Randomized controlled trial of nocturnal splinting for active workers with symptoms of carpal tunnel syndrome

OBJECTIVES: To determine whether nocturnal splinting of workers identified through active surveillance with symptoms consistent with carpal tunnel syndrome (CTS) would improve symptoms and median nerve function as well as impact medical care. DESIGN: Randomized controlled trial. SETTING: A Midwestern auto assembly plant. PARTICIPANTS: Active workers with symptoms suggestive of CTS based on a hand diagram. INTERVENTION: The treatment group received customized wrist splints, which were worn at night for 6 weeks; the control group received ergonomic education alone. MAIN OUTCOME MEASURES: Change in wrist, hand, and/or finger discomfort, carpal tunnel symptom severity index, median sensory nerve function, and the percentage of subjects who had carpal tunnel release surgery. RESULTS: The splinted group, unlike the controls, had a significant reduction in wrist, hand, and/or finger discomfort and a similar trend in the Levine carpal tunnel symptom severity index, which was maintained at 12 months. A secondary analysis showed that more median nerve impairment at baseline was associated with less clinical improvement among controls but not among the splinted group. CONCLUSIONS: Workers identified with CTS symptoms in an active symptom surveillance tended to benefit from a 6-week nocturnal splinting trial, and the benefits were still evident at the 1-year follow-up. The splinted group improved in terms of hand discomfort regardless of the degree of median nerve impairment, whereas the controls showed improvement only among subjects with normal median nerve function. Results suggest that a short course of nocturnal splinting may reduce wrist, hand, and/or finger discomfort among active workers with symptoms consistent with CTS.     

Carpal tunnel syndrome in patients on long-term hemodialysis

Sixteen cases with carpal tunnel syndrome (CTS) were reported out of 412 patients on long-term hemodialysis due to chronic renal failure. Clinical symptoms included numbness in the area innervated by the median nerve in 100% of symptomatic hands and pain in the wrist and hand in 81%. This pain usually became severer at night and during hemodialysis. Muscle atrophy was noted in 41% of the hands. Nerve conduction studies revealed prolonged distal sensory latency, slowed sensory nerve conduction velocity across the wrist and normal distal motor latency in 18%, prolonged distal motor latency in 51% and no response in motor or sensory stimulation in 31%. Evidence of denervation on electromyography was seen in 36% of the hands. Patients were conservatively treated avoiding daily activities precipitating the condition with volar wrist splint only at night in 18% and in 90% with steroid hormone injection in the carpal tunnel. Median nerve release was performed in 18% of the hands. Amyloid deposit was demonstrated in 3 of 4 operated hands. Although the relation between long-term hemodialysis and the occurrence of the amyloid deposition in the carpal tunnel has not been established, the present data along with other recent reports strongly indicate that amyloid deposit in the carpal tunnel on hemodialysis patients could be one of the most possible cause of CTS.     

Extra-median spread of sensory symptoms in carpal tunnel syndrome suggests the presence of pain-related mechanisms

Patients with carpal tunnel syndrome (CTS) may complain of sensory symptoms outside the typical median nerve distribution. The study is aimed to understand which clinical features are associated with the extra-median distribution of symptoms in CTS. We recruited 241 consecutive CTS patients. After selection, 103 patients (165 hands) were included. The symptoms distribution was evaluated with a self-administered hand symptoms diagram. Patients underwent objective evaluation, neurographic study and a self-administered questionnaire on subjective complaints. No clinical or electrodiagnostic signs of ulnar nerve involvement were found in the 165 hands. Median distribution of symptoms was found in 60.6% of hands, glove distribution in 35.2% and ulnar distribution in 4.2%. Objective measures of median nerve lesion (tactile hypaesthesia and thenar muscles hypasthenia) and neurographic involvement were significantly more severe in median hands than in the other groups. Subjective complaints (nocturnal pain, numbness and tingling sensations) were significantly more severe in glove hands. Neurophysiological and objective measures were not correlated with subjective complaints. The severity of the objective examination and neurographic involvement and the intensity of sensory complaints appear to be independent factors that influence the symptoms distribution. Extra-median spread of sensory symptoms was associated with higher levels of pain and paresthesia. We suggest that central nervous system mechanisms of plasticity may underlie the spread of symptoms in CTS.     

Ultrasound Findings in Less Frequent Causes of Carpal Tunnel Syndrome

The most common etiology of carpal tunnel syndrome (CTS) is idiopathic. However, secondary causes of CTS should be considered when symptoms are unilateral, or electrodiagnostic studies are discrepant with the clinical presentation. Imaging of the carpal tunnel should be performed when secondary causes of CTS are suspected. An ultrasound evaluation of the carpal tunnel can assess for pathologic changes of the median nerve, detect secondary causes of CTS, and aid in surgical planning.     

Increase of vibration threshold during wrist flexion in patients with carpal tunnel syndrome

The most prominent symptoms of carpal tunnel syndrome (CTS) are sensory, with intermittent numbness, paraesthesiae and pain in the fingers innervated by the median nerve. No consistent signs are found by neurological examination, however. Conventional sensibility tests are positive in only about 50% of the cases. This applies also to quantitative tests such as measurement of the perception threshold for vibration (VT). In an attempt to find a more reliable indication and improve the diagnostic value of sensory testing, determination of VT was combined with provocation by means of wrist flexion. In a patient group with neurophysiologically verified CTS, all patients exhibited an increase to at least twice the VT value in the fingers innervated by the median nerve. No increase was seen in the little finger or in a control group of patients with digital paraesthesiae but with normal neurophysiological findings. It is concluded that VT measurements during wrist flexion can be used as a supplementary or alternative diagnostic criterion to indicate that the nerve dysfunction is located in the carpal tunnel.     

Outcome of surgical release among diabetics with carpal tunnel syndrome

OBJECTIVE: To compare the results of surgical decompression of carpal tunnel syndrome (CTS) in patients with diabetes with those of patients with idiopathic CTS. DESIGN: Prospective case series. SETTING: Ambulatory care in Italy. PARTICIPANTS: Twenty-four consecutive patients with diabetes type 1 or 2 and CTS (mean age, 66.7 y) were matched for age and sex with 72 patients (mean age, 66.2 y) with idiopathic CTS. INTERVENTIONS: All patients underwent surgical release of CTS by the mini-incision of palm technique. MAIN OUTCOME MEASURES: Clinical and electrophysiologic evaluation and patient self-administered Boston Questionnaire (BQ) for the assessment of severity of CTS symptoms and hand functional status before and 1 and 6 months after surgery. RESULTS: After surgical release, almost all patients of both groups reported an absence of pain, disappearance or reduction of paresthesia, and improvement in hand function. One month after surgery, there was a significant improvement in clinical status, BQ scores, and distal conduction velocities of the median nerve. A further improvement was evident at 6-month follow-up. There were no differences between the 2 groups in the number of surgical complications, in clinical and electrophysiologic status, or in BQ scores before and after surgery. The improvement in distal conduction velocities of the median nerve, BQ scores, and clinical and electrophysiologic status were similar in the 2 groups after surgery. CONCLUSION: Diabetes is not a risk factor for poor outcome of surgical decompression of CTS. Patients with diabetes have the same probability of positive surgical outcome as patients with idiopathic CTS.     

An unusual cause of carpal tunnel syndrome

Tuberculosis is an uncommon cause of carpal tunnel syndrome. We report a patient with systemic lupus erythematosus who developed hand numbness. Ultrasonic, operative and microbiological findings supported the diagnosis of median nerve compression secondary to a tuberculous abscess. The symptoms resolved with surgical excision and antituberculous chemotherapy.     

High-resolution ultrasonography of the carpal tunnel

Twenty-eight wrists of 25 patients with carpal tunnel syndrome (CTS) and 28 wrists of 14 normal control subjects were studied with high-frequency real-time ultrasonography. Three general findings could be observed in CTS, regardless of its cause: swelling of the median nerve at the entrance of the carpal tunnel; flattening of the median nerve in the distal carpal tunnel; and increased palmar flexion of the transverse carpal ligament. Quantitative analysis proved these findings to be significant. We conclude that high-resolution sonography is able to diagnose median nerve compression in the carpal tunnel syndrome and to detect some of its potential causes.     

A comparison of the benefits of sonography and electrophysiologic measurements as predictors of symptom severity and functional status in patients with carpal tunnel syndrome

Kaymak B, Özçakar L, Çetin A, Candan Çetin M, Ak?nc? A, Hasçelik Z. A comparison of the benefits of sonography and electrophysiologic measurements as predictors of symptom severity and functional status in patients with carpal tunnel syndrome.

Objectives

To clarify whether sonography or electrophysiologic testing is a better predictor of symptom severity and functional status in carpal tunnel syndrome (CTS) and to assess the diagnostic value of sonography in patients with idiopathic CTS.

Design

Cross-sectional.

Setting

University hospital physical medicine and rehabilitation clinic.

Participants

Thirty-four hands with CTS and 38 normative hands were evaluated.

Interventions

Not applicable.

Main Outcome Measures

The Boston Carpal Tunnel Questionnaire, which comprised symptom severity and functional status scale, was applied to CTS patients. Bilateral upper-extremity nerve conduction studies of median and ulnar nerves and sonographic imaging of the median nerve were performed in all participants. Sonographic evaluation was performed by a physician blinded to the physical and electrophysiologic findings of the subjects.

Results

Cross-sectional areas (CSAs) of the median nerve at the carpal tunnel entrance and proximal carpal tunnel were 12.5±2.6 and 10.6±2.6 versus 15.6±4.2 and 11.5±3.2 in CTS patients versus controls, respectively. Increased CSA of the median nerve at the carpal tunnel entrance (P<.002) and at the proximal carpal tunnel (P<.000) were detected in the hands with CTS. Flattening ratios did not differ in a statistically significant manner between the groups (P>.05). The best predictor of symptom severity was median nerve sensory distal latency and that of functional status was median nerve motor distal latency. The optimum cutoff value for median nerve CSA was 11.2mm² at the carpal tunnel entrance and 11.9mm² at the proximal carpal tunnel. Sensitivity, specificity, and positive and negative predictive values at the proximal carpal tunnel (88%, 66%, 71%, 80%, respectively) were higher than those at the carpal tunnel entrance (68%, 62%, 65%, 66%, respectively).

Conclusions

The best predictors of symptom severity and functional status in idiopathic CTS seem to be the electrophysiologic assessments rather than sonographic measurements. On the other hand, sonography may be helpful in the diagnosis of idiopathic CTS.     

Physical therapy intervention following surgical treatment of carpal tunnel syndrome in an individual with a history of postmastectomy lymphedema

BACKGROUND AND PURPOSE: This case report describes the physical therapy examination, intervention, and outcomes for a patient with lymphedema following breast cancer treatment who underwent carpal tunnel release. CASE DESCRIPTION: The patient was a 53-year-old woman with right upper-limb lymphedema and symptoms of carpal tunnel syndrome (CTS) in her right hand who underwent a carpal tunnel release. Management of her lymphedema included the use of general anesthesia with reduced tourniquet time in conjunction with physical therapy, which included use of compression bandaging, limb positioning, and exercise. OUTCOMES: Following surgical release, the patient's numbness and pain were alleviated. Right-hand grip strength increased following active exercise. Girth of the forearm decreased 1 to 1.5 cm at the 2 most distal measurement sites, and girth of the arm increased 1.5 to 2 cm 6 months after surgery. DISCUSSION: This case supports the option of elective hand surgery for CTS in an individual with chronic lymphedema.     

Does wrist immobilization following open carpal tunnel release improve functional outcome? A literature review

Carpal Tunnel Syndrome (CTS) is a compressive neuropathy of the median nerve in the carpal tunnel. It is the most common peripheral entrapment neuropathy. The surgical management includes dividing the flexor retinaculum to decompress the median nerve. Post-operative mobilization of the wrist is controversial. Some surgeons splint the wrist for 2–4 weeks whilst others encourage early mobilization. The literature has been inconclusive as to which method is most beneficial. The purpose of this study is to review the literature regarding the effectiveness of wrist immobilization following open carpal tunnel decompression. We reviewed all published clinical trials claiming to evaluate the mobility status following open carpal tunnel release. Studies not in the English language as well as those with small number of patients (n < 30) were excluded. There were five studies that fulfilled the eligibility criteria and were included in this review. We conclude that there is no beneficial effect from post-operative immobilization after open carpal tunnel decompression when compared to early mobilization.     

Arnold-Chiari malformation with syrinx presenting as carpal tunnel syndrome: a case report

A 26-year-old administrative assistant presented with 3 years of left-hand dysesthesia involving primarily the first 3 digits. Her symptoms increased at night and with keyboard use. Through 12 visits to primary and specialty care physicians over 3 years, she experienced minimal improvement with splints and moderate improvement with gabapentin. On presentation, careful questioning revealed an abrupt onset of symptoms 3 years previously, related to a 2-week episode of gastritis associated with recurrent emesis. Examination revealed a negative Tinel sign over the median nerve at the wrist, decreased left biceps reflex, positive Spurling test, and decreased sensation over the palmar and dorsal surfaces of the left hand in the C5-6 distribution. The atypical onset of symptoms, poor response to therapy, and physical findings suggested the possibility of a radicular or central neurologic etiology for the patient's hand numbness. Magnetic resonance imaging demonstrated a Chiari I malformation with a syrinx extending from C2 to T10, with the greatest diameter at C4. Neurosurgical decompression led to a decrease in symptoms. A meticulous history and physical examination should be performed on patients with presumed carpal tunnel syndrome with an atypical onset of symptoms or response to therapy.     

Central sensitization in carpal tunnel syndrome with extraterritorial spread of sensory symptoms

Extraterritorial spread of sensory symptoms is frequent in carpal tunnel syndrome (CTS). Animal models suggest that this phenomenon may depend on central sensitization. We sought to obtain psychophysical evidence of sensitization in CTS with extraterritorial symptoms spread. We recruited 100 unilateral CTS patients. After selection to rule out concomitant upper-limb causes of pain, 48 patients were included. The hand symptoms distribution was graded with a diagram into median and extramedian pattern. Patients were asked on proximal pain. Quantitative sensory testing (QST) was performed in the territory of injured median nerve and in extramedian territories to document signs of sensitization (hyperalgesia, allodynia, wind-up). Extramedian pattern and proximal pain were found in 33.3% and 37.5% of patients, respectively. The QST profile associated with extramedian pattern includes: (1) thermal and mechanic hyperalgesia in the territory of the injured median nerve and in those of the uninjured ulnar and radial nerves and (2) enhanced wind-up. No signs of sensitization were found in patients with the median distribution and those with proximal symptoms. Different mechanisms may underlie hand extramedian and proximal spread of symptoms, respectively. Extramedian spread of symptoms in the hand may be secondary to spinal sensitization but peripheral and supraspinal mechanisms may contribute. Proximal spread may represent referred pain. Central sensitization may be secondary to abnormal activity in the median nerve afferents or the consequence of a predisposing trait. Our data may explain the persistence of sensory symptoms after median nerve surgical release and the presence of non-anatomical sensory patterns in neuropathic pain.     

Carpal tunnel syndrome in chronic renal dialysis patients

Pain, dysesthesias, sensory changes, and weakness in hands of uremic patients receiving renal dialysis are usually attributed to peripheral neuropathy or vascular steal syndrome. Our experience suggested superimposed carpal tunnel syndrome (CTS) as an additional etiology. This premise was studied by using electromyography and standardized electrodiagnostic techniques to measure median and ulnar conduction velocities and distal motor and sensory latencies. Of 48 patients tested, 15 (31%) had symptomatic CTS, confirmed by electrodiagnosis. Seven of these patients had bilateral CTS. Twelve patients subsequently had surgical flexor retinaculum release, resulting in relief of symptoms. Thirty-seven of the 48 patients tested, including all 15 with CTS, had peripheral neuropathy. Of the patients with peripheral neuropathy, and who were on dialysis longer than 5 years, 57% also had CTS. Slowing of ulnar nerve conduction velocity across the elbow was found in 11 arms, including 3 with CTS. The high incidence of CTS in this renal dialysis population appears to be related to nerve compression secondary to a thickened transverse carpal ligament. Increasing time on dialysis was related to an increased incidence of CTS. However, the presence of forearm access (AV fistula or cannula) was not crucial to the development of CTS. CTS is treatable and should be considered in the differential diagnosis of hand and arm symptoms in chronic dialysis patients.     

Congenital carpal tunnel syndrome: case report of autosomal dominant inheritance and review of the literature

Carpal tunnel syndrome (CTS) is unusual in childhood, and familial occurrence has been reported infrequently. A case of CTS in a seven-year-old boy, associated with abnormal thickening of the transverse carpal ligament and aplasia of the median nerve distal to this ligament, is described. Clinical, electrodiagnostic, and surgical findings are presented: all were consistent with absence of the median nerve distal to the transverse carpal ligament. Family history of CTS was positive in a pattern consistent with autosomal dominant transmission in three generations. Thickening of the transverse carpal ligament has been described, although infrequently, in childhood and familial CTS. Aplasia of the median nerve distally has not been reported in association with this anatomic abnormality. Case reports of familial CTS are reviewed, and other congenital anomalies which should be considered in the differential diagnosis of CTS in children and adults are discussed.     

The lumbrical provocation test in subjects with median inclusive paresthesia.

OBJECTIVE: To investigate the value of the Lumbrical Provocation Test (LPT) in predicting carpal tunnel syndrome (CTS) among patients with symptoms suspicious for CTS. DESIGN: Prospective unigroup technique with blinded comparison of a clinical diagnostic test with 2 commonly used methods of diagnosing CTS: electrodiagnosis and a hand diagram. SETTING: Outpatient veterans referred by a heterogeneous group of specialists and generalists to a Veterans Affairs medical center electrodiagnostic laboratory. PATIENTS: Ninety-six consecutive patients who were referred to the electrodiagnostic laboratory with median inclusive paresthesia were evaluated. INTERVENTIONS: LPT: hold hand as fist for 1 minute (to evaluate changes in paresthesia); electrodiagnostic evaluations: median and ulnar mixed nerve, antidromic sensory, and motor latencies; and hand symptom diagram to describe pain. MAIN OUTCOME MEASURES: Evaluation of symptoms of paresthesia (with or without pain) inclusive of the median nerve distribution distal to the wrist. Prevalence sensitivity, specificity, and positive and negative predictive value of LPT, and electrodiagnosis, and hand diagram tests. RESULTS: Compared with the findings obtained with electrodiagnosis, the sensitivity of the LPT was.37; specificity,.71; positive predictive value,.59; and negative predictive value,.50. Compared with the findings obtained with the use of the hand diagram as a clinical measure, the sensitivity of the LPT was.43, specificity,.71, positive predictive value,.59, and negative predictive value,.56. CONCLUSION: The LPT has minimal use in predicting CTS in patients with median inclusive paresthesia compared with 2 commonly used methods of diagnosing CTS.     

高频超声对ECTR术后神经解剖学参数的动态评估价值

目的 探讨高频超声对关节镜下腕管松解术后神经解剖学参数的动态评估价值。方法 随访31例（44腕）腕管综合症患者术前3天,术后2周、4周、3月、6月、1年正中神经卡压近端水肿范围、腕管入口正中神经直径及横截面积,并根据横截面积绘制高频超声诊断腕管综合征ROC曲线。结果 术后各神经解剖学参数逐步改善,术后1个月至3个月各解剖学参数改善最明显。高频超声对CTS具有较高的诊断效能。结论 高频超声能够对关节镜下腕管松解术后神经解剖学参数进行有效地的动态评估。     

Familial carpal tunnel syndrome in three generations of a black family

This is a report of familial carpal tunnel syndrome (CTS) occurring in seven members of three generations of a black family. Two of the cases had associated flexor tendonitis with trigger finger symptoms. Twenty members of four generations had nerve conduction studies. The age of those affected by CTS ranged from 29 to 67 years of age. Two subjects to date required bilateral CTS surgical releases. The familial CTS appears to have an autosomal dominant pattern of CTS inheritance with high penetrance. This is believed to be the first report of familial CTS in a black family.     

Trigger finger at the wrist caused by an intramuscular lipoma within the carpal tunnel: A case report

BACKGROUNDTrigger finger at the wrist, which occurs with finger movement, is an uncommon presentation. Few reports describing cases of trigger finger at the wrist have been published. Thus, we present a case of an intramuscular lipoma arising from an anomalous flexor digitorum muscle belly in a 48-year-old female patient causing painful finger triggering at the wrist and carpal tunnel syndrome (CTS).CASE SUMMARYA 48-year-old woman with complaints of a catching sensation during wrist motion and a progressive tingling sensation on the palmar aspect of the right hand for approximately 2 years was referred to our hospital. Triggering of the index to middle finger was evident with a palpable and audible clunk over the carpal tunnel during passive motion. Tinel’s sign was positive over the carpal tunnel of the right wrist with a positive Phalen’s test. Nerve conduction studies of the median nerve demonstrated a right CTS. Ultrasound examination revealed a 2.5 cm × 2.0 cm subcutaneous hyperechoic mass with no obvious blood flow at the wrist of the right arm. Surgical excision of the tumor and muscle mass led to a resolution of the patient’s symptoms, and any triggering or discomfort disappeared. The patient has had no evidence of recurrence at more than 1 year of follow-up.CONCLUSIONTriggering of the fingers at the wrist is rare. It must be noted that there are many possible causes and types of triggering or clicking around the wrist. Accurate diagnosis is mandatory to avoid inaccurate treatment of patients with trigger wrist. During the diagnosis and treatment of CTS, attention should be paid to the variation of tendon tissue in the carpal tunnel, to avoid only focusing on the release of transverse carpal ligament and ignoring the removal of anomalous muscle belly.     

Lack of predictive power of the "tethered" median stress test in suspected carpal tunnel syndrome

OBJECTIVE: To investigate the value of the "tethered" median nerve stress test (TMST) in predicting electrodiagnostically confirmed carpal tunnel syndrome (CTS) in patients with symptoms suggestive of CTS. STUDY DESIGN: Blinded comparison of a clinical diagnostic test with neurophysiologic testing. SETTING: Portland (OR) Veterans Administration Medical Center Electrodiagnostic Laboratory. PATIENTS: One hundred two consecutive patients referred for symptoms suggestive of CTS. Study inclusion criteria were referral for evaluation of symptoms of paresthesia (with or without pain) inclusive of the median nerve distribution distal to the wrist. RESULTS: Fifty-seven percent of referred patients had electrodiagnostically confirmed CTS. The sensitivity of the TMST was 50%. The specificity was 59.1%. The positive predictive value was 61.7%. The negative predictive value was 47.3%. CONCLUSION: The TMST does not have utility in predicting electrodiagnostic consult results in veteran patients with symptoms suggestive of CTS.