胸双极立体心电图对心肌缺血的定位诊断研究

胸双极立体心电图采用正交系基础上的13导联球体构型导联系统，是仅次于正交系的最简单的全方位空间框架结构，操作简便。胸双极立体心电图旨在弥补常规心电图的空间缺陷，能有效的探察右室、后壁、高侧壁、下侧壁和小范围的心肌缺血。分别用常规心电图仪和自行研制的胸双极立体心电图分析系统描记常规心电图(ECG)和立体心电图(BC-SECG)对32例心肌缺血患进行检测。结果显示，立体心电图较常规心电图对心肌缺血定位诊断更详细。     

正常人头胸导联和常规导联右胸异常Q波的比较

目的:比较常规导联心电图及头胸导联心电图所记录的正常人右胸导联Q波的特征.材料与方法:采用导联心电图机及头胸导联心电图机分别检查50个正常成人(30名男性,20名女性)的右胸心电图,记录Q波出现的频率及幅度.结果:头胸导联所记录到的Q波数及Q波幅度均显著低于常规导联心电图.结论:正常人头胸导联心电图较常规心电图较少出现右胸假性异常Q波.     

三导联重建十二导联心电图的算法研究

从三导联心电图重建为十二导联心电图,能够为动态心电图监测提供有益的辅助信息,本文从导联向量的概念出发,讨论了重建的算法,对重建结果进行了相关系数,Ｒ波幅值,ＳＴ段的分析,其中ＳＴ段的上升,下降以及起始点和终点的幅值的绝对误差一般小于５０μＶ,相对误差一般小于０．１５,重建结果在一定的程度上得可以接受的,由于不同病人的导联向量值,电极位置存在差异,这些误差有时难以避免,进一步的结论需要临床的更多的实     

肢体导联电极移位对心电图时域值及高频成分的影响

为克服肢体导联的肌电干扰，将４个肢体导联电极均移至躯干部，比较分析正常人、病人电极移位前后的常规心电图（ＥＣＧ）时域值和高频心电图（ＨＦＥＣＧ）的高频成分的改变。初步发现了既能保护各波波形方向、时程基本不变，又能有效地排除肌电干扰，幅度有所增加的躯干电极安放位置。     

15导联同步心电图数据采集的研究

本文从硬件和软件两个方面介绍了一种以微机为上位机的15导联同步心电图采集系统，将临床应用的12导联ECG和3通道VCG有机地结合在一起，同步采样，为临床心电图和向量心电图同步采集提供了新的硬件设计。     

维生素B1肌注对140例脚气病的诊治体会

脚气病的早期临床表现很难鉴别诊断及治疗。本文对140例病人用维生素B1 100mg肌注进行临床观察，确诊脚气病119例并全部治愈。其诊断方法和治疗可供临床参考。现报告如下。     

模糊推理在基于心电图ST-T的心肌缺血判别中的应用

心电图(ECG)作为检测心肌缺血的一种方便、经济、无创的工具,其临床表现主要为ST-T段改变。由于心肌缺血很多情况下是瞬时发生,并且是无症状的,此时医务人员往往无法预料而不能及时采取干预措施,若能实现计算机的自动实时监控和及时预警,在心脏疾病诊断中具有重要的意义。本文融合目前比较公认的定量判断指标,主要包括:ST段偏移量、T波峰点幅值、ST/HR值,且在医务人员的协助指导下,应用模糊推理对心肌缺血进行了判别,经MIT-BIH数据库和公共数据库(LTST)中心电数据的验证,其敏感性和阳性预测值分别达到75%和78%,特异性和阴性预测值分别达到85%和87%。该方法更接近人的思维和认识,易于临床检测和工程实现。     

医学生心电图肢体导联各波电压幅值的研究

本文对医学生心电图肢体导联中Ｐ、Ｒ、Ｓ、Ｔ波的幅值变化范围进行了研究。结果表明，医学生（年龄在１７岁～２０岁之间）心电图肢体导联各波的电压幅值同成人心电图比较有明显差别。Ｐ波幅值９５％上限在０．２３６ｍＶ～０．６４７ｍＶ之间，比成人Ｐ、Ｔ波电压幅值上限明显偏低；Ｒ、Ｓ波电压幅值平均值同成人正常值比较，经ｔ检验表明，三分之二的数值具有高度显著性（或显著性）差别。可见，医学生心电图肢体导联中人Ｐ、Ｓ、Ｔ波电压幅值范围不同于一般成年人的正常值范围。     

184例儿童简易运动试验ST-T改变的临床分析

目的分析儿童简易运动试验临床参考意义。方法固定一人对2~14岁儿科门诊和住院患儿184例常规心电图后加做简易运动试验,心率超过基础心率30%~40%时,记录即刻长Ⅱ导心电图,有ST-T改变者,继续观察持续时间。结果心肌炎、高度疑似心肌炎的患儿运动后ST-T改变率高达65.2%,心肌炎患儿运动试验ST-T改变完全恢复正常需半个月至半年不等。结论简易运动试验方便易行,安全性大,可重复性强,对心肌炎的诊断、治疗疗程、判断预后和指导患儿恢复期活动量有一定的参考价值。     

Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency

We have previously shown that a nutritional model of B vitamin deficiency and homocysteine cycle alteration could lead to increased amyloid β deposition, due to PSEN1 and BACE over-expression and consequent increase in secretase activity. We hypothesize that nutritional factors causing homocysteine cycle alterations (i.e. hyperhomocysteinemia) could induce sequence-specific DNA hypomethylation and “aberrant” gene activation.Aim of present study was to analyze the methylation pattern of PSEN1 promoter in SK-N-BE neuroblastoma cells and TgCRND8 mice, in a B vitamin (folate, B12 and B6) deficiency paradigm. PSEN1 methylation status has been evaluated through bisulphite modification and genomic sequencing. We demonstrate that B vitamin deficiency induces hypomethylation of specific CpG moieties in the 5′-flanking region; S-adenosylmethionine has been supplemented as methyl donor to reverse this effect. PSEN1 promoter methylation status is correlated with gene expression. These findings pinpoint a direct relationship between B vitamin-dependent alteration of homocysteine cycle and DNA methylation and also indicate that PSEN1 promoter is regulated by methylation of specific CpG moieties.     

Vitamin E deficiency with normal serum vitamin E concentrations in children with chronic cholestasis

We studied serum vitamin E levels and the ratio of serum vitamin E to serum lipid levels in 11 children with chronic cholestasis complicated by vitamin E deficiency, as defined by characteristic neurologic signs or sural-nerve histopathology in addition to impaired intestinal absorption of vitamin E. Eight of the children had low levels of serum vitamin E, as well as low ratios of serum vitamin E to total lipids and to cholesterol. However, three patients had normal serum vitamin E levels but low ratios of serum vitamin E to total lipids (two of the three had normal ratios of vitamin E to cholesterol). In four patients who were not vitamin E-deficient, all three values were normal. We conclude that vitamin E deficiency may exist in a child with a normal serum vitamin E concentration and that the ratio of serum vitamin E to total serum lipids is the most reliable biochemical index of vitamin E status during chronic childhood cholestasis.