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多原发恶性肿瘤(multiple primary malignantneoplasams,MPMNs),尤其是3个癌瘤以上的MPMNs较为罕见,但近年来其发病率有增高的趋势.现报告我院收治的双侧多原发性肺癌合并同期原发口腔癌1例,并通过对相关文献复习,以提高对此类疾病的认识. 相似文献
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汪绪伦 《内科急危重症杂志》2018,24(4):345-347
正原发性主动脉食管瘘是由于动脉壁糜烂、溃疡,穿破邻近食管所致,临床上罕见,Salmon 1843年正式报道首例,至1998全世界报道的病例不超过250例~[1,2],超过80%为主动脉肠瘘,主动脉食管瘘极为罕见~[3]。因发病凶险,诊断困难,极易误诊,死亡率高。我院2017年5月确诊1例,通过复习该病例诊治经过,并结合文献报道的15例,探讨该病的临床 相似文献
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<正>原发性支气管肺癌(简称"肺癌")是最常见的恶性肿瘤之一,近几年因环境污染的日益严重,发病率逐年上升。肺癌是世界范围内肿瘤死亡的首要原因,即使目前在诊断及治疗上已取得了重大的进步,但其各个分期总的5年生存率仍仅有14%,而早期诊断率低是主要因素。肺癌常见转移部位为脑、骨、肝及肾上腺,软组织转移包括骨骼肌转移十分罕见。本文报道我院收治的1例以肌肉疼痛为首发症状的肺腺癌骨骼肌转移病例,同时复习相关文献了解肺癌伴骨骼肌转移的临床特点及诊治现状。 相似文献
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目的 分析原发性肺黑色素瘤(PMML)的流行病学及临床、病理特点,提高临床医师对PMML的诊断水平.方法 报道了济宁市第一人民医院呼吸科1例经病理确诊的PMML,并对其病理特点及32例PMML患者的治疗进行回顾分析.结果 患者,男,22岁,主因“反复咯血8个月,加重3d”于2011年3月31日在我院呼吸科住院治疗.肺CT是多发结节灶,后行胸腔镜肺活检病理示黑色素瘤.迄今为止,国外诊断PMML 32例,国内报道22例,主要症状为咯血,咳嗽.影像学为孤立性病灶多见.结论 本例肺内多发结节的PMML患者在国内外都是首例报道.手术是目前最好的方法,晚期可以给予放化疗. 相似文献
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多原发性肺癌是指一侧肺或两侧肺的不同部位发生2个或2个以上原发癌,其组织类型相同或不同,但各肿瘤之间无从属关系[1].多原发性肺癌的发生率报道不一,0.2%~20%不等[2],发病原因认为与宿主的肿瘤易感性、免疫功能异常、罹患第1种肿瘤后生存期延长、首次术后放化疗、内分泌紊乱等潜在因素有关.自1924年Beyreuther描述了第1例双原发性肺癌(double primary lung cancer,DPLC)后,其发病率和诊断便不断有报道[3].近年来发病有增多趋势,检出率不断增加,正确认识和处理该病有着重要的临床意义.我科今年收治1例DPLC(右上肺鳞癌+左下肺小细胞癌)患者,现报告如下,并结合文献进行探讨. 相似文献
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目的探讨肺癌骨骼肌转移的临床、影像学特点、治疗方法和预后。方法收治的2例肺癌骨骼肌转移患者及国内外相关文献进行回顾性分析。结果疼痛是骨骼肌转移最常见的症状。多数转移灶可以触及。骨骼肌转移病灶增强CT检查提示边缘强化中央密度减低的肿块影。CT或超声引导下穿刺活检有助于明确诊断。在原发肿瘤控制的情况下,单发骨骼肌转移患者接受骨骼肌手术或根治放疗生存期更长。结论肺癌骨骼肌转移预示疾病进展,如果肺原发病灶可治愈,对于骨骼肌单发转移,应积极争取外科手术治疗或根治放疗。 相似文献
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Ryota Horibe Taku Hatakeyama Tatsuru Ishikawa Takeyuki Sawai Midori Hashimoto Hiromitsu Domen Yasunari Takakuwa Masaaki Satoh Kaoru Nishiyama 《Internal medicine (Tokyo, Japan)》2022,61(3):401
A 78-year-old woman with multiple lung nodules, epithelial growth factor receptor (EGFR) exon 20 insertion mutations, and diagnosed with advanced lung adenocarcinoma (cT4N3M1a, stage IVA), was referred to our hospital. She received immune checkpoint inhibitor (ICI) therapy. The therapy showed remarkable antitumor effects; only a single nodule remained in the right upper lobe. The nodule was diagnosed as adenocarcinoma through a biopsy. We subsequently performed right upper lobectomy for multiple primary lung cancer (MPLC). The surgical specimen contained EGFR exon 19 deletion mutations and not exon 20 insertion mutations. 相似文献
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Chihiro Murano Shuhei Suzuki Sho Nakamura Hiroyuki Takeda Tadahisa Fukui Takashi Yoshioka 《Internal medicine (Tokyo, Japan)》2021,60(22):3645
Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare malignant tumor expressing NUT with BRD4/3 rearrangements and is sometimes misdiagnosed as germinoma, especially in alpha-fetoprotein (AFP)-elevated cases. A 28-year-old man had a mediastinal tumor with multiple bone metastases and elevated AFP levels. Imaging/laboratory findings led to a pathological diagnosis of extragonadal germinoma. After unsuccessful treatment with etoposide-cisplatin, he was re-diagnosed with sarcoma due to vimentin-positive findings. He was treated with adriamycin-ifosfamide, which resulted in disease-control. A posthumous examination clarified the NUT rearrangement. Even in cases with characteristic findings, such as elevated AFP levels and vimentin positivity, NMC should be considered as a differential diagnosis. We note, however, that adriamycin-ifosfamide has some efficacy in such cases. 相似文献
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Takashi Egawa Keita Masuzawa Sohei Nakayama Ichiro Maeda Satoshi Tsunematsu Yukio Suzuki Yusuke Suzuki 《Internal medicine (Tokyo, Japan)》2021,60(20):3273
Chemotherapy for multiple primary malignancies is challenging. We herein report a case of synchronous primary lung adenocarcinoma and hepatocellular carcinoma (HCC). A 72-year-old man was admitted for the evaluation of an abnormal shadow on his lung. Computed tomography revealed a lung nodule in the right upper lobe and multiple liver masses. He was diagnosed with synchronous primary lung adenocarcinoma and HCC. Atezolizumab, bevacizumab, carboplatin, and paclitaxel (ABCP) chemotherapy was efficacious for both tumors. ABCP chemotherapy may be a potential treatment option for synchronous primary lung adenocarcinoma and HCC. 相似文献
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目的:分析老年起病的弥漫大B细胞淋巴瘤合并肺癌的临床特点、治疗效果,提高对老年起病的恶性淋巴瘤合并或继发第二肿瘤(实体瘤)的认识水平。方法:报道1例老年起病的弥漫大B细胞淋巴瘤患者同时罹患肺癌的病例,并复习文献。结果:本例患者因肝脏活组织检查确诊弥漫大B细胞淋巴瘤,治疗过程中肺部肿块逐渐增大,肺部活组织检查确诊肺癌。结论:弥漫大B细胞淋巴瘤可与肺癌同时或相继发生,当治疗效果存疑时,应及时进行活组织检查,避免贻误病情。 相似文献
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Yuki Yoshimatsu Noriyuki Ebi Ryunosuke Ooi Takuto Sueyasu Saori Nishizawa Miyuki Munechika Kohei Yoshimine Yuki Ko Hiromi Ide Kosuke Tsuruno Kazunori Tobino 《Internal medicine (Tokyo, Japan)》2021,60(7):1067
The efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in lung squamous cell carcinoma is said to be low. Thus far, only four cases of osimertinib in lung squamous cell carcinoma have been published. We experienced a case of EGFR mutant lung squamous cell carcinoma in which fifth-line treatment with osimertinib was effective after T790M EGFR mutation turned positive. Osimertinib was resumed after sixth-line chemotherapy was ineffective, showing efficacy again. Osimertinib may be a promising treatment option for EGFR mutant lung squamous cell carcinoma. This is the first report to show its effect in a case of rechallenge after intervening chemotherapy. It may therefore be important to evaluate EGFR in never-smoker lung squamous cell carcinoma patients. 相似文献
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Loizos Antoniades M.D. Ph.D. Christos Eftychiou M.D. Petros M. Petrou M.B.Ch.B. Athanasios Bagatzounis M.D. † Michalis Minas M.D. 《Echocardiography (Mount Kisco, N.Y.)》2009,26(2):214-219
Primary cardiac lymphoma is defined as a non-Hodgkin's lymphoma mainly located in the heart and/or the pericardium. It is rare and affects elderly men. Common manifestations are pericardial effusion and heart failure. Diagnosis is usually late and prognosis is poor. We report a case of a patient with a large primary cardiac lymphoma who presented with chest pain and negative T-waves in electrocardiogram. Transthoracic echocardiogram showed a large mass in the right atrium and right ventricle while transesophageal echocardiogram also revealed the presence of large mobile masses in the right atrium, which were considered to be thrombi. Tissue biopsy showed a high-grade B-cell diffuse lymphocytic lymphoma. The patient was treated with chemotherapy and radiation with complete remission and prolonged survival. 相似文献
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Akihiro Nakayama Jun Arai Yumi Otoyama Ikuya Sugiura Yoko Nakajima Atsushi Kajiwara Yuki Ichikawa Shojiro Uozumi Yuu Shimozuma Manabu Uchikoshi Masashi Sakaki Sakiko Tazawa Eisuke Shiozawa Toshiko Yamochi Masafumi Takimoto Hitoshi Yoshida 《Internal medicine (Tokyo, Japan)》2022,61(2):189
There are few case reports of hepatocellular carcinoma (HCC) metastasis to the skeletal muscle. A 78-year-old man developed a mass in the right shoulder. Washout of contrast medium during contrast-enhanced ultrasonography (CEUS) in both the primary HCC and the metastatic site was detected. Several nodules were scattered throughout the liver on an autopsy. In addition, the moderately differentiated HCC had metastasized to the right teres major muscle. Rare muscular metastasis should be considered if a hepatic tumor is moderately or poorly differentiated HCC. Early washout during CEUS is consistent with a pathological diagnosis of moderately or poorly differentiated HCC. 相似文献
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Iyad Subei M.D. Bashar Attar M.D. FACG Gregory Schmitt M.D. Hulya Levendoglu M.D. FACG 《The American journal of gastroenterology》1987,82(8):769-772
Gastric tuberculosis is a rare entity; it usually occurs secondary to another lesion(s), mainly in the lungs. Only a few cases of primary gastric tuberculosis have been reported in the literature. Most commonly, gastric tuberculosis lesion(s) is located in the lesser curvature of the antrum and prepylorus, so the clinical picture is similar to that of peptic ulcer, in addition to the constitutional symptoms seen in tuberculosis in general. We report a case of a young man presented with abdominal pain acute gastric outlet obstruction due to a large mass in the lesser curvature of the antrum and the pylorus. The histological examination revealed caseating granuloma with the presence of acid-fast bacilli. Partial gastrectomy with Bilroth II reconstruction was performed and the patient was put on antituberculosis medications. There was no evidence of the tuberculous lesion anywhere else. Patient's follow-up observation in the clinic was uneventful. 相似文献
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In recent years, the decline in youth smoking rates has stopped as the tobacco industry strives to successfully reclaim market
areas where it has lost favor. The plateau in lung cancer incidence and stagnation in progress toward smoking abstinence illustrates
the necessity for renewed efforts to fight tobacco use. Barriers to fighting tobacco use exist in both the clinical arena
and within the general population, but can be overcome. Primary care physicians (PCPs) are uniquely poised to successfully
treat nicotine dependence with strategic targeting of these barriers, improved training in smoking cessation techniques, and
focused political efforts in tobacco control. Herein, this article describes the landscape of tobacco use in America and provides
background, methodology, and resources for PCPs to help achieve the goals of Healthy People 2010 in reducing the illness,
disability, and death that occur as a result of tobacco use and exposure to secondhand smoke. 相似文献