阵发性房颤射频消融术后心功能的变化

目的 探讨阵发性房颤射频消融术对患者心功能的影响.方法 对150例某院行射频消融术治疗的阵发性房颤患者的手术效果进行评价,所有患者均随访12个月,根据复发情况对患者左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左室射血分数(LVEF)以及前后径、上下径、左右径、LVAmax水平进行评价.结果 所有...     

连续性干预在阵发性房颤射频消融术后患者中的应用价值

目的探究连续干预在阵发性房颤患者射频消融术后的应用效果。方法选取2016年12月～2018年6月我院收治的阵发性房颤患者74例,均行射频消融术治疗,依据入院时间顺序分为两组各37例。对照组予以常规干预,于此基础上,观察组予以连续干预。统计对比两组用药依从性、干预满意度,观察比较两组干预前后负性情绪评分:抑郁(SDS)、焦虑(SAS),观察比较干预前后生活质量评分。结果干预后,观察组SAS、SDS评分均低于对照组,差异均有统计学意义(P<0.05);观察组用药依从性高于对照组,差异有统计学意义(P<0.05);观察组干预后生活质量评分高于对照组,差异有统计学意义(P<0.05);观察组干预满意度高于对照组,差异有统计学意义(P<0.05)。结论对行射频消融术的阵发性房颤患者予以连续干预,可显著改善患者负性情绪,提高用药依从性及生活质量,且患者对干预满意度较高。     

射频消融术治疗老年阵发性房颤的疗效分析

选取2008年9月～2012年1月我院接受射频消融术治疗的阵发性房颤患者为研究对象,选取其中〉60岁患者35例为研究组,选取同期〈60岁患者33例为对照组。两组患者均采用射频消融术治疗,对比两组患者的手术时间、手术成功率及并发症发生情况。结果两组患者手术成功率、手术时间及穿刺部位血肿指标对比均无统计学意义（P〉0.05）,而两组患者的曝光时间比较,差异显著（P〈0.01）。研究组患者复发率为20.41%,对照组复发率为15.15%,差异无统计学意义（P〉0.05）。对于阵发性房颤老年患者实施射频消融术治疗安全有效,不因年龄而影响治疗效果,值得推广应用。     

射频消融术对高血压合并阵发性房颤患者 血生化和心肌标志物水平的影响

目的探讨高血压合并阵发性房颤患者射频消融术(RFCA)后血生化和心肌标志物水平的变化。方法将该院收治的128例高血压合并阵发性房颤患者按入院先后顺序随机等分为强生组和圣犹达组各64例,两组围术期血生化指标、心肌标志物、消融相关指标及安全性进行比较分析。结果两组术后1d血清C反应蛋白(CRP)、谷丙转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)水平均明显升高,差异有统计学意义(P0.05),术后7d均恢复至术前水平;强生组与圣犹达组各时间点血生化指标比较,差异无统计学意义(P0.05);两组术后1、7d血清肌酸激酶同工酶MB(CK-MB)、肌钙蛋白T(cTnT)均先上升后下降,差异有统计学意义(P0.05),血清N-末端脑钠肽前体(NT-proBNP)水平均呈下降趋势,差异有统计学意义(P0.05),强生组与圣犹达组各时间点心肌标志物比较,差异无统计学意义(P0.05);两组肺静脉隔离(PVI)成功率比较,差异无统计学意义(P0.05);强生组消融时间、手术时间均少于圣犹达组,差异有统计学意义(P0.05);两组术后均未出现严重并发症。结论 RFCA对高血压合并阵发性房颤患者安全有效,强生压力消融导管具有手术时间短、消融时间短的优势,临床中应根据患者病情和医院条件进行合理选择。     

有氧运动对阵发性房颤患者射频消融术后复发、运动功能和生活质量的影响

目的:探讨有氧运动干预对阵发性房颤患者射频消融术后复发、左心结构、运动功能及生活质量的影响。方法:收集我科行射频消融术的阵发性房颤患者122例,分为观察组60例和对照组62例,对观察组进行有氧步行运动干预,比较2组干预前后的房颤复发率、左心结构、运动功能及生活质量改善情况。结果:2组干预前后组间窦性心率人数比较均差异无统计学意义,但在术后1年时,观察组窦性心率人数比例高于对照组(P 0. 05)。观察组术后1年左心房内径(LAD)、左心室射血分数(LVEF)及左心室重量指数(LVMI)均优于对照组(均P 0. 05),6min步行试验的运动距离与对照组比较无显著性差异,但Borg呼吸困难评分低于对照组(P 0. 05);观察组术后1年除躯体疼痛外各生活质量方面评分均显著高于对照组(均P 0. 05)。结论:有氧运动可以降低阵发性房颤患者射频消融术后复发率,改善左心结构和运动耐力并提高其生活质量。     

房颤患者行射频消融术的护理

目的总结房颤患者射频消融治疗的护理经验。方法对我院27例房颤患者进行射频消融治疗,术前加强心理护理,做好手术准备工作,术中、术后密切观察,及时处理并发症。结果成功12例,有效9例,失败或需要二次手术6例。患者术前对治疗方法和相关准备有充分的了解,均能以良好的心态对待手术。结论有效的护理可减轻病人术前、术后的心理压力,同时应密切观察术中、术后并发症的发生,最大限度地减轻并发症的危害。     

房颤患者射频消融术中术后并发症护理

回顾分析14例房颤行射频消融术治疗患者在术中、术后出现并发症的观察和护理.本组出现急性心包填塞3例,麻痹性肠梗阻l例,肺静脉狭窄5例,严重皮下血肿并出血性休克1例,急性左心衰1例,心包及胸腔积液3例,除肺静脉狭窄无症状未做治疗外,其余患者经及时治疗护理均康复出院.认为在术中、术后,应严密病情观察及生命体征监测,如血压、心率、心律、呼吸变化;时刻询问患者自觉症状,是否有头晕、胸闷、胸痛、气促等.术前配血,准备心包穿刺物品、升压药、止血药等急救药品,术中一旦出现心包填塞,立即予快速补液、升压、输血、止血,严密观察病情变化,做好穿刺引流和抢救准备,观察出血是否增加等;术后出现麻痹性肠梗阻时.予禁食、胃肠减压等;术后询问患者有无胸闷、气促、咳嗽等症状,及时发现肺静脉狭窄或闭塞的发生;做好心理护理,解除患者思想顾虑.     

1例房颤射频消融术后并发气胸患者的护理

总结了1例房颤射频消融术后并发气胸患者的护理体会,主要包括急救、病情观察、胸腔闭式引流的护理和饮食护理等措施.认为细致及时的护理有助于患者早日康复.     

临床路径在房颤射频消融术患者中的应用

目的探讨临床路径在房颤射频消融术患者中的应用效果。方法根据现行的诊疗护理内容,制订房颤射频消融术的临床路径表。选择房颤射频消融术患者180例,依据患者入院顺序分成观察组和对照组。对照组患者按常规进行护理和健康教育指导。观察组患者根据临床路径表进行护理,比较两组患者的平均住院日、满意度、并发症等指标的差异。结果观察组患者平均住院日和平均住院费用明显低于对照组(P0.01),患者满意度和健康知识测评结果优于对照组(P0.01),两组术后并发症的发生率比较差异无统计学意义(P0.05)。结论推广临床路径有助于在保证护理质量的前提下,减少患者住院日和住院费用,减轻患者经济压力,提高满意度。     

二维斑点追踪成像技术评价阵发性房颤患者射频消融术前后左心房功能

目的 探讨二维斑点追踪成像技术（2D-STI）评价经导管射频消融术（RFCA）前后阵发性房颤（AF）患者左心房功能的变化。方法 对30例因阵发性AF接受RFCA治疗患者（AF组）分别于术前、术后3天、1个月及3个月行超声心动图检查,另选30名健康志愿者为对照组。常规测量左心房前后径（LAD）、二尖瓣舒张早期血流峰值流速（E峰）、二尖瓣环舒张早期速度（Em）,计算E/Em;测量左心房收缩前容积（LAV_P）、最小容积（LAV_min）和最大容积（LAV_max）,计算左心房主动排空率（LAAEF）、左心房被动排空率（LAPEF）;以2D-STI获得左心房各节段应变及应变率曲线,测量并计算左心室收缩期及左心室舒张早、晚期左心房平均峰值应变（mSs、mSe、mSa）、应变率（mSRs、mSRe、mSRa）以及左心房僵硬度（LASt）。比较RFCA前后阵发性AF患者左心房结构和功能的变化。结果 与对照组比较,AF组术前LAD、LAV_p、LAV_min、LAV_max、E/Em、LASt增大,LAPEF、LAAEF、E、Em、mSs、mSe、mSa、mSRs、mSRe、mSRa减低（P均<0.05）。AF患者RFCA术前及术后3天、1个月、3个月左心房应变参数及LASt总体差异均有统计学意义（P均<0.05）,术后3天mSs、mSe、mSa、mSRs、mSRe、mSRa较术前减低,LASt较术前增高（P均<0.05）;术后3个月mSs、mSe、mSa、mSRs、mSRe、mSRa较术前增高,LASt较术前减低（P均<0.05）;术后1个月、3个月mSs、mSe、mSa、mSRs、mSRe、mSRa较术后3天增高,LASt较术后3天减低（P均<0.05）;术后3个月mSRs较术后1个月增高（P<0.05）。结论 阵发性AF患者RFCA术后3天左心房功能下降,术后1个月辅泵功能有所改善,术后3个月左心房储备、辅泵、管道功能均明显改善。     

老年心房颤动患者左心房收缩功能及其影响因素分析

目的评价老年阵发性心房颤动患者左心房收缩功能的改变,并进一步探讨导致其改变的主要影响因素。方法应用彩色多普勒超声诊断技术,测量52例老年阵发性心房颤动患者及50例正常对照组的左心房射血力(LAEF)、左心房射血力指数(LAEFI),并进行比较;应用多因素逐步回归方法探讨阵发性心房颤动患者LAEFI改变的主要影响因素。结果阵发性心房颤动组LAEF、LAEFI均较正常对照组增大(P<0.01);Logistic回归分析显示LAE-FI改变是阵发性心房颤动的独立危险因素(P<0.01,OR:2.36);多因素逐步回归分析显示阵发性心房颤动患者LAEFI改变与收缩压(SBP)、年龄(AGE)、左室质量指数(LVMI)具有显著回归效果,回归方程为Y=-0.223+0.002325 AGE+0.0008012 SBP+0.0004265 LVMI。结论 LAEFI改变是心房颤动发作的独立危险因素;年龄、SBP、LVMI是影响阵发性心房颤动患者左心房收缩功能的重要因素。     

Echocardiographic features of patients with paroxysmal atrial fibrillation

Background. There are several risk factors for the initiation of paroxysmal atrial fibrillation (PAF) and the underlying mechanisms are multifactorial. Our study aims to explore the echocardiographic parameters that can identify in patients with PAF compared to normal subjects. Methods. Eighty consecutive patients who were with PAF detected by 24-h Holter monitoring (HM) were assigned in our study. The control group (n = 80) consisted individuals with no PAF on HM. Indication for HM was palpitations at rest. All patients underwent routine echocardiographic evaluation. Patients with aortic and mitral stenosis, hyperthyroidism, and hypothyroidism were excluded from the study. Comprehensive clinical data were collected. Results. Mean age of the patients with PAF was 63 ± 11 years and of those 42% were male subjects. There was no difference in the prevalence of hypertension in both groups. Mean left ventricular ejection fraction (LVEF) was 57 ± 15% in PAF group and 64 ± 2% in control subjects (p < 0.001). Mean values of left atrial (LA) diameter for PAF and control groups were 3.7 ± 0.6 cm vs. 3.1 ± 0.4 cm (p < 0.001), respectively. Patients with PAF had more severe valve insufficiency, higher values of mean pulmonary artery systolic pressures (PAP) (29 ± 10 mmHg vs. 25 ± 2 mmHg, respectively; p = 0.001) and deteriorated MV inflow velocities (E:A ratio 0.9 ± 0.4 vs. 1.1 ± 0.3, respectively; p = 0.008) when compared to control group. In multivariate logistic regression analysis, LA diameter predicted the development of PAF after adjusted for age and gender. Conclusion. Our results indicate that LA diameter predicts the development of PAF.     

Long-term outcome of right and left atrial radiofrequency ablation in patients with persistent atrial fibrillation

OBJECTIVES: To investigate the clinical outcome of right and left atrial radiofrequency ablation after the first 12 months in patients with drug-refractory persistent atrial fibrillation (AF), and to identify predictors of long-term success. METHODS: We analyzed the clinical outcome of 74 consecutive patients with a follow-up >12 months who underwent right and left atrial ablation for persistent AF. Patients who did not present symptomatic or asymptomatic atrial tachyarrhythmias (AT) lasting >30 seconds after the first 3 months of follow-up were defined responders to pulmonary veins ablation. RESULTS: After a mean follow-up of 20.2 +/- 6.3 months (12-36), 52/74 (70%) patients were deemed responders. AT relapsed within the first 12 months in 19/74 (26%) patients (17 AF and 2 left atrial flutter). Among those patients who did not relapse within the first 12 months, only 3 patients (5%) presented AF after the first year of follow-up. At the multivariate analysis presence of early AT relapse and history of AF >7 years inversely correlated with a successful long-term clinical outcome. CONCLUSION: Right and left atrial ablation, alone or in association with antiarrhythmic drugs, prevented AT relapses in 70% of patients with drug-refractory persistent AF also after the first 12 months. Presence of AT relapse within the first 3 months and history of AF >7 years identified patients with a lower probability of successful long-term clinical outcome.     

导管射频消融术治疗阵发性心房颤动合并快慢综合征的临床效果

目的分析导管射频消融术治疗阵发性心房颤动合并快慢综合征的临床效果。方法选择2015年3月至2020年3月我院收治的58例阵发性心房颤动合并快慢综合征患者作为研究对象,采用随机数字表法将其分为参照组和导管射频消融组,各29例。参照组接受常规抗心律失常药物治疗,导管射频消融组在参照组基础上接受导管射频消融术治疗。比较两组的治疗效果。结果治疗3个月后,两组左室舒张末期内径(LVEDD)小于治疗前,平均心率(MEHR)、左室射血分数(LVEF)高于治疗前,且导管射频消融组优于参照组(P<0.05)。治疗3个月后,两组最长RR间期(MRRI)短于治疗前,左房中侧径小于治疗前,且导管射频消融组优于参照组(P<0.05)。治疗3个月后,导管射频消融组症状控制优良率为93.10%,明显高于参照组的68.97%(P<0.05)。治疗12个月后,导管射频消融组房颤复发率为3.45%,明显低于参照组的34.48%(P<0.05)。结论导管射频消融术治疗阵发性心房颤动合并快慢综合征患者效果显著,可明显改善患者的心功能指标,控制症状,降低房颤复发率,部分患者可避免起搏器植入。     

阵发性房颤复律后左心耳功能变化及其影响因素的研究

目的研究阵发性心房颤动患者自动复律后左心耳功能变化及其影响因素。方法应用经食管超声心动图检测38例阵发性房颤患者复律后当日和复律后第7天的左心耳血流最大排空速度,同时测定血浆心钠素、房颤持续时间、左房内径等其他指标,并与20例正常对照组作比较。结果阵发性房颤患者复律当日左心耳血流最大排空速度（35．95±5．48）cm／s,明显低于复律后1周时（63．03±5．64）cm／s及正常对照组（64．37±6．93）cm／s,复律后1周时与正常对照组差异无统计学意义;多因素回归分析显示房颤持续时间、心钠素是复律当13左心耳血流最大排空速度的独立影响因素。结论阵发性房颤存在左心耳功能顿抑,其严重程度同房颤持续时间及心钠素水平有关。     

实时三维超声心动图评价阵发性心房颤动患者射频消融术后右心房大小和机械功能变化

目的 应用实时三维超声心动图评价阵发性心房颤动患者射频消融术后右房大小和机械功能的变化,并探讨右房与左房大小和机械功能变化之间的相关性.方法 35例阵发性心房颤动患者接受射频消融手术.应用实时三维超声心动图、经胸超声心动图及组织多普勒超声心动图分别于术前、术后1月及术后3月测量右房收缩末期容积及面积、右房射血分数、三尖瓣舒张晚期A峰速度、组织多普勒三尖瓣环舒张晚期A'峰速度、三维右房收缩末期容积、三维右房射血分数、左房收缩末期容积及面积、左房射血分数、二尖瓣舒张晚期A峰速度、组织多普勒二尖瓣环舒张晚期A'峰速度、三维左房收缩末期容积、三维左房射血分数.结果 35例患者均成功获得满意的三维超声心动图及组织多普勒图像.左房收缩末期面积与三维左房收缩末期容积从术后1月开始即出现了明显的缩小[分别为(18.8±6.3)cm2对(21.5±6.2)cm2,(38.8±17.0)ml对(46.1±20.0)ml,均P＜0.05].心房机械功能方面,三维左房射血分数在术后1月较术前明显下降,到术后3月逐步上升接近术前水平[(41.1±13.7)%对(51.7±15.9)%,(41.1±13.7)%对(45.6±18.3)%,P＜0.05].右房的大小与机械功能的所有参数术后与术前相比差异无统计学意义.术后1月与3月时,右房容积及机械功能的变化与左房容积和机械功能的变化无明显相关性(r值分别为0.23,0.26,0.32,0.03,P＞0.05).结论 实时三维超声心动图能精确定量心房的容积和机械功能.阵发性心房颤动患者射频消融术后左房明显缩小,而右房大小及机械功能均无明显改变.

Abstract：

Objective To assess the changes of right atrial size and mechanical function after radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation using real-time threedimensional echocardiography(RT-3DE), and to study the correlation between the changes of left atrial(LA)and right atrial(RA) volume and function. Methods Thirty-five patients with paroxysmal atrial fibrillation were undergone radiofrequency catheter ablation (RFCA) successfully. Transthoracic echocardiography (TTE),tissue Doppler imaging(TDI) and RT-3DE were performed before, 1 month and 3 months after procedure respectively. Late systolic volume and area of RA and LA,ejection fraction(EF) of RA and LA,late diastolic peak velocity of mitral valve inflow, tricuspid valve inflow and late diastolic peak velocity of mitral annulus and tricuspid annulus were recorded. Results The 3DE images of all patients were satisfied.LA max area and 3DE LA max volume were significantly reduced at 1 months and 3 months after procedure compared with basic stage [ ( 18.8 ± 6.3) cm2 vs (21.5 ± 6.2) cm2 , (38.8 ± 17.0) ml vs (46.1 ± 20.0) ml,P ＜ 0.05]. 3DE LA EF also declined markedly at 1 month after RFCA, and restored at 3 months later compared with baseline [(41.1 ± 13.7) % vs (51.7 ± 15.9) %, (41.1 ± 13.7) % vs (45.6 ± 18.3) %, P ＜0.05]. The size and mechanical function of the right atrial after procedure were no obvious changes. There were no evidently correlation between the changes of LA and RA volume and function. Conclusions RT3DE can provide a precise method to quantify the value of atrial volume and function. The LA size and volume are significantly reduced after RFCA in patients with paroxysmal atrial fibrillation, however, the RA size and function are no obvious changes.     

Catheter ablation vs. amiodarone plus losartan for prevention of atrial fibrillation recurrence in patients with paroxysmal atrial fibrillation

Background  Although amiodarone plus angiotensin II receptor blockers (ARBs) and catheter ablation may improve sinus rhythm maintenance of paroxysmal atrial fibrillation (AF), their clinical efficacies have not been compared. This prospective cohort study was designed to compare clinical efficacy of catheter ablation and amiodarone plus losartan on sinus rhythm maintenance in patients with paroxysmal AF.
Materials and methods  A total of 240 patients with paroxysmal AF were assigned to four groups. CPVA group ( n =  60) was treated with circumferential pulmonary vein ablation (CPVA), SPVI group ( n  = 60) with segmental pulmonary vein isolation, AMIO group ( n  = 60) with amiodarone and AMIO + LO group ( n  = 60) with amiodarone plus losartan. The endpoint was documented recurrence of AF > 30 s by Holter or conventional 12-lead ECG in the 1-year follow-up period.
Results  During 12 months of follow-up, the primary end point was reached in 28 patients in CPVA group, 14 patients in SPVI group, 25 patients in AMIO group and 13 patients in AMIO + LO group, respectively. The sinus rhythm in SPVI and AMIO + LO group were significant higher than that in CPVA and AMIO group ( P  < 0·01 and 0·025), and no difference between CPVA and AMIO group. The maintenance rate of sinus rhythm in SPVI group was similar to that in AMIO + LO group.
Conclusions  This study demonstrates that segmental pulmonary vein isolation in preventing AF recurrence is similar to amiodarone plus losartan, but it is superior to CPVA and amiodarone alone in patients with paroxysmal AF. Larger multicentre studies are needed to confirm its long-term outcomes.     

导管射频消融治疗对心房纤颤患者左心房功能的影响

目的探讨心房纤颤射频消融术对患者左心房功能中远期的影响。方法选择2008年12月以来于我科接受房颤射频消融治疗的患者共20例,均于术前和术后6个月进行心脏超声检查,分别测定患者舒张末期左房容积、左房压和左心房射血力,比较手术前后各项指标的变化。结果与术前相比,接受房颤射频消融术后6个月,患者舒张末期左房容积显著减小(P<0.05),左房压无显著变化(P>0.05),而左心房射血力显著增加(P<0.05)。结论心房纤颤患者接受射频消融术后6个月,患者的左心房功能明显改善。