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自噬调控机制及与肿瘤关系研究进展 总被引：10，自引：0，他引：10
自噬是真核细胞通过降解自身的细胞质和细胞器实行“自我消化”的一系列生化过程，它是广泛存在于真核细胞中的生命现象。近年来的研究发现肿瘤的增殖、凋亡信号途径与自噬信号途径相互交错影响，自噬与肿瘤细胞的生存死亡有重要的关系，这预示着自噬将成为肿瘤研究中的一个新热点。 相似文献
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Autophagy is a lysosomal degradation pathway that can sequester cytosolic material, including organelles, nonspecifically in a process called nonselective macroautophagy, or target specific protein aggregates designated for destruction in a process called selective autophagy. Autophagy is one mechanism that enables tumor cells to survive stressors in the tumor microenvironment, as well as injuries caused by treatments such as chemotherapy and radiation therapy. The complexity of the role of autophagy in cancer is underscored by evidence that autophagy can allow premalignant cells to escape the genotoxic stress and inflammation that promote tumorigenesis, and that some tumor cells exhibit loss of autophagy capacity altogether through molecular mechanisms that have not yet been defined. Efforts to understand and modulate the autophagy pathway will be crucial to maximize the full therapeutic potential of cancer therapies that are currently hindered by tumor cell autophagy as a resistance mechanism. Cancer Res; 72(17); 4294-9. ?2012 AACR. 相似文献