中药外治法改善类风湿性关节炎患者关节功能的作用

目的:观察自拟中药汽疗薰蒸方治疗类风湿性关节炎的临床疗效,以及对患者免疫功能的调节。方法:共选入150例类风湿性关节炎患者,为2002-01/2005-01哈尔滨医科大学附属第一医院中西医结合科住院患者,随机分为治疗组100例和对照组50例。治疗组患者进行中药汽疗(方药组成:制川乌15kg,制草乌15kg,乌梢蛇1条,全蝎5g,蜈蚣2条,威灵仙20g,海风藤20g,伸筋草20g,透骨草20g,羌活15g,独活15g,防已15g,地龙15g,鸡血藤25g),1次/d,30min/次;对照组患者给予常规抗类风湿性关节炎药物治疗:青霉素静脉滴注,1次/d,同时口服西乐葆片,200mg/次,2次/d,治疗1个疗程(10d)后,观察两组患者的临床症状中关节肿胀、疼痛、压痛、晨僵和功能障碍的改善情况,并对主要指标血沉、类风湿因子、C反应蛋白、免疫球蛋白(IgA,IgG)等进行评估和监测。结果:参选的150人全部完成数据采集,无脱落者。①两组疗效比较:治疗组总有效率优于对照组(94%,66%,P<0.01)。②治疗后症状体征各运动功能评分:治疗组关节疼痛度、关节压痛度、活动度、肿胀度、晨僵时间均低于对照组[(0.92±0.56),(1.19±0.60)分;(3.13±1.89),(4.21±2.42)分;(0.54±0.43),(0.98±1.44)分;(4.46±2.80),(8.05±3.28)分;(18.52±10.23),(24.78±11.21)min,P<0.01]。③治疗后实验室指标变化:治疗组血沉、类风湿因子、C反应蛋白、IgA、IgG均低于对照组[(25.15±14.28),(46.23±14.59)mm/h;(29.43±15.98),(46.44±19.67)滴度;(14.57±8.90),(19.43±10.12)mg/L;(2.16±1.40),(2.98±1.95)g/L;(14.82±4.37),(18.94±5.51)g/L,P<0.01]。结论:中药汽疗治疗类风湿性关节炎疗效显著,可明显改善人体的免疫功能,且方法简便易行。     

类风湿性关节炎的中药外治法

中草药外治疗法是自然医学的重要手段之一。通过熏洗、泡、贴敷、脐疗等多种途径，既可直接作用于体表病灶，就近驱邪；又可通过穴位经络、皮肤黏膜的吸收有效调整内脏功能，就外治法在类风湿性关节炎中的应用做以探讨。     

类风湿性关节炎的中药外治法

中草药外治疗法是自然医学的重要手段之一。通过熏洗、泡、贴敷、脐疗等多种途径,既可直接作用于体表病灶,就近驱邪;又可通过穴位经络、皮肤黏膜的吸收有效调整内脏功能,就外治法在类风湿性关节炎中的应用做以探讨。     

毫米波作用肾上腺区改善类风湿性关节炎患者关节功能及疼痛程度

类风湿性关节炎的药物治疗效果不稳定，采用毫米波作用于肾上腺区治疗类风湿性关节炎53例，并与常规药物治疗组(53例)对比，结果发现治疗1个疗程后，前组的关节功能恢复程度及疼痛改善情况均优于后组。说明毫米波作用于肾上腺区确能改善类风湿性关节炎患的关节功能及疼痛程度。     

雷公藤缓释片对类风湿性关节炎患者关节功能的影响

为观察雷公藤缓释片对类风湿性关节炎患者关节功能的影响。38例类风湿性关节炎患者接受了雷公藤缓释片治疗，治疗前后分别用关节功能评估(signal of function impairment，SOFI)量表测评关节功能。服药1个月后，痊愈3例，显效16例，有效14例，无效5例，总有效率87％(33／38)，治疗后平均SOFI评分明显优于治疗前，提示雷公藤缓释片对类风湿性关节炎有较好疗效，同时还能显著改善关节功能。     

复方丹参改善骨性关节炎患者关节功能58例

采用复方丹参注射液结合中医辨证治疗骨性关节炎(ostenarthritis，OA)患58例，结果发现复方丹参治疗骨性关节炎疗效确切，在改善某些症状方面效果显。     

健脾通络法对类风湿关节炎调节性T细胞及肺功能的影响

目的观察新风胶囊对类风湿关节炎(RA)患者肺功能、肺部、关节、全身症状及调节性T细胞(Treg)的影响,并探讨其作用机制。方法将66例RA患者随机分为两组:新风胶囊(XFC)组(研究组)和风湿骨痛(FSGT)组(对照组),观察两组治疗前后各指标的变化。结果与对照组比较,研究组患者肺功能、肺部、关节及全身症状明显改善,同时,CD4+CD25+CD127-Treg升高(P<0.01或P<0.05)。结论复方新风胶囊通过上调CD4+CD25+CD127-Treg,从整体水平调节免疫平衡,改善RA患者肺功能和肺部症状。     

中药湿热敷联合红外线理疗治疗类风湿性关节炎的疗效观察

[目的]观察中药湿热敷联合红外线理疗治疗类风湿性关节炎的临床疗效.[方法]将180例类风湿性关节炎病人按就诊先后顺序分为对照组与治疗组,每组90例.对照组给予常规治疗及护理,治疗组在常规治疗护理基础上加用中药湿热敷联合红外线理疗,比较两组病人治疗前后关节症状、体征改善情况.[结果]治疗组临床治疗总有效率（91.11％）高于对照组（66.67％）.[结论]中药湿热敷联合红外线理疗治疗类风湿性关节炎并加强护理干预,可显著减轻病人疼痛,提高疗效.     

Structum therapy of patients with rheumatoid arthritis

AIM: To study efficacy of the chondroprotector chondroitin sulphate (structum, Pier Fabr Medicament Production, France) in patients with rheumatoid arthritis (RA) and secondary osteoarthrosis of the knee joints. MATERIAL AND METHODS: 15 women with a long history of RA (mean duration 11.9 years) entered an open non-randomized trial of structum. The patients had a severe progressive highly active RA with a definite x-ray stage of the disease. 13 patients had a positive rheumatoid factor (1:80 to 1:1280) and involved knee joints which had been affected for 1 to 10 years (mean 5.3 years). The second x-ray stage was in 8 patients, the third stage of knee joints arthrosis was in 7 ones. A marked pain syndrome in the knee joints upon movement (mean 64.7 mm by VAS) was observed in all the examinees and at rest (mean 28 mm by VAS) in 13 of 15 patients. Structum was given according to a standard scheme: 500 mg 3 times a day for 3 weeks than 500 mg 2 times a day for up to 6 months. Basic drugs for RA were the same for all the observation period. RESULTS: Structum noticeably improved knee joint function (mean Leken's index 12.8, 11.3 and 9.4 scores before the treatment, on treatment month 3 and 6. Movement pain syndrome VAS reduced from 64.7 mm at the start to 51 mm 3 months and 37.5 mm 6 months later, rest VAS--from 19 to 10.3 and 6.4 mm, respectively. The demand in intraarticular glucocorticoids went down from 52 injections at the start of therapy to 6 after 6 months. Side effects for 6 months were absent. Overall efficacy was good (73.3% and 80%) as judged by the doctors and patients, respectively. After 6 months of therapy control x-rays found no progression of destructive changes in the knee joints (by MRI--in 4 patients). CONCLUSION: Structum has a marked positive therapeutic effect in patients with severe and long-term course of RA with associated pronounced secondary joint arthrosis.     

The effect of water exercise therapy given to patients with rheumatoid arthritis

It is well known that patients suffering from rheumatoid arthritis have a reduced muscular function. The positive effect of physical training on rheumatic patients has been shown. In this study the effect of exercise therapy performed in a heated swimming pool has been evaluated for eight patients in a non-acute stage of rheumatoid arthritis. The median pre-treatment maximal isometric and isokinetic quadriceps strength was 88 Nm (44-146) and 99 Nm (62-149) respectively, which was 61% and 70% of that found in a control group of healthy persons. After 2 months exercise therapy the median maximal isometric and isokinetic quadriceps strength increased by 38% and 16% compared to the pre-treatment value (p less than 0.02 and p less than 0.05). All patients, except one who developed cardiac arrhythmia during the second test, accomplished a submaximal bicycle test (a.m. Astrand). An increase in the aerobic capacity was observed in all patients after the training period.     

类风湿性关节炎患者关节滑膜组织蛋白质组学

背景:已有研究表明滑膜炎持久反复发作,最终导致关节内软骨和骨的破坏,国内关于类风湿性关节炎滑膜组织的蛋白质组学研究报道较少。目的:通过比较类风湿性关节炎患者和无关节滑膜损伤患者滑膜组织蛋白质表达的差异,探讨类风湿性关节炎可能的发病机制,寻找类风湿性关节炎致病相关蛋白。方法:选取6例无关节滑膜损伤患者及6例活动期类风湿性关节炎患者行关节镜手术得到的滑膜组织,提取总蛋白质后进行双向凝胶电泳,考马斯亮蓝染色,PDQUEST软件分析,对差异蛋白质点采用基质辅助激光解析电离质谱(MALDI-TOF-MS)技术进行鉴定,并用Mascot软件在SwissProt和NCBInr数据库中进行同源比较和分析鉴定。结果与结论:建立了类风湿性关节炎组及对照组滑膜组织双向凝胶电泳图谱,获得130个差异在2倍以上的蛋白质点数,选取其中分辨清楚的39个点进行鉴定,初步鉴定出29个蛋白质,其中21个蛋白质点在类风湿性关节炎组中表达上调,8个表达下调,其功能涉及功能代谢、细胞信号传导、抗氧化、分子伴侣等。结果表明类风湿关节炎滑膜病变是一个多种蛋白质参与的复杂过程,这些表达差异蛋白质可能是类风湿性关节炎发病的内在因素。     

Physical therapy management of patients with juvenile rheumatoid arthritis

Juvenile rheumatoid arthritis (JRA) is the most common pediatric rheumatic disease and is a leading cause of childhood disability. Physical therapists play a crucial role in the treatment of these children and serve as essential members of the interdisciplinary treatment team. An understanding of the etiology and background of this disease is critical to appropriate evaluation, goal setting, and treatment planning. This review article will provide an overview of the epidemiology, immune system pathophysiology, and clinical characteristics of JRA. Physical therapy principles of care, evaluation procedures, and treatment techniques will be covered in depth. In addition, common orthopedic manifestations and their management, including surgical approaches, will be discussed.     

蜂针疗法治疗类风湿性关节炎的疗效观察

目的观察蜂针疗法对类风湿关节炎患者的临床疗效。方法将75例符合类风湿性关节炎诊断标准的患者随机分为蜂针组、药物组和蜂针+药物组。比较3组的疗效。结果治疗结束后以及治疗结束后3个月随访,3组患者关节疼痛度、关节肿胀度、关节压痛度、晨僵时间(h)、关节疼痛数变化、HAQ、ESR、RF、CRP均有显著差异(P0.05)。结论蜂针疗法能有效缓解类风湿关节炎患者的临床症状。