Kidney carcinoma in Bourneville-Pringle disease]

We report a case of renal cell carcinoma in a 28-year-old woman with Bourneville-Pringle's disease. A review of the literature revealed 16 cases of renal cell carcinoma associated with tuberous sclerosis. The incidence of angiomyolipoma among patients with Bourneville-Pringle's disease is cited in the literature as 40-80%, but this is based solely on two early publications, while other publications suggest a considerably higher incidence of renal cell carcinoma in Bourneville-Pringle's disease, as in other phacomatoses (Hippel-Lindau's disease). We therefore recommend screening for renal cell carcinoma in patients with Bourneville-Pringle's disease.     

Follicular carcinoma in a thyroglossal duct.

The case of a 24-year-old woman with follicular carcinoma arising de novo in a thyroglossal duct is reported. A review of the literature disclosed seven case reports of thyroglossal duct carcinoma with a mixed papillary-follicular pattern. There are three criteria for the diagnosis of follicular carcinoma of a thyroglossal duct: presence of a thyroglossal duct, absence of carcinoma within the thyroid gland and angioinvasion. A plan of treatment, based on the literature survey, should include Sistrunk excision of the tumour if possible, and subtotal thyroidectomy should be performed to eliminate the presence of a primary thyroid carcinoma.     

Synchronous Squamous Cell Carcinoma of the Anorectum and Proctosigmoid—a Case Report

Primary squamous cell carcinoma of the rectum is extremely rare. Squamous cell carcinoma of the anorectum is a known entity evaluation and treatment protocols have been well defined. The occurrence of squamous cell carcinoma of rectosigmoid in concurrence with squamous cell carcinoma of the anal canal is extremely rare and the first case to be reported in the literature. A 48-year-old male patient presented with difficulty in passing stools. The clinical examination, colonoscopy, and the histopathology revealed synchronous proctosigmoid and the anorectal neoplasm. A case like this will pose a diagnostic challenges; squamous cell carcinoma of the rectum is not defined in the medical literature; synchronous squamous cell carcinoma will pose both diagnostic dilemmas and treatment challenges like whether to conserve the sphincter or not. Because squamous cell carcinoma of the anorectum can be treated by chemoradiotherapy, even this case is initially thought of treating by neoadjuvant chemoradiotherapy followed by low anterior resection followed by adjuvant treatment. Since there was no medical literature to support this treatment, ultimately multidisciplinary tumor board decision was made for abdominoperineal resection. Patient was treated with abdominoperineal resection and adjuvant chemoradiation. The diagnostic dilemmas and the management issues have been discussed.     

Apocrine carcinoma of the male breast

Apocrine carcinoma of the male breast is an extremely rare tumour. Only two cases have been published in the medical literature. There is insufficient data about clinical presentation, management and prognostic features of apocrine carcinoma in the male breast. In this study, the clinical presentation, magnetic resonance imaging and histopathological features and management of a 76‐year‐old male with apocrine carcinoma in the left breast are discussed. We present, to best of our knowledge, the third case of apocrine carcinoma of the male breast in medical literature.     

Four unusual neoplasms of the nasopharynx

Epidermoid carcinoma and angiofibroma are the commonly diagnosed lesions of the nasopharynx. Less common are unusual tumors of epithelial origin as well as those from endothelial and mesenchymal precursors. Otolaryngologists must be knowledgeable in the literature associated with these tumors to facilitate early diagnosis and to institute appropriate therapy. Cases of verrucous carcinoma, inverted papilloma, adenoid cystic carcinoma, and extramedullary plasmacytoma are presented. Current literature is reviewed and accepted modes of treatment are outlined.     

Disseminated intravascular coagulation complicating Ender's nailing of a pathologic fracture in prostatic carcinoma. A case report

Disseminated intravascular coagulation (DIC) occurred after closed Ender's pinning of a pathologic fracture of the humerus in a 58-year-old man with metastatic prostatic carcinoma. A review of the oncologic and urologic literature revealed that coagulopathy can be associated with prostatic carcinoma. This association seems not to have been previously reported in the orthopedic literature.     

Cystic adenoid cancer of the esophagus. Report of a case and review of the literature

A 59-year-old man had adenoid cystic carcinoma of the esophagus. The tumor, in the lower third of the esophagus, was resected; the patient died 7 months after surgery from widespread distant metastases. The initial diagnostic was epidermoid carcinoma on the biopsy. In the literature adenoid cystic carcinoma are frequently associated with epithelial abnormalities. Also of interest within the literature was the fact that radiotherapy and combination chemotherapy may be an effective treatment modality for this cancer.     

Multiloculated renal cell carcinoma

Multiloculated renal cell carcinoma and multilocular renal cyst with renal cell carcinoma are uncommon diseases. We report on 2 cases of multiloculated renal cell carcinoma. To our knowledge 16 cases of multiloculated renal cell carcinoma and multilocular renal cyst with renal cell carcinoma have been previously described in detail. The authors review the literature and discuss the aetiology and diagnosis of the disease.     

Hepatoid carcinoma of the pancreas

Extrahepatic hepatocellular carcinoma differentiation has been demonstrated in primary malignancies of the stomach. To date, only five cases of hepatocellular differentiation of the pancreas have been reported in the literature. An example of hepatoid carcinoma of the pancreas is reported in this study. A single case of hepatoid carcinoma of the pancreas is presented with long-term follow-up and review of the literature. This rare malignancy of the pancreas represents a hepatocytic transdifferentiation of pancreatic cells to form a combination of both primary ductal adenocarcinoma and hepatocellular differentiation.     

Long-term remission of metastatic small cell carcinoma of the prostate

Metastatic small cell carcinoma of the prostate portends a poor prognosis. Survival expectancy is generally estimated in months with few reports in the literature of patients surviving more than 2 years. We report a case of one of the longest known surviving patients in continuous complete remission with metastatic small cell carcinoma of the prostate and review the available literature reporting longer-term survival in this condition.     

An unusual case of primary small cell neuroendocrine carcinoma of the breast

Primary small cell neuroendocrine carcinoma of breast is a rare entity, with only case reports in literature. Histologically, these tumors are similar to small cell carcinoma of the lung with some evidence of ductal carcinoma-in-situ with areas of ductal, lobular, or papillary differentiation. Immunoreactivity for neuroendocrine markers is present in two thirds of cases, while 33-50% are positive for estrogen receptor or progesterone receptor. Her2/neu expression has not been reported in small cell carcinoma of the breast. Here we are presenting 53-year-old women with locally advanced primary small cell neuroendocrine carcinoma of breast. We will discuss clinicopathological findings, treatment options, prognosis and review of the literature on primary small cell carcinoma of breast.     

Trichilemmal carcinoma in an African American.

BACKGROUND: Trichilemmal carcinoma is an uncommon cutaneous neoplasm found primarily on the sun-exposed skin of the elderly. OBJECTIVE: To report a case of trichilemmal carcinoma presenting as a forehead nodule in an African American patient. METHODS: Case report and review of the literature. RESULTS: Our patient is the first reported case in the English language literature of trichilemmal carcinoma in an African American individual with skin phototype VI. CONCLUSION: The occurrence of trichilemmal carcinoma in our African American patient suggests the diagnosis of trichilemmal carcinoma be added to the differential diagnosis of a nodule on the head region in this patient population.     

A CASE OF TRANSITIONAL CELL CARCINOMA OF THE RENAL PELVIS,CLEAR CELL RENAL CARCINOMA,AND ANALGESIC NEPHROPATHY

A case of synchronous transitional cell carcinoma of the renal pelvis and clear cell renal carcinoma in a woman with analgesic nephropathy is presented. The literature is briefly reviewed.     

Carcinoma arising in fibroadenoma of the breast--a case report and review of the literature

A 47 year old woman with two isolated lumps in her right breast underwent an excisional biopsy and the histological findings of both lesions revealed fibroadenoma with an in situ lobular carcinoma. Patey's modified radical mastectomy was performed after which careful follow-up was continued. To date, a total 161 cases of carcinoma arising in a fibroadenoma have been reported in the world literature and a review of these literature is given following the case report.     

A pathologic-anatomical feature of carcinoma of large bowel in Japan

Summary The pathologic-anatomical features of large bowel carcinoma were compared between Japan and the United States in gross as well as histological type using 197 surgical specimens from western Japan during the period of 1963 through 1970. The result together with the materials collected from the literature suggested that there seemed to be definite difference in the anatomical distribution. A relatively high incidence of carcinoma of the rectum and concomitant low incidence of carcinoma of the sigmoid and descending colons in Japan was found to be the major difference when compared with the data published in the American literature. Some difference was also noted in a relatively high incidence of polypoid-type carcinoma and in a relatively low incidence of annular-type carcinoma among Japanese materials in contrast to those of American materials. The reason for these difference is not clearly understood at present and further collection of materials and pertinent data are necessary.     

Collecting duct carcinoma of the kidney: a case report and review of the literature.

Collecting duct carcinoma of the kidney is unique and rarely reported. The histological and ultrastructural characteristics of this tumor are well described in the pathological literature. However, there are few reports documenting the clinical presentation and long-term prognosis in patients with this unusual malignancy. Collecting duct carcinoma arises from the epithelium of the collecting tubules within the medulla and secondarily invades the renal cortex. The tumor occurs in a younger age group than is typical for renal cell carcinoma and most patients appear to have metastatic disease at presentation. We describe a case of this uncommon tumor and review the literature.     

Non-Functional Parathyroid Carcinoma: A Review of the Literature and Report of a Case Requiring Extensive Surgery

Parathyroid carcinoma is a rare malignancy, and only accounts for 0.5–2% of cases of primary hyperparathyroidism. Less than 10% of parathyroid carcinomas are non-functional, and as such, they have been rarely reported in the literature. Importantly, margin status at resection is related to prognosis, and only a handful of case reports of non-functional carcinoma note this important parameter. Here we report the first case of non-functional parathyroid carcinoma with negative margins, and review the literature on this rare entity. Whether functional or non-functional, parathyroid carcinoma can often be difficult to differentiate from benign parathyroid adenoma. While diagnosis has been based on clinical and histological criteria, recent data concerning the molecular underpinnings of parathyroid carcinoma may allow for improved accuracy in distinguishing benign and malignant parathyroid tumors.     

Familial polyposis coli and periampullary carcinoma.

An 80-year-old woman with periampullary carcinoma was found, at autopsy, to have polyposis coli. A brief review of the literature indicates that, although the association of Gardner's syndrome with duodenal and pancreatic carcinoma is well established, the patient described in this report is only the second with polyposis coli in whom a periampullary carcinoma developed.     

Renal carcinoma manifesting as breast mass

A patient is described who initially presented with Stage I breast carcinoma and then with a T2, N0, M0 carcinoma of a kidney with moderately well-differentiated clear-cell features. Five years later, a contralateral breast mass developed which was histologically identical with renal primary tumor. Breast metastasis from renal primary carcinoma has been noted in the literature in 6 other cases, although this is only the third actual case report. This is the first case report of such a bizarre progression of disease. This patient is currently well, without clinically detectable tumor and illustrates the variable nature of metastatic renal cancer. The literature on renal cancer metastasizing to the breast is reviewed.     

Transitional cell carcinoma of distal female urethra

A rare case of carcinoma of female urethra from transitional cell origin is reported. The occurrence of primary transitional cell carcinoma in the urethra is being discussed, with review of the literature.