Q开关Nd：YAG激光联合高能超脉冲CO2激光治疗脂溢性角化病

目的：评价两种激光联合治疗脂溢性角化病的疗效。方法：l70例患者半随机分两组，96例采用联合治疗，74例单用Q-开关Nd：YAG激光治疗作对照。结果：联合治疗组治疗一次痊愈率为85.4％，二次痊愈率为95．8％；而单一组治疗一次痊愈率为67．6％，二次痊愈率为91．9％，两组比较治疗一次痊愈率有显著性差异。结论：Q开关Nd：YAG激光联合高能超脉冲CO2激光治疗脂溢性角化病更有效、快捷，无明显副作用，可作为首选治疗手段。     

调Q激光与超脉冲CO2激光治疗多发性扁平疣疗效比较

目的:比较调Q激光与超脉冲CO2激光治疗多发性扁平疣的疗效.方法:60例多发性扁平疣患者随机分为调Q激光组和超脉冲CO2激光组,每组30例,观察治疗效果、结痂时间、脱痂时间、色素沉着和瘢痕情况.结果:调Q激光组痊愈率86.7％,超脉冲OO2激光组痊愈率80％,两组病例痊愈率无明显差异,调Q激光组皮损处色素沉着率明显较超脉冲CO2激光组低,且结痂时间、脱痂时间也均较短,无瘢痕形成.结论:调Q激光治疗多发性扁平疣疗效优于超脉冲CO2激光.     

Q开关1064nm激光及超脉冲CO_2激光治疗340例眼睑汗管瘤

目的观察Q开关1064nm激光及超脉冲CO2激光治疗眼睑汗管瘤的临床疗效。方法应用Q开关1064nm激光及超脉冲CO2激光分别治疗212例及128例患者。结果 340例患者疗效显著,总有效率89.7%,两种激光分别有效率90.1%、89.1%,两者间差异无统计学意义（P〉0.05）。结论 Q开关1064nm激光及超脉冲CO2激光治疗眼睑部汗管瘤安全、有效。     

Q开关Nd:YAG激光联合咪喹莫特乳膏治疗扁平疣的疗效观察

目的观察Q开关Nd:YAG激光联合咪喹莫特乳膏治疗面部扁平疣的临床疗效。方法将62例扁平疣患者随机分成治疗组(32例)和对照组(30例),治疗组使用Q开关532 nm Nd:YAG激光治疗,后期外用喹莫特乳膏,对照组单外用咪喹莫特乳膏,观察疗效。结果治疗组的痊愈率为78.1%,总有效率为96.9%,对照组的痊愈率为46.7%,总有效率为76.7%,2组疗效差异均有统计学意义(P0.01)。结论 Q开关Nd:YAG联合咪喹莫特乳膏治疗扁平疣疗效好,值得临床推广。     

调Q开关Nd：YAG染料激光治疗太田痣209例疗效观察

目的：评估调Q开关Nd:YAG染料激光治疗太田痣临床疗效。方法：应用调Q开关Nd:YAG染料激光治疗209例太田痣。波长700nm,脉宽30us,能量密度5．6J／cm^2。每次治疗后色素未消退,间隔3－6月再行下一次治疗。结果：调Q开关Nd:YAG染料激光治疗4－6次后,192例效果极显,17例效果显,治疗后患均无疤痕。结论：调Q开关Nd:YAG染料激光治疗太田痣效果满意、安全。     

585 nm Q开关脉冲激光、强脉冲光及长脉宽Nd:YAG激光治疗皮肤血管性疾病临床疗效比较

目的:观察比较585nmQ开关脉冲激光、强脉冲光及长脉宽1064nm Nd:YAG激光治疗皮肤血管性疾病的临床疗效和不良反应.方法:分别应用585nm Q开关脉冲激光(能量密度3.0～6.0 J/cm2,脉宽10ns)、590～1200 nm强脉冲光(能量密度30～60 J/cm2,脉宽3.0～5.5 ms)以及长脉宽1064nm Nd:YAG激光(能量密度120-145J/cm2,脉宽20～50ms)共治疗1415例毛细血管扩张、977例蜘蛛痣、742例血管瘤及442例鲜红斑痣患者.结果:585 nm Q开关脉冲激光、强脉冲光及长脉宽Nd:YAG激光治疗毛细血管扩张的有效率分别为86.3%、89.7%及88.6%;治疗蜘蛛痣的有效率分别为97.2%、96.5%及98.8%;治疗血管瘤的有效率分别为51.2%、59.6%及74.2%;治疗鲜红斑痣的有效率分别为28.4%、33.1%及40.3%.长脉宽Nd:YAG激光治疗血管瘤及鲜红斑痣的瘢痕发生率分别为8.5%和10.7%.结论:3种治疗方法对毛细血管扩张、蜘蛛痣及鲜红斑痣疗效无明显差异;长脉宽1064nm Nd:YAG激光治疗血管瘤的有效率明显优于585nm Q开关脉冲激光及强脉冲光,但瘢痕发生率也较高.     

Q开关Nd:YAG激光和585nm脉冲染料激光治疗色素性、血管性皮肤病1686例

目的评估Q开关Nd:YAG激光和585nm脉冲染料激光治疗色素性皮肤病和血管性皮肤病的疗效。方法分别采用Q开关Nd:YAG激光治疗色素性皮肤病400例、585nm脉冲染料激光治疗血管性皮肤病1177例,并采用二者治疗病毒疣109例,观察疗效。结果Q开关Nd:YAG激光对色素性皮肤病的有效率由高到低依次为:雀斑(100%)、文身(87.50%)、脂溢性角化(84.60%)、斑痣(46.70%)、咖啡斑(40.40%);585nm脉冲染料激光对血管性皮肤病的有效率由高到低为:蜘蛛痣(98.30%)、草莓状血管瘤(91.40%)、红斑期酒渣鼻(83.30%)及颜面毛细血管扩张(80.00%);二者对病毒疣的有效率分别为:寻常疣90.10%、尖锐湿疣66.70%、扁平疣52.60%。结论Q开关Nd:YAG激光治疗色素性皮肤病、585nm脉冲染料激光治疗血管性皮肤病及二者治疗病毒疣疗效较好。     

倍频调QNd:YAG激光和IPL强脉冲光治疗雀斑的疗效观察

目的观察倍频调QNd：YAG激光和IPL强脉冲光治疗雀斑的疗效。方法采用倍频调QNd：YAG激光和IPL强脉冲光治疗雀斑，进行疗效观察。结果激光组痊愈率和有效率分别为56.2％和100％；IPL强脉冲光组痊愈率和有效率分别为35．1％和100％。两组痊愈率比较差异有统计学意义（P〈0．01）。结论采用激光和强脉冲光治疗雀斑都是有效的方法，应根据不同患者的类型选择治疗方法。     

Q开关Nd:YAG激光联合化瘀祛斑胶囊治疗黄褐斑疗效观察

目的观察Q开关Nd:YAG激光联合化瘀祛斑胶囊治疗黄褐斑的疗效。方法将90例黄褐斑患者随机分为2组,每组45例,治疗组予Q开关Nd:YAG激光联合化瘀祛斑胶囊治疗,对照组仅予单纯Q开关Nd:YAG激光治疗。Q开关Nd:YAG激光治疗每周1次,治疗8周后改为每2周1次治疗8周,疗程共16周。化瘀祛斑胶囊2次/d,5粒/次,连服16周。于治疗第8周、第16周评判疗效,随访12周观察复发率。结果 16周时治疗组有效率为84.4%,对照组为68.9%,差异有统计学意义(P0.05);治疗组复发率为17.8%,对照组复发率为37.8%,差异有统计学意义(P0.05)。结论 Q开关Nd-YAG激光联合化瘀祛斑胶囊较单纯应用激光治疗更有效,复发率低,值得临床推广。     

Q开关Nd:YAG激光联合红花逍遥片治疗黄褐斑临床观察

目的探讨Q开关Nd:YAG激光联合红花逍遥片治疗黄褐斑的疗效和安全性。方法将210例黄褐斑患者随机分为3组,每组各70例。治疗组予Q开关Nd:YAG激光治疗联合红花逍遥片口服;对照1组单纯予Q开关Nd:YAG激光治疗;对照2组单纯口服红花逍遥片。Q开关Nd:YAG激光治疗每周1次连续10周,后2周1次再治疗6周,共16周。红花逍遥片口服2片,3次/d连续16周。分别于5,10和16周时评价临床疗效。结果 16周时治疗组有效率为90.00%,对照1组为80.00%,对照2组为41.00%,差异有统计学意义(P均0.01);治疗组不良反应发生率为26.00%,对照1组为21.00%,对照2组为17.00%,差异无统计学意义(P0.05)。结论 Q开关Nd:YAG激光联合红花逍遥片治疗黄褐斑比两者单独应用效果好。     

Comparison of Q-switched Nd:YAG laser alone versus its combination with ultrapulse CO2 laser for the treatment of black tattoo

Background: Q-switched lasers are conventionally used for the treatment of black tattoo. However, they require multiple sittings, and the response may be slow due to competing epidermal pigment in dark skin. Objective: To compare the efficacy of Q-switched Nd:YAG laser alone with its combination with ultrapulse CO₂ for the removal of black tattoo. Materials and methods: Sixty patients with black tattoo were randomized into two groups viz., group A and group B. Group A was treated with QS Nd:YAG laser (1064 nm) alone, and group B received combination of ablative ultrapulse CO₂ followed by fixed-dose QS Nd:YAG laser (1064 nm), at 6-week interval for a maximum of 6 sittings. After each sitting, 3 independent physicians noted percentage of improvement that was evaluated using visual analogue scale (VAS) and grading system for tattoo ink lightening (TIL). Results: Combination laser (group B) showed statistically significant improvement in mean VAS score in the last 2 noted visits as compared to 1st session (p < 0.007, p < 0.001) and TIL mean score in last three noted visits as compared to 1st session (p < 0.008, p < 0.020, and p < 0.004). There was no statistically significant difference in the side effect profile of both the groups. Conclusion: For refractory professional tattoos, combination of ultrapulse CO₂ laser and QS Nd:YAG laser is superior to QS Nd:YAG laser alone.     

Nd:YAG激光治疗尿道内尖锐湿疣的疗效观察

目的评价Nd:YAG激光治疗尿道内尖锐湿疣(CA)的疗效。方法96例尿道内CA患者随机分为治疗组55例,采用Nd:YAG激光治疗;对照组41例,采用CO2激光治疗,两组术后均予卡介菌多糖核酸治疗,比较两组的治愈率及复发率。结果两组一次性治愈率差异有显著性(P<0.05),治疗组(92.45%)高于对照组(71.05%)。两组复发率差异有显著性(P<0.05),治疗组(7.55%)低于对照组(28.95%)。结论Nd:YAG激光治疗尿道内尖锐湿疣治愈率高、复发率低,优于CO2激光,是治疗尿道内尖锐湿疣安全、有效的方法。     

强脉冲光联合Q开关Nd：YAG激光治疗雀斑的疗效观察

目的：探讨强脉冲光联合Q开关Nd：YAG激光治疗雀斑的疗效。方法：将65例泛发性雀斑患者分为两组。对照组32例采用强脉冲光治疗,每3周一次,5次为一疗程。治疗组33例在疗程的第二次（术后3周）,采用Q开关Nd：YAG激光治疗,其余治疗方法、疗程同对照组。治疗后第6周及12周观察治疗效果。结果：治疗后6周及12周对照组和治疗组的疗效比较,差异有统计学意义（P〈0.05）。结论：强脉冲光联合Q开关Nd：YAG激光治疗泛发性雀斑创伤微小,治疗时间短,痛苦较轻,治愈率高;良好的护理对提高治愈率起着十分重要的作用。     

Q开关1064nm Nd:YAG激光碳膜术治疗中重度痤疮疗效与安全性评价

目的:评价Q开关1064 nm Nd:YAG激光碳膜术治疗寻常痤疮的疗效与安全性。方法:中重度痤疮患者166例随机分为实验组(83例)和对照组(83例)。对照组给予米诺环素胶囊100 mg,1天2次口服;克林霉素甲硝唑搽剂外用,1天3次。实验组在对照组治疗的基础上行Q开关1064 nm Nd:YAG激光碳膜术,10天治疗一次。结果:治疗40天后实验组有效率为87.76%,明显高于对照组的65.31%,差异有显著性(P0.05)。两组均未见明显不良反应发生。结论:Q开关1064 nm Nd:YAG激光碳膜术可提高药物治疗痤疮的疗效。     

Q开关Nd:YAG激光联合高能超脉冲CO2激光治疗脂溢性角化病

目的评价两种激光联合治疗脂溢性角化病的疗效.方法170例患者半随机分两组,96例采用联合治疗,74例单用Q-开关NdYAG激光治疗作对照.结果联合治疗组治疗一次痊愈率为85.4%,二次痊愈率为95.8%;而单一组治疗一次痊愈率为67.6%,二次痊愈率为91.9%,两组比较治疗一次痊愈率有显著性差异.结论Q-开关NdYAG激光联合高能超脉冲CO2激光治疗脂溢性角化病更有效、快捷,无明显副作用,可作为首选治疗手段.     

Treatment of early-stage erythematotelangiectatic rosacea with a Q-switched 595-nm Nd:YAG laser

Erythematotelangiectatic rosacea presents as persistent erythema and telangiectasia with frequent flushing and blushing on the facial and extrafacial skin. Additionally, papulopustular rosacea shows acneiform papules, pustules, and nodules with persistent plaque-form edema. Despite garnering only grade-C or -D level recommendations, a 585-nm or 595-nm flashlamp-pumped pulsed-dye laser can be considered as an effective therapeutic modality for the treatment of rosacea in patients who are refractory to topical and/or systemic treatments. In this report, treatment with a Q-switched 595-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser with low non-purpuragenic fluence proved to be safe and effective in treating early-stage erythematotelangiectatic rosacea in two female Korean patients. Laser treatment for rosacea was delivered with the settings of pulse energy of 0.4–0.5 J/cm², pulse duration of 5–10 ns, 5-mm spot size, 5 Hz, and 500 shots. Additionally, we found that remarkable therapeutic effects were achieved for both rosacea and melasma by combining Q-switched quick pulse-to-pulse 1,064-nm Nd:YAG and Q-switched 595-nm Nd:YAG laser treatments, which required only the changing of handpieces equipped with solid dye. In conclusion, we suggest that treatment with a Q-switched 595-nm Nd:YAG laser with low fluence may provide an additional therapeutic option for treating early-stage erythematotelangiectatic rosacea.     

Comparison of a single treatment with Q-switched ruby laser and Q-switched Nd:YAG laser in removing black-blue Chinese tattoos

Abstract

Background: Black and blue are two popular colors in Chinese tattooing. Two Q-switched lasers, ruby and Nd:YAG, are effective for tattoo removal. No reference with regard to a comparison of the effects and adverse reactions in Chinese individuals has been made in the literature. Objective: To compare a single treatment of black-blue tattoos with the Q-switched ruby laser and Q-switched Nd:YAG (1064 nm) laser. Methods: A total of 35 Chinese patients with black-blue tattoos at the laser center of the Institute of Dermatology, Chinese Academy of Medical Sciences were enrolled into a self-control study. Tattoos were split into two parts or two nearby tattoos on the same body part were used; one side was treated with the Q-switched ruby laser and the other with the Q-switched Nd:YAG laser. Immediate response, treatment outcome and adverse effects were compared. The statistical significance level was set at p< 0.05. Results: Edema and exudation were more common immediately after ruby laser treatment (p< 0.05). The Q-switched Nd:YAG laser had a significant difference in tattoo lightening versus the Q-switched ruby laser after a single treatment (p<0.05). There was no significant difference in adverse effects between the two lasers. Conclusion: The Q-switched Nd:YAG laser is more effective at tattoo lightening for Chinese individuals. Its immediate response after treatment is slighter than the Q-switched ruby laser.     

Q开关Nd:YAG 1064 nm激光照射对体外培养的PIG细胞黑素合成的影响

目的 探讨Q开关Nd:YAG 1064 nm激光照射对体外培养的人表皮黑素细胞系PIG细胞黑素合成的影响。方法 选择Medlite C6 Q开关Nd:YAG激光照射体外培养的PIG细胞,MTT法检测PIG细胞的活性,多巴氧化法检测酪氨酸酶活性的变化,荧光定量反转录（RT）-PCR和Westenr印迹分别检测酪氨酸酶相关蛋白（TRP）转录和蛋白表达水平。结果 ①在不影响细胞存活率的范围内,1 J/cm2照射后24 h时,PIG细胞酪氨酸酶活性（0.563 ± 0.014）与空白对照组（0.501 ± 0.019）比较轻度增加（P ＜ 0.05）,酪氨酸酶与TRP-1 mRNA表达（分别为1.40 ± 0.11,1.28 ± 0.03）与空白对照组（1.0）比较明显上调（P ＜ 0.05）,而TRP-2 mRNA表达（0.91 ± 0.17）并无明显变化（P ＞ 0.05）,其蛋白水平的变化与转录水平相符。②在不影响细胞活性的范围内,3 J/cm2照射后24 h时,PIG细胞酪氨酸酶活性（0.343 ± 0.012）与空白对照组（0.501 ± 0.019）比较明显下降（P ＜ 0.05）,酪氨酸酶、TRP-1和TRP-2的mRNA表达（分别为0.70 ± 0.02、0.73 ± 0.04、0.68 ± 0.04）和蛋白表达（分别为0.64 ± 0.05、0.86 ± 0.17、0.69 ± 0.11）与空白对照组（1.0）相比均不同程度的降低（P ＜ 0.05）。结论 Q开关Nd:YAG 1064 nm激光照射可以影响PIG细胞的黑素合成。在不影响细胞存活率的范围内,能量密度为1 J/cm2的Q开关 Nd:YAG 1064 nm激光照射能够刺激黑素合成,而3 J/cm2的照射对黑素合成有抑制作用。     

Q开关1064 nm Nd:YAG激光治疗黄褐斑所致点状色素减退:2年随访研究

目的:了解大光斑低能量模式Q开关1064 nm激光治疗黄褐斑后所致点状色素减退恢复情况。方法:对大光斑低能量模式Q开关1064 nm Nd:YAG激光治疗5次以上的180例黄褐斑患者随访2年。结果:15例出现点状色素减退(8.33%),2年后1例痊愈,2例有改善,13例无变化。结论:大光斑低能量Q开关1064 nm激光治疗黄褐斑所致的点状色素减退斑可持续2年以上。