脑出血患者血清胆红素和脂质变化分析

目的探讨血清胆红素和脂质水平与脑出血（CH）的关系。方法对117例CH患者的血清胆红素、胆固醇等指标进行检测，并与114例健康对照者进行比较。结果CH患者血清甘油三酯（TG）、高密度脂蛋白胆固醇（HDL—C）及DBIL/IBIL比值较对照组显著降低（P〈0.001或P〈0．05），胆固醇（TC）、直接胆红素（DBIL）较对照组低，总胆红素（TBIL）、间接胆红素（IBIL）、低密度脂蛋白胆固醇（LDL—C）较对照组高，但差异无统计学意义（P〉0.05）。结论血清HDL—C降低可作为CH的危险因素，TG和DBIL/TBIL比值与CH关系密切。     

胆红素和脂质对脑卒中发病影响的差异性探讨

目的探讨血清胆红素和脂质及其综合指数与脑出血(CH)、短暂性脑缺血发作(TIA)及脑梗死(CI)的关系。方法对128例CH、108例TIA及104例CI急性期患者血清胆红素、胆固醇等指标进行检测,并进行对比分析。结果CI组年龄显著高于CH组(P<0.05)。TIA、CI组患者血清总胆红素(TBIL)、间接胆红素(IBIL)、高密度脂蛋白胆固醇(HDL-C)显著低于CH组(P<0.05或P<0.01),血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、非高密度脂蛋白胆固醇(n-HDL-C)水平及LDL-C/HDL-C、TC/HDL-CTG/HDL-C比值显著高于CH组(P<0.05或P<0.01);CI组患者血清直接胆红素(DBIL)/IBIL比值显著高于CH组(P<0.01),血清IBIL、HDL-C水平显著低于TIA组(P<0.05),血清LDL-C、n-HDL-C水平及LDL-C/HDL-C、TC/HDL-C比值显著高于TIA组(P<0.05或P<0.01),各组间其它指标间差异无统计学意义(P>0.05)。结论血清胆红素和脂质及其综合指数不同程度的变化与脑卒中关系密切。     

老年腔隙性脑梗死患者血清胆红素和血脂水平的相关性研究

目的研究老年腔隙性脑梗死患者血清胆红素和血脂水平,探讨它们在老年腔隙性脑梗死发病机制中的作用。方法78例老年腔隙性脑梗死患者（腔梗组）,与72例无腔隙性脑梗死患者（对照组）,抽空腹静脉血,测定血清总胆红素（TBIL）、直接胆红素（DBIL）、间接胆红素（IBIL）、甘油三酯（TG）,总胆固醇（TC）,低密度脂蛋白胆固醇（LDL-C）,高密度脂蛋白胆固醇（HDL-C）水平及TC／HDL-C比值,两组进行比较。结果在老年人腔隙性脑梗死患者中TG、TC、LDL—C、TC／HDL—C水平明显高于对照组（P〈0．05）,而TBIL、DBIL、IBIL、HDL-C水平明显低于健康对照组（P〈0．05）。结论TG、TC、LDL-C水平,TC／HDL—C比值升高,TBIL、DBIL、IBIL、HDL-C水平降低与老年人腔隙性脑梗死发病密切相关。老年腔隙性脑梗死患者存在胆红素和脂质代谢紊乱,胆红素和脂质代谢紊乱参与了老年腔隙性脑梗死事件的发生。     

血清血脂和胆红素水平与脑白质病变的相关性研究

目的探讨血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白A-I (ApoA-I)、载脂蛋白B(ApoB)、脂蛋白(Lp)(a)、ApoB/ApoA-I、总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)水平与脑白质病变(WML)的关系。方法纳入WML患者106例及对照组80例,根据Fazekas法将WML组分为Ⅰ级组、Ⅱ级组、Ⅲ级组。比较WML组与对照组之间临床资料、血脂及胆红素的水平的差异;采用多变量Logistic回归分析各血脂指标、胆红素与WML的关系;采用单因素方差分析各血脂指标、胆红素与WML严重程度的关系。结果与对照组比较,WML组年龄、高血压病、糖尿病、既往卒中的比例均明显升高(均P0.05),WML组血清TG浓度明显升高,HDL、ApoA-I、TBIL、DBIL、IBIL水平均明显降低(均P0.05)。多变量Logistic回归分析显示,血清HDL(OR=1.49,95%CI:1.02～2.16;P=0.044)、ApoA-I(OR=1.78,95%CI:1.25～2.64;P0.001)、TBIL(OR=0.45,95%CI:0.22～0.63;P=0.007)、DBIL(OR=0.43,95%CI:0.24～0.82;P=0.034)、IBIL(OR=0.51,95%CI:0.31～0.73;P=0.008)是WML的独立危险因素,多因素Logistic回归分析显示,血清HDL、ApoA-I、TBIL、DBIL、IBIL水平与WML严重程度相关(均P0.05)。结论血清HDL、ApoA-I、TBIL、DBIL、IBIL可能是WML的独立危险因素,且与WML严重程度相关。     

脑血管病与血脂的关系

目的 探讨脑血管病(CVD)与血脂的关系。方法 检测53例脑出血(CH)及60例脑梗死(CI)患者的血脂,并与60名同龄健康对照组比较。结果 CH组TC、HKL一C、LDL-C高于对照组;TG低于对照组,但均无显著性差异(P>0.05)。CI组HDL-C显著低于对照组和CH组(P<0.005);TC、TG、LDL-C高于对照组,但无显著性差异(P>0.05〕;TG明显高于CH组(P<0.05)。结论 HDL-C是CI的保护因素,CH和CI与血脂的关系不同,甚至完全相反,他们有着不同的发病机制。     

抑郁症患者单胺类神经递质与血脂的相关性

目的：探讨抑郁症患者血浆单胺类神经递质与血脂的关系。方法：检测55例抑郁症患者和21例正常人的血浆去甲肾上腺素(NE)、5—羟色胺(5—HT)、血清总胆固醉(CH0)、甘油三酯(TG)、高密度脂蛋白—胆固醇(HDL-C)和低密度脂蛋白—胆固醇(LDL-C)。结果：抑郁症患者的血浆5—HT浓度和血清CH0浓度显著低于正常对照组，血浆NE浓度显著高于正常对照组；抑郁症患者的血浆5-HT浓度和血清CH0浓度呈显著正相关，血浆NE浓度与血清HDL-C浓度呈显著正相关。结论：抑郁症患者的血脂代谢异常与血浆单胺类神经递质有关。     

青年缺血性脑卒中与血脂代谢异常关系的分析

目的探讨青年缺血性脑卒中与血脂代谢异常之间的关系,并评价其危险因素。方法对56例青年缺血性脑卒中患者、52例年龄匹配的青年健康对照组;59例老年缺血性脑卒中患者、54例年龄匹配的老年健康对照组的血脂、血糖及血压等指标进行分析。结果青年缺血性脑卒中患者的总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)含量显著高于青年对照组(P<0.05);高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A含量低于青年对照组(P<0.05)及老年缺血性脑卒中组(P<0.05)。结论脂质代谢异常是引起青年缺血性脑卒中的主要因素之一,其中HDL-C降低可能是缺血性脑卒中最重要的危险因素。     

脑梗死患者血清胆红素浓度的变化及意义

目的通过脑梗死患者和同期健康体检者血清胆红素水平的测定以探讨其与动脉粥样硬化发病间的关系。方法采用全自动生化仪测定80例脑梗死患者和60例同年龄段健康体检者的血清胆红素、胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLc)水平,并进行统计学分析。结果脑梗死组患者血清总胆红素、直接胆红素及间接胆红素水平较低,与健康对照组比较差异有统计学意义(均P<0.05)。结论血清胆红素水平偏低是动脉粥样硬化发病的危险因素。     

不同血脂水平的原发性高血压患者血浆高敏C-反应蛋白检测及临床分析

目的 探讨不同血脂水平高血压病患者炎症因子血浆高敏C-反应蛋白(hsCRP)的表达水平及临床意义.方法 我们对86例高血压病患者根据不同血脂水平分为正常血脂组(NC组)和高血脂症组(HC组),另选45例体检健康对照组用CRP检测仪和全自动生化分析仪检测hsCRP、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)浓度进行单因素方差分析.结果 NC、HC组与健康对照组相比,hsCRP明显升高(P＜0.05),而HC组与NC组比较hsCRP也明显升高(P＜0.05).HC组中CH 、LDL-C、TG 明显高于NC组与健康对照组(P＜0.05),NC组与健康对照组相比,CH 、LDL-C、TG均未见显著差异(P＞0.05).3组中HC组HDL-C明显低于NC组与健康对照组(P＜0.05),NC组与健康对照组之间HDL-C未见显著差异(P＞0.05).结论 炎症参与了高血压的进展,对不同血脂水平高血压患者hsCRP将会成为反映高血压进展程度,预测未来风险的一个良好指标.     

脑梗死患者血尿酸、脂蛋白(a)含量的研究

目的探讨脑梗死患者血尿酸、血清脂蛋白(a)含量的变化及其意义。方法对85例脑梗死患者测定其血总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、脂蛋白(a)及血尿酸(UA)水平,与对照组40例结果进行比较。结果脑梗死患者TC、TG、HDL水平与对照组相比无明显差异(P>0.05),UA、LDL、Lp(a)水平较对照组明显升高(P<0.01);其中脑梗死合并糖尿病者较无糖尿病者,血UA、Lpo(a)亦有明显升高(P<0.05),两组与正常对照组比较均有显著性差异(P<0.05)。结论血尿酸、Lpo(a)含量增高与脑梗死存在一定关系,是脑梗死的重要危险因素。     

Latent Toxoplasma gondii infection is associated with decreased serum triglyceride to high-density lipoprotein cholesterol ratio in male patients with schizophrenia

BackgroundPrevious studies suggested a complex association between Toxoplasma gondii (TG) infection and host lipid metabolism. Both TG infection and metabolic disturbances are very common in patients with schizophrenia, but this relationship is not clear.MethodsIn this cross-sectional study, we evaluated the association between TG seropositivity, serum lipid levels, body mass index (BMI) and metabolic syndrome (MetS) in 210 male inpatients with schizophrenia.ResultsIn our sample of schizophrenia patients, with the mean age of 43.90 ± 12.70 years, the rate of TG seropositivity was 52.38% and the prevalence of MetS was 17%. Patients with the TG antibodies had lower serum triglyceride levels and body weight compared to TG seronegative patients, despite having more frequently received antipsychotics (clozapine, olanzapine risperidone and quetiapine), which are well known to induce weight gain and metabolic abnormalities. However, the only significant change in metabolic parameters, observed in TG seropositive patients with schizophrenia, was decreased serum triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio. No associations were observed between TG seropositivity and serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and glucose levels, waist circumference, BMI and the rate of MetS.ConclusionThis is the first report of the association between TG infection and decreased serum triglyceride to HDL-C ratio in a sample of carefully selected men with chronic schizophrenia.     

Lipid profiles and outcome in patients treated by intravenous thrombolysis for cerebral ischemia

OBJECTIVE: To determine whether low low-density lipoprotein cholesterol (LDL-C) but not high-density lipoprotein cholesterol (HDL-C) and triglyceride concentrations are associated with worse outcome in a large cohort of ischemic stroke patients treated with IV thrombolysis. METHODS: Observational multicenter post hoc analysis of prospectively collected data in stroke thrombolysis registries. Because of collinearity between total cholesterol (TC) and LDL-C, we used 2 different models with TC (model 1) and with LDL-C (model 2). RESULTS: Of the 2,485 consecutive patients, 1,847 (74%) had detailed lipid profiles available. Independent predictors of 3-month mortality were lower serum HDL-C (adjusted odds ratio [(adj)OR] 0.531, 95% confidence interval [CI] 0.321-0.877 in model 1; (adj)OR 0.570, 95% CI 0.348-0.933 in model 2), lower serum triglyceride levels ((adj)OR 0.549, 95% CI 0.341-0.883 in model 1; (adj)OR 0.560, 95% CI 0.353-0.888 in model 2), symptomatic ICH, and increasing NIH Stroke Scale score, age, C-reactive protein, and serum creatinine. TC, LDL-C, HDL-C, and triglycerides were not independently associated with symptomatic ICH. Increased HDL-C was associated with an excellent outcome (modified Rankin Scale score 0-1) in model 1 ((adj)OR 1.390, 95% CI 1.040-1.860). CONCLUSION: Lower HDL-C and triglycerides were independently associated with mortality. These findings were not due to an association of lipid concentrations with symptomatic ICH and may reflect differences in baseline comorbidities, nutritional state, or a protective effect of triglycerides and HDL-C on mortality following acute ischemic stroke.     

复发性与初发性脑梗死患者胰岛素抵抗的比较

目的 研究复发性与初发性脑梗死患者的胰岛素抵抗(IR)情况.方法 对42例复发性脑梗死、40例初发性脑梗死和30例对照组进行研究.测定并比较三组人群的体重指数(BMI)、平均动脉压(MAP)、糖化血红蛋白(HbAlC)、胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(ISI)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、颈动脉内膜-中层厚度(CIMT)等指标.结果 对照、初发卒中及复发卒中三组人群的HOMA-IR、ISI和CIMT存在显著的组间差异(P<0.05).脑梗死患者的ISI与TG、LDL-C、BMI、CIMT以及MAP呈负相关,与HDL-C呈正相关.结论 IR与脑梗死复发的关系需要进一步研究证实.     

Serum lipid concentrations in patients with comorbid generalized anxiety disorder and major depressive disorder.

OBJECTIVE: To examine the lipid levels in a sample of patients with comorbid generalized anxiety disorder (GAD) and major depressive disorder (MDD). METHODS: Serum lipid concentrations were examined in 40 patients with both GAD and MDD, in 27 patients with MDD only, in 26 patients with GAD only, and in 24 healthy control subjects. RESULTS: All mean serum cholesterol concentrations are presented in Table 1. The mean serum total cholesterol concentration in patients with both GAD and MDD was significantly higher than in MDD-only patients, GAD-only patients, and control subjects. The triglyceride concentration was also significantly higher in patients with both GAD and MDD than in MDD-only patients, GAD-only patients, and control subjects. Patients with both GAD and MDD had a lower mean high-density lipoprotein cholesterol (HDL-C) concentration than did patients with GAD only and control subjects. The serum concentration of low-density lipoprotein cholesterol (LDL-C) was higher in patients with both GAD and MDD than in patients with MDD only and GAD only and healthy control subjects. CONCLUSIONS: Our findings indicate that the patients with both GAD and MDD have increased serum cholesterol, triglyceride, and LDL-C and reduced HDL-C levels. These patients may have a greater risk of mortality from coronary artery disease (CAD) than do patients with either depression or anxiety disorder.     

Associations between sleep duration and abnormal serum lipid levels: data from the Korean National Health and Nutrition Examination Survey (KNHANES)

BackgroundShorter or longer sleep duration has been reported to be associated with abnormal serum lipid levels, but the findings have been inconsistent. This study examined associations between sleep duration and abnormal serum lipid levels in a Korean adult population.MethodsThis study used the data of 13,609 people aged ≥20 years from the Korean National Health and Nutrition Examination Survey (KNHANES) in 2010–2012. Sleep duration was classified into five groups: ≤5, 6, 7 (reference category), 8, and ≥9 hours. The serum concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride were measured and defined in terms of abnormal serum lipid levels. Multiple logistic regressions were performed to determine the associations between sleep duration and abnormal serum lipid levels. The covariates included age, sex, education, marital status, current smoking, alcohol consumption, physical activity, body mass index, hypertension, diabetes, depressive symptoms, and stress level.ResultsSelf-reported sleep duration of ≤5 hours was significantly associated with high TC and high LDL-C levels in unadjusted models, but after adjusting for age and sex, the statistical significance disappeared. On the other hand, after adjusting for covariates, self-reported sleep duration of ≥9 h was significantly associated with low HDL-C levels (odds ratio = 1.30; 95% confidence interval = 1.09–1.54).ConclusionsThese findings suggest that longer sleep duration is associated with low HDL-C levels among Korean adults.     

Serum lipoprotein levels in patients with neuromyelitis optica elevated but had little correlation with clinical presentations

Objective

To explore the relationship between serum lipoproteins and clinical presentations of NMO patients. To investigate the differences of serum lipoprotein levels between NMO and MS patients.

Patients and methods

Serum lipoprotein levels were measured in 56 NMO patients, 53 MS patients and 54 health subjects. Serum lipoprotein levels in all participants and relevant clinical parameters of NMO patients were investigated. Statistical analyses were performed using the SPSS statistical software.

Results

NMO patients had significantly higher serum cholesterol (TC), triglyceride, low-density lipoprotein cholesterol, apolipoprotein B (apoB), lipoprotein (a) levels and TC/HDL-C, apoB/apoA-1 ratios than health control group. NMO patients had significantly higher serum apoB level and apoB/apoA-1 ratio than MS patients. There was little correlation between serum lipoproteins and NMO presentations.

Conclusion

The elevated lipoprotein levels in NMO patients could be just secondary changes with limited value in clinical prediction. However, elevated apoB level and apoB/apoA-1 ratio in NMO might indicate severer disability and might provide some useful information in the differential diagnosis with MS.     

胰岛素抵抗与脑血管病的关系

目的 :探讨胰岛素抵抗与脑梗死、脑出血之间的关系。方法 :选取 34例脑梗死 ,4 4例脑出血病人 ,分别检测血压、血脂、空腹血糖 (FPG)、空腹胰岛素 (FINS)等各项指标 ,30例健康人作为对照组。结果 :脑梗死、脑出血组与正常对照组比较 :FPG、FINS明显增高 ,而胰岛素敏感指数 (ISI)明显降低 ;收缩压 (SBP)、舒张压 (DBP)、总胆固醇 (TC)、甘油三脂 (TG)、低密度脂蛋白 (LDL)、载脂蛋白B(apoB)也升高 ;相反 ,高密度脂蛋白 (HDL)、载脂蛋白A(apoA)、apoA/apoB降低。脑梗死与脑出血两组之间比较 ,脑出血组的DBP明显高于脑梗死组 ,其余指标均无统计学差别。结论 :胰岛素抵抗是脑血管病的独立危险因素 ,但与中风类型无关     

载脂蛋白A5-1131T>C基因多态性与脑卒中的关系

目的 探讨载脂蛋白(Apo)A5-1131T>C基因多态性与脑卒中的关系. 方法 对327例脑卒中患者(其中脑梗死患者194例,脑出血患者133例)及311名健康对照者的ApoA5-1131T>C基因多态性及血脂水平进行检测. 结果 脑梗死患者的-1131C等位基因频率明显高于对照者,差异有统计学意义(P<0.05);脑出血患者与对照者比较,差异没有统计学意义(p>0.05).在脑卒中患者中,C等位基因携带者的甘油三酯(TG)水平明显高于非C携带者.差异有统计学意义(p<0.05),总胆固醇(TC)、高密度蛋白胆固醇(HDDC)和低密度脂蛋白胆固醇(LDL-C)比较差异无统计学意义(p>0.05).LOgistic回归单变量分析显示TC+CC基因型与脑梗死风险增加相关,与脑出血无关;校正体重指数(BMD、高血压、糖尿病和HDL-C等相关因素的影响后.C等位基因仍显示为脑梗死的独立危险因素(OR=1.932,95%CI为1.057-3.532,P=0.032).结论 脑梗死患者ApoA5-1131C等位基因携带率明显高于对照者,ApoA5-1131T>C基因多态性对血清TG水平有影响.ApoA5-1131T>C基因变异可能增加缺血性脑卒中的易感性.     

肺炎衣原体感染与偏头痛的关系

目的探讨慢性肺炎衣原体(CPn)感染与偏头痛的关系。方法所有病例分为观察组(56例)与对照组(30例)。肺炎衣原体血清特异性IgG、IgM抗体采用酶联免疫吸附试验法,血清胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)浓度检测采用全自动生化仪。结果观察组和对照组肺炎衣原体感染率分别为62.50%和36.67%,差异有统计学意义(P<0.05)。结论偏头痛患者肺炎衣原体感染率明显增高,肺炎衣原体感染与偏头痛有关,可能是偏头痛发作的病因之一,深入研究可能探索偏头痛的发病机制及防治新途径。