美沙拉秦联合培菲康治疗轻中度溃疡性结肠炎的疗效分析

目的观察美沙拉秦联合培菲康治疗轻、中度溃疡性结肠炎的临床效果。方法将确诊的78例轻、中度溃疡性结肠炎患者随机分为治疗组（n=40）,采用美沙拉秦缓释颗粒每次1.0 g,每天4次,联合培菲康胶囊每次420 mg,每天3次进行治疗;对照组（n=38）美沙拉秦缓释颗粒用法同治疗组。疗程8周。观察两组治疗前后临床症状变化情况,根据结肠镜检查结果分析疗效。结果治疗组临床症状较对照组明显改善,总有效率和对照组相比差异有统计学意义。结论美沙拉秦联合培菲康治疗轻、中度溃疡性结肠炎临床疗效显著,不良反应少,较单用美沙拉秦能更好改善患者的临床症状。     

不同血液净化方式对维持性血液透析患者骨代谢的影响

 目的 探讨不同的血液净化方式对维持性血液透析患者骨代谢的影响。方法 选取维持性血液透析患者105例,随机均分成3组:血液透析组(HD),血液透析+血液透析滤过组(HF)和血液透析+血液灌流组(HP)。治疗8个月后,检测各组血Ca、P、iPTH、beta-CTX、PINP和FGF23等骨代谢相关指标。结果 与试验开始时相比,HD组的P[(2.73±0.83) vs(2.27±0.54) mmol/L]和PTH[(453.2±44.2) vs (438.7±41.0) pg/ml]水平显著升高(P<0.05),HF组的FGF23[(410.3±99.5) vs (450.7±88.6) ng/ml]水平显著下降(P<0.05),HP组PTH[(370.9±35.5) vs (458.3±49.2) pg/ml]、beta-CTX[(2.01±1.34) vs (2.74±1.26) ng/ml]和FGF23[(408.7±89.9) vs (459.9±76.1) ng/ml]水平均显著下降(P<0.05)。结论 联合血液透析滤过,尤其是联合血液灌流较单纯血液透析改善骨代谢的效果更明显。     

机器人三维靶向定位系统在CT引导下肺穿刺活检术中的应用

 目的 探讨MAXIO^TM机器人三维靶向定位系统在CT引导下肺穿刺活检术中的应用。方法 选择2017-08至09 40例经评估适合行肺穿刺活检术患者,随机分为试验组和对照组,每组20 例。试验组采用MAXIOTM机器人三维靶向定位系统在CT引导下行肺穿刺活检术,对照组采用传统格栅定位器行CT引导下穿刺活检。比较试验组与对照组平均操作时间、一次性穿刺成功率、扫描次数、并发症发生率、活检病理诊断阳性率。结果 试验组和对照组肺穿刺平均操作时间分别为(24.0±3.9)min和(27.3±4.1)min,两组比较差异无统计学意义(t=-1.91,P>0.05);试验组和对照组一次性穿刺成功率分别为75%(15/20)和25%(5/20),两组比较差异有统计学意义(χ²=8.10,P<0.05);试验组和对照组平均扫描次数分别为(4.1±0.5)次和(6.0±1.3)次,两组比较差异有统计学意义(t=-4.65,P<0.05);试验组和对照组并发症发生率分别为10%(2/20)和40%(8/20),两组比较差异有统计学意义(χ²=4.68,P<0.05);试验组和对照组活检病理诊断阳性率分别为100%(20/20)和90%(18/20),两组比较差异无统计学意义(χ²=2.05,P>0.05)。结论 MAXIO^TM机器人三维靶向定位系统在CT引导下肺穿刺活检术前较为精确地规划了穿刺路径,机械臂实时立体引导操作,一次性穿刺成功率提高,扫描次数减少,辐射剂量降低,并发症发生率低,具有较高的临床应用价值。     

富氢盐水抑制大鼠压疮深部骨骼肌NLRP3炎性小体活化

 目的 观察富氢盐水对大鼠压疮深部骨骼肌氧化应激及炎性反应的干预效果,探讨NLRP3炎性小体在其中的生物效应。方法 30只SD大鼠随机分为对照组(C)、压疮+生理盐水组(PU+S)和压疮+富氢盐水组(PU +HS)。PU+S和PU +HS组大鼠双下肢制备压疮模型。模型建立成功后,PU +HS组大鼠每日腹腔注射富氢盐水(10 ml/kg体重)1次,连续5 d。末次注射后24 h处死大鼠,检测骨骼肌MDA 、IL-1β含量、Caspase-1活性、NLRP3和ASC蛋白表达。结果 PU+HS组与PU+S组比较,MDA 、IL-1β含量和Caspase-1活性均显著降低(分别为14.92±3.11 vs 27.40 ±4.42,1.13±0.25 vs 1.42±0.35和0.69±0.18 vs 1.05±0.19,P<0.05),NLRP3和ASC蛋白表达均显著降低(分别为122.29±19.96 vs 178.49±18.62,105.33±16.67 vs 129.49±18.77,P<0.01)。结论 富氢盐水可能通过抑制氧化应激下调NLRP3炎性反应小体活化水平,进而抑制压疮诱导深部骨骼肌的炎性反应。     

糖尿病视网膜病变与超氧化物歧化酶活性值的关系

 目的 探讨糖尿病视网膜病变(diabetic retinopathy, DR)与超氧化物歧化酶(superoxide dismutase, SOD)活性值的关系。方法 选取2016-06到2018-02在眼科门诊诊断为DR的患者32例(DR组),患病时间12~25年。检测DR患者血清中SOD活性值并与10名健康人(对照组)进行比较。按国际DR分组标准,将32例DR分成背景期、轻度非增殖期与严重非增殖期,并对SOD活性值进行组间两两比较。结果 对照组血清中SOD活性值为(177.27±29.61)U/mg,DR组为(128.69±39.93)U/mg, DR组SOD活性值明显降低(P<0.01);DR背景期组为(144.68±40.05)U/mg,轻度非增殖期组为(128.41±28.01)U/mg,严重非增殖期组为(94.83±26.51)U/mg,DR背景期组和严重非增殖期组比较,差异有统计学意义(P<0.05)。结论 血清SOD活性值随DR病变的进展而逐渐降低,提示DR病变的发 生、发展与血清 SOD活性值下降有关 。     

酪酸梭菌活菌散剂在治疗新生儿高胆红素血症中的作用

目的探讨酪酸梭菌活菌散剂在治疗新生儿高胆红素血症中的作用。方法106例高胆红素血症患儿分为治疗组与对照组,治疗组56例高胆红素血症的足月新生儿在蓝光等常规治疗的基础上加酪酸梭菌活菌散剂3口服．治疗,对照组50例除未服用酪酸梭活菌散剂治疗外,其余治疗方法与治疗组相同,比较两组的胆红素下降速度。结果治疗组56例中,治疗2天及5天后胆红素水平下降明显,且无特殊并发症,住院天数缩短。治疗效果明显优于对照组。结论在常规治疗方法上加用酪酸梭菌活菌散剂治疗新生儿高胆红素血症疗效肯定,安全性较高。     

高压氧对缺氧缺血性脑损伤新生大鼠脑皮质线粒体生物合成的影响

 目的 观察高压氧对缺氧缺血性脑损伤新生大鼠脑皮质线粒体生物合成的影响及其相关信号通路。方法 新生7日龄Wistar大鼠48只随机分为假手术组(Sham,16只),HIBD模型组(HIBD,16只)和高压氧治疗HIBD组(HBO+HIBD,16只)。结扎左侧颈总动脉后暴露于92% 氮气和8%氧气缺氧环境中2 h 制备HIBD 模型。HIBD +HBO 组在缺氧缺血后给予高压氧干预,每次持续90 min,每日1次,连续7 d。末次高压氧干预后24 h,每组动物随机抽取8只处死,检测脑皮质COXⅣ、PGC-1α、Tfam和NRF1表达。剩余动物饲养至40日龄进行Morris水迷宫检测。结果 HBO+HIBD组与HIBD组比较,逃避潜伏期显著缩短[(21.49 ±3.77)s vs (42.50±6.46)s,P<0.01],穿越平台次数、COXⅣ、PGC-1α、Tfam和NRF1表达均显著升高[分别为(7.41±1.13)次 vs (5.26±0.78)次,(82.15±14.84)kPa vs (62.83±11.02)kPa,(112.19±18.41)kPa vs (67.26±10.40)kPa,(92.15±13.99)kPa vs (76.40±9.32)kPa和(72.29±12.88)kPa vs (49.28±7.14)kPa,P<0.05~0.01]。结论 高压氧可通过上调PGC-1过-NRF1/Tfam通路促进脑皮质线粒体生物合成,从而改善大鼠HIBD后空间学习记忆能力。     

理气活血滴丸对冠心病心绞痛的疗效及对患者情绪状态、血清CRP、TNF-α、IL-6水平的影响

 目的 分析理气活血滴丸对冠心病心绞痛的疗效及对患者情绪状态、血清CRP、TNF-α、IL-6水平的影响。方法 选取2014-04至2016-08收治的94例冠心病心绞痛患者,随机分成对照组和观察组,各47例。对照组患者给予常规治疗,观察组患者在此基础上辅以理气活血滴丸治疗。连续治疗4周,并随访6个月以上,对比两组临床症状改善情况、复发率、远期生活质量及治疗前后血清CRP、TNF-α、IL-6水平的差异。结果 对照组总有效率为82.98%,随访期间复发率为19.15%;观察组总有效率为97.87%,复发率为4.26%,组间差异有统计学意义(P<0.05)。治疗前两组HAMD评分、SF-36评分差异无统计学意义(P>0.05),治疗后6个月时观察组患者HAMD评分低于对照组,SF-36评分高于对照组,组间差异有统计学意义(P<0.05)。治疗前两组患者血清CRP、TNF-α、IL-6水平差异无统计学意义;治疗后观察组血清CRP、TNF-α、IL-6水平低于对照组,组间差异有统计学意义(P<0.05)。治疗期间对照组不良反应发生率为10.64%,观察组不良反应发生率为14.89%,组间差异无统计学意义。结论 采用理气活血滴丸辅助治疗冠心病心绞痛有助于减轻患者的临床症状,并改善患者的远期生活质量,降低血清炎性反应因子水平是其治疗冠心病心绞痛的作用机制之一。     

思密达联合地塞米松保留灌肠治疗溃疡性结肠炎的疗效观察

目的：对思密达联合地塞米松保留灌肠治疗溃疡性结肠炎的临床疗效进行分析探讨。方法：将活动期轻、中度溃疡性结肠炎患者82例随机分为两组,治疗组44例给予思密达6g加地塞米松5mg加入0．9％氯化钠100ml充分混匀后直肠滴入,每日2次,7天为一疗程,间隔5天行下一个疗程,连用两个疗程,同时给予口服美沙拉秦缓释颗粒1g/次,每日3次,待病情稳定后口服美沙拉秦缓释颗粒1g／次,每日一次巩固疗效。对照组38例给予口服美沙拉秦缓释颗粒1g／次,每日3次,待病情稳定后逐渐减量至治疗组剂量巩固治疗。两个疗程后,对两组患者临床疗效进行分析探讨。结果：两组经治疗后,治疗组治愈32例,有效10例,无效2例,总有效率为95％;对照组治愈13例,有效15例,无效10例,总有效率为73％。治疗组临床总有效率高于对照组,两组比较差异有统计学意义（P〈0．05）。两组患者均有上腹不适、恶心等症状,治疗组与对照组均为3例,嘱患者进食后再服药症状好转。结论：思密达联合地塞米松保留灌肠治疗溃疡性结肠炎有较好的疗效,且复发率低,不良反应轻微,是治疗轻、中度溃疡性结肠炎的首选。     

脑卒中下肢功能障碍镜像疗法和综合康复治疗疗效比较

 目的 比较镜像疗法和综合康复治疗对脑卒中患者下肢功能障碍的临床疗效。方法 选择2015-03至2016-09来秦皇岛市第一医院康复理疗科做康复治疗的脑卒中患者86例,根据excel表格随机数字表法随机分为两组:采用镜像疗法治疗组(镜像疗法组,43例)和综合康复治疗组(综合康复组,43例),共治疗4周。比较两组治疗前后FMA评分、MBI评分、神经功能损伤评分、Brunnstrom分级以及FAC分级。结果 研究结果显示,镜像疗法组治疗后FMA评分(23.46±5.09)、MBI评分(46.97±6.77)显著高于综合康复组FMA评分(18.77±4.17)、MBI评分(39.87±5.52)(P<0.05)。镜像疗法组治疗后神经功能损伤评分(9.81±2.31)显著低于综合康复组神经功能损伤评分(18.97±3.56)(P<0.05),治疗后镜像疗法组Brunnstrom分级和FAC分级显著优于综合康复组(P<0.05)。结论 镜像疗法是治疗脑卒中后下肢功能障碍的有效方法,能改善下肢运动功能及日常生活能力,提高生存质量,值得推广应用。     

The Role of Popliteal Lymph Nodes in Differentiating Rheumatoid Arthritis from Osteoarthritis by Using CE 3D-FSPGR MR Imaging: Relationship of the Inflamed Synovial Volume

Objective

We wanted to assess the role of the popliteal lymph nodes for differentiating rheumatoid arthritis (RA) from osteoarthritis (OA), and we also wanted to investigate the relationship between the popliteal lymph nodes and the inflamed synovial volume (ISV) by using contrast enhanced (CE), fat suppressed, three dimensional-fast spoiled gradient echo (3D-FSPGR) MR imaging.

Materials and Methods

Contrast enhanced 3D-FSGPR MR imaging of 94 knees (21 with RA and 73 with OA) was analyzed. A lymph node was defined as being ''observed'' if it could be seen in at least two planes of the three orthogonal reformatted planes. The number of observed lymph nodes, the mean of the smallest dimension of each lymph node and the existence of central fatty change were recorded. The OA group was graded according to the ISV calculated by a segmentation method: grade I was < 20 cm³; grade II ranged from 20 cm³ to 40 cm³; and grade III was > 40 cm³. Statistical analysis of the number and the mean size of the popliteal lymph nodes among the four groups (the RA group and the grade I-III OA groups) was performed.

Results

The prevalence of the observed popliteal lymph nodes was significantly different between all the OA groups or between the grade III OA group and the RA group (p < 0.0001, 0.0001, respectively). The popliteal lymph node was observed in 32 out of 73 OA cases, whereas it was visible in all of the 21 RA cases. The number (mean ± standard deviation) of lymph nodes in the grade I OA group, the grade II OA group, the grade III OA group and the RA group was 1.2 ± 0.4, 1.2 ± 0.4, 1.3 ± 0.5, and 2.7 ± 1.1, respectively. The mean size (mean ± standard deviation) of the lymph nodes was 3.8 ± 1.0 mm, 3.6 ± 1.1 mm, 4.1 ± 0.8 mm, and 5.4 ± 1.3 mm, respectively. The incidence of central fatty changes was significantly lower in the RA group than in all the OA groups and the grade III OA group. When differentiating RA from OA, and when the differentiation was confined to the RA group and grade III OA group, respectively, the criteria of the number of lymph nodes, their size, their central fatty change and a combination of all these three criteria showed statistical significance (Az values for the former were 0.869, 0.847, 0.776, and 0.942; Az values for the latter were 0.855, 0.799, 0.712, and 0.916). The number and mean size of the lymph nodes correlated with the ISVs (r = 0.49, p < 0.001; 0.50, 0.001, respectively).

Conclusion

The number, size and central fatty changes in the popliteal lymph nodes observed on the MR images might serve as simple and useful markers in differentiating RA disease from OA disease. These markers would be particular helpful in cases of severe synovial enhancement where the ISVs of both RA and OA overlap. The number and mean size of the lymph nodes also correlated well with the ISV.     

Changes in joint position sense after surgically treated chronic lateral ankle instability

Background: A search of the literature shows that the effect of surgery on ankle proprioception has been hardly investigated. Objective: To examine the effect of anatomical reconstruction of the anterolateral capsuloligamentous complex on ankle joint position sense. Methods: A prospective study using the "slope box" test. Ten consecutive patients were included in the study, and 10 healthy athletes represented the control group. Results: Similar test-retest reliability rates (overall reliability 0.92; p = 0.0013) were obtained to those of the original designers of the method. There were no significant differences with respect to side dominance (p = 0.9216). Investigation of the characteristics of mean absolute estimate errors showed that the controls tested became error prone in the range of slope altitudes 7.5–25° in every direction, compared with the range 0–5° (range of p values 0.00003–0.00072). The results of the intervention group showed that, for the two main directions of interest (anterior and lateral), preoperative differences in mean absolute estimate errors between injured (anterior 3.91 (2.81)°; lateral 4.06 (2.85)°) and healthy (anterior 2.94 (2.21)°, lateral 3.19 (2.64)°) sides (anterior, p = 0.0124; lateral, p = 0.0250) had disappeared (postoperative differences: anterior, p = 0.6906; lateral, p = 0.4491). The afflicted ankle had improved significantly after surgery in both important directions (anterior, p<0.0001; lateral, p = 0.0023). Conclusions: The study shows that differences in joint position sense between healthy and injured ankles disappeared as the result of surgery. Preoperative data show that proprioceptive malfunction is a cause of functional instability. If treatment is by means of surgery, the retensioning of the original anterolateral structures is inevitable, even if other grafting or surgical techniques are used.     

Comparison between CT Colonography and Double-Contrast Barium Enema for Colonic Evaluation in Patients with Renal Insufficiency

Objective

To compare the CT colonography (CTC) and double-contrast barium enema (DCBE) for colonic evaluation in patients with renal insufficiency.

Materials and Methods

Two sequential groups of consecutive patients with renal insufficiency who had a similar risk for colorectal cancer, were examined by DCBE (n = 182; mean ± SD in age, 51 ± 6.4 years) and CTC (n = 176; 50 ± 6.7 years), respectively. CTC was performed after colon cleansing with 250-mL magnesium citrate (n = 87) or 4-L polyethylene glycol (n = 89) and fecal tagging. DCBE was performed after preparation with 250-mL magnesium citrate. Patients with colonic polyps/masses of ≥ 6 mm were subsequently recommended to undergo a colonoscopy. Diagnostic yield and positive predictive value (PPV) for colonic polyps/masses, examination quality, and examination-related serum electrolyte change were retrospectively compared between the two groups.

Results

Both the CTC and DCBE were positive for colonic polyps/masses in 28 (16%) of 176 and 11 (6%) of 182 patients, respectively (p = 0.004). Among patients with positive findings, 17 CTC and six DCBE patients subsequently underwent a colonoscopy and yielded a PPV of 88% (15 of 17 patients) and 50% (3 of 6 patients), respectively (p = 0.089). Thirteen patients with adenomatous lesions were detected in the CTC group (adenocarcinoma [n = 1], advanced adenoma [n = 6], and non-advanced adenoma [n = 6]), as compared with two patients (each with adenocarcinoma and advanced adenoma) in the DCBE group (p = 0.003). Six (3%) of 176 CTC and 16 (9%) of 182 DCBE examinations deemed to be inadequate (p = 0.046). Electrolyte changes were similar in the two groups.

Conclusion

In patients with renal insufficiency, CTC has a higher diagnostic yield and a marginally higher PPV for detecting colorectal neoplasia, despite a similar diagnostic yield for adenocarcinoma, and a lower rate of inadequate examinations as compared with DCBE.     

Reversal in fatigued athletes of a defect in interferon gamma secretion after administration of Lactobacillus acidophilus

Background

Fatigue and impaired performance in athletes is well recognised and has been loosely linked to “overtraining”. Reduced concentration of IgA in the saliva and increased shedding of Epstein Barr virus (EBV) have been associated with intense training in elite athletes.

Objective

To determine whether athletes presenting with fatigue and impaired performance had an immune defect relevant to defective containment of EBV infection, and whether a probiotic preparation (Lactobacillus acidophilus) shown to enhance mucosal immunity in animal models could reverse any detected abnormality.

Results

The fatigued athletes had clinical characteristics consistent with re‐activation of EBV infection and significantly (p  =  0.02) less secretion of interferon (IFN) γ from blood CD4 positive T cells. After one month of daily capsules containing 2 × 10¹⁰ colony forming units of L acidophilus, secretion of IFNγ from T cells had increased significantly (p  =  0.01) to levels found in healthy control athletes. A significant (p  =  0.03) increase in salivary IFNγ concentrations in healthy control athletes after the one month course of L acidophilus demonstrated in man the capacity for this probiotic to enhance the mucosal IFNγ concentration.

Conclusion

This is the first evidence of a T cell defect in fatigued athletes, and of its reversal following probiotic therapy.     

Influence of vibration on delayed onset of muscle soreness following eccentric exercise

Delayed onset muscle soreness (DOMS), which may occur after eccentric exercise, may cause some reduction in ability in sport activities. For this reason, several studies have been designed on preventing and controlling DOMS. As vibration training (VT) may improve muscle performance, we designed this study to investigate the effect of VT on controlling and preventing DOMS after eccentric exercise.

Methods

Fifty healthy non‐athletic volunteers were assigned randomly into two experimental, VT (n = 25) and non‐VT (n = 25) groups. A vibrator was used to apply 50 Hz vibration on the left and right quadriceps, hamstring and calf muscles for 1 min in the VT group, while no vibration was applied in the non‐VT group. Then, both groups walked downhill on a 10° declined treadmill at a speed of 4 km/hour. The measurements included the isometric maximum voluntary contraction force (IMVC) of left and right quadriceps muscles, pressure pain threshold (PPT) 5, 10 and 15 cm above the patella and mid‐line of the calf muscles of both lower limbs before and the day after treadmill walking. After 24 hours, the serum levels of creatine‐kinase (CK), and DOMS level by visual analogue scale were measured.

Results

The results showed decreased IMVC force (P = 0.006), reduced PPT (P = 0.0001) and significantly increased mean of DOMS and CK levels in the non‐VT group, compared to the VT group (P = 0.001).

Conclusion

A comparison by experimental groups indicates that VT before eccentric exercise may prevent and control DOMS. Further studies should be undertaken to ascertain the stability and effectiveness of VT in athletics.     

The repeatability and criterion related validity of the 20 m multistage fitness test as a predictor of maximal oxygen uptake in active young men

Objective: To investigate the repeatability and criterion related validity of the 20 m multistage fitness test (MFT) for predicting maximal oxygen uptake (Vo_2max) in active young men. Methods: Data were gathered from two phases using 30 subjects (±s; age = 21.8±3.6 years, mass = 76.9±10.7 kg, stature = 1.76±0.05 m). MFT repeatability was investigated in phase 1 where 21 subjects performed the test twice. The MFT criterion validity to predict Vo_2max was investigated in phase 2 where 30 subjects performed a continuous incremental laboratory test to volitional exhaustion to determine Vo_2max and the MFT. Results: Phase 1 showed non-significant bias between the two applications of the MFT (_diff±s_diff = –0.4±1.4 ml kg^–1 min^–1; t = –1.37, p = 0.190) with 95% limits of agreement (LoA) ±2.7 ml kg^–1 min^–1 and heteroscedasticity 0.223 (p = 0.330). Log transformation of these data reduced heteroscedasticity to 0.056 (p = 0.808) with bias –0.007±0.025 (t = –1.35, p = 0.190) and LoA±0.049. Antilogs gave a mean bias on the ratio scale of 0.993 and random error (ratio limits) x/÷1.050. Phase 2 showed that the MFT significantly underpredicted Vo_2max (_diff±s_diff = 1.8±3.2 ml kg^–1 min^–1; t = 3.10, p = 0.004). LoA were ±6.3 ml kg^–1 min^–1 and heteroscedasticity 0.084 (p = 0.658). Log transformation reduced heteroscedasticity to –0.045 (p = 0.814) with LoA±0.110. The significant systematic bias was not eliminated (_diff±s_diff = 0.033±0.056; t = 3.20, p = 0.003). Antilogs gave a mean bias of 1.034 with random errorx/÷1.116. Conclusions: These findings lend support to previous investigations of the MFT by identifying that in the population assessed it provides results that are repeatable but it routinely underestimates Vo_2max when compared to laboratory determinations. Unlike previous findings, however, these results show that when applying an arguably more appropriate analysis method, the MFT does not provide valid predictions of Vo_2max.     

护理管理APP在创伤骨科围术期的应用效果

 目的 观察护理管理APP在创伤骨科围术期的应用效果。方法 选择解放军总医院骨科2016年1-5月收治的踝部骨折患者82例,随机分为试验组(应用护理管理APP,42例)和对照组(进行常规护理宣教,40例)。入院后在病情转归的各时间节点,向试验组患者移动端APP推送健康教育资料,进行护理宣教。对照组按传统围术期管理的方式给予常规护理宣教。比较两组患者出院时护理效果和依从性的差异。结果 试验组和对照组患者满意度分别为99.52%和88.43%,差异有统计学意义(t=14.127,P=0.000)。试验组和对照组患者健康教育落实评分为(18.76±1.59)分和(14.75±1.41)分,两组比较差异有统计学意义(t=12.069,P=0.000)。试验组和对照组患者依从性评分为(93.4±3.9)分和(81.8±5.9)分,两组比较差异有统计学意义(t=10.96,P=0.00)。结论 相比于传统护理宣教,通过护理管理APP平台构建的新型护患沟通模式能够有效地对患者进行围术期健康教育,增强护患沟通效果,提高患者依从性。