肺原发性脑膜瘤一例并文献复习

目的:探讨肺原发性脑膜瘤的临床病理学特点.方法:运用光学显微镜和免疫组化PV6000二步法观察1例肺原发性脑膜瘤组织形态学和免疫组织化学特点,选取国内外38篇有关该肿瘤的文献,并纳入分析.结果:该肿瘤由梭形细胞和上皮样细胞构成,多数肿瘤细胞排列戍特有的漩涡状结构.免疫组化显示,肿瘤细胞vinmentin、EMA、S-100蛋白和CD99表达阳性,Ki-67阳性率<5%,Bcl-2、SMA、Calretinin、CD21、CD34、CD35和Cytokeratins表达阴性.复习文献发现,报道的该肿瘤有共同的组织学形态、免疫组化表达和电镜超微结构.结论:肺原发性脑膜瘤生长缓慢,境界清楚,其形态学特点与中枢神经系统脑膜瘤相似,大多数为单发,良性,手术易切除.     

原发性恶性食管黑色素瘤一例报告并文献复习

原发性食管恶性黑色素瘤(primary malignant melanoma of the esophagus,PMME)是一种较为罕见的食管恶性肿瘤,仅占食管原发性恶性肿瘤的0.1%～0.2%[1]。我院于2011年2月收治PMME 1例,现结合文献复习对其临床及病理特点报告如下。1病例资料患者×××,男性,62岁,因胸骨后隐痛3个     

伴发于直肠腺癌的肛周佩吉特病1例报告及文献复习

乳腺外佩吉特病（extramamnlary Paget’s disease．EPD）多发生于外阴、阴囊、会阴、腋下、肛用或外耳道等处、肛周佩吉特病（perianal Paget’s disease．PPD）约占EPD的5.4%^[1],     

消化道原发性上皮样血管肉瘤一例报道并文献复习

目的 :探讨消化道原发性上皮样血管肉瘤 (epithelioidangiosarcoma ,EA )的临床表现、病理特征及治疗预后。方法 :对1例原发于胃的上皮样血管肉瘤进行组织形态学、免疫组织化学分析并复习相关文献。结果 :胃大弯侧距离贲门口 3 0cm处见一带蒂的 2 1cm× 1 8cm× 1 5cm的肿块。术后 4个月发生肿瘤肝转移而死亡。结合文献 ,消化道原发性EA男性多于女性 ,平均发病年龄为 60 4岁 ,临床表现及大体无特征性 ;瘤细胞呈上皮样特征 ,不典型增生明显 ,表达CD3 1、CD3 4 、Vim。结论 :消化道原发性EA是一种罕见的高度恶性肿瘤 ,术前确诊困难 ,预后差 ,转移率高 ,平均生存时间为约 7个月 ,主要与上皮样血管内皮瘤、恶性黑色素瘤、转移癌等相鉴别     

肛管直肠恶性黑色素瘤：附一例报告及文献复习

肛管直肠恶性黑色素瘤（附一例报告及文献复习）陈学明，李杰莱阳中心医院（２６５２００）患者，女４７岁。肛门部反复出现肿物及便血１０月余。于１９９３年１月１３日入院。于十个月前自感便后肛门有异物感，并触及樱桃大小肿物，上缘触不清，粪便表面并有鲜血及少许粘...     

舌背原发性恶性黑色素瘤1例报告并文献复习

舌部原发性恶性黑色素瘤（malignant melanoma,MM）极为罕见,国内文献报道共5例。舌背原发性MM仅英国的Rowland等报道1例,因其组织发生不甚明确,且极为罕见,易误诊为转移性肿瘤或乳头状瘤、血管瘤等。现报告1例舌背原发性MM,并结合文献对其临床病理特征及组织学发生等进行探讨。     

乳腺原发性血管肉瘤一例报道并文献复习

目的:探讨乳腺血管肉瘤的临床病理特点.为判断其预后及治疗提供依据.方法:采用CD31、CD34、CD99和Vim等抗体进行免疫组织化学SP法染色观察.结果:以乳腺无痛性肿决为首发症状,术前B超、钼靶检查缺乏特异性.镜检瘤细胞呈腺泡状.裂隙状,绕血管放射状排列,多样性表现是乳腺血管肉瘤组织学形态特点.免疫组织化学染色显示,CD31、CD34、CD99和Vim均阳性.结论:乳腺原发性血管肉瘤罕见,临床表现缺乏特异性,病理形态学多样,预后差,易复发转移.CD31和CD34对乳腺血管内瘤的鉴别诊断有较好的应用价值.     

甲状腺显示胸腺样分化的癌1例报告并文献复习

甲状腺显示胸腺样分化的癌(carcinoma showingthymus-like differentiation,CASTLE),该肿瘤是一种发生在甲状腺内或是周围的具有鳞状上皮分化的恶性肿瘤[1],是类似于胸腺上皮性肿瘤结构的甲状腺癌,同义词有甲状腺淋巴上皮样癌(lymphoepithelioma-like carcinoma of the thyroid gland)、甲状腺内的上皮     

原发性甲状旁腺癌误诊3例报告并文献复习

甲状旁腺癌(parathyroid carcinoma,PTC)是一种较为罕见的内分泌肿瘤,1933年Sainton和Millot首次报道了1例功能性甲状旁腺腺癌,全球至今共报道大约700例[1]。本院2001年9月~2007年1月期间共收治3例PTC,现报道如下,并结合文献进行讨论。1临床资料例1,男性,75岁。因发现右颈部肿块伴进行性吞咽困难、声音嘶哑1周入院。既往6年前患者腰椎脱位病史。体检:右颈前区可扪及一约7.0 cm×5.5cm质硬无压痛肿块,可随吞咽活动。喉镜检查:右声带旁中位固定,声门下前右隆起,表面充血,右梨状窝积液。MRI示右颈部可见一3.8 cm×1.9 cm×3.3 cm大小的团…     

22例肛管直肠恶性黑色素瘤的临床分析并文献复习

背景与目的：肛管直肠恶性黑色素瘤恶性度高,其治疗方法尚存在争议．本研究旨在总结肛管直肠恶性黑色素瘤的诊断及治疗经验。方法：回顾性分析1977年至2003年江苏省肿瘤医院收治的22例肛管直肠恶性黑色素瘤患者的临床及病理资料．包括临床表现、诊断、手术方式和预后,并复习相关文献。结果：本组22例．占同期收治的大肠恶性肿瘤的0．4％（22／5205）,男性6例,女性16例．中位年龄61岁。主要临床表现为：便血86％（19／22）、肛门疼痛或不适59％（13／22）、肛门口肿物27％（6／22）等。首次就诊误诊率86％（19／22）,术前病理诊断确诊率48％（10／21）。无远处转移16例,伴远处转移6例。行腹会阴联合切除术11例．局部广泛切除术5例（2例复发后补充腹会阴联合切除术）,Park’s术2例．Hartmann’s术1例,乙状结肠双腔造瘘术3例。术后1、3、5年生存率分别为45．4％、18．1％、9．1％,中位生存时间12个月（95％CI：6～18个月）。结论：肛管直肠恶性黑色素瘤少见,易误诊,预后差。腹会阴联合切除术可作为无远处转移的肛管直肠恶性黑色素瘤患者的首选术式。     

Solitary gastric recurrence from ovarian carcinoma: a case report and literature review

BACKGROUND: Isolated gastric recurrence due to ovarian cancer is a rare event and is usually associated with gastrointestinal symptoms. CASE REPORT: We report a case of an isolated gastric recurrence of ovarian carcinoma in an otherwise asymptomatic 42-year-old woman in whom diagnosis was made using the FDG-PET/CT scan followed by laparoscopy. CONCLUSIONS: In rare cases, ovarian cancer can directly recur on the stomach without any symptoms. FDG-PET/CT scan and diagnostic laparoscopy are effective in leading to an early diagnosis of disease recurrence.     

Solitary splenic metastasis: case report and review of the literature

Solitary splenic lesion is a rare presentation of a previous or current malignancy. We describe a case of an isolated splenic lesion caused by endometrial carcinoma and summarize all the published reports on solitary splenic metastasis.     

Solitary oral plexiform neurofibroma: review of literature and report of a case

Plexiform neurofibroma (PN) is a rare, benign tumor of nerve sheath origin, which frequently manifests as part of neurofibromatosis type 1. The article presents a case of solitary PN in a 4-year-old girl, which manifested as a double lip and without systemic or familial involvement. A review of the literature on solitary PN in the oral soft tissue demonstrates the scarcity of such cases.     

Solitary intracranial plasmacytoma--a case report and review of the literature

A 49 year old man had had headache and some cranial nerve paralyses for about three years. A tentative diagnosis of meningioma of the skull base or chordoma was made before his death. In the postmortem examination, a large tumor lying on the skull base was found. The sella turcica, a part of the basilar bone were destroyed. The neoplasm had invaded the adjacent cerebrum, cranial nerves and extra-cranial tissues. Histopathologically, the lesion showed a typical poorly-differentiated plasmacytoma. Both clinic and pathologic characteristics of this tumor are discussed and the literature on solitary intracranial plasmacytoma is reviewed.     

Solitary intracranial subdural osteoma: case report and review of the literature

Intracranial subaural osteomas without any relation to osseous or meningeal tissues are rare, with only five cases including the present one having been reported so far. In most patients headache, which was always localized at the site of the lesion, was the most frequent complaint and subsided after complete resection of the neoplasm. The mechanism of origin of such lesions remains unknown.     

Solitary mastocytoma of the lung: a case report and a brief review of the literature

We report a case of a 51-year-old woman with a solitary mast cell tumor of the lung, a rare neoplasm with only three previous cases reported in the literature. Unlike the reported cases, the tumor in our observation was bulky, measuring 14 cm of diameter and budding into the segmental bronchus. Histological examination was consistent with mastocytoma and further investigations excluded the diagnosis of systemic mastocytosis. The differentiating features of this neoplasm and a review of literature are herein presented.     

Solitary Langerhans cell histiocytosis of frontal lobe: a case report and literature review

The brain parenchymal Langerhans cell histiocytosis （LCH） without systemic disease or lytic skull lesions is extremely rare. We report a 23-year-old male presenting with new onset 1 hour seizure with loss of consciousness 20 days prior to admission, and recurrent seizure 2 weeks later. Brain magnetic resonance imaging （MRI） showed an irregularly mass with enhancement involving the right frontal lobe. Microscopically, the lesion was characterized by sheets of Langerhans cells in addition to reactive inflammatory elements. Immunohistochemically, Langerhans cells were positive for Langerin, CDla and S-100 protein. The patient received no chemotherapy or radiotherapy after surgery. After 24 months of follow-up, no recurrence or other systemic lesions were observed. Although there is no standard treatment for solitary cerebral LCH, the prognosis generally appears to be good.     

Solitary fibrous tumor of small bowel mesentery: a case report and review of the literature

Solitary fibrous tumor is an extremely rare clinical entity, most commonly manifested in the pleura and peritoneum. An increasing number of cases are found to occur at extrapleural sites. We report a case of solitary fibrous tumor arising from the mesentery of the small intestine. A 53-year-old man presented with a large abdominal mass which was initially thought to be a gastrointestinal stromal tumor. The tumor was successfully removed surgically and the diagnosis of solitary fibrous tumor was confirmed on immunohistochemical analysis. To our knowledge this is the first reported case of a solitary fibrous tumor arising from the small bowel mesentery.     

Solitary brain metastasis from classic biphasic pulmonary blastoma: a case report and review of the literature

BACKGROUND: Classic biphasic pulmonary blastoma (CBPB) is a rare and aggressive primary malignancy, brain metastases of this type of tumor are even rarer. CASE REPORT: A 51-year-old male patient with a solitary cerebral metastasis, diagnosed ten months after left pneumonectomy for a CBPB, was treated by surgery and accelerated hypofractionated radiotherapy. RESULTS: The patient died 15 months after partial removal of the brain metastasis. Literature review revealed only 4 cases of solitary brain metastases from this type of malignancy. The present case is the second one reported with a combined treatment of surgery and radiotherapy resulting in the longest survival. CONCLUSION: The best treatment for CBPB is difficult to determine because of the small number of cases, however, the combination of surgery with radiotherapy seems to be effective. The effectiveness of chemotherapy has not been ascertained.