心律失常患者冠脉造影结果与冠心病相关性临床探讨

目的：分析冠心病患者冠脉造影结果，探讨心律失常与冠心病的相关性。方法：对213例有心律失常且疑似冠心病的患者进行冠脉造影检查，按照冠脉造影结果，将患者分为A、B两组，并对心律失常与冠状动脉病变的关系进行分析。结果：两组冠脉造影结果阳性共122例，占总数的57．28％，A组110例患者中，冠脉造影结果证实为冠心病的患者105例，阳性率为95．45％；B组103例患者中，冠脉造影诊断为冠心病者17例阳性率为16．50％，与A组相比差异有非常显著性（P〈0．05）。结论：临床医生在诊断心律失常患者病因时要慎重，以免误诊给患者带来负面影响。     

心律失常与冠心病相关性临床探究

目的 分析根据冠心病患者冠状动脉造影结果 ,探讨心律失常与冠心痛的相关性.方法 回顾性分析151例有心律失常的疑似冠心病患者进行冠状动脉造影检查,按照冠状动脉造影结果,将患者分为A、B2组.对其心律失常与冠脉病变的关系进行分析.结果 2组冠脉造影结果 阳性87例,占总数的57.62%.A组75例患者中,冠脉造影结果 证实为冠心病的患者144例,阳性率为95.36%,B组78例患者中,冠脉造影诊断为冠心病者17例阳性率为16.65%,与A组相比差异有非常显著意义(P＜0.05).结论 临床医生在诊断心律失常患者藕因时要慎重,以免误诊给患者带来负面影响.     

浅谈心律失常与冠心病相关性的临床分析

目的浅谈心律失常与冠心病相关性的临床分析。方法选取我院2014年7月至2015年7月50例有心律失常的疑似冠心病患者进行冠状动脉造影检查,按照冠状动脉造影结果,将患者分为A、B2组,对其心律失常与冠脉病变的关系进行分析。结果 2组冠脉造影结果阳性27例,占总数的57.62%,A组25例患者中,冠脉造影结果证实为冠心病的患者24例,阳性率为96.0%,B组25例患者中,冠脉造影诊断为冠心病者4例阳性率为16.0%,与A组相比差异有非常显著意义(P0.05)。结论临床医生在诊断心律失常患者病因时要慎重,以免误诊给患者带来负面影响。     

老年心律失常、心肌缺血冠状动脉造影分析

目的 :探讨老年心律失常、心肌缺血与冠脉病变的关系。方法 :老年冠脉造影 1 1 2例 ,分为心律失常组 5 1例 ,心肌缺血组6 1例 ,分析两组冠状动脉病变阳性率和危险因素之间的关系。结果 :心律失常组冠脉病变阳性率 2 7.4 % ,单支、多支病变各占1 3.7% ,心肌缺血组阳性率 73.7% ,单支、多支病变分别占 2 9.5 %和 4 4 .2 % ,心律失常组血糖、血脂水平和心绞痛症状明显低于心肌缺血组 (P <0 .0 5 )。结论 :老年心肌缺血诊断冠心病敏感性较高 ,心律失常诊断冠心病准确性低 ,确诊均应做冠脉造影     

临床疑似冠心病患者冠状动脉病变分析

目的分析临床疑似冠心病患者的冠脉造影结果,了解疑似病例中冠心病的阳性率及冠状动脉粥样硬化症和正常冠脉所占的比例。方法随机抽取88例冠心病疑似病例,对其冠状动脉造影结果进行回顾性分析。据有无典型心绞痛将88例患者分成A、B两组,比较两组患者冠心病的阳性率。并根据静息心电图有无缺血性ST-T改变将其分为C、D两组,比较两组患者冠心病的阳性率。结果 A、B两组患者冠脉造影冠心病阳性率比较差异有统计学意义(P<0.01)。C、D两组患者冠脉造影冠心病阳性率比较差异无统计学意义(P>0.05)。接受冠状动脉造影检查的患者未出现相关并发症。结论冠心病疑似患者应及早完善冠状动脉病变检查,建议行冠脉造影,便于明确诊断及早期进行冠心病一级或二级预防与治疗。排除冠心病后可减轻患者精神压力及经济负担。     

冠脉造影在冠心病诊治中的作用

目的：讨论冠脉造影在冠心病诊断及治疗中的作用。方法：对临床诊断冠心病的53例病人进行冠脉血管造影，男41例，女12例，年龄43－77岁，其中心律失常组7例，心衰组3例，心绞痛24例，心梗组19例。结果：心律失常6例，心衰3例。女性10例冠脉造影结果均无固定性狭窄，18例冠脉腔内成形术PTCA及支架植入后16例效果满意，结论：心律失常，心衰及女性诊断冠心病须慎重，冠脉造影为冠心病诊断最可靠的方法及选择有效治疗的必要检查方法。     

女性绝经前后运动平板试验假阳性率的对比研究

目的分析在胸痛患者中运动平板试验阳性对冠心病的诊断符合率。比较男性组、女性绝经前组、绝经后组运动平板假阳性率的差异。方法运动平板试验均采用Bruce方案,使用美国GE公司CardioSys-CE-0459运动平板机。对268例临床有胸痛症状的运动平板试验阳性患者行冠状动脉（冠脉）造影检查,冠脉狭窄≥50%诊断为冠心病。以冠脉造影结果为金标准,比较男性组（146例）、女性绝经期前组（39例）及绝经期后组（83例）运动平板试验的假阳性率。结果冠脉造影确诊冠心病176例（65.67%）,其中男性105例,女性71例;冠脉造影阴性者92例（34.33%）,男性41例,女性51例。女性绝经后组〔30.12%（25/83）〕与男性组〔28.08%（41/146）〕比较,运动平板的假阳性率差异无统计学意义（χ2=0.107,P=0.428）,绝经前组〔66.67%（26/39）〕与男性组（28.08%）及绝经后组（30.12%）比较差异均有统计学意义（χ2=19.83,P=0.000;χ2=14.57,P=0.000）。结论胸痛患者在冠脉造影前行运动平板试验筛查,阳性者再行冠脉造影可大大提高冠脉造影检查的阳性率。与绝经后组及男性组比较,绝经期前女性运动平板试验假阳性率较高,绝经后女性与男性无明显差异。     

96例心律失常患者冠脉造影结果分析

目的研究不明原因的心律失常与冠状动脉病变之间的关系。方法 96例不明原因心律失常患者根据冠脉造影结果分为阳性组和阴性组。比较两组之间临床资料特点及心律失常类型。结果冠脉造影阳性组较阴性组合并有更多的临床症状、心血管病危险因素及心电图缺血改变,两组比较差异有显著性（P〈0.05）,阳性组中病窦综合征、房室传导阻滞及室性心律失常三种心律失常比阴性组多见,两组比较差异有显著性（P〈0.05）。结论心律失常患者合并冠脉病变多与临床症状、心血管病危险因素及心电图缺血改变等临床特点有关,而心律失常类型中,病窦综合征、房室传导阻滞及室性心律失常三者冠脉病变阳性率高,应尽早行冠脉造影以确定下一步治疗方案。     

冠状动脉造影180例临床价值分析

目的分析冠状动脉造影的临床意义。方法选取拟诊断为冠心病的患者180例,根据疾病类型分三组,稳定型心绞痛组48例,不稳定型心绞痛组90例,心肌梗死组42例,均行冠状动脉造影术,分析动脉穿刺及造影结果。结果180例患者均造影成功,其中172例患者经桡动脉途径造影,7例经肱动脉,1例经股动脉穿刺造影,冠状动脉造影总阳性率为68.9%,其中心肌梗死组的阳性率显著高于稳定型和不稳定型心绞痛组(P<0.01),而不稳定型与稳定型心绞痛患者的阳性率比较无统计学差异(P>0.05)。稳定型心绞痛组单支病变与多支病变相差不大,不稳定型心绞痛组以单支病变为主,心梗则以多支病变为主。结论经桡动脉途径行冠脉介入诊疗是安全可靠的,并发症少,能减轻患者的痛苦,冠脉造影仍被视为冠心病诊断的"金标准"。     

老年心律失常与冠状动脉病变关系

目的 探讨不同原因的心律失常与冠状动脉病变的关系,方法 对４２例拟诊冠心病的老年心律失常患者行冠状动脉造影,２４例有典型心绞痛和心电图心肌缺血改变的心律改变的心律失常（Ａ组）,１８例为无典型心绞痛和心电图心肌缺血改变的心律失常（Ｂ组）结果Ａ组冠状动脉造影阳性率８７．５％,Ｂ组冠状动脉造影阳性率１６．６％,两组比较,Ｐ〈０．００１,而绝经期前后１２例中８例冠状动脉有病史,结论 绝经期心律失常患者有     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.