漫话信息疗法

信息疗法这个概念,是在研究气功运气疗法时所提出,它的内容包括针灸、气功和按摩等疗法。信息疗法是借助很少量的物质或能量(作为载体),用以向人体内输入适当的信息,从而启动人体内部的自我调节系统(自我控制系统),使疾病所造成的失衡状态得到纠正。它是一种非特异性疗法,很少引起不良反应;此外,它和药物疗法、物理疗法等没有拮抗作用。有人多年来采用这种方法治疗高血压,神经官能症、胃下垂、脑震荡后遗症,慢性气管炎、甲亢、急性肾炎和慢性肾炎等确有良效。     

心理疗法治原发性高血压

目前,应用于原发性高血压病的心理疗法有生物反馈疗法、音乐疗法和催眠疗法等。 生物反馈疗法就是利用仪器将体内某些生物学信息(如肌电、皮肤温度、皮肤电阻、心率、血压、脑电等)加以处理,以视觉或听觉方式呈现给患者,通过训练他们认识这些信号,学会有意识地控制自身的心理和生理活动,达到调整机体功能、防病治病的目的。生物     

九味镇心颗粒联合脑电生物反馈疗法治疗广泛性焦虑障碍的对照研究

目的:比较九味镇心颗粒联合脑电生物反馈疗法与单一的脑电生物反馈疗法治疗广泛性焦虑障碍(GAD)的临床疗效.方法:78例GAD患者随机分为两组,研究组40例予九味镇心颗粒6 g,po,tid,同时联合脑电生物反馈疗法治疗;对照组38例予单一的脑电生物反馈疗法治疗.疗程均为6周.采用汉密尔顿焦虑(HAMA)、焦虑自评量表(SAS)、临床总体印象-疗效总评量表(CGI-GI)、药物不良反应量表(TESS)评定治疗效果.结果:研究组总有效率为90.0％,对照组总有效率为68.4％,两组疗效差异有统计学意义(P＜0.01);研究组在治疗的2,4,6周末,HAMA减分率均高于对照组(P＜0.01).结论:九味镇心颗粒联合脑电生物反馈疗法治疗广泛性焦虑障碍较单一的脑电生物反馈疗法具有更好的疗效,起效较对照组快,不良反应轻微,易耐受,依从性好.     

奥拉西坦联合肌电生物反馈疗法治疗血管性痴呆疗效观察

目的:探讨奥拉西坦联合肌电生物反馈疗法治疗血管性痴呆(VD)的临床效果。方法:随机将2017年1月~2017年6月某院收治的104例VD患者随机分为A、B两组(A=52,B=52)。两组患者均给予奥拉西坦治疗,B组加用肌电生物反馈疗法,对比两组患者治疗前后MMSE、ADL和SF-36评分。结果:治疗后B组患者MMS、ADL和SF-36评分均高于A组(P<0.05)。结论:奥拉西坦联合肌电生物反馈疗法治疗可有效改善VD智力水平、自主生活能力和生活质量,具有较高的临床推广价值。     

针刺配合肌电生物反馈疗法治疗脑卒中后肢体功能障碍

目的观察近年来针刺配合肌电生物反馈疗法治疗脑卒中后肢体障碍的临床疗效。方法选取在我院接受治疗的84例患有脑卒中后肢体功能障碍的患者进行回顾性探讨。随机的分为三组即针刺组(A组)和肌电生物反馈疗法组(B组)和针刺加肌电生物反馈疗法组(C组),每组都要接受神经内科的常规治疗。治疗5周后观察患者的恢复状况,与5周之前的病情进行比较。结果三组经过治疗之后的有效率分别为70.47%、72.29%、97.47%。治疗的总有效率相比较有显著性差异(P<0.05)。针刺配合肌电生物反馈疗法疗效明显优于其他两组。结论针刺配合肌电生物反馈疗法治疗脑卒中后肢体功能障碍效果明显,可在临床上广泛推广。     

171例皮温生物反馈效果的观察

皮温(皮肤温度)反馈属生物反馈(亦称心理反馈),皮温的变化受环境温度,精神因素等的影响,但这些原因引起的皮温变化往往不被人所意识到。可是人能不能有意识地控制自己的皮温呢?皮温属于植物性机能,如果人能通过意识的反作用,在一定程度上控制皮温,那么将会对康复医学生物反馈方面的研究提供重要的材料。皮温反馈属生物反馈(亦控称心理反馈)。我们对50名正常人,21名练气功者,110名植物性神经功能紊乱而引起的神经血管性头疼患者进行了皮温反馈的训练。     

电刺激生物反馈疗法在盆底功能障碍患者中的疗效观察

目的探讨电刺激生物反馈疗法对盆底功能障碍(pelvic floor dysfunction,PFD)患者的治疗效果。方法选取2015年9月至2017年3月在葫芦岛市妇婴医院分娩的179例产后患有盆底功能障碍的患者,随机分为对照组(89例)和观察组(90例)。对照组患者予以常规盆底肌锻炼(pelvic floor muscle exercises,PFME);观察组患者在对照组的基础上予以电刺激生物反馈疗法。治疗后随访进行问卷调查,检测其盆底肌收缩力,尿失禁比率和生活质量。结果治疗后,观察组患者与对照组相比,其盆底肌力显著增强,尿失禁比率显著下降,同时生活质量评分显著增高,存在明显统计学差异(P<0.05)。结论电刺激生物反馈疗法对盆底功能障碍患者具有良好的治疗效果,有效提高患者的生活质量。     

治肿瘤:提倡“营造心理环境”——AFR脑电反馈肿瘤治疗仪开拓肿瘤治疗新思路

医学界普遍认为:绝大多数肿瘤患者因消极情绪延迟了疾病的治疗。针对肿瘤疾病,营造一个积极、健康的心理环境是治疗的第一前提。AFR 脑电反馈肿瘤治疗仪,首次将生物反馈疗法与音乐放松想像疗法有效结合,为肿瘤的治疗提供了一条新思路。     

生物反馈技术对孕期高血压疾病和分娩的影响

目的了解心理学的生物反馈技术对孕妇高血压疾病的影响。方法围生期管理的孕妇用SCL-90焦虑自评量表筛选出有焦虑、抑郁者200例,随机分为实验组和对照组,各100例。对实验组进行心理疏导和生物反馈疗法。结果两组血压随着产程进展对照组血压增变幅度较实验组大,且实验组顺产率显著高于对照组(P<0.05)。结论焦虑症状随着孕程进展明显加重,生物反馈疗法可以明显缓解孕妇焦虑心理引起的血压变化,从而减少孕妇用药的危险因素,降低了剖宫产率。     

丁苯酞联合肌电生物反馈技术对急性脑梗死患者疗效及血清超敏C-反应蛋白水平的影响

目的 观察丁苯酞联合肌电生物反馈技术对急性脑梗死的疗效及对超敏C-反应蛋白水平的影响.方法 选取急性脑梗死患者90例,按随机数字表法随机分为对照组、肌电反馈组和丁苯酞联合肌电反馈组(联合组),对照组给予抗血小板聚集、调脂稳定斑块、改善脑供血等常规药物治疗2周,肌电反馈组在对照组基础上加用肌电生物反馈促进偏瘫侧肢体功能恢复.联合组在肌电反馈组治疗基础上加用丁苯酞注射液,静脉点滴2周,并于治疗前后进行NIHSS评分、日常生活能力的Barthel评分并观察不良反应及治疗的有效率,测定治疗前后3组患者超敏C-反应蛋白水平.结果 治疗后对照组、肌电反馈组、联合治疗组总有效率分别为60％、80％、96.67％,3组总有效率比较差异有统计学意义(P<0.05).3组患者治疗前NIHSS评分、日常生活能力Barthel评分差异无统计学意义(P>0.05),治疗14 d后2组患者各项评分均有所改善(P<0.05),且联合组优于对照组及肌电反馈组(P<0.05).超敏C-反应蛋白水平在3组患者治疗前后均有下降,且联合组优于对照组及肌电反馈组.结论 应用丁苯酞结合肌电生物反馈疗法能更有效改善患者神经功能缺损症状,减轻脑梗死患者炎性反应,促进患者偏瘫肢体功能恢复,且联合治疗不良反应少,安全有效.     

试论气功入静状态下的意念导入性心理治疗

目的介绍一种适合中国文化背景和心理特点,并具有中医特色的心理治疗技术——气功入静状态下的意念导入性心理治疗。方法以临床治疗经验为基础,介绍有关气功入静状态下的意念导入性心理治疗的技术特点及操作方法。结果气功入静状态下的意念导入性心理治疗是中医系统心理疗法(SPT)技术体系的核心技术,经过二十多年的经验积累与创新,已逐步规范,趋于成熟。结论气功入静状态下的导入性心理治疗技术是中医心理学与现代临床心理学相结合的治疗方式,有较高的临床价值,值得进一步研究和规范。     

皮温生物反馈对偏头痛疗效-Meta分析

目的系统评价皮温生物反馈对偏头痛的疗效。方法运用Cochrane系统评价方法,检索PubMed和CNKI数据库,筛选皮温生物反馈治疗偏头痛的随机对照试验(RCT),计算头痛发作频率的效应值,应用RevMan5.1软件进行合并分析。结果共初检出102篇文献,经筛选最终纳入25项研究进行分析,共297例患者。Meta分析结果显示,皮温生物反馈组的结局效应值大于对照组,差异有统计学意义(Z=8.76,P<0.01)。结论皮温生物反馈疗法对预防(或治疗)偏头痛可能有效。但由于本系统评价纳入的随机对照试验数目不多,有必要开展更多设计严谨,大样本、多中心的随机对照试验来确证这种趋势。     

气功对心血管机能的双向性调节

我们系统地观察了气功对人体神经、内分泌、血液、循环、呼吸、消化、排泄、体温、生殖和分析器等十大系统的影响,其中气功对心血管机能的调节较为明显。从150人次练功者和动物接受外气所获得的结果,均说明自身练功或气功外气对心血管机能有良好的双向性调节作用。 1 方法 1.1 人体实验;将练功者分成三个组(血压正常组、高血压患者组和血压偏低     

Characterization of Temperature Profiles in Skin and Transdermal Delivery System When Exposed to Temperature Gradients <Emphasis Type="BoldItalic">In Vivo</Emphasis> and <Emphasis Type="BoldItalic">In Vitro</Emphasis>

Purpose

Performance of a transdermal delivery system (TDS) can be affected by exposure to elevated temperature, which can lead to unintended safety issues. This study investigated TDS and skin temperatures and their relationship in vivo, characterized the effective thermal resistance of skin, and identified the in vitro diffusion cell conditions that would correlate with in vivo observations.

Methods

Experiments were performed in humans and in Franz diffusion cells with human cadaver skin to record skin and TDS temperatures at room temperature and with exposure to a heat flux. Skin temperatures were regulated with two methods: a heating lamp in vivo and in vitro, or thermostatic control of the receiver chamber in vitro.

Results

In vivo basal skin temperatures beneath TDS at different anatomical sites were not statistically different. The maximum tolerable skin surface temperature was approximately 42–43°C in vivo. The temperature difference between skin surface and TDS surface increased with increasing temperature, or with increasing TDS thermal resistance in vivo and in vitro.

Conclusions

Based on the effective thermal resistance of skin in vivo and in vitro, the heating lamp method is an adequate in vitro method. However, the in vitro-in vivo correlation of temperature could be affected by the thermal boundary layer in the receiver chamber.

     

Paclitaxel/tetrandrine coloaded nanoparticles effectively promote the apoptosis of gastric cancer cells based on "oxidation therapy"

Paclitaxel (Ptx) has demonstrated encouraging activity in the treatment of gastric cancer. Development of drug-containing biodegradable polymeric nanoparticles (np) becomes one of the solutions to relieve side effects of Ptx. However, Ptx-loaded nanoparticles prepared by the nanoprecipitation method are unstable in the aqueous phase. Here we report that tetrandrine (Tet) effectively increases the stability of Ptx-loaded nanoparticles when Tet is coencapsulated with Ptx into mPEG-PCL nanoparticles. The current study demonstrates the synergistic antitumor effect of Tet and Ptx against gastric cancer cells, which provides the basis of coadministration of Tet and Ptx by nanoparticles. It is reported that the cellular chemoresistance to Ptx correlates with intracellular antioxidant capacity and the depletion of cellular antioxidant capacity could enhance the cytotoxicity of Ptx. Tet effectively induces intracellular ROS production. Therefore, the present study provides a promising novel therapeutic strategy basing on "oxidation therapy" that it could amplify the antitumor effect of paclitaxel by employing Tet as a pro-oxidant. More intracellular Tet accumulation by endocytosis of Ptx/Tet-np than equivalent doses of free drug leads to more intracellular ROS induction, which could efficiently enhance the cytotoxicity of Ptx by sequential inhibition of ROS-dependent Akt pathway and activation of apoptotic pathways, all of which would mediate the superior cytotoxicity of Ptx/Tet-np over free drug. The present results suggest that the codelivery of Ptx and Tet by nanoparticles provides a novel therapeutic strategy basing on "oxidation therapy" against gastric cancer.     

抗病毒治疗联合海带湿敷对急性肿胀腮腺炎患者临床疗效的影响

目的探讨抗病毒治疗联合海带湿外敷对急性肿胀腮腺炎患者临床疗效的影响。方法将120例急性肿胀腮腺炎患者随机分为观察组和对照组,每组各60例。对照组接受标准抗病毒治疗及护理,观察组在此基础上予以海带外敷局部理疗,每日4次,每次60min。观察并记录2组腮腺局部皮温、疼痛强度、并发症发生率、治疗效果及时间。结果 2组患者治疗5d后,在局部皮温、疼痛视觉模拟评分(VAS)数字评分、治疗有效率、满意度及出院时间等方面比较,差异具有统计学意义(均P<0.05);而并发症发生率差异则无统计学意义(P>0.05),观察组治疗有效率、满意度均高于对照组,且治愈时间则低于对照组。结论抗病毒治疗联合海带湿外敷可减轻急性肿胀腮腺炎患者局部疼痛、降低腮腺处皮温、缩短住院时间及提高患者舒适满意度。     

Delivery of theophylline into excised human skin from alkanoic acid solutions: a "push-pull" mechanism

Human skin samples are permeable to theophylline delivered from 1.5% solutions in various alkanecarboxylic acids and their mixtures. The respective permeability coefficients of theophylline, calculated from steady-state flux, correlate negatively with the permeability coefficients of the donor carboxylic acids and positively with the excess free energy of theophylline in the donor phase, or "push" effect. An exception is propionic acid which enhances the penetration of theophylline by promoting its solubility in the skin-propionic acid medium through the "pull" effect. The two effects operate jointly in the delivery of theophylline from a mixture of propionic and a higher acid such as lauric, resulting in a much higher flux than expected from theory. The "push" effect can be estimated from the solubility parameters of theophylline and those of the holding phases even though regular solution behavior is not strictly obeyed. The increase in the permeability coefficient with partial molal volume of theophylline in the donor phase seems to reach an upper limit or decrease beyond 119 cm3.mol-1.     

糖尿病足坏疽合并下肢动脉硬化闭塞症介入治疗适应证的选择

目的探讨糖尿病足坏疽合并下肢动脉硬化闭塞症的患者,根据其下肢动脉闭塞的程度选择介入治疗的适应证。方法对糖尿病合并下肢动脉硬化闭塞症患者90例,102条肢体行下肢动脉内介入治疗,根据术中、术后1、3、6个月动脉血管的再通情况,回顾性分析下肢动脉狭窄、闭塞的程度、部位、分级、临床症状对介入治疗效果的影响及预后的关系。结果90例102条患肢术中下肢动脉通畅率达90.2%（92/102）;术后1个月以及术后3个月测定的下肢动脉磁共振血管造影（MRA）、超声、踝/肱指数（AB I）、下肢皮肤温度以及肢体凉、麻、痛、皮肤苍白或发绀的缺血状况较术前有不同程度改善,足伤口愈合时间缩短。结论糖尿病足坏疽合并下肢动脉硬化闭塞症的患者行介入治疗时,合理的选择适应证,对能否再通动脉血管、维持时间的长短以及糖尿病足的预后至关重要。     

Reductions in and relations between "craving" and drinking in a prospective, open-label trial of ondansetron in adolescents with alcohol dependence

Recently, we reported that ondansetron (a 5-HT3 antagonist) as an adjunct to cognitive behavioral therapy (CBT) produced significant within-group decreases (improvement) in drinking in adolescents with alcohol dependence. We previously have hypothesized that the mechanism of ondansetron treatment response in adolescents with alcohol dependence should be similar to early onset adult alcoholics, wherein blockade of serotonin-3 receptors may decrease dopamine release and subsequent alcohol consumption and craving. We now suggest that one mechanism by which ondansetron diminishes drinking in adolescents with alcohol dependence is through a reduction in "craving" as measured by the Adolescent Obsessive-Compulsive Drinking Scale (A-OCDS). We conducted an 8-week, prospective, open-label study of ondansetron (4 microg/kg b.i.d.) in 12 adolescents (age 14-20 years) who had alcohol dependence. Results showed that "irresistibility" and total scores as measured by the A-OCDS were correlated significantly with drinking indices (drinks/day, percent days abstinent) at the end of treatment, and that "irresistibility" and total A-OCDS scores decreased significantly by the end of treatment. These preliminary results suggest that the A-OCDS can be useful as an outcome measure in clinical studies of adolescents with alcohol dependence.