5对孪生子尿道下裂的尿道修复术

目的 探讨孪生子尿道下裂的临床特点及尿道修复术疗效.方法 自1997年1月至2009年9月本院收治的5对孪生子的尿道下裂患者,进行一期尿道修复术,其中6例应用镍钛记忆合金尿道支架行尿道再造.结果 5对孪生子患者随访6个月～3年,术后尿瘘1例,尿道憩室1例,总并发症发生率为20.0%,其中6例应用镍钛合金尿道支架者无尿瘘、尿道狭窄等并发症,其余患者排尿通畅而无尿瘘,阴茎无下弯畸形,尿道口位置良好.结论 镍钛记忆合金尿道支架可减少尿道下裂术后并发症的发生,尿道下裂患者如有孪生背景者,需鉴别是否为同卵双生,有利于进一步的病因分析,对双胎共患者建议同期行尿道修复术.     

Successful hypospadias repair with ventral based vascular dartos pedicle for urethral coverage

PURPOSE: We describe an easy technique to reliably harvest a vascularized dartos pedicle for urethral coverage at the time of urethroplasty in hypospadias surgery. The complication of urethrocutaneous fistula in hypospadias surgery as a result of using this technique is also evaluated. MATERIALS AND METHODS: A retrospective review (July 1999 to September 2002) identified 180 pediatric patients who had undergone primary hypospadias surgery by a single surgeon. A modified technique of harvesting a vascularized dartos pedicle was incorporated in 111 hypospadias repairs. A ventral based vascularized dartos pedicle of tissue was used to cover a modified urethroplasty as described by Snodgrass. RESULTS: The intraoperative meatal position before urethroplasty was subcoronal in 95 cases, penile/midshaft in 11 and penoscrotal in 5. The majority of patients (90 of 111) were younger than 12 months at surgery. Ages ranged from 5 months to 16 years (mean 21.1 months). Of the 111 patients reconstruction using the ventral based vascularized dartos pedicle to cover the urethroplasty was successful in 109 (98.2%), and at followup they have an acceptable cosmetic result with no evidence of urethrocutaneous fistula. In 1 patient with distal hypospadias a urethrocutaneous fistula developed, which was recognized 20 months postoperatively. Another patient with penoscrotal hypospadias had a proximal fistula at 6 months. There were no recognized intraoperative urethral injuries or complications. Followup ranged from 3 to 38 months (mean 19.1). CONCLUSIONS: The ventral based vascularized dartos pedicle urethral coverage procedure is an easy and reliable technique to harvest adequate vascularized tissue to cover a hypospadias urethroplasty. In this small single surgeon series, this technique appears to have contributed to a low rate of urethrocutaneous fistulas after hypospadias repair.     

CONGENITAL ANTERIOR URETHROCUTANEOUS FISTULA

PURPOSE: Congenital anterior urethrocutaneous fistula is a rare anomaly that may present in an isolated fashion or in association with other penile abnormalities, such as chordee or hypospadias. There have been 18 cases of congenital anterior urethrocutaneous fistula reported in the literature. We present 14 additional cases of congenital anterior urethrocutaneous fistula. MATERIALS AND METHODS: We treated 14 patients with congenital anterior urethrocutaneous fistula, of whom 9 were uncircumcised at presentation. Two patients had evidence of chordee and 4 had distal hypospadias. RESULTS: The type of repair was determined by the anatomical variations of this anomaly. All cases were corrected electively by various techniques based on the degree of the defect, including primary closure via a Thiersch-Duplay urethroplasty, pedicle flap urethroplasty, hinged flap urethroplasty and interpositioned island pedicle tube or onlay urethroplasty. CONCLUSIONS: To our knowledge the embryological events that cause anterior urethrocutaneous fistula are unclear but they likely result from a defective urethral plate or an abnormality of the infolding of the urethral groove. Surgical technique must be individualized to fit the defect. While there has been considerable skepticism regarding the existence of congenital urethrocutaneous fistula, the fact that 9 of our 14 patients were uncircumcised confirms the congenital nature of this lesion.     

镍钛尿道支架管在尿道下裂修复术中的作用

目的探讨镍钛记忆合金尿道支架管在预防尿道下裂术后尿瘘及尿道狭窄中的作用.方法 2001年1月～2004年12月,应用镍钛记忆合金尿道支架管作为尿道支架修复63例尿道下裂,其中阴茎近端型19例,阴茎阴囊型22例,阴囊会阴型8例,为一期尿道重建;尿道下裂术后尿瘘行尿瘘修补术10例;尿道下裂术后尿道狭窄再次重建尿道4例.结果 63例伤口均Ⅰ期愈合,术后获随访2个月～2年,排尿通畅,均无尿瘘和尿道狭窄发生.其中62例于术后2～3个月后拔除尿道支架,1例于12个月后拔除.结论镍钛记忆合金尿道支架管可有效预防尿道下裂术后尿瘘及尿道狭窄的发生.     

Unstented tubularized incised plate urethroplasty combined with foreskin reconstruction for distal hypospadias

BACKGROUND AND AIM: Urethral stent has recently been proven to be unnecessary for normal healing in an animal model of tubularized incised plate (TIP) urethroplasty. We report our experience with unstented TIP repair combined with foreskin reconstruction for distal hypospadias in children. PATIENTS AND METHODS: We retrospectively reviewed the records of 162 children consecutively treated by TIP urethroplasty for a distal or mid-shaft hypospadias without urethral stent over a 6 years period. The mean age +/- SEM at surgery was 15.7 +/- 1.2 months. A foreskin reconstruction was performed with the hypospadias repair in 136 boys (84%). One hundred thirty one children (81%) underwent this surgery as an outpatient procedure. RESULTS: With a mean follow-up of 12.4 +/- 1.0 months, urethrocutaneous fistula was observed in 9 children (5.6%), and meatal stenosis in 4 (2.5%). Postoperative urinary retention requiring suprapubic catheter insertion was observed in 4 cases (2.5%) without later complications. Cutaneous dehiscence of the reconstructed foreskin occurred in 6 children (4.4%) and phimosis in 13 (9.5%). CONCLUSIONS: Absence of urethral stent after TIP urethroplasty for distal hypospadias repair does not seem to increase postoperative complication rate. Foreskin reconstruction in distal hypospadias surgery has an acceptable complication rate.     

Distal hypospadias: which repair?

OBJECTIVE: To compare the function, complications and cosmesis after a modified Thiersch-Duplay and Mathieu unstented urethroplasty. PATIENTS AND METHODS: Over a 5-year period 381 consecutive patients (not randomized) with distal hypospadias were evaluated. A modified Thiersch-Duplay with dorsal incised urethral plate tubularization (group A) was undertaken in 170 (45%) and a parameatal based flip-flap Mathieu hypospadias repair (group B) in 211 (55%). No urinary diversion or stent was used in any of the 381 patients. RESULTS: In both groups the mean (sd) follow-up was 3.1 (1.4) years. All 381 patients voided spontaneously after surgery and none developed urinary retention needing catheterization. In groups A and B, respectively, the overall late complications were 12 (7.1%) and 32 (15.2%) (P=0.001), with urethrocutaneous fistula in six (3.5%) and 26 (12.3%; P=0.001); secondary surgery for fistula repair was successful in all boys in A and 89% in B. The glanular meatus was a vertical slit in all in group A and 86% in B (P=0.02). In both groups, 71% of the children who are now toilet-trained and standing to void have a good calibre, single and straight urinary stream in a forward direction. CONCLUSIONS: Stenting or urinary diversion is unnecessary after distal hypospadias surgery. The functional results were good in those standing to void. A more natural vertical slit-like glanular meatus was easily created using the modified Thiersch-Duplay urethroplasty, with a lower fistula rate.     

尿道下裂术后尿道狭窄继发附睾炎的诊治

【摘要】〓目的〓探讨尿道下裂术后尿道狭窄继发附睾炎的临床特点与疗效。方法〓2005年1月至2011年2月收治的尿道下裂术后尿道狭窄46例患者中8例继发附睾炎,对该类患者予抗感染及对症治疗后,尽早行尿道探查、尿道狭窄段切开或切除及组织瓣移植尿道成形术等方法修复尿道狭窄。结果〓8例尿道狭窄继发急性附睾炎患者术后8天内附睾炎症状基本消失。1例患者阴茎伤口感染致阴茎中部尿瘘于3月后成功行尿瘘修补术,余7例患者伤口愈合良好,无尿瘘发生,排尿通畅,尿线粗。随访3~12月,8例患者均无尿道狭窄复发,无急性附睾炎复发,慢性附睾炎者临床症状较术前明显改善。结论〓本组患者中,尿道下裂术后尿道狭窄继发附睾炎见于严重的尿道狭窄患者及年龄偏大患者;尿道下裂术后尿道狭窄应积极处理,一旦出现急性附睾炎时应在抗感染等保守治疗前提下,尽早行尿道成形修复狭窄段尿道,恢复正常尿流。     

Effect of the depth and width of the urethral plate on tubularized incised plate urethroplasty

PURPOSE: We determined the effect of the depth and width of the urethral groove on tubularized incised plate urethroplasty for distal hypospadias. MATERIALS AND METHODS: We retrospectively reviewed the records of 48 patients who underwent tubularized incised plate urethroplasty for distal hypospadias between September 1996 and December 1998 for whom preoperative evaluation of the depth and width of the urethral groove was available. Patients were examined by an independent clinician a median of 28 months after surgery when the neourethra was calibrated and urinary stream assessed. RESULTS: Of the 48 patients 46 were available for clinical examination. The urinary stream was straight in 40 boys and angled in 8, while none sprayed. Urethral fistula developed in 6 patients with a urethral plate of less than 8 mm. wide (p = 0.001). The urethral groove was deep in 13 cases, moderate in 20 and shallow in 15. There were no differences among these 3 groups in regard to urinary stream direction or fistula rate. Of the boys with a shallow urethral groove 6 (40%) have a neourethral caliber of 6Fr or less versus 3 (15%) with a moderate and 0 with a deep groove. This difference was statistically significant (p = 0.028). Each patient in whom meatal stenosis developed had a shallow urethral groove. CONCLUSIONS: Urethral groove depth appears to influence neourethral caliber after tubularized incised plate urethroplasty. A shallow groove predisposes to a narrower neourethra and meatal stenosis subsequently. We observed no evidence that incising the urethral plate increases the final urethral diameter. Urethral fistula after tubularized incised plate urethroplasty was associated with an initially narrow urethral plate.     

镍钛记忆合金尿道支架管在尿道下裂修复中的应用（附128例报告）

目的：探讨镍钛记忆合金尿道支架管在尿道下裂修复中的优点及应用前景。方法：2007年1月～2010年6月应用镍钛记忆合金尿道支架管作为尿道支架修复128例尿道下裂患者,均为一期尿道重建。结果：术后1～3个月自行脱落或拔除尿道支架,所有患者随访6～24个月,7例出现尿瘘,1例术后发生尿道狭窄,其余均获成功,手术成功率为93．75％（120／128）。结论：镍钛记忆合金尿道支架管可有效预防尿道下裂术后尿瘘及尿道狭窄的发生。     

Tubularized incised-plate urethroplasty for secondary hypospadias surgery

PURPOSE: Reoperation for failed hypospadias has been considered to be seriously bothersome because abundant penile skin does not tend to remain for urethroplasty or for penile shaft skin coverage. In this study, the tubularization of incised urethral plate was employed for those who had no excessive penile skin after failure of hypospadias repair. METHODS: Five patients with hypospadias underwent tubularized incised-plate urethroplasty as salvage surgery. The surgical techniques necessary for the performance of the reoperation were not different from those for the primary repair. The urethral plate was incised sufficiently deeply in its midline from the tip of the glans to the regressed meatus. The incised urethral plate was tubularized without tension over a catheter of an appropriate size. RESULTS: Four of those who underwent secondary tubularized incised-plate urethroplasty were successfully repaired without complications. A urethrocutaneous fistula occurred at the corona in the remaining patient. CONCLUSIONS: The absence of preputial skin in reoperative cases makes tubularized incised-plate urethroplasty the ideal option, although the series was small and postoperative duration is still short. In addition, this procedure can give excellent functional and cosmetic results even in patients who require revisional hypospadias surgery.     

自制尿道引流管在尿道下裂手术中的应用

目的观察自制尿道引流管在尿道下裂手术中的应用效果,探讨尿道下裂术后合适的引流方法。方法2001年1月至2006年1月,应用自制尿道引流管联合Foley导尿管引流修复74例尿道下裂,其中远端型尿道下裂(阴茎头、冠状沟、阴茎前1/3)22例,中段尿道下裂(阴茎中1/3)28例,近端型尿道下裂(阴茎阴囊交界、阴囊、会阴)10例,行一期尿道重建;尿道下裂术后尿道狭窄5例,尿道下裂术后尿瘘9例,行再次手术。结果74例患者术后获随访4个月~4年,3例拔导尿管后出现尿瘘,3例术后出现尿道狭窄,其中5例均已获二期手术治愈。其余67例一期治愈,无尿瘘和尿道狭窄发生。结论尿道引流管和Foley导尿管联合经尿道引流是一种尿道下裂术后有效、可行的引流方法。     

Results of closure of urethrocutaneous fistulas in children

We reviewed 34 patients undergoing repair of urethrocutaneous fistulas. In 85 per cent of the cases fistulas occurred after hypospadias repair. Midshaft fistulas were closed successfully using a multilayered de-epithelialized "pants over vest" technique. Of 19 cases with midshaft fistulas closed by this method there were no recurrences and 13 (68 per cent) were performed as nondiverted outpatient procedures. Eleven coronal fistulas were repaired by a skin advancement technique that was successful in 10. Of these 11 procedures 10 were done on an outpatient basis without diversion. Most urethrocutaneous fistulas can be closed successfully without urinary diversion on an outpatient basis.     

口腔内黏膜尿道成形治疗前尿道狭窄10年经验总结

目的 探讨口腔内黏膜尿道成形治疗尿道狭窄的长期效果. 方法 2001年1月至2010年12月,应用口腔内黏膜(颊黏膜和舌黏膜)尿道成形治疗前尿道狭窄255例.尿道狭窄段长度3 ～18 cm,平均6 cm.尿道成形采用保留原尿道板的扩大尿道成形术或埋藏黏膜条背侧替代尿道成形术.对49例尿道狭窄段≥8 cm者采取双侧颊黏膜拼接、颊粘膜与舌黏膜拼接或双侧连续长条舌黏膜尿道成形. 结果 术后随访8 ～120个月,平均37个月.230例患者排尿通畅,尿线粗,最大尿流率为16～51 ml/s,平均26 ml/s.尿道造影显示重建段尿道管腔通畅.总成功率90.2％.25例患者于术后1年内发生并发症,其中尿道再次狭窄17例,尿道皮肤瘘8例.17例尿道再狭窄患者中15例再次行口腔内黏膜尿道成形,2例吻合口狭窄行尿道内切开,术后排尿通畅;8例尿道皮肤瘘均接受尿瘘修补术后治愈. 结论 口腔颊黏膜和舌黏膜均是良好的尿道替代物,舌黏膜取材较颊黏膜更为便利;口腔内多种黏膜的组合移植重建尿道是治疗长段前尿道狭窄( ≥8 cm)的有效方法.     

Treatment of complex hypospadias by the Snodgrass technique]

PURPOSE: Successful use of the Snodgrass modification of Tiersch-Duplay urethroplasty for repair of distal hypospadias has been reported. Given the features of the repair: technical simplicity, preservation of the urethral plate, single suture line in the urethroplasty and no need for vascularized pedicle graft, we felt that the technique could be applied to the treatment of proximal hypospadias. METHODS: A retrospective review of the records of 35 patients with either midshaft or penoscrotal hypospadias who underwent a Snodgrass type of hypospadias repair was carried out. Age at surgery was 3 to 54 months (mean age: 8.4 months). No patients with significant chordee were included. All patients had indwelling urethral stents for 5 to 7 days postoperatively. Follow-up ranged from 6 months to 3 years. RESULTS: There were no immediate postoperative complications. Four patients experienced a urethrocutaneous fistula in association with meatal stenosis. After meatal dilatation, 2 of these fistulae closed spontaneously for an overall fistula rate of 5.7%. The overall cosmetic result of the glans and urethral meatus was noted to be excellent. Urinary stream was normal in all cases. CONCLUSION: Our results indicate that the Snodgrass modification of Tiersch-Duplay hypospadias repair provides satisfactory cosmetic and functional results in the treatment of proximal hypospadias with a low surgical complication rate. In young patients, it is our procedure of choice for penile and penoscrotal hypospadias without major degrees of chordee.     

保留尿道板手术修复尿道下裂术后尿瘘

目的 总结保留尿道板手术修复尿道下裂术后尿瘘的l临床经验.方法 尿道下裂术后尿瘘患儿224例.患儿术后时间均>6个月,尿瘘瘘口直径>1.0 cm.应用尿道板切开卷管尿道成形术(Snodgrass)102例,年龄2～16岁,平均3.7岁;Duplay尿道成形手术86例,年龄2～14岁,平均3.5岁;Onlay岛状包皮瓣尿道成形术修复20例;尿道口基底皮瓣法(Flip-Flap)修复16例.结果 224例术后随访均≥6个月.Snodgrass手术102例,成功86例(84.3%),发生尿道狭窄3例,尿瘘复发13例;Duplay手术86例,成功75例(87.2%),发生尿道狭窄2例,尿瘘复发9例.2组手术疗效比较差异无统计学意义(P>0.05).Onlay手术20例,成功19例,尿瘘复发1例.Flip-Flap手术16例,成功14例,尿瘘复发2例.结论 尿道下裂术后尿瘘修补方法应根据患儿的具体条件选择.Snodgrass尿道成形术成功率与Duplay手术相当,可以更多应用,保证阴茎外观满意.     

Folding and everting distal end of graft flap to reduce orifice stenosis following onlay urethroplasty

Aim: Orifice stenosis remained to be a common complication of hypospadias repair. We had modified the preputial island flap urethroplasty by folding and everting the distal end of the pedicle graft flap to prevent the neo-orifice from stenosis. Methods: Sixteen patients had undergone hypospadias repair using a modified onlay island flap technique. A urethral catheter was retained for 8 days to 10 days after operation. Results: Satisfactory results were seen in all the patients with a cosmetically fine appearance. One patient had a urinary tract infection and another,urethrocutaneous fistula and both were amply treated. No glanular adhesion or stenosis occurred. A long-term follow up of 6 months to 4 years (mean: 2 years) in 15 patients did not find any complication. Conclusion: The modified preputial island flap urethroplasty technique is an easy, reliable and effective approach to reduce orifice stenosis in hypospadias repair. ( Asian J Androl 2003 Jun; 5:159-161 )     

保留尿道板一期尿道成形治疗尿道下裂

目的：探讨尿道板在尿道成形术中的应用价值。方法：对31例尿道下裂患儿施行保留尿道板一期尿道成形术。术式主要有Mathieu术(14例)、Onlay island flap术(7例)和Snodgrass术(10例)。31例均为阴茎体型尿道下裂。表现为阴茎轻度下弯,其中7例为第一次尿道成形术失败者。结果：总成功率为90．3％。术后2例出现尿漏,1例出现尿道狭窄。全部病例随访3～12个月,阴茎外观均接近正常,无下弯。尿道开口于阴茎头部,排尿通畅。结论：保留尿道板成形手术操作相对简单,易掌握,成功率高,适用于阴茎体型及阴茎下弯较轻的尿道下裂患者,对于尿道成形失败者也是一种非常有效的治疗方法。     

切开尿道板管状成形术治疗尿道下裂35例报告

目的 :探讨切开尿道板管状成形术治疗小儿尿道下裂的临床效果。　方法 :尿道下裂患者 35例 ,年龄 1～12岁 ,均属阴茎型尿道下裂 ,其中 ,阴茎头型 5例、阴茎体型 2 7例、阴茎阴囊型 3例。采用正中切开尿道板 ,应用手术放大镜进行显微外科技术缝合 ,管状尿道成形术一期修复尿道下裂。　结果 :本组 35例患者 ,一次性治愈 30例 ,术后出现尿瘘 2例 ,尿道口狭窄 3例 ;随访 1～ 5年 ,32例无排尿异常。　结论 :尿道板接近正常尿道粘膜 ,血运丰富、伸延性好 ,切开尿道板管状成形术是一期修复阴茎型尿道下裂比较理想的术式。     

Management of urethrocutaneous fistula after hypospadias repair: 10 years' experience.

OBJECTIVES: To report the outcome of managing urethrocutaneous fistula after hypospadias repair over 10 years. PATIENTS AND METHODS: Forty-seven patients (mean age 7.6 years, range 2-18) underwent repair of 57 urethrocutaneous fistulae after hypospadias surgery. The fistula was single in 37 patients and multiple in 10; 42 fistulae were small (< 4 mm) and 15 large (> 4 mm). Twenty-one fistulae were at the corona, 15 at the anterior shaft, 16 at the mid-shaft and five were penoscrotal. The interval between primary hypospadias repair and the first attempt at fistula repair was 6-12 months. Small fistulae were repaired using a multilayer simple closure technique, and large fistulae repaired using rotational and advancement skin flaps. Suprapubic urinary diversion was used in all patients with large fistulae or small multiple fistulae (25 patients); an overnight urethral catheter was used in the remaining patients. RESULTS: Simple closure was successful in 30 of 42 small fistulae (71%); eight were successfully closed by secondary closure, while four needed a third closure. Rotational and advancement skin flaps were successful in 13 of 15 large fistulae; one required secondary flap repair and one was closed simply. Most recurrences (78%) were of coronal fistulae; there was recurrence in four of 25 (16%) patients in whom suprapubic diversion was used, in contrast to 10 of 22 (45%) with no suprapubic diversion. CONCLUSIONS: Although simple closure of a fistula is easy and not time-consuming it is followed by a significantly higher rate of recurrence than when skin flaps are used. Rotational and advancement flaps are the optimal methods for repairing fistulae after hypospadias, particularly for large and coronal fistulae. Thus, the appropriate indication for simple closure is small fistulae at the penile shaft. Suprapubic diversion is important in those with large or multiple fistulae.