Effects of Xuezhikang Capsule(血脂康胶囊) on Blood Lipids,Platelet Activation and Coagulation-Fibrinolysis Activity in Patients with Hyperlipidemia

Objective: To investigate the effects of Xuezhikang capsule (XZK, 血脂康胶囊) on blood lipids level, platelet activation and coagulation-fibrinolysis activity in patients with hyerlipidemia. Methods:Seventy-six patients of hyperlipidemia were randomly divided into two groups, the XZK group (n = 38) treated with XZK 600mg, taken two times per day and the Simvastatin (SIM) group (n = 38) treated with SIM 20mg per day, with the treatment lasting 8 weeks for both groups. Levels of fasting serum lipids, including total cholesterol (TC), triglyceride (TG), high and low density l ipoprotein cholesterol (HDL-C and LDL-C),plasma GMP-140, fibrinogen (FIB), tissue plasminogen activator (t-PA), plasminogen activator inhibitor type-1 (PAl-) and prothrombin time (PT) were all measured before and 8 weeks after treatment. Data were compared before and after treatment and also compared with those measured in 20 healthy subjects of control. Results: Before treantment the levels of TC, TG and LDL-C were obviously higher and HDL-C level was significantly lower in hyperlipidemia patients than those in healthy subjects ( P＜0.05 or P＜0.01). After 4-8 weeks of XZK treatment, the levels of TC, TG, LDL-C and FIB and activities of GMP-140 and PAl-1 were obviously lowered (P＜0.05 or P＜0.01). But in the SIM group there was no obvious change in FIB (P＞0.05), instead it showed obvious increase of HDL-C and decrease of TC and LDL-C after treatment ( P＜0.05 or P＜0.01). Conclusion: XZK could inhibit platelet activity and improve coagulation-fibrinolysis function, besides its lipids lowering effect.     

Effect of Tongmai Jiangzhi Oral Liquid (通脉降脂口服液) on Serum P-selectin,von Willebrand Factors and D-Dimer in Patients with Atherosclerosis

Objective: To explore the role of cytokines on the pathogenesis of atherosclerosis, and the effect of Tongmai Jiangzhi oral liquid (通脉降脂口服液,TMJZ) on cytokines through observing serum P-se-lectins (Ps), von Willebrand (vWF), and D-dimer (D-D) in atherosclerosis (AS) patients. Methods: Sixty-three AS patients were randomly divided into the treated group (n = 33, treated with TMJZ, 10 ml each time, three times a day) and the control group (n = 30, treated with Lovastatin, 10 mg, once daily). The levels of serum lipids (enzymatic methods), Ps, vWF, and D-D were measured before and after 8 weeks of treatment. Results: Serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), apo-protein B-100 (apoB-100) were significantly decreased (P<0.05 or P< 0.01) and high-density lipoprotein cholesterol (HDL-C) was significantly raised (P<0.05) after TMJZ treatment. Serum Ps, vWF, and D-D also declined (P<0.05) after treatment. There was no significant difference between the tre     

Effect of detoxification, removing stasis and nourishing yin method on corticosteroid-induced hyperlipidemia in patients with systemic lupus rythematosus

Objective:To observe the effect of TCM therapy for detoxification,removing stasis,and nourishing yin on corticosteroid-induced hyperlipemia in patients with systemic lupus erythematosus (SLE),and to investigate its mechanism.Methods:One hundred and seventy patients with SLE were randomly assigned to the integrative medicine group (IM group) and the Western medicine group (WM group),85 in each group.Also,30 healthy subjects selected from blood donors were enrolled in the normal control (NC) group.All patients were treated mainly with prednisone, while those in the IM group were given TCM therapy additionally,and the therapeutic course for both groups was 6 successive months.The changes of serum total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-G),low density lipoprotein cholesterol (LDL-C),very low density lipoprotein cholesterol (VLDL-C) and apolipoprotein A (ApoA) were determined and observed.A 2-year follow-up study was carried out in 16 patients of the WM group and 25 of the IM group.Results:Before treatment,no significant difference had been found among the three groups in the serum levels of lipids and lipoproteins.After the 6-month treatment,as compared with the WM group,the IM group showed lower levels of TC,TG,LDL-C,and VLDL-C (P<0.05 or P<0.01) and higher levels of HDL-C and ApoA (P<0.05).A similar effect was also shown by the follow-up study in the IM group (P<0.05 or P<0.01). Conclusion:TCM therapy for detoxification,removing stasis,and nourishing yin can effectively regulate the levels of serum lipids and lipoproteins in preventing and treating SLE patients with corticosteroid- induced hyperlipemia.     

Serum Lipoprotein (a) Concentration in Patients with Nephrotic Syndrome and Its Clinical Implication

Serum lipoprotein(a) [Lp(a)] concentration was determined in 42 patients with primary nephrotic syndrome (NS) and the relationships between Lp (a) and plasma lipids, apolipoproteins, serum creatinine (Scr), albumin, urinary proteins (Upro) were also analyzed. The results showed that: (1) serum Lp(a) concentrations in the patients with NS were higher than those in healthy controls;(2) the levels of serum Lp (a) were correlated positively with total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), apolipoprotein B (Apo-B), Upros (Upro). It is concluded that the NS patients had the potential risk of suffering from coronary artery disease, glomerular sclerosis and thrombosis. The remission of NS may partially decrease the serum Lp(a) levels. Further studies are needed to explore the prevention and treatment of dislipedemia in patients with NS.     

Effect of Yiqi Huoxue（益气活血） Herbs on Vascular Endothelial Cells and Platelets in Patients with Chronic Cor Pulmonale

Objective: To observe the clinical effect of Yiqi Huoxue (益气活血, YQHX) herbs in treating the patients with chronic cor pulmonale and to explore its mechanism by determining the relationship of oxidation/antioxidation system and how such herbs change on the function of endothelial cells and platelets. Methods: Fifty-eight patients were divided into two groups: conventional therapy group (control group, 28 paventional management. The treated group were treated with YQHX 150 ml, twice a day, plus the conventional treatment, and the clinical efficacy was recorded. The lipid peroxidation (LPO), superoxide dismutase (SOD), α-granule membrane protein (GMP140), partial pressure of arterial oxygen (PaO2), partial pressure of carbon dioxide in artery (PaCO2) and circulating endothelial cells (CEC) were measured respectively before and after treatment, and the relationship between various parameters were analyzed. The results were compared with those of 10 healthy subjects got at the same period. Results: (1) The effective rate and PaO2 of the treated group was higher than that of the control group and there were no difference in PaCO2 between the two groups. (2) The levels of LPO, GMP140, CEC in all the patients before therapy were significantly higher than those of the healthy group, and there were marked decrease in the levels of those after treatment (all P＜0. 01). On the contrary, the levels of SOD in all the patients before therapy were markedly lower than those in the healthy subjects and increased after treatment, P＜0.01. (3) The increase of SOD in the treated group was significantly more obvious than that of the control group. In the treated group, the decrease of LPO, GMP140, CEC were markedly more obvious than those in the control group (all P＜0.01).(4) The number of CEC, as well as GMP140, was negatively correlated to PaO2 (P＜0.01) and SOD (P＜0.01), which was positively correlated to LPO (P＜0.01). There was a positive correlation between CEC and GMP140 (P＜0.05). Conclusion: YQHX herbs in treating chronic cor pulmonale proved to be effective by balancing the oxidation and antioxidation, protecting the pulmonary endothelial cells and activated platelets and helpful in treating respiratory failure.     

Clinical Assessment on Treatment of Hyperlipidemia with Pushen Capsule (蒲参胶囊)

Objective: To explore the therapeutic effect of Pushen capsule (PSC, 蒲参胶囊) in treating primary hyperlipidemia. Methods: Two hundred and forty patients with primary hyperlipidemia were randomly divided into two groups, the 120 patients in the treated group treated with PSC (4 capsules, tid) and the 120 patients in the control group treated with Zhibituo tablet (脂必妥, 3 tablets, tid), and they were administered at the same time with Zhibituo placebo. The therapeutic course for both groups was 4 weeks. The therapeutic effect and the effects on blood lipids and viscosity were observed. Results: The effective rate in thetreated group was 76. 3%, which was significantly higher than that in the control group (48. 7% , P< 0. 01). PSC showed a significant lowering effect on TC, TG and LDL-C and raising effect on HDL-C, and the effect in lowering TG was significantly better than that of Zhibituo (P<0.01). PSC also showed a certain effect in decreasing whole blood viscosity of both high-sheared and low-shear     

Clinical study of trilogy detoxicating therapy combined with routine Western medicine on patients with chronic renal failure

Objective： To investigate the mechanism of Trilogy Detoxicating Therapy in treating patients with chronic renal failure （CRF）. Methods： A total of 142 patients were assigned to the Trilogy Detoxicating Therapy group （the treatment group, 82 patients） and the Western medicine treatment group （the control group, 60 patients）. All of the patients were treated with NovoNorm 1 mg and metformin hydrochloride tablets 0.15 g thrice per day for lowering the blood glucose, as well as Perindopril 4 mg twice daily for lowering blood pressure, recombinant human erythropoietin 2 000 U and a hypodermic injection thrice a week for rectifying anemia, 30 days as one course of treatment, and all patients were treated for two courses. Patients in the treatment group were treated with the Trilogy Detoxicating Therapy [dispersing the five-zang （脏） organs, expelling toxins through colonic dialysis and skin dialysis fumigation] in addition to the aforementioned drugs. Parameters observed and recorded in the study included renal function [serum creatinine （SCr）, blood urea nitrogen （BUN）], blood lipids [triglyceride （TG）, total cholesterol （TC）, low-density lipoprotein C （LDL-C）, high-density lipoprotein C （HDL-C）], plasma total protein （TP）, hemoglobin （Hb）, serum interleukin-6 （IL-6）, and tumor necrosis factor-α （TNF-α） before and after the treatment. Results： After two courses of treatment, the levels of SCr, BUN, TG, TC, LDL-C, serum IL-6 and TNF-α decreased significantly, meanwhile HDL-C increased in the treatment group （P〈0.05 or P〈0.01）. In contrast, no obvious changes of the above mentioned items occurred in the control group. In both groups, the levels of TP and Hb were significantly elevated （P〈0.05 or P〈0.01）, but the changes were more obvious in the treatment group （P〈0.01）. Conclusion： Trilogy Detoxicating Therapy played a therapeutic role on patients with CRF possibly through lowering the levels of blood lipids, serum IL-6 and TNF- α     

Clinical Effect and Action Mechanism of Weicao Capsule(威草胶囊)In Treating Gout

Obiective:To study the therapeutic effect of Weicao Capsule(威草胶囊,WCC)on gout.Methods:Two hundred gout patients were assigned to two groups.The treated group was groups were given the respective treatments orally 3 times a day,2 capsules each time with 2 weeks as one course and all patients received 2 successive courses of treatment.Changes of blood β2-microglobulin(β2-M),hemoglobin(Hb),24 h urinary protein(24 h UP),pH value of urine and blood uric acid(BUA)as well as kidney function were observed.Results:After treatment,IeveI of β2-M got lowered significantly,Hb and 24 h UP,blood urea nitrogen,serum creatinine and the clearance rate of creatinine,as well as blood lipids all improved obviously in the treated group(all P＜0.01),while these parameters remained unchanged in the control group (P＞0.05).The pH value of urine was improved in both groups showing an insignificant difference between them(P＞0.05).BUA was decreased in both groups with a decrease to a larger extent in the treated group(P＜0.01).The total effective rate was 87% in the treated group,which was superior to that in the control group(62%,P＜0.05).Conclusion:WCC has a favorable therapeutic effect on gout and its mechanism of action for improving renal function and reducing urinary protein could be related with the lowering of blood β2-M,BUA and lipids.     

Protective Effects of Xiongshao Capsule (芎芍胶囊) on Anti-inflammatory Function of High-Density Lipoprotein in An Atherosclerosis Rabbit Model

Objective: To observe the effects of Xiongshao Capsule(芎芍胶囊, XSC) on anti-inflammatory properties of high-density lipoprotein(HDL), myeloperoxidase(MPO) and paraoxonase 1(PON1) in serum of atherosclerosis(AS) rabbit model and explore the anti-inflammatory protective effects of XSC on HDL. Methods: Sixty rabbits were randomized into the control, the model, XSC low-, medium-and high-dose(Rhizoma Chuanxiong + Radix Paeoniae rubra : 0.6+0.3, 1.2+0.6, 2.4+1.2 g·kg-1·day-1, respectively), and simvastatin(1 g·kg-1·day-1) groups. The model rabbits were fed with high-fat diet and respective drugs for 15 weeks. The blood and thoracic aortas samples were collected at the end of 15 weeks. The levels of serum MPO and PON1 as well as total cholesterol(TC) and free cholesterol(FC) in aorta wall cells were tested by enzyme linked immunosorbent assay. Results: TC and FC in the model group were significantly higher than those in the control group(P0.01). Compared with the model group, TC and FC in the XSC groups were significantly lower(P0.05 or P0.01), so was simvastatin group(P0.01). There was no significant difference in PON1 level between groups(P0.05), even between model and control groups(P0.05). The serum MPO level in the model group was significantly higher than that in the control group(P0.05), which was significantly lower in XSC groups as well as simvastatin group(P0.05 or P0.01), and no difference was found between XSC groups and simvastatin group(P0.05). Conclusions: XSC can reduce the serum MPO level in AS rabbits to protect the anti-inflammatory function of HDL, maintaining the normal lipid transport function. TC and FC levels in aorta cells decline, and this process initiated by XSC plays an anti-AS role.     

The Effect of Foods Containing Refined Konjac Meal on Human Lipid Metabolism

A total of 110 elderly people with hyperlipidemia were randomly assigned to one of two groups. The experimental group consumed an ordinary diet plus foods containing refined Konjac meal, and the control group consumed only the ordinary diet. The experiment was carried out for 45 days. The results indicate that for the experimental group blood levels of triglyeendes (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) were significantly lowered (P < 0.01) at the end of the trial, whereas high-density lipoprotein cholesterol (HDL-C) and apoprotein (Al) levels were significantly elevated (P<0.01). In contrast, for the control group, the changes in the above parameters were insignificant. The differences in TC. TG, LDL-C, and HDL-C levels between the two groups were statistically significant. The effects of refined Konjac meal on lipid levels in the blood were somewhat different between patients with hyperlipidemia and subjects with risk critical values only. For the former, TG and TC were decreased by 83.8±133.5 mg/dl, and 42.4±23.4 mg/dl. respectively: but for the latter, they are decreased only by -1.1±23.1 mg/dl and 8.3± 18.2 mg/dl, respectively; the difference mentioned above is Statistically significant (P<0.01). 1990 Academic Press. Inc.     

Effects of Xuezhikang capsule on blood lipids, platelet activation and coagulation-fibrinolysis activity in patients with hyperlipidemia

Objective: To investigate the effects of Xuezhikang capsule (XZK) on blood lipids level, platelet activation and coagulation-fibrinolysis activity in patients with hyerlipidemia.Methods: Seventy-six patients of hyperlipidemia were randomly divided into two groups, the XZK group (n = 38) treated with XZK 600mg, taken two times per day and the Simvastatin (SIM) group (n = 38) treated with SIM 20mg per day, with the treatment lasting 8 weeks for both groups. Levels of fasting serum lipids, including total cholesterol (TC), triglyceride (TG), high and low density lipoprotein cholesterol (HDL-C and LDL-C), plasma GMP-140, fibrinogen (FIB), tissue plasminogen activator (t-PA), plasminogen activator inhibitor type-1 (PAI-) and prothrombin time (PT) were all measured before and 8 weeks after treatment. Data were compared before and after treatment and also compared with those measured in 20 healthy subjects of control.Results: Before treantment the levels of TC, TG and LDL-C were obviously higher and HDL-C level was significantly lower in hyperlipidemia patients than those in healthy subjects (P<0.05 orP<0.01). After 4–8 weeks of XZK treatment, the levels of TC, TG, LDL-C and FIB and activities of GMP-140 and PAI-1 were obviously lowered (P<0.05 orP<0.01). But in the SIM group there was no obvious change in FIB (P>0.05), instead it showed obvious increase of HDL-C and decrease of TC and LDL-C after treatment (P<0.05 orP<0.01).Conclusion: XZK could inhibit platelet activity and improve coagulation-fibrinolysis function, besides its lipids lowering effect.     

Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis

Objective: To explore the role of cytokines on the pathogenesis of atherosclerosis, and the effect of Tongmai Jiangzhi oral liquid (TMJZ) on cytokines through observing serum P-selectins (Ps), von Willebrand (vWF), and D-dimer (D-D) in atherosclerosis (AS) patients.Methods: Sixty-three AS patients were randomly divided into the treated group (n = 33, treated with TMJZ, 10 ml each time, three times a day) and the control group (n = 30, treated with Lovastatin, 10 mg, once daily). The levels of serum lipids (enzymatic methods), Ps, vWF, and D-D were measured before and after 8 weeks of treatment.Results: Serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), apo-protein B-100 (apoB-100) were significantly decreased (P<0.05 orP<0.01) and high-density lipoprotein cholesterol (HDL-C) was significantly raised (P<0.05) after TMJZ treatment. Serum Ps, vWF, and D-D also declined (P<0.05) after treatment. There was no significant difference between the treated and the control groups in these parameters except serum HDL-C level.Conclusion: TMJZ has good therapeutic effect in regulating serum lipids, improving endothelial cell function, inhibiting activation of platelets, and preventing the disturbance of blood coagulation/fibrinolysis function in patients with AS. Project supported by Science and Technology Committee of Zhengzhou Railway Department (No. 03W30)     

个体化减重干预对肥胖合并T2DM患者体质量指数、糖脂代谢的影响

目的 探讨个体化减重干预对肥胖合并2型糖尿病（T2DM）患者体质量指数（BMI）、糖脂代谢的影响。方法 选取2019年1月—2019年12月连云港第一人民医院收治的90例肥胖合并T2DM患者,随机分为对照组和观察组,每组45例。均予以常规降糖药物治疗,对照组同时予以基础饮食、运动干预,观察组同时予以个体化减重干预,均持续3个月。比较两组利拉鲁肽用药剂量;检测并比较治疗前、治疗1个月后、治疗2个月后、治疗3个月后的BMI、糖脂代谢指标;比较两组治疗期间不良事件发生率。结果 两组利拉鲁肽用药剂量比较,差异无统计学意义（P >0.05）;观察组与对照组治疗前、治疗1个月后、治疗2个月后、治疗3个月后的BMI、空腹血糖（FBG）、餐后2小时血糖（2 hPG）、糖化血红蛋白（HbA1c）、胰岛素抵抗指数（HOMA-IR）、胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）比较,采用重复测量设计的方差分析,结果 ①不同时间点的BMI、FBG、2 hPG、HbA1c、HOMA-IR、TC、TG、LDL-C、HDL-C有差异（P <0.05）;②两组的BMI、FBG、2 hPG、HbA1c、HOMA-IR、TC、TG、LDL-C、HDL-C有差异（P <0.05）,观察组BMI、FBG、2 hPG、HbA1c、HOMA-IR、TC、TG、LDL-C均低于对照组,观察组HDL-C高于对照组;③两组的BMI、FBG、2 hPG、HbA1c、HOMA-IR、TC、TG、LDL-C、HDL-C变化趋势有差异（P <0.05）。两组治疗期间不良事件发生率比较,差异无统计学意义（P >0.05）。结论 个体化减重干预可降低肥胖合并T2DM患者的BMI,调节糖脂代谢,且不良事件不会显著增多,相较于常规干预作用更大。     

Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats

Objective: To observe the effect of Gengnianchun Recipe (GNC) on bone mineral density (BMD), bone biomechanical parameters and serum lipid level in the bilaterally ovariectomized (OVX) rats and to explore the prophylactic and therapeutic action of GNC on ovariectomy induced osteoporosis and hyperlipidemia.Methods: OVX SD rats, 10 –12 months old, were divided into different groups and fed with GNC 2 g/d, GNC 1 g/d and Nilestriol 0. 125 mg/week, respectively for 4 months to observe the change of BMD and bone biomechanical parameters of the lumbar vertebrae, and the serum levels of total cholesterol (TC), triglyceride(TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), and to compare the effect of the two drugs on the morphology of the uterus.Results: There was marked reduction in BMD and biomechanical parameters in lumbar vertebrae (P< 0.01) and increase of serum TC and LDL-C levels (P< 0. 01) in rats after OVX. GNC or Nilestriol significantly improved the decreased BMD and biomechanical parameters of the lumbar vertebrae (P< 0.05 orP< 0.01), and reduced the serum TC and LDL-C levels (P< 0.01). In the Nilestriol group, the wet weight of uterus got increased obviously (P< 0.01), the number of uterine glands increased, uterine columnar epithelium thickened, and the mitotic figures in the epithelial stroma and myointimal cells augmented. But no such effect in wet weight and morphology of uterus was found in the GNC group.Conclusion: GNC could increase the BMD and biomechanical parameters of the lumbar vertebrae, reduce the serum TC and LDL-C levels, yet produce no adverse reaction in stimulating proliferation and hypertrophy of uterus. Supported by Shanghai Funds for Gynecology of Integrated Traditional and Western Medicine (No. 96-III-001), the National Natural Science Foundation of China (No. 30472259), Shanghai Scientific Funds for Integrated Traditional and Western Medicine (No. 2004L020A).     

系统性硬化病血脂和同型半胱氨酸水平异常的临床研究

目的 探讨系统性硬化病(SSc)患者血脂和同型半胱氨酸(Hcy)的变化及其与病情活动度的关系。 方法 对65例SSc患者和65名年龄、性别配对的健康体检者(对照组)的甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、极低密度脂蛋白胆固醇(VLDL-C)、血清同型半胱氨酸(Hcy)、C反应蛋白(CRP)等的水平进行检测分析,并根据血脂情况把SSc患者分为高脂血症组和非高脂血症组,利用统计软件检验各组之间的差异,并进行相关分析。 结果 与对照组相比,SSc患者TG(P=0.000)、VLDL-C(P=0.000)升高,总胆固醇(P=0.025)、LDL-C(P=0.038)及HDL-C(P=0.000)下降。SSc患者高Hcy血症和高血脂率分别为69.23%和38.46%。血清Hcy水平与皮肤厚度总分值(r=0.759,P=0.006)和CRP(r=0.398,P=0.028)水平呈正相关,血清HDL-C水平与SSC疾病严重程度Valentini评分(r=-0.319,P=0.0413)和CRP(r=-0.270,P=0.045)呈负相关,而Hcy水平与TG、TC水平无明显相关性(P>0.05)。 结论 SSc 患者的血脂和Hcy的异常与疾病活动度有关,这有可能增加SSc患者发生心血管不良事件的风险。     

生长激素联合醋酸亮丙瑞林治疗特发性中枢性性早熟女童的疗效及安全性分析

目的 探究生长激素联合醋酸亮丙瑞林治疗特发性中枢性性早熟的疗效及安全性。方法 选取2020年1月—2022年1月贵州省安顺市人民医院收治的90例特发性中枢性性早熟女童,采用随机数字表法分为对照组与研究组,每组45例。对照组采用醋酸亮丙瑞林治疗,研究组采用生长激素联合醋酸亮丙瑞林治疗。收集两组患儿的临床资料,比较治疗前后的性激素[黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E₂)]、子宫容积、卵巢容积、血脂[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]及空腹血糖(FPG),观察并记录两组患儿的不良反应情况。结果 研究组患儿治疗前后的LH、FSH、E₂、子宫容积、卵巢容积、TC、TG、HDL-C、LDL-C、FPG比较,差异无统计学意义(P>0.05);研究组女童治疗前后的子宫容积、TC、TG、HDL-C、LDL-C、FPG的差值比较,差异无统计学意义(P>0.05),研究组女童治疗前后的LH、FSH、E₂、卵巢容积的差值高于对照组(P <0...     

清脑益智方对血管性痴呆大鼠脑血流量及血脂水平的影响

[目的] 考察清脑益智方（QNYZF）对血管性痴呆（VaD）大鼠脑血流量（CBF）及血脂水平的影响。[方法] 选用健康雄性SD大鼠,随机分为假手术组、模型组、QNYZF低、中、高剂量组,采用双侧结扎颈总动脉（2-VO）法复制大鼠VaD模型。灌胃给药4周后,采用MOOR激光多普勒血流监测仪检测大鼠CBF,测完后取血、离心,收集血清,通过全自动生化仪检测血清中总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）含量。[结果] 与假手术组比较,模型组大鼠CBF降低（P<0.05）;与模型组比较,给予QNYZF干预后,中、高剂量组大鼠CBF升高（P<0.05或P<0.01）。与假手术组比较,模型组大鼠血清中TC、TG和LDL-C含量升高（P<0.05）,而HDL-C含量无明显变化（P>0.05）;给予QNYZF干预后,各剂量的QNYZF均可降低VaD大鼠血清中TC、TG和LDL-C含量（P<0.05或P<0.01）,而对HDL-C含量无明显影响（P>0.05）。[结论] QNYZF可有效改善VaD大鼠的CBF,其作用机制与降低血脂水平、改善血脂异常有关。     

新诊断2型糖尿病合并代谢综合征患者血清LDL-C/HDL-C比值的临床研究

目的 探讨新诊断2型糖尿病(T2DM)合并代谢综合征(MS)患者血清低密度脂蛋白胆固醇(LDL-C)/高密度脂蛋白胆固醇(HDL-C)比值变化及其与各临床指标的相关性。方法 选择新诊断T2DM患者140例,根据是否合并MS分为MS组73例、非MS组67例,另设立正常对照组73例。所有研究对象均行口服葡萄糖耐量试验(OGTT)及胰岛素释放试验,并检测血糖、胰岛素、血脂等相关生化指标,计算各组LDL-C/HDL-C比值。比较各组临床指标及LDL-C/HDL-C比值水平变化,分析LDL-C/HDL-C比值与各指标的相关性。根据LDL-C/HDL-C水平三分位分组,比较各组MS患病率。结果MS组(3.18±0.85)及非MS组(2.61±0.93)LDL-C/HDL-C均高于对照组(2.26±0.70),且MS组的LDL-C/HDL-C亦高于非MS组,差异有统计学意义(P<0.05)。根据LDL-C/HDL-C水平三分位分组,各组MS患病率分别为11.27%、35.21%、56.34%,随着LDL-C/HDL-C水平升高MS患病率升高(P<0.05)。相关分析显示,LDL-C/HDL-C比值与体质指数(BMI)、腰围(WC)、腰臀比(WHR)、收缩压、舒张压、餐后2h血糖(PPG)、空腹胰岛素(FINS)、餐后2h胰岛素(PSI)、胰岛素抵抗指数(HOMA-IR)、三酰甘油(TG)、血浆总胆固醇(CHOL)、LDL-C呈正相关(P<0.05),与HDL-C呈负相关(P<0.01)。以LDL-C/HDL-C为因变量作多元逐步回归分析,有HDL-C、LDL-C、FINS进入方程(P<0.01)。结论 T2DM合并MS患者LDL-C/HDL-C的比值升高,且高水平LDL-C/HDL-C比值患者的MS患病率高,LDL-C/HDL-C比值较单纯LDL-C浓度能更好地评估MS发生的危险性,为MS的预防和治疗提供更简便、有效的方案。     

妊娠糖尿病患者血清Betatrophin、Omentin-1水平与糖脂代谢及胰岛素抵抗的相关性

目的 探讨妊娠糖尿病（GDM）患者血清Betatrophin、脂肪组织中网膜素１（Omentin-1）水平变化特点,分析其与糖脂代谢和胰岛素抵抗的相关性。方法 选择2019年5月—2020年8月承德市中心医院妇产科接诊的179例孕妇。采用酶联免疫吸附试验检测所有孕妇妊娠10～14周血清Betatrophin、Omentin-1水平。所有孕妇妊娠24～26周进行口服葡萄糖糖耐量试验（OGTT）,其中,119例被诊断为GDM（GDM组）,60例血糖水平正常的孕妇为对照组。检测两组孕妇的总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、空腹血糖（FBG）、空腹胰岛素（FINS）及糖化血红蛋白（HbA1c）水平。采用稳态模型计算胰岛素抵抗指数（HOMA-IR）。分析Betatrophin、Omentin-1与GDM患者糖脂代谢指标的相关性。多元线性逐步回归分析GDM患者HOMA-IR的影响因素。结果 GDM组孕前体重指数（BMI）、FBG、FINS、HOMA-IR、HbA1c、TC、LDL-C、Betatrophin水平高于对照组（P <0.05）,Omentin-1水平低于对照组（P <0.05）。相关性分析结果显示GDM患者血清Betatrophin与TG（r_s =0464）、HOMA-IR（r =0.610）、LDL-C（r =0.512）呈正相关（均P <0.05）,Omentin-1水平与孕前BMI（r_s =-0.304）、LDL-C（r =-0.543）、FBG（r =-0.475）、FINS（r =-0.435）、HOMA-IR（r =-0.576）呈负相关（均P <0.05）。多元线性逐步回归分析结果显示TG、LDL-C、Betatrophin、Omentin-1是GDM患者HOMA-IR的影响因素（P <0.05）。结论 GDM患者血清Betatrophin水平升高,Omentin-1水平降低,Betatrophin、Omentin-1均与GDM患者糖脂代谢、胰岛素抵抗有关。     

甘草酸对非酒精性脂肪性肝炎大鼠治疗效果研究

目的 研究甘草酸对非酒精性脂肪性肝炎（NASH）大鼠的治疗效果及其作用机制。方法 雄性SD大鼠40只随机分为5组：正常组,模型组,低、中、高剂量甘草酸治疗组（60、120、180mg/kg）,以高脂饮食喂养16周构建大鼠NASH模型,于造模第7周起进行不同剂量甘草酸治疗10周,HE染色观察肝组织病理学变化,并对总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、丙二醛（MDA）、超氧化物歧化酶（SOD）及还原型谷胱甘肽（GSH）进行检测。结果 高脂饮食诱导的NASH大鼠模型中,肝组织可见肝细胞脂肪病变,血清中TC、TG、LDL-C、AST、ALT及MDA明显升高,HDL-C、SOD及GSH显著降低;而经过中、高剂量甘草酸治疗后发现,肝细胞脂肪病变程度降低,血清中TC、TG、LDL-C、AST、ALT及MDA明显降低,HDL-C、SOD及GSH明显升高,与模型组相比差异均具有统计学意义（P<0.05）。结论 甘草酸能够经过抑制氧化应激损伤、改变血脂水平来改善NASH大鼠肝功能及抑制肝脏病变程度,对NASH治疗具有潜在的临床意义。