乳腺肿物~(99m)Tc甲氧基异丁基异腈显像的临床价值

目的　评价99mTc甲氧基异丁基异腈 (MIBI)乳腺显像对乳腺癌诊断的价值。方法　对 195例 2 0 4处乳腺肿物患者分 3组进行99mTc MIBI显像 ,并与病理对照 ,另选择无乳腺疾病者 2 0例作对照组。99mTc MIBI在乳腺中有异常浓聚且阈值数大于健侧相对应区 10 %时为阳性。结果　本研究中乳腺癌病变 10 0处 ,阳性显像 92处 ;乳腺良性病变 70处 ,阳性显像 12处 ;隐匿性病变 34处 ,阳性显像 6处 ,3处为乳腺癌 ;对照组 2 0例显像均阴性。99mTc MIBI对乳腺疾病的诊断准确率为 92 0 %、灵敏度为 91 8%、特异度为 92 %、阳性预测值为 86 %、阴性预测值为 92 %。结论　 99mTc MIBI对乳腺癌的诊断及良恶性病变的鉴别有较高的敏感性和准确性。     

^99m锝腋窝扫描在选择乳腺癌手术方案中的临床价值

目的 保留未被癌浸润的腋淋巴结,使其进一步发挥免疫功能。方法 术前经肿物针吸细胞学检查和切除肿物组织学检查确诊为乳腺癌,并以＾９９ｍ锝－甲氧基异丁基异腈（＾９９ｍＴｃ－ＭＩＢＩ）窝显像判断腋淋巴结有无癌浸润。以术后腋窝组织标本病理检查结果作为金标准,将２种检查方法的敏感性,特异性和准确性相比较。结果 外科检查的敏感性、特异性、准确性分别为６４．３％、７３．９％、７０．３％;＾９９ｍＴｃ－ＭＩＢＩ腋     

乳腺肿物99mTc甲氧基异丁基异腈显像的临床价值

目的 评价^99mTc甲氧基异丁基异腈（MIBI）乳腺显像对乳腺癌诊断的价值。方法 对195例和204处乳腺肿物患者分3组进行^99mTc－MIBI显像,并与病理对照,另选择无乳腺疾病者20例作对照组。^99mTc－MIBI在乳腺中有异常浓聚且阈值数大于健侧相对应区10％时为阳性。结果 本研究中乳腺癌病变100处,阳性显像92处;乳腺良性病变70处,阳性显像12处;隐匿性病变34处,阳性显像6处,3处为乳腺癌;对照组20例显像均阴性。^99mTc－MIBI对乳腺疾病的诊断准确率为92．0％,灵敏度为91．8％、特异度为92％、阳性预测值为86％、阴性预测值为92％。结论 ^99mTc－MIBI对乳腺癌的诊断及良恶性病变的鉴别有较高的敏感性和准确性。     

99mTc-MIBI乳腺肿块显像诊断乳腺癌的初步临床应用

1995年3月至1997年10月作者对88例乳腺肿块患者术前进行99ｍ锝-甲氧基异丁基异睛(99ｍＴｃＭＩＢＩ)显像,全部病例均经外科手术,都有病理组织学资料。50例患者同时与近红外线扫描进行了比较,现报告如下。一、对象与方法1.一般资料:因乳腺肿块住院的外科患者88例,随机作为研究对象,均为女性,年龄22～27岁,平均42岁,肿块直径1～8ｃｍ。2.检查方法:静脉注射99ｍＴｃＭＩＢＩ370ＭＢｑ(兆贝克勒尔)后定时采相。在5分、30分、60分图像中有一个时相肿块部位有明显显像剂聚集为阳性,未见聚集或少量聚集为阴性。二、结果88例患者的乳腺肿块99ｍＴｃ-…     

99mTc-甲氧基异丁基异腈显像诊断乳房肿块的临床价值

目的 评价^99mTc-甲氧基异丁基异腈（MIBI）显像鉴别乳房肿块良恶性的价值。方法 对106例乳房肿块行^99mTc-MIBI显像检查,全部病例均经手术治疗,与病理结果比较,结果 106例中乳腺癌56例,显像阳性48例,假阴性主要为肿块较小的乳腺癌;良性病变50例,显像阴性40例,假阳性主要为血供丰富的大纤维腺瘤。该法诊断乳腺癌的灵敏度为85.7%,特异性为80.0%,阳性预告值82.8%、阴性预告值83.3%、总正确诊断率为83.0%。结论 ^99mTx-MIBI显像是鉴别乳房良恶性肿块的有效的、无创性检查方法,但对大纤维腺瘤和较小的恶性肿块诊断作用较差。     

~(99m)Tc-甲氧基异丁基异腈显像诊断乳房肿块的临床价值

目的　评价99mTc 甲氧基异丁基异腈 (MIBI)显像鉴别乳房肿块良恶性的价值。方法　对 10 6例乳房肿块行99mTc MIBI显像检查 ,全部病例均经手术治疗 ,与病理结果比较。结果　 10 6例中乳腺癌 5 6例 ,显像阳性 48例 ,假阴性主要为肿块较小的乳腺癌 ;良性病变 5 0例 ,显像阴性 40例 ,假阳性主要为血供丰富的大纤维腺瘤。该法诊断乳腺癌的灵敏度为 85 7%、特异性为 80 0 %、阳性预告值 82 8%、阴性预告值 83 3 %、总正确诊断率为 83 0 %。结论　99mTc MIBI显像是鉴别乳房良恶性肿块的有效的、无创性检查方法 ,但对大纤维腺瘤和较小的恶性肿块诊断作用较差。     

^99m锝-MDP全身骨显像在诊断肺癌亚临床骨转移中的作用

目的探讨^99m锝-亚甲基二磷酸盐（MDP）全身骨显像在诊断肺癌亚临床转移中的意义。方法对病理确诊为肺癌且自觉无全身骨骼疼痛的150例患者术前骨扫描结果进行回顾性分析。结果16例肺癌患者显示单发或多发骨骼转移。结论对确诊为肺癌患者术前进行^99m锝-NDP全身骨显像，可以早期发现亚临床骨转移，有利于临床分期、选择治疗方案及判断预后。     

~(99m)Tc-MIBI乳腺显像与乳腺X线照相在乳腺癌诊断中的价值

目的　评价99mTc MIBI乳腺显像与乳腺X线照相检测乳腺癌的实用性。方法　对 10 0例10 6个经临床检查可疑乳腺病灶的妇女进行乳腺钼靶X线照相和99m Tc MIBI乳腺显像检查 ,并与病理学诊断结果进行对比。结果　与病理组织学诊断比较 ,钼靶照相检测乳腺癌特异性为 44 .6% ,阳性预测值为 3 1.7% ;99mTc MIBI乳腺显像检测乳腺癌的特异性为 87.8% ,阳性预测值为 76.9%。结论　99mTc MIBI乳腺显像对乳腺癌的诊断较乳腺X线照相具有较大的临床价值     

~(99m)Tc-奥曲肽和~(99m)Tc-MIBI显像在乳腺癌临床的应用价值

目的　探讨99mTc 奥曲肽和99mTc MIBI显像在乳腺癌中的应用价值。方法　对我院住院手术治疗的2 6例怀疑为乳腺癌的乳腺肿块患者术前行99mTc 奥曲肽和99mTc MIBI显像。以术后病理检查结果作为金标准 ,分析比较两种显像的灵敏度、特异性和准确性。结果　乳腺肿块99mTc 奥曲肽显像的灵敏度、特异性和准确性分别是94 .4 %、87.5 %和 92 .3% ,99mTc MIBI显像分别是 88.9%、75 .0 %和 84 .6 % ,两者相比特异性和准确性间差异有显著性意义 (P<0 .0 5 ,P<0 .0 1) ;对于腋窝淋巴结转移的探测 ,99mTc 奥曲肽显像的灵敏度、特异性和准确性分别是6 6 .7%、92 .9%和 80 .8% ,99mTc MIBI分别是 5 8.3%、85 .7%和 73.1% ,两者相比特异性的差异有显著性意义 (P<0 .0 1)。结论　乳腺癌99mTc 奥曲肽显像优于99mTc MIBI显像 ,术前99mTc 奥曲肽显像有助于乳腺癌手术方式的选择。     

^99mTc-MIBI全身显像诊断分化型甲状腺癌转移灶的应用价值

甲状腺癌发病率呈逐步增加的趋势[1] 。目前 ,13 1Ｉ全身显像一直被认为是分化型甲状腺癌术后诊断转移灶的金标准 ,但诊断的灵敏度不高 ,因为并非所有的转移灶都具有摄取13 1Ｉ的能力。99ｍＴｃ—ＭＩＢＩ作为一种亲肿瘤显像剂 ,已广泛应用于肺癌、乳腺癌及脑肿瘤的显像 ,用于甲状腺癌术后转移灶的显像较少。本文通过对甲状腺癌术后并转移的 2 4例病人行99ｍＴｃ—ＭＩＢＩ全身显像 (ＷＢＭＩＢＩ)及13 1Ｉ全身显像(ＷＢＩ) ,并结合甲状腺球蛋白 (Ｔｇ)的测定 ,以评价ＷＢＭＩＢＩ用于甲状腺癌术后转移灶检测的应用价值 ,现报道如下。1　资…     

The relationship between benign breast proliferation (fibrocystic mastopathy) and the appearance of breast carcinoma

Fibrocystic mastopathy (FM), a benign lesion, is considered by many author like a premalignant lesion. Breast carcinoma (CA) represents the most frequent female tumor and the second mortality cause through cancer, after the bronchopulmonary cancer. At the Department of Pathology from Tg. Mure?, we selected 190 cases, for 10 month: 102 presented FM, 41 CA and 47 CA + FM. In every case, we have examined 2 slides stained with HE. In difficult cases, we performed special stains (van Gieson, H-PAS, Alcian). We studied the pulmonary tumor, adjacent mammary tissue and axillary lymph nodes. The present data of literature and the experience of the Department of Pathology from Tg. Mure? showed a strong relationship between the presence of FM and the appearance of CA: both lesions have a common field of hormonal disfunction and intraductal and intralobular hyperplasia (an microscopic feature of mastopathy) increase the risk of CA.     

Mammoscintigraphy with Tc-99m sestamibi in the evaluation of benign and malignant breast disease

Ninety-eight women and 3 men (age range, 16–88 years; mean 46 years) with 103 lesions underwent technetium-99m methoxyisobutylisonitrile (^99mTc-sestamibi, ^99mTc-MIBI) breast scintigraphy prior to biopsy to assess the value of this technique for the detection of breast carcinomas and for their differentiation from benign breast masses. Scans of 29 patients were ^99mTc-sestamibi-positive and 72 were ^99mTc-sestamibi-negative. Scintimammographic findings were true positive in 21 (72%) biopsy confirmed carcinomas and true negative in 65 (89%) benign lesions. ^99mTc-sestamibi scans were false-negative in 7 cases of breast cancer: 4 infiltrating ductal carcinomas and 3 infiltrating ductal with an intraductal component. There were 8 false positive scans which included 4 fibroadenomas, 2 papillomas and 2 areas of chronic inflammation. The mean size of the ^99mTc-sestamibi-positive carcinomas was 2.9 ± 1.2 cm, which contrasts to the size of ^99mTc-sestamibi-negative breast malignancies, which averaged 1.8 ± 0.6 cm (P < 0.0005). The sensitivity of using ^99mTc-sestamibi for detection of breast carcinoma was 75% and its specificity 89%. The positive and negative predictive values were 88% and 93% respectively. Interobserver agreement between the 2 independent and blinded nuclear medicine physicians was 98%. Size of tumor is a critical factor in the detection of sestamibi uptake. ^99mTc-sestamibi can help in the investigation of breast masses.     

Tc-99m sestamibi uptake in the chest mimicking a malignant lesion of the breast

The use of nuclear medicine imaging of the breast has resulted in the improved diagnosis of breast cancer (Radiology 196 (1995) 421; J. Nucl. Med. 36 (1995) 1758). It's use is becoming more widespread, particularly as breast optimized scintigraphy with a high-resolution, breast-specific gamma camera has been developed (J. Nucl. Med. 43 (2002) 909; J. Nucl. Med. 45 (2004) 553). With the increasing use of breast-optimized scintigraphy, pitfalls in the interpretation of breast-optimized scintigraphy are being recognized. This report describes a previously unrecognized cause for a false positive interpretation of scintimammography due to tumor uptake of the radiotracer in the chest as a result of physiologic activity in the auricular aspect of the right atrium.     

环孢素对大鼠膀胱肿瘤细胞增殖、凋亡和新生血管形成的影响

目的 探讨环孢素对N-丁基-N-(4-羟丁基)亚硝胺(BBN)诱导的大鼠膀胱肿瘤细胞增殖、凋亡及肿瘤新生血管形成的影响.方法实验组大鼠10只在用BBN诱导膀胱肿瘤的同时用环孢素进行药物干预,对照组大鼠10只仅用BBN诱导膀胱肿瘤.取2组大鼠膀胱标本免疫组化方法检测肿瘤增殖细胞核抗原(PCNA)表达情况,计算肿瘤细胞增殖指数;TUNEL方法检测肿瘤细胞凋亡情况,计算肿瘤细胞凋亡指数;免疫组化方法检测肿瘤CD31表达情况,计算肿瘤微血管密度(MVD).结果 实验组和对照组肿瘤细胞增殖指数分别为(35.3±8.6)%和(28.7±8.0)%,P＜0.05;凋亡指数分别为(2.5±0.8)%和(4.3±1.3)%,P＜0.05;微血管密度分别为32.5±8.2和26.3±8.1,P＜0.05.结论 环孢素可能通过影响肿瘤细胞增殖、凋亡和肿瘤新生血管形成等机制对膀胱肿瘤生长产生促进作用.