacles and technical problemsencountered by the AIDS Task Force of the European Communityare enumerated.     

Prices of pharmaceuticals in poor countries are much lower than in wealthy countries

Keeping pharmaceuticals affordable in poor countries is important for public health. Economic models suggest that manufacturers should be able to charge substantially lower prices in those markets than in industrialized countries without drastically reducing their profits. We report the results of a study of thirty drugs in twenty-nine countries, showing that many prices are already substantially discounted in middle-income and developing countries, compared to prices in the United States and other industrialized countries, and do not exceed long-run marginal costs. We also argue that the so-called peak load pricing model offers an economic foundation for fair drug pricing in the case of developing countries, and is a better solution than other pricing models to the problem of how to reduce drug prices in these countries to the level of manufacturers' marginal costs.     

Aligning new interventions with developing country health systems: Target product profiles,presentation, and clinical trial design

Abstract

Many new interventions are being created to address health problems of the developing world. However, many developing countries have fragile health systems and find it difficult to accommodate change. Consequently, it is essential that new interventions are well aligned with health systems and their users. Establishing target product profiles (TPPs) is a critical, early step towards tailoring interventions to suit both of these constituencies. Specific analyses can help identify and establish relevant TPP criteria such as optimal formulation, presentation and packaging. Clinical trials for a new intervention should be designed to address both TPP-specific questions and anticipated use of the intervention in target countries. Examples are provided from research on malaria vaccines that are also applicable to other new public health interventions.     

Emergency preparedness and public health systems lessons for developing countries

Low- and middle-income countries, where emerging diseases often make their debut, are also likely to bear the harshest consequences of a potential influenza pandemic. Yet public health systems in developing countries are underfunded, understaffed, and in many cases struggling to deal with the existing burden of disease. As a result, developed countries are beginning to expand assistance for emergency preparedness to the developing world. Given developing countries' weak infrastructure and many competing public health priorities, it is not clear how to best direct these resources. Evidence from the U.S. and other developed countries suggests that some investments in bioterror and pandemic emergency preparedness, although initially implemented as vertical programs, have the potential to strengthen the general public health infrastructure. This experience may hold some lessons for how global funds for emergency preparedness could be invested in developing countries to support struggling public health systems in responding to current health priorities as well as potential future public health threats.     

Lymphoedema management: An international intersect between developed and developing countries. Similarities,differences and challenges

Abstract

Lymphoedema is a chronic swelling condition that contributes to disability, dysfunction and lost quality of life. Significant disparities exist worldwide regarding the availability of resources necessary to identify, treat and manage lymphoedema. This disparity transcends socio-economic status and is a common problem in both developed and developing countries. The overall impact of lymphoedema as a public health problem, however, is underestimated, principally due to the lack of epidemiologic data. These problems pose barriers to optimal identification and management of this disabling, lifelong condition.

In 1997, the World Health Organization (50.29) resolved that lymphatic filariasis should be eliminated as a public health problem. A component of this strategy focuses on disability management for those suffering from lymphatic filariasis-related morbidity. This initiative has enhanced lymphoedema awareness in developing countries. However, significant deficits persist in health care providers' knowledge, educational initiatives and basic disease identification and treatment.

In developed countries, lymphoedema continues to be an underrecognised condition and assumed to be only cancer-related. Health care resources allocated to treat and manage the disease are insufficient for basic and ongoing care, resulting in disease progression and disability. The International Lymphoedema Framework project, established in 2002, seeks to establish a consensus for best practices in the management of lymphoedema worldwide to reduce this disability burden.

A basic global construct for lymphoedema management is needed to decrease morbidity and promote optimal disease management across all cultural and socio-economic boundaries. Many countries are unaware of the importance of lymphoedema management and have not defined a national strategy with respect to this problem. The objective of this article is to define similarities and differences in strategies for lymphoedema management between developed and developing countries and advocate for a cohesive and concerted approach to disease management.     

Approaches to control sexually transmitted diseases in Haiti, 1992-95.

Despite major obstacles, activities to control sexually transmitted diseases (STDs) were initiated in Haiti in 1992 in collaboration with local nongovernmental organizations. The approaches included review of available local data, assessment of STD case management practices and constraints, and development of specific STD control activities at the primary health care level, such as systematic screening of all pregnant women for syphilis and improved comprehensive syndrome-based STD case management. The activities included conduct of local studies, presentation and dissemination of results to key audiences, training of health care providers, improvement of local capacities, and consensus-building on implementation of STD control approaches. STD awareness and case management improved considerably; for example, 69% of the clinicians interviewed reported correct STD treatments in the north-eastern primary health care centres in 1995, compared with < 10% in 1992. At the end of the project, national STD case management guidelines were developed by consensus between the various organizations and the Ministry of Health. Lessons learned included the importance of local data generation and of communication and collaboration with various institutions for consensus-building, the need for continued training, and field supervision to ensure behaviour change among STD care providers. A national STD control programme should be implemented as soon as possible in both the public and private sector. External funding will remain critical to control this important public health problem in Haiti.     

World Health Organization global oral health strategies for oral health promotion and disease prevention in the twenty-first century

Despite great improvements in oral health in the past decades, oral disease remains a major public health problem worldwide. The burden of oral disease is particularly high among the disadvantaged population groups in both developing and developed countries. The pattern of oral disease reflects distinct risk profiles across countries that are related to living conditions, lifestyles, environmental factors, and the availability and accessibility of oral health services. In several developing countries, people at large do not benefit from preventive oral health programmes. It is expected that the incidence of dental caries will increase in the near future in many of these countries as a result of growing consumption of sugars and inadequate exposure to fluorides. With the rising use of tobacco in developing countries, the risk of periodontal disease, tooth loss and oral cancer may therefore increase. Several oral diseases are linked to non-communicable chronic diseases or conditions that share common risk factors, such as diabetes, obesity and cancer. Similarly, general diseases often have oral manifestations (e.g. diabetes or HIV/AIDS). Worldwide strengthening of public health programmes through implementation of effective oral disease prevention measures and health promotion is urgently needed, and use of common risk factors approaches should integrate oral health within national health programmes. The challenges to oral health improvement are particularly high in developing countries. The World Health Organization Global Oral Health Programme formulates policies and actions for the improvement of oral health, strategies that are fully integrated with chronic disease prevention and general health promotion. At the 60th World Health Assembly in 2007, the WHO Member States agreed on an action plan for oral health and integrated disease prevention, thereby confirming the approach of the Oral Health Programme. The policy forms the basis for future development of oral health programmes.     

Some observations on the communicable diseases as public health problems

Notwithstanding the deficiencies in reporting, an attempt is made in the present study to provide some useful information on the importance of the communicable diseases in the world over the decade 1957-58 to 1967-68. In this period health authorities in the developing countries almost invariably reported communicable diseases as their main public health problems, whereas, in the developed countries, the only communicable diseases still considered as public health problems were tuberculosis, venereal diseases, and hepatitis. In the developing countries nearly half of the principal causes of death were communicable diseases, and in both the developing and developed countries respiratory infections ranked high on the list. Deaths from tuberculosis have come down markedly in the developed countries and to a lesser degree in the developing countries. Infectious diseases of childhood are no longer a problem in the developed countries but are still important in the developing countries. The communicable diseases of importance to the developing countries may be divided into two groups—those requiring long-term development for their solution (e.g., dysentery, typhoid fever, parasitic diseases, and respiratory infections) and those that would respond rapidly to control by such methods as immunization.     

Lymphoedema management: an international intersect between developed and developing countries. Similarities, differences and challenges

Lymphoedema is a chronic swelling condition that contributes to disability, dysfunction and lost quality of life. Significant disparities exist worldwide regarding the availability of resources necessary to identify, treat and manage lymphoedema. This disparity transcends socio-economic status and is a common problem in both developed and developing countries. The overall impact of lymphoedema as a public health problem, however, is underestimated, principally due to the lack of epidemiologic data. These problems pose barriers to optimal identification and management of this disabling, lifelong condition. In 1997, the World Health Organization (50.29) resolved that lymphatic filariasis should be eliminated as a public health problem. A component of this strategy focuses on disability management for those suffering from lymphatic filariasis-related morbidity. This initiative has enhanced lymphoedema awareness in developing countries. However, significant deficits persist in health care providers' knowledge, educational initiatives and basic disease identification and treatment. In developed countries, lymphoedema continues to be an underrecognised condition and assumed to be only cancer-related. Health care resources allocated to treat and manage the disease are insufficient for basic and ongoing care, resulting in disease progression and disability. The International Lymphoedema Framework project, established in 2002, seeks to establish a consensus for best practices in the management of lymphoedema worldwide to reduce this disability burden. A basic global construct for lymphoedema management is needed to decrease morbidity and promote optimal disease management across all cultural and socio-economic boundaries. Many countries are unaware of the importance of lymphoedema management and have not defined a national strategy with respect to this problem. The objective of this article is to define similarities and differences in strategies for lymphoedema management between developed and developing countries and advocate for a cohesive and concerted approach to disease management.     

Human rights and maternal-fetal HIV transmission prevention trials in Africa.

The human rights issues raised by the conduct of maternal-fetal human immunodeficiency virus transmission trials in Africa are not unique to either acquired immunodeficiency syndrome or Africa, but public discussion of these trials presents an opportunity for the United States and other wealthy nations to take the rights and welfare of impoverished populations seriously. The central issue at stake when developed countries perform research on subjects in developing countries is exploitation. The only way to prevent exploitation of a research population is to insist not only that informed consent be obtained but also that, should an intervention be proven beneficial, the intervention will be delivered to the impoverished population. Human rights are universal and cannot be compromised solely on the basis of beliefs or practices of any one country or group. The challenge to the developed countries is to implement programs to improve the health of the people in developing countries both by improving public health infrastructure and by delivering effective drugs and vaccines to the people.     

Public health requirements for rapid progress in global health

Abstract

Effective public health interventions can save hundreds of millions of lives in developing countries, as well as create broad social and economic benefits. Unfortunately, public health approaches and solutions applied in developed countries are often assumed to be inappropriate or unattainable in developing countries. This has sometimes forestalled effective interventions in parts of the world where they are most needed, despite conditions that now facilitate lasting solutions to both long-standing and emerging global public health problems. Core public health functions are similar regardless of a country's income level. Although some resource-intensive approaches from industrialised nations are inappropriate in less developed countries, many basic public health measures achieved decades ago in developed countries are urgently needed, highly appropriate, extremely cost-effective and eminently attainable in developing countries today. About half of the disease burden in low and middle-income countries is now from non-communicable diseases, but non-communicable disease epidemics that will otherwise increase rapidly in the developing world can be avoided or reversed. Progress of public health in developing countries is possible, but will require sufficient funding and human resources; improved physical plant and information systems; effective programme implementation and regulatory capacity; and, most importantly, political will at the highest levels of government.