肺癌病理特征及CT征象与EGFR的相关性分析

目的 探讨肺癌病理特征、CT征象与EGFR的相关性分析。方法 选取我院2019年6月～2020年6月期间住院患者96例,患者均在术前2周内接受肺薄层高分辨率CT检查,并于术后进行组织病理分析确诊为肺腺癌。所有病灶均进行EGFR基因检测,统计患者临床病理、组织病理以及CT检测表现,分析其与EGFR基因突变之间的相关性。结果 经分析存在EGFR基因突变患者46例,EGFR基因未突变50例,主要为19号外显子和21号外显子突变,无吸烟者EGFR基因突变发生率高于吸烟者(P <0.05);病灶直径3 cm以下EGFR基因突变发生率高于3 cm及以上(P <0.05),有胸腺侵犯者EGFR基因突变发生率高于无胸腺侵犯者(P <0.05);病灶含实性成分灶EGFR基因突变率高于纯磨玻璃病灶(P <0.05),有毛刺征灶EGFR基因突变率高于无毛刺征灶病灶(P <0.05),有胸膜凹陷征灶EGFR基因突变率高于无胸膜凹陷征灶(P <0.05); EGFR基因突变患者TTP、BV水平高于EGFR基因未突变者(P <0.05)。结论病灶直径在3 cm以下,存在胸...     

周围型肺癌CT征象和动态CT增强与肿瘤微血管密度相关性研究

目的探讨周围型肺癌CT征象和动态CT增强表现与肿瘤微血管密度的关系。方法30例经手术病理证实为周围型肺癌,术前行螺旋CT平扫和动态增强扫描,并观察其征象并测量感兴趣区CT值。病理标本采用免疫组织化学染色SP法表达抗体CD34,并进行病理学观察。结果肿瘤微血管密度与周围型肺癌组织学类型无关(P>0.05),与肿瘤的分化程度、CT影像上肿瘤直径、分叶征、棘状突起、血管集束征、胸膜凹陷征、纵隔淋巴结转移均有密切相关(P<0.05),而与毛刺征无关(P>0.05);肺腺癌的强化幅度略高于鳞癌,但没有统计学意义(P>0.05),肺腺癌与鳞癌的强化幅度均与其MVD值呈正相关(r=0.619,P<0.05;r=0.586,P<0.05)。结论周围型肺癌CT征象和动态CT增强有助于对肺癌的血管密度和预后的评价。     

肺腺癌临床及CT特征在预测EGFR基因突变中的价值

【摘要】目的：探讨肺腺癌临床及CT特征在预测表皮生长因子受体（EGFR）基因突变中的价值。方法：回顾性分析2012年2月-2018年10月我院经病理证实且行胸部CT扫描及EGFR基因检测的单发肺腺癌患者803例,根据基因检测结果分为EGFR基因突变阳性组（426例,53.05%）和阴性组（377例,46.95%）,比较两组临床及CT特征的差异。联合上述有统计学差异的临床及CT特征,建立Logistic回归模型,利用曲线下面积（AUC）判断该模型在预测EGFR基因突变中的效能。结果：①临床特征与EGFR基因突变的关系：两组患者年龄无统计学差异（62±10 vs 61±11）;女性(69.46% vs 39.03%)及不吸烟患者(66.37% vs 36.16%)EGFR基因突变率显著高于男性及吸烟患者,差异有统计学意义（P均＜0.001）,而Ⅰ~Ⅱ期与Ⅲ~Ⅳ期患者EGFR基因突变率无统计学差异（57.75% vs 50.83%）。②CT特征与EGFR基因突变的关系：在803例患者中,两组肿瘤大小［(3.36±1.83cm) vs （3.79±2.12cm)］差异有统计学意义(P＜0.05),且周围型分布(55.28% vs 45.74%)、存在毛刺征(60.45% vs 50.26%)、GGO(66.67% vs 50.87%)、充气支气管征(70.83% vs 49.93%)、血管集束征 (76.92% vs 45.39%)、胸膜牵拉征(64.95% vs 39.47%)及双肺多发转移 (62.86% vs 51.58%)的肺腺癌EGFR基因突变率较高,而存在含气腔隙(46.67% vs 53.33%)、坏死 (33.93% vs 56.15%)、胸腔积液(46.15% vs 55.26%)及胸内淋巴结肿大(48.67% vs 59.87%)的肺腺癌EGFR基因突变率较低,差异均有统计学意义（P均＜0.05）;在608例增强患者中,EGFR突变组(40.79±23.43)HU与非突变组(35.81±20.72)HU静脉期△CT值差异有统计学意义（P＜0.05）。③联合临床及CT特征的Logistic回归分析：女性、不吸烟、GGO、充气支气管征、血管集束征、胸膜牵拉征及双肺多发转移为EGFR基因突变的独立预测因子,ROC曲线分析示该回归模型预测EGFR基因突变的AUC为0.771,其敏感度和特异度分别为74.82%、68.53%。结论：肺腺癌的临床及CT特征对EGFR基因突变状态具有重要的预测价值。     

高分辨率CT磨玻璃影与周围型肺腺癌病理分级的相关性分析

目的 探讨高分辨率CT伴/不伴磨玻璃影(GGO)与肺腺癌病理分级的相关性.资料与方法 回顾性分析109例直径≤3 cm周围型肺腺癌患者的高分辨率CT和病理资料,分析高分辨率CT伴/不伴GGO与周围型肺腺癌病理分级的相关性.结果 高分化腺癌、高中分化腺癌、中分化和中低以及低分化腺癌中GGO的显示率之间存在显著差异(P<0.05).结论 伴发GGO的周围型肺腺癌分化程度较高.     

肺腺癌EGFR突变的临床特征及影像学特点

目的探讨原发性肺腺癌表皮生长因子受体(EGFR)基因突变状态与临床特征及影像学特点的相关性。方法用焦磷酸测序法检测164例经手术确诊的肺腺癌患者EGFR基因18、19、20和21外显子突变状态,结合临床特征、胸部CT影像学特点进行回顾性分析。结果总体EGFR基因突变率为53.0%,其中女性为64.7%,男性为40.5%,两者差异具有统计学意义(P=0.002);不吸烟者为61.7%,吸烟指数<400者为61.1%,吸烟指数≥400者为25.6%,差异具有统计学意义(P<0.001);肺腺癌中高分化组的突变率为81.3%,中分化组为55.8%,低分化组为47.6%,差异具有统计学意义(P=0.039);家族史、淋巴结转移、TNM分期与突变率无明显相关。CT像上,伴空泡或空洞性病变组突变率高(72.4%)(P=0.021);肿瘤直径、磨玻璃影、毛刺征、分叶征、血管集束征与突变率无明显相关。结论原发性肺腺癌中,EGFR基因在女性、非吸烟和吸烟指数<400者及病理上分化程度高的患者中突变率高;影像学提示肿瘤伴有空泡或空洞性病变组突变率高。     

18F－FDG PET/CT肿瘤内代谢异质性参数预测肺腺癌EGFR基因突变的价值

目的探讨18F-FDG PET/CT传统代谢参数、CT征象及肿瘤内代谢异质性参数预测肺腺癌表皮生长因子受体(EGFR)基因突变的价值。方法回顾性纳入2016年1月至2020年6月间在济宁医学院附属医院经病理证实的147例肺腺癌患者[男73例、女74例, 年龄(59.8±10.2)岁], 分析EGFR基因突变组与野生组患者在临床资料(吸烟史、肿瘤位置及临床分期)、CT征象(最大径、有无磨玻璃成分、分叶征、毛刺征、空泡征、空气支气管征、胸膜凹陷征及支气管截断征)、18F-FDG PET/CT传统代谢参数[SUVmax、SUVmean、肿瘤代谢体积(MTV)及病灶糖酵解总量(TLG)]及肿瘤内代谢异质性参数[CV、异质性指数(HI)]间的差异。采用两独立样本t检验、Mann-WhitneyU检验或χ2检验分析数据;通过多因素logistic回归分析EGFR基因突变的预测因素;采用ROC曲线分析探讨不同参数对EGFR基因突变的预测效能。结果 147例患者中, EGFR基因突变型87例, EGFR野生型60例。2组患者在性别(男/女)、吸烟史(有/无)、原发灶位置(周围/中心)、胸膜凹陷征(有/...     

周围型肺腺癌和鳞癌CT、病理表现与c-erbB-2蛋白异常表达的相关性研究

目的 :研究周围型肺腺癌和鳞癌的CT征象、病理分级与c erbB 2蛋白异常表达的关系。方法 :6 2例经手术、病理证实的周围型肺腺癌、鳞癌术前CT扫描 ,并运用免疫组织化学技术ABC法对手术切除标本进行c erbB 2蛋白检测。将检测结果与肿瘤的CT征象、病理分级进行比较 ,对统计数字进行卡方检验。结果 :①腺癌c erbB 2蛋白的过度表达高于鳞癌 (P <0 .0 5 )。②分化程度低、有肺门和 /或纵隔淋巴结转移者c erbB 2蛋白的过度表达率明显增高 (P <0 .0 5 ,P <0 0 1)。③具有棘突征、血管连接征的周围型肺腺癌和鳞癌c erbB 2蛋白过度表达率明显高于无以上征象者 ;而瘤体最大直径 >3cm的腺癌高于瘤体最大直径≤ 3cm的腺癌。④肿瘤强化明显者 ,其c erbB 2蛋白过度表达率增高 (P <0 .0 5 )。结论 :周围型肺癌c erbB 2蛋白的过度表达与组织学类型及CT表现有关 ,某些CT征象可用来判断肿瘤的生物学行为     

孤立性浸润性肺腺癌CT征象与EGFR基因突变的相关性分析

目的 探讨孤立性浸润性肺腺癌CT影像学表现与表皮生长因子受体(EGFR)基因突变的相关性。方法 选取75例经手术病理证实为浸润性肺腺癌的患者，且均进行了EGFR基因测定。将75例分为两组：基因突变型组(52例)和基因野生型组(23例)。分析每例患者的临床资料及CT影像学征象，包括性别、年龄、临床症状、抽烟史，结节大小、结节边界、结节的形态及内部特征，如空泡征、分叶征、空气支气管征、血管聚集征、胸膜牵拉、凹陷征、 G/T值(磨玻璃成分与GGN的最大径之比)等，观察比较上述征象在两组病例中是否具有差异性。计数资料采用卡方检验，定量资料采用两独立样本t检验，并将单因素分析中有价值的变量纳入多因素回归分析，再通过非条件二分类logistic回归分析预测孤立性浸润性肺腺癌发生基因突变的独立危险因素，纳入ROC曲线，将有统计学意义的危险因素作为预测指标，从而进一步对此类浸润性肺腺癌结节是否存在基因突变进行提示预测。结果 两组患者的年龄，吸烟史，临床症状、结节边界，分叶征，血管集束征，支气管充气征等差异无统计学意义(P>0.05)。将结节最大径，胸膜凹陷，G/T比单因素分析具有意义的变量，纳入...     

囊腔性肺腺癌的靶扫描CT特征与病理对照分析

目的探讨囊腔性肺腺癌的CT影像特征与肿瘤侵袭程度的关系。方法选取并分析经病理证实的28例囊腔性肺腺癌患者(微浸润腺癌7例,浸润性腺癌21例)的临床资料、病理类型和CT表现。根据病变CT密度不同分为Ⅰ、Ⅱ、Ⅲ、Ⅳ共四型。根据病灶浸润程度分微浸润与浸润性肺腺癌两组。对两组的CT征象采用T检验、卡方检验及Fisher确切概率法进行比较分析。结果 28例患者中,微浸润和浸润性肺腺癌两组病灶的大小、非囊腔成分的大小、非囊腔成分的密度、整体形态、毛刺、胸膜牵拉凹陷影像学征象差异有统计学意义(P 0.05)。囊腔性肺腺癌的病理亚型是腺泡为主型浸润性腺癌占39.29%,乳头为主型的浸润性腺癌占25.00%、贴壁型的微浸润性腺癌占25.00%。囊腔性微浸润腺癌在Ⅱ、Ⅲ型病变中更常见;浸润性腺癌在Ⅲ、Ⅳ型病灶更常见。结论囊腔性腺癌组织学亚型以腺泡为主型、乳头为主型及贴壁为主型常见。薄层CT靶扫描及多平面重建有助于早期囊腔性腺癌术前准确诊断。非囊腔成分及囊腔形态等影像学表现有助于这类病变的定性诊断以及浸润程度的预测。     

周围型肺癌CT征象与病理对照研究

目的探讨原发性周围型肺癌(以下简称肺癌)螺旋CT征象与组织病理学间的相关性。方法回顾性分析56例原发性周围型肺癌螺旋CT征象及组织病理类型,对各种CT征象及其组织病理类型进行统计对照。结果不同组织病理类型病灶大小无统计学差异(P>0.05)。鳞癌病灶的分叶征较其他组织学类型病灶多见(P<0.05),且多伴有肺炎;腺癌病灶的毛刺征、胸膜凹陷征较其他组织学类型病灶多见(P<0.05),且多伴有胸腔积液;肺泡癌病灶的空泡征较其他组织学类型病灶多见。不同病理类型病灶的平扫CT值,增强60s后CT值及CT差值均无统计学差异(P>0.05)。结论原发性周围型肺癌螺旋CT征象与组织病理类型之间存在着一定的内在关系,CT检查可为周围型肺癌初步定性。     

Ⅰ ~ⅢB期可切除周围型非小细胞肺癌患者临床及高分辨率CT影像特征与EGFR基因突变的相关性研究

目的 探讨Ⅰ ~ⅢB期可切除周围型非小细胞肺癌（NSCLC）患者的临床及高分辨率CT（HRCT）影像特征与表皮生长因子受体（EGFR）基因突变的相关性。 方法 回顾性分析2019年1月至2021年4月于惠州市中心人民医院行手术切除、术后行EGFR基因检测且临床分期为Ⅰ ~ⅢB期的周围型NSCLC患者164例,其中男性86例、女性78例,年龄（60.3±9.3）岁。根据EGFR基因检测结果将患者分为EGFR基因突变型组和野生型组,分析患者的临床及HRCT影像特征并进行统计学分析。计量资料的比较采用两独立样本t检验,计数资料的比较采用χ2检验或Fisher确切概率检验。筛选差异有统计学意义的指标纳入二元Logistic 回归分析。采用受试者工作特征（ROC）曲线的曲线下面积对构建的回归模型的诊断效能进行评估。 结果 164例NSCLC患者中,EGFR基因突变型组114例（69.51%）、野生型组50例（30.49%）。与EGFR野生型组比较,EGFR基因突变型组多见于女性、年龄<60岁、无吸烟史、病理类型为肺腺癌的患者,且2组间的差异均有统计学意义（χ2=21.91、−4.71、34.64,Fisher确切概率法,均P<0.05）。HRCT影像特征中,EGFR基因突变型组肿瘤最大径小于野生型组[（2.52±1.51） cm对（4.12±6.07） cm],且肿瘤多位于右肺,密度类型多为磨玻璃影和（或）混合磨玻璃影,多伴有分叶征、支气管充气征和胸膜牵拉征,与EGFR野生型组相比,差异均有统计学意义（t=2.14,χ2=10.13~19.05,均P<0.05）。2组患者在术后临床分期、癌胚抗原水平、肿瘤伴有毛刺征、坏死、血管集束征、空泡征、空洞征、胸腔淋巴结肿大中的差异均无统计学意义（χ2=0.40~2.33,Fisher确切概率法,均P>0.05）。Logistic回归分析结果显示,患者无吸烟史（OR=0.225,95%CI：0.066~0.764）和肿瘤伴有分叶征（OR=3.344,95%CI：1.079~10.360）是EGFR基因突变的独立预测因子（均P<0.05）,回归模型的ROC曲线的曲线下面积为0.858。 结论 Ⅰ ~ⅢB期可切除周围型NSCLC的临床及HRCT影像特征与EGFR基因突变具有一定的相关性,对指导临床评估患者情况有重要意义。     

Peripheral lung adenocarcinoma: correlation of thin-section CT findings with histologic prognostic factors and survival

PURPOSE: To evaluate the prognostic importance of thin-section computed tomographic (CT) findings of peripheral lung adenocarcinomas. MATERIALS AND METHODS: The subjects were 127 patients with adenocarcinomas smaller than 3 cm in largest diameter who underwent at least a lobectomy with hilar and mediastinal lymphadenectomy. The margin characteristics of nodules and the extent of ground-glass opacity (GGO) within the nodules at preoperative thin-section CT were analyzed retrospectively. Regional lymph node metastasis (LNM) and vessel invasion (VI) were histologically examined in surgical specimens. Survival curves were calculated according to the Kaplan-Meier method. RESULTS: The frequencies of LNM (4% [1 of 24]) and VI (13% [three of 24]) in adenocarcinomas with GGO components of more than 50% were significantly lower than those with GGO components of less than 10% (LNM, P <.05; VI, P <.01). The patients with GGO components of more than 50% showed a significantly better prognosis than those with GGO components less than 50% (P <.05). All 17 adenocarcinomas smaller than 2 cm with GGO components of more than 50% were free of LNM and VI, and all these patients are alive without recurrence. Coarse spiculation and thickening of bronchovascular bundles around the tumors were observed more frequently in tumors with LNM or VI than in those without LNM or VI (P <.01). CONCLUSION: Thin-section CT findings of peripheral lung adenocarcinomas correlate well with histologic prognostic factors.     

粟粒型肺结核和粟粒性肺转移瘤的螺旋CT鉴别特征

目的探讨粟粒型肺结核和粟粒性肺转移瘤的螺旋CT表现特征,以提高肺部弥漫性粟粒性病变的影像诊断水平。方法收集经临床证实的34例粟粒型肺结核和54例粟粒性肺转移瘤的螺旋CT资料,观察肺粟粒结节的分布、大小,肺密度,肺门、纵隔淋巴结增大及肺内并发病灶。结果CT图像上,34例粟粒型肺结核中,结节均匀分布28例(28/34,82%),大小一致23例(23/34,68%),密度均匀25例(25/34,74%)以及毛玻璃征26例(26/34,76%)。54例粟粒性肺转移瘤的粟粒结节分布、大小、密度大多不均匀,分别为49例(49/54,91%),39例(39/54,72%),41例(41/54,76%),毛玻璃征(GGO)8例(8/54,15%)。两者在结节分布、大小、密度均匀性和伴毛玻璃征方面均有统计学差异(P<0.05)。肺内其它改变:9例(9/34,26%)结核的肺门和纵隔淋巴结增大,而肺转移瘤有29例(29/54,54%);结核性胸腔积液15例(15/34,44%),肺转移瘤30例(30/54,56%);心包积液中,结核8例(8/34,24%),肺转移瘤20例(20/54,37%)。结论血行播散型肺结核和粟粒性肺转移瘤在结节分布、大小和密度等方面螺旋CT表现特征明显不同,这些特征与它们的血行播散途径和相应的病理解剖改变有密切关系。     

High-resolution CT analysis of small peripheral lung adenocarcinomas revealed on screening helical CT

OBJECTIVE: The purpose of this study was to determine the correlation between high-resolution CT morphologic features of small peripheral lung adenocarcinomas and tumor growth patterns. MATERIALS AND METHODS: We examined high-resolution CT morphologic features of 59 small, surgically resected peripheral lung adenocarcinomas (diameter, 6-20 mm) that were detected on screening for lung cancer using low-dose helical CT. Among these adenocarcinomas, 14 (24%) were visible and 45 (76%) were invisible on conventional chest radiography. The correlation between high-resolution CT morphologic features and tumor growth patterns was analyzed. RESULTS: Sixteen (94%) of 17 type A (Noguchi's classification) adenocarcinomas appeared as nodules of pure ground-glass attenuation (high-resolution CT type I). Ten (71%) of 14 type B tumors appeared as heterogeneous, low-attenuation nodules (type II). Seven (29%) of 24 type C tumors appeared as nodules with ground-glass attenuation in the periphery and a high-density central zone (type III), and 12 (50%) of 24 type C tumors appeared as homogeneous nodules with soft-tissue density (type IV). Among tumors with a replacement growth pattern, the size and CT values of type C tumors were larger than those of type A or type B tumors (p < 0.05), whereas the percentage of ground-glass attenuation and retained air space in type C tumors was smaller than those in type A or type B tumors (p < 0.01). All (100%) four type D tumors appeared to be homogeneous nodules with soft-tissue density (type IV). CONCLUSION: Small peripheral lung adenocarcinomas shown on CT exhibit four high-resolution CT patterns that corresponded to the histopathologic findings of different tumor growth patterns.     

Relationship between 18F-FDG PET/CT Semi-Quantitative Parameters and International Association for the Study of Lung Cancer,American Thoracic Society/European Respiratory Society Classification in Lung Adenocarcinomas

ObjectiveTo investigate the relationship between ¹⁸F-FDG PET/CT semi-quantitative parameters and the International Association for the Study of Lung Cancer, American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) histopathologic classification, including histological subtypes, proliferation activity, and somatic mutations.Materials and MethodsThis retrospective study included 419 patients (150 males, 269 females; median age, 59.0 years; age range, 23.0–84.0 years) who had undergone surgical removal of stage IA–IIIA lung adenocarcinoma and had preoperative PET/CT data of lung tumors. The maximum standardized uptake values (SUVmax), background-subtracted volume (BSV), and background-subtracted lesion activity (BSL) derived from PET/CT were measured. The IASLC/ATS/ERS subtypes, Ki67 score, and epidermal growth factor/anaplastic lymphoma kinase (EGFR/ALK) mutation status were evaluated. The PET/CT semi-quantitative parameters were compared between the tumor subtypes using the Mann–Whitney U test or the Kruskal–Wallis test. The optimum cutoff values of the PET/CT semi-quantitative parameters for distinguishing the IASLC/ATS/ERS subtypes were calculated using receiver operating characteristic curve analysis. The correlation between the PET/CT semi-quantitative parameters and pathological parameters was analyzed using Spearman’s correlation. Statistical significance was set at p < 0.05.ResultsSUVmax, BSV, and BSL values were significantly higher in invasive adenocarcinoma (IA) than in minimally IA (MIA), and the values were higher in MIA than in adenocarcinoma in situ (AIS) (all p < 0.05). Remarkably, an SUVmax of 0.90 and a BSL of 3.62 were shown to be the optimal cutoff values for differentiating MIA from AIS, manifesting as pure ground-glass nodules with 100% sensitivity and specificity. Metabolic-volumetric parameters (BSV and BSL) were better potential independent factors than metabolic parameters (SUVmax) in differentiating growth patterns. SUVmax and BSL, rather than BSV, were strongly or moderately correlated with Ki67 in most subtypes, except for the micropapillary and solid predominant groups. PET/CT parameters were not correlated with EGFR/ALK mutation status.ConclusionAs noninvasive surrogates, preoperative PET/CT semi-quantitative parameters could imply IASLC/ATS/ERS subtypes and Ki67 index and thus may contribute to improved management of precise surgery and postoperative adjuvant therapy.     

Detection of lung cancer on chest radiographs: analysis on the basis of size and extent of ground-glass opacity at thin-section CT

PURPOSE: To evaluate the detection of small peripheral lung tumors on chest radiographs on the basis of the size of the tumor and its extent of ground-glass opacity (GGO) at thin-section computed tomography (CT). MATERIALS AND METHODS: Chest radiographs of 75 patients with peripheral carcinomas 20 mm in diameter or smaller (26 localized bronchioloalveolar carcinomas [BACs], 49 other carcinomas) and 60 normal chest radiographs were retrospectively reviewed individually by 10 radiologists. The extent of GGO within the lesions at thin-section CT was reviewed retrospectively. The detection rates for localized BAC and other carcinomas on chest radiographs were calculated and were correlated with tumor size and extent of GGO. RESULTS: The mean sensitivity for detection of small peripheral carcinomas was 58.5% +/- 8.8 (standard error) for localized BAC and was 78.6% +/- 5.1 for other carcinomas (P =.024). Lesions that were smaller than 15 mm in diameter and had an extent of GGO of 70% or greater at thin-section CT were more difficult to detect than tumors that had larger diameters or less extensive GGO (chi(2) = 8.13, df = 1, P =.004). CONCLUSION: The detection of small peripheral carcinomas on chest radiographs is influenced by tumor size and extent of GGO as seen at thin-section CT.     

>5mm肺部纯磨玻璃结节的MDCT表现与病理对照研究

目的：探讨肺部不同侵袭程度纯磨玻璃结节(pGGN)的 CT 表现,提高肺部 pGGN 诊断准确率。方法回顾分析本院表现为肺部>5 mm 且经病理证实的 pGGN 患者的临床资料与 CT 图像,按照病理结果分为浸润前、微浸润及浸润性3组,对患者的临床资料及结节的 CT 表现进行分析,包括患者的性别、年龄,结节的大小、密度及 CT 征象(病灶形态、边缘、瘤肺界面、内部结构、邻近结构)。结果共获取来自102例患者的104个 pGGN,患者的性别、年龄,结节密度、病灶形态、支气管充气征在3组间无显著统计学差异(P =0.313;P =0.566;P =0.108;P =0.194),结节的大小、分叶、瘤肺界面、含气腔隙、胸膜凹陷及血管改变在3组间有显著统计学差异(P =0.000;P =0.040;P =0.005;P =0.028;P =0.023;P =0.003),浸润性组的肿瘤大小明显大于浸润前及微浸润组(P =0.000;P =0.008),结节大小的受试者工作特征曲线(ROC)中鉴别浸润性腺癌的最佳界值为1.05 cm,曲线下面积(AUC)为0.75,灵敏度和特异度分别为86.2%和46.7%。结论pGGN 的大小、分叶、瘤肺界面、含气腔隙、胸膜凹陷及血管改变对结节侵袭性程度判断可提供帮助。     

磨玻璃密度小肺癌CT表现与病理类型相关性研究

目的：探讨磨玻璃密度（GCO）小肺癌的CT表现与病理类型相关性。方法：搜集43例（45个）表现为纯磨玻璃密度（pGGO）或混合磨玻璃密度（mGGO）的周围型小肺癌,根据GGO占整个病灶比例的不同分三型,分别与病理对照。并有12个小肺癌术前行中长期动态观察。结果：I型（GGO成分占91％-100％）11个,病理均为细支气管肺泡癌（BAC）;II型（GGO成分占51％。90％）21个,BAC11,BAC伴高分化腺癌4个,高分化腺癌4个,中分化腺癌2个;Ⅲ型（GGO成分占≤50％）13个,BAC3个,中分化腺癌5个,低分化腺癌3个,低分化鳞癌2个;通过三型间比较发现GGO所占比例越高,小肺癌的病理分化越好,GGO成分占≥50％时,病理多数为BAC（22／32）;同时对部分小肺癌术前中长期动态观察及术后随访,发现肿瘤生长缓慢、预后良好。结论：局限性GGO不仅是周围型肺癌的重要征象之一,而且通过半定量分析GGO所占比例的多少,能一定程度上预测其病理类型、分化程度、倍增时间及预后。     

MSCT对肺部局灶性磨玻璃结节的诊断价值

目的：探讨不同病理类型的肺局灶性磨玻璃结节(GGO)的 MSCT 表现,以提高对其的认识。方法回顾性分析87例经手术病理证实或临床随访 GGO 病例的薄层 CT 资料,包括8例炎性病变,2例良性肿瘤,11例腺瘤样增生(AAH),19例原位腺癌(AIS),17例腺癌,30例跟踪复查病例,分析不同病理类型的 MSCT 特征。结果8例炎性病变中边缘模糊6例(75.0%),而机化性肺炎较大不规则,边缘清晰;30例浸润前病变(AAH、AIS)中病灶大小0.8~2.0 cm 的28例(93.3%),圆形或者类圆形26例(86.7%),边缘清晰25例(83.8%),血管贯穿征象25例(83.8%);17例腺癌中病灶大小>2.0 cm 的15例(88.2%),不规则形、分叶13例(76.5%),边缘毛糙8例(47.0%),胸膜凹陷征10例(58.8%);36例原位腺癌+腺癌中,实性成分9例(特异性95.2%),空泡征5例(特异性95.2%),血管贯穿伴增粗13例(特异性100%)。结论不同病理类型 GGO 的 MSCT 表现具有较高的特征性。