润燥止痒胶囊联合左西替利嗪治疗慢性湿疹疗效观察

目的观察润燥止痒胶囊联合左西替利嗪并外用糠酸莫米松乳膏治疗慢性湿疹的疗效。方法将84例患者随机分成2组,各42例。对照组口服左西替利嗪10mg,并外用糠酸莫米松乳膏,均1次/d。治疗组在对照组的基础上加用润燥止痒胶囊4粒口服,3次/d,,两组疗程均为4周。结果治疗组有效率为83.33%,对照组为57.14%,差异有显著性(χ2=6.891,P<0.01)。结论润燥止痒胶囊联合左西替利嗪,并外用糠酸莫米松乳膏治疗慢性湿疹疗效确切。     

复方苦参止痒软膏联合糠酸莫米松乳膏治疗慢性湿疹的效果观察

目的探讨复方苦参止痒软膏与糠酸莫米松乳膏联合治疗对慢性湿疹患者临床症状与皮肤生理功能的改善效果。方法回顾性分析2017年10月-2018年10月期间在本院治疗的116例慢性湿疹患者的临床资料,依据上述入选者临床药物治疗方式的不同,分为对照组(糠酸莫米松乳膏,58例)与观察组(复方苦参止痒软膏+糠酸莫米松乳膏,58例),比较2组患者治疗前与治疗4周后,皮损面积评分、皮损瘙痒评分、靶皮损面积、皮肤生理功能[皮肤油脂、角质层含水量(WCSC)、经表皮水分流失(TEWL)]以及湿疹病情缓解情况。结果治疗4周后,观察组患者皮损面积评分与皮损瘙痒评分均低于对照组患者,靶皮损面积少于对照组患者,差异有统计学意义(P<0.05);治疗4周后,观察组患者皮肤油脂、WCSC值高于对照组患者,TEWL值低于对照组患者,差异有统计学意义(P<0.05);治疗4周后,观察组患者湿疹面积及严重程度指数(EASI)低于对照组患者,差异有统计学意义(P<0.05)。结论慢性湿疹患者经复方苦参止痒软膏与糠酸莫米松乳膏联合治疗,可有效缩减皮损面积,利于缓解皮损瘙痒症状,提高皮肤生理功能,促使患者病情尽快好转。     

除湿止痒洗剂联合地奈德乳膏治疗湿疹的疗效

目的 观察除湿止痒洗剂联合地奈德乳膏治疗湿疹的有效性与安全性.方法 采用随机、单盲、平行对照的方法对63例湿疹患者应用除湿止瘁洗剂联合地奈德乳膏外用治疗,同时设立对照组64例单独外用地奈德乳膏,治疗12d后评价疗效.结果 试验组总有效率为87.30％,与对照组70.31％相比,差异有统计学意义（P＜0.01）;试验组和对照组发生局部刺激反应分别为6.3％和7.8％,差别无统计学意义.结论 除湿止痒洗剂联合地奈德乳膏治疗湿疹较为有效、安全.     

玉泽皮肤屏障修护身体乳在慢性湿疹治疗过程中的作用

目的探讨皮肤屏障修护身体乳在慢性湿疹治疗过程中的作用。方法 124例患者随机分为试验组(84例)和对照组(40例)。2组均使用0.1%糠酸莫米松乳膏2次/d;试验组每天使用玉泽皮肤屏障修护身体乳2次,对照组不使用皮肤屏障修护身体乳。2周后均停用糠酸莫米松乳膏,并将试验组随机分为Ⅰ组和Ⅱ组,试验Ⅰ组43例继续使用皮肤屏障修护乳2周,而试验Ⅱ组41例停用皮肤屏障修护身体乳。在治疗2周和4周后进行湿疹面积和严重程度指数评分(EASI)以及临床疗效评估,治疗结束后第4周和第8周比较3组的复发率。结果治疗2周和4周后,试验Ⅰ、Ⅱ组湿疹面积及严重程度指数(EASI)评分明显低于对照组,有效率明显高于对照组,差异均有统计学意义(P0.05);试验Ⅰ、Ⅱ组间比较差异均无统计学意义(P0.05)。治疗结束后第4周和第8周,3组复发率比较,试验Ⅰ组复发率(6.98%,9.30%)明显低于试验Ⅱ组(24.39%,34.15%)和对照组(32.50%,47.50%),差异均有统计学意义(P0.05)。结论玉泽皮肤屏障修护身体乳联合糠酸莫米松乳膏可以提高慢性湿疹的临床疗效;皮肤屏障修护身体乳的连续使用4周可降低慢性湿疹的复发率,且安全性好。     

糠酸莫米松乳膏联合康复新液治疗阴囊湿疹的疗效观察

目的:观察糠酸莫米松乳膏联合康复新液治疗阴囊湿疹的疗效。方法:将70例阴囊湿疹患者随机分为糠酸莫米松乳膏联合康复新液治疗组及单用糠酸莫米松乳膏对照组各35例,7天为1疗程,疗程结束后统计疗效。治疗后2周统计复发情况。结果:治疗组及对照组总有效率分别为82.86%和68.57%,两组比较差异无统计学意义(2=1.05,P>0.05),2周后统计复发情况发现治疗组复发5例(17.24%),对照组复发18例(75.00%),两组比较差异有统计学意义(2=15.56,P<0.05)。结论:糠酸莫米松乳膏联合康复新液治疗阴囊湿疹远期效果较好,复发率低,值得临床推广。     

全蝎膏治疗慢性湿疹疗效观察

目的 观察全蝎膏治疗慢性湿疹疗效.方法 收集60例慢性湿疹患者随机平均分为2组,即治疗组和对照组,每组30例.治疗组:全蝎膏早1次外用,联合0.1％糠酸莫米松乳膏晚1次外用.对照组:0.1％糠酸莫米松乳膏晚1次外用.结果 治疗第1周,治疗组有效率为86.7％,对照组有效率为63.3％,2组差异有统计学意义(P＜0.05...     

糠酸莫米松乳膏治疗湿疹皮炎类皮肤病多中心临床研究

目的 评价0.1%糠酸莫米松乳膏治疗湿疹皮炎类皮肤病疗效和安全性。方法 本研究采用随机、双盲、平行对照的临床研究方法。受试者分别接受国产糠酸莫米松乳膏和艾洛松治疗。患者每日局部涂药1次,连续用药4周。在治疗始及治疗后第1～4周对各观察指标进行评估记录。结果 本研究共入选受试者284例(试验组和对照组各142例)中湿疹143例,神经性皮炎141例。治疗后1～4周,两组患者各项症状/体征指标计分及总计分均有明显下降。试验组和对照组组间比较差异无统计学意义。治疗结束时,湿疹患者试验组基愈率和总有效率分别为78.87%、97.18%;对照组基愈率和总有效率分别为84.51%、92.96%。神经性皮炎患者试验组基愈率和有效率分别为75.71%、100%;对照组基愈率和总有效率分别为80.28%、94.37%。两组患者总体评价试验组基愈率77.30%,有效率98.58%。对照组基愈率82.39%,有效率93.64%。两组间疗效比较差异无统计学意义。研究中两组均未发生不良反应。试验组发生接触性皮炎1例。结论 0.1%糠酸莫米松乳膏治疗湿疹、神经性皮炎使用方便,安全性好。     

CO2点阵激光联合糠酸莫米松乳膏治疗慢性湿疹随机对照研究

 目的:探讨CO2点阵激光联合糠酸莫米松乳膏治疗慢性湿疹的临床疗效。方法：将60例慢性湿疹患者随机分为治疗组及对照组,各30例,治疗组给予CO2点阵激光治疗,间隔2周治疗一次,共3次,同时外用糠酸莫米松乳膏每日1次,连续6周;对照组仅外用糠酸莫米松乳膏每日1次,连用6周。比较两组治疗疗效。结果：治疗组和对照组治疗后总积分分别为(0.73±0.89)分和（3.83±1.55）分,两者差异有统计学意义（t=9.45,P<0.01）。治疗组和对照组有效率分别为93.33%和36.67%,差异有统计学意义（  X²=21.17,P<0.01）。治疗组治愈患者中有3例（11.54%)3个月后复发,对照组无治愈病例。治疗组在激光治疗时均出现轻微可耐受的疼痛,均未影响治疗;对照组无不良反应。结论：CO2点阵激光联合糠酸莫米松乳膏治疗慢性湿疹安全有效。     

透明质酸修护生物膜辅助治疗干燥性湿疹的多中心对照研究

目的 探讨透明质酸修护生物膜辅助治疗干燥性湿疹的结果.方法 5家医院82例干燥性湿疹分为试验组和对照组.试验组外搽糠酸莫米松乳膏和透明质酸修护生物膜,对照组仅外搽糠酸莫米松乳膏,每天2次,14 d后停用糠酸莫米松乳膏,试验组继续外搽透明质酸修护生物膜,分别于首诊、治疗后7、14、28、42、56 d随访.比较两组皮损SCORAD评分、总改善率、受试者自评、复发率、经皮水分丢失(TEWL)值及角质层含水量.结果 ①试验组比对照组皮损SCORAD评分显著改善,42 d时SCORAD评分,试验组(4.42±2.64)、对照组(6.03±4.02),56 d时试验组(3.49±2.78),对照组(6.06±4.28),两组比较,差异有统计学意义(P均＜ 0.05)；②试验组改善率高于对照组,停用糠酸莫米松乳膏后,试验观察56 d时,差异有统计学意义(均P＜ 0.05)；③停用糠酸莫米松乳膏后,观察28、42、56 d时试验组均无复发,对照组复发率分别为11.4％、11.4％、20％,两组比较,差异有统计学意义(均P＜0.05)；④试验组TEWL下降低于对照组,56 d时,试验组TEWL(10.35±2.02)与对照组TEWL(17.28±4.06)比较,差异有统计学意义(P＜0.05)；试验组角质层含水量高于对照组,42 d时试验组角质层含水量(29.10±5.39)、对照组(23.12±4.76),56 d时,试验组角质层含水量(31.79±4.09)、对照组(22.87±4.85),两组比较,差异有统计学意义(均P＜0.05).试验组未发生不良反应.结论 透明质酸修护生物膜可以辅助治疗干燥性湿疹,降低复发率,促进皮肤屏障功能的恢复,安全性高.     

氟芬那酸丁酯软膏联合糠酸莫米松乳膏治疗慢性湿疹疗效观察

目的观察氟芬那酸丁酯软膏联合糠酸莫米松乳膏治疗慢性湿疹的疗效。方法氟芬那酸丁酯软膏与糠酸莫米松乳膏联用为治疗组,前者连用4周,后者连用2周,单用糠酸莫米松乳膏为对照组,连用4周。根据评分标准进行疗效比较。结果两组有效率无显著性差异(χ2=0.0071,P>0.05)。结论氟芬那酸丁酯软膏的应用可减少治疗慢性湿疹时对糖皮质激素的依赖。     

0.05%卤米松乳膏治疗皮炎湿疹类皮肤病多中心、随机对照、开放研究

目的观察0.05%卤米松乳膏治疗皮炎湿疹类皮肤病的疗效和安全性,并与0.1%糠酸莫米松乳膏进行比较。方法采用多中心、随机、开放试验,对92例亚急性湿疹和神经性皮炎患者外用0.05%卤米松乳膏或0.1%糠酸莫米松乳膏进行治疗,观察记录患者的临床表现和治疗反应。结果0.05%卤米松乳膏临床疗效优于0.1%糠酸莫米松乳膏,有效率分别为91.3%和71.7%(P<0.05),治疗指数分别为86.79%和74.37%(P<0.05)。结论0.05%卤米松乳膏治疗亚急性湿疹和神经性皮炎效果好,不良反应轻。     

0.05%地奈德乳膏治疗三种常见皮肤病的疗效观察

目的评价0.05%地奈德乳膏治疗特应性皮炎、脂溢性皮炎及寻常性银屑病的临床疗效及安全性。方法采用开放式研究。分别应用0.05%地奈德、1%丁酸氢化可的松及0.1%糠酸莫米松乳膏治疗特应性皮炎、脂溢性皮炎及寻常性银屑病。对患者治疗前后红斑、糜烂、浸润、丘疹、渗出/结痂、瘙痒及皮损面积的总积分进行评价。结果治疗2周后,地奈德组的临床疗效明显优于丁酸氢化可的松组,差异有显著性(P<0.05),两组均未见明显不良反应;地奈德组的疗效与糠酸莫米松组相当(P>0.05),但后者有1例出现瘙痒,1例出现红斑加重。结论应用0.05%地奈德乳膏治疗特应性皮炎、脂溢性皮炎及寻常性银屑病疗效可靠,临床使用安全。     

复方甘草酸苷联合维A酸乳膏和糠酸莫米松乳膏治疗寻常性银屑病疗效观察

目的探讨复方甘草酸苷联合维A酸乳膏和糠酸莫米松乳膏治疗寻常性银屑病的临床疗效。方法165例患者随机分为两组,试验组81例,口服复方甘草酸苷联合维A酸乳膏和糠酸莫米松乳膏外用;对照组84例,仅外用维A酸乳膏和糠酸莫米松乳膏,疗程均为4周,随访3个月。结果试验组有效率为76．54％,明显高于对照组（48．81％）（P〈0．01）;试验组不良反应发生率为13．58％,比对照组低（20．24％）（P〈0．05）;试验组治愈患者复发率为24．00％,低于对照组（36．00％）（P〈O．05）。结论复方甘草酸苷联合维A酸乳膏和糠酸莫米松乳膏外用治疗寻常性银屑病疗效优于仅给予维A酸乳膏和糠酸莫米松乳膏外用,且患者不良反应和复发率明显降低。     

Tacrolimus 0.1% vs mometasone furoate topical treatment in allergic contact hand eczema: a prospective randomized clinical study

Tacrolimus is a macrolide immunosuppressant that has been demonstrated to inhibit T-lymphocyte activation without the side-effects of corticosteroids. The safety profile of tacrolimus makes it a promising therapeutic option for dermatitis. To evaluate and compare the therapeutic ability of tacrolimus 0.1% ointment and mometasone furoate 0.1% ointment in patients with chronic hand eczema and positive patch tests. Thirty adults with chronic hand eczema and positive patch test reaction to relevant contact allergens were treated with tacrolimus 0.1% ointment or mometasone furoate 0.1% ointment in a single-centre, randomized comparative study. The scores of the evaluated clinical parameters (erythema, infiltration, vesiculation, desquamation, presence of cracks and itching) did not differ between Groups A and B at any of the four time points (p>0.05).On the other hand, in both groups, a significant difference was detected in all parameters between baseline and Day 90 recorded values. Tacrolimus is a promising alternative therapy for contact dermatitis patients as it is effective from the first month of treatment, well tolerated and offers similar therapeutic results to topical corticosteroid therapy.     

Unique immunobullous disease in a child with a predominantly IgA response to three desmosomal proteins

Chronic hand eczema can be incapacitating, and there is little knowledge of the efficacy and safety of long-term treatment with topical corticosteroids. We compared the efficacy and safety of two different schedules for the treatment of chronic hand eczema with a potent topical corticosteroid, mometasone furoate. In a prospective, open, randomized trial, 120 patients with chronic hand eczema were treated daily with mometasone furoate fatty cream until the dermatitis cleared or for a maximum of 9 weeks. Those who cleared were randomized to treatment for up to 36 weeks with mometasone furoate on Sunday, Tuesday and Thursday (group A), mometasone furoate on Saturday and Sunday (group B) or no further corticosteroid treatment (group C). In the event of relapse, patients were permitted daily treatment with mometasone furoate for 3 weeks on two separate occasions. For 50 of 106 randomized patients, daily treatment for 3 weeks controlled their dermatitis; 29 needed 6 weeks and 27 needed 9 weeks of treatment. During the maintenance phase, 29 of 35 (83%) in group A, 25 of 37 (68%) in group B and nine of 34 (26%) in group C had no recurrences (P = 0.001, chi2-test). Side-effects were minimal. It is concluded that long-term, intermittent treatment of chronic hand eczema with mometasone furoate fatty cream is effective and safe.     

丁酸氢化可的松软膏治疗儿童异位性皮炎临床疗效观察

目的:评价丁酸氢化可的松软膏治疗儿童异位性皮炎的临床疗效。方法:采用自身对照,治疗侧用丁酸氢化可的松软膏;对照侧用0.1％糠酸莫米松霜。结果:共观察了46例异位性皮炎患儿,丁酸氢化可的松软膏的有效率为84.78%,0.1％糠酸莫米松霜的有效率为91.30％,二者差异无显著性(x2=0.93,P>0.05)。二组均未观察到明显的不良反应。结论:丁酸氢化可的松软膏是一种高效、安全的外用皮质类固醇激素制剂,可以应用于治疗儿童异位性皮炎。     

Mometasone furoate 0.1% and salicylic acid 5% vs. mometasone furoate 0.1% as sequential local therapy in psoriasis vulgaris

Background and objective  Treatment in psoriasis vulgaris continues to unmet needs in terms of efficacy, quality of life and costs. Patients with moderate forms of psoriasis are using topical corticosteroids as first-line therapy and patients with severe forms also use this therapy. Optimization of this treatment is made by the use of combination drugs or by the sequential or rotational therapies. A multicentric clinical study was performed to measure the efficiency of mometasone furoate 0.1% and salicylic acid 5% and mometasone furoate 0.1% as sequential local therapy in psoriasis.
Methods  This was a randomized, multicentre trial with two patient groups receiving active treatment. The study group ( N  = 184) received mometasone furoate 0.1% and salicylic acid 5% for the first 7 days of treatment, and in the following 14 days, the patients used mometasone furoate 0.1%. The second group ( N  = 176) was treated with mometasone furoate 0.1% for 21 consecutive days. Psoriasis Area Severity Index (PASI) score and Dermatology Life Quality Index (DLQI) were calculated.
Results  After the first week of treatment in the study group, the reduction of PASI score was 44%, statistically significant greater than the reduction of PASI score in the second group (37%). Quality of life estimated by DLQI indicated significant lower values in the first (study) group.
Conclusion  The sequential treatment mometasone furoate 0.1% and salicylic acid 5% followed by mometasone furoate 0.1% proves to be efficient, safe and an excellent option for the following sequence: in-patient and out-patient.

Conflict of Interest

None declared.     

青鹏软膏治疗慢性湿疹的疗效观察

目的 探讨外用青鹏软膏治疗慢性湿疹的有效性和安全性。方法 选择慢性湿疹患者95例,以随机数字表法将患者分为外用青鹏软膏组（33例）、0.2%氢化可的松乳膏组（32例）、10%尿素软膏组（30例）,3组均每日用药2次,疗程为4周,定期复诊,记录患者的治疗效果及不良反应。结果 青鹏软膏、氢化可的松乳膏、尿素软膏组治疗慢性湿疹总有效率分别为78.8%、84.4%、46.7%。青鹏软膏组与氢化可的松乳膏组疗效比较,差异无统计学意义（P > 0.05）;青鹏软膏组与尿素软膏组疗效比较,差异有统计学意义（P < 0.05）。青鹏软膏组2例出现局部皮肤发红、伴灼热感,氢化可的松乳膏组1例出现局部刺痛感,患者均可耐受,不影响治疗,无严重不良事件发生。结论 外用青鹏软膏治疗慢性湿疹安全有效。     

冷冻联合糠酸莫米松乳膏治疗面部稳定期白癜风疗效研究

目的探讨冷冻联合糠酸莫米松乳膏治疗面部稳定期白癜风的临床疗效及安全性。方法选取我院2016年8月~2019年3月期间皮肤科门诊诊断为白癜风的120例患者作为研究对象,随机分为两组各60例,其中对照组每晚用糠酸莫米松软膏涂搽局部皮损,1次/d,连续用药2周后停药1周,间歇用药,研究组在前者的治疗之前先应用液氮冷冻治疗皮损,间隔3天治疗1次,1周2次,两组疗程均为3个月,对比两组的复色时间及临床疗效。结果研究组总有效率为91.67%明显高于对照组(78.33%),差异有统计学意义(χ~2=4.183,P <0.05)。结论冷冻联合糠酸莫米松乳膏治疗面部稳定期白癜风疗效满意,安全性好,患者易耐受,值得临床推广应用。