鼻咽癌放疗后第二原发舌癌的临床分析

目的探讨鼻咽癌放疗后第二原发舌癌的临床特点及治疗效果，探索影响其预后的因素。方法1975年1月1日-2000年12月31日在中山大学肿瘤防治中心头颈科接受首治的舌癌患者共1263例，从中筛选此前有鼻咽癌放疗史者共53例，采用Kaplan—Meier法计算累积生存率，Cox回归方法进行多因素分析。结果53例中40例患者死亡，接受治疗的51例患者总的5年和10年生存率分别为41．64％、35．69％；舌癌发生在舌尖、侧缘、舌腹和舌背分别为0例、26例（49．06％）、8例（15．09％）和19例（35．85％）；舌癌临床检查颈淋巴转移6例（11．32％）后经病理证实为3例（5．66％）；第二原发舌癌治疗后18例复发（33．96％）。单因素分析提示原发灶大小（P=0．0005）、临床TNM分期（P=0．0017）影响预后；多因素分析显示临床与病理综合分期（P=0．000）、两癌发生的时间间隔（P=0．003）是影响预后的独立因素。结论鼻咽癌放疗后第二原发舌癌发生在舌背的比例较高，其淋巴转移率较低；临床和病理综合分期以及两癌发生的时间间隔是影响预后的独立因素；对鼻咽癌放疗后第二原发舌癌进行早期诊断，行手术或包含手术的综合治疗，可能会获得更好的疗效。     

影响早期舌癌预后的因素及颈部的治疗

目的 分析早期舌体鳞癌的预后相关因素及颈淋巴处理方式对生存率的影响,探讨早期舌癌的颈部治疗策略.方法 回顾性分析1994年1月至2003年12月期间152例经手术治疗的早期舌癌患者的临床及随访资料,任意分为颈部观察组与颈清扫组两大组,其中颈清扫组分为肩胛舌骨肌上清扫组和全颈清扫组(即全颈清扫和改良颈清扫).分析早期舌癌预后的临床病理因素和颈部治疗与否及不同的颈淋巴处理方式对颈部复发转移和生存率的影响.结果 全组病例随访5年以上或至患者死亡,5年随访率为94.7%.颈部观察组32例与颈清扫组120例的颈部复发率分别为34.4%和14.2%,差异有统计学意义(χ2=6.865,P<0.01);Kaplan-Meier法统计5年生存率分别为68%和79%,差异无统计意义(χ2=1.699,P>0.05).肩胛舌骨肌上清扫组与全颈清扫组的颈部转移复发率及5年生存率差异均无统计学意义(P值均>0.05).病理诊断有淋巴结转移和治疗后颈部复发转移患者的5年生存率明显低于无淋巴结转移和治疗后无颈部复发转移者,差异均有统计学意义(P值均<0.01).结论 隐匿性淋巴转移和复发是影响早期舌癌预后最主要的因素.肩胛舌骨肌上淋巴清扫虽然不能提高5年生存率,但能明显地降低颈部复发率.鉴于早期舌癌的隐匿性高且颈部复发挽救率低,建议对未过中线的早期舌癌应行同侧Ⅰ、Ⅱ、Ⅲ区的清扫,以减少颈部复发率.     

手术在局部晚期喉咽鳞状细胞癌综合治疗中的应用

目的评价手术联合诱导化疗＋同步放/化疗对于改善局部晚期喉咽鳞状细胞癌总体预后的价值。方法回顾性分析中山大学肿瘤防治中心2003年6月～2015年12月收治的122例III～IV期喉咽鳞状细胞癌临床资料,入组患者均接受2程诱导化疗,根据后续治疗将患者分为手术组（62例,手术＋同步放/化疗）和非手术组（60例,同步放/化疗）,比较两组患者的临床病理参数、疗效差异及预后的影响因素。采用SPSS 22.0统计软件对所有数据进行分析。结果入组患者中手术组62例,死亡45例;非手术组60例,死亡38例。单因素分析示:分化程度、肿瘤临床分期III/IV期和是否颈淋巴结转移（P<0.05）是影响患者预后生存的独立因素; 多因素分析示：分化程度（P=0.010）、肿瘤临床分期III/IV期（P=0.044）是影响患者预后生存的重要因素。分层分析诱导化疗有效组,手术组患者3年和5年总生存率（overall survival,OS）为93.2％和86.0％,非手术组患者的3年和5年OS分别为74.3％和60.2％,两组之间差异具有统计学意义(χ2=5.274,P=0.022) 。结论对于局部晚期喉咽鳞癌患者,诱导化疗+手术+同步放/化疗的综合治疗模式虽然不能有效提高患者总生存率和无瘤生存率,但对诱导化疗有效者显示了良好的疗效及安全性,可能从手术治疗中获益。     

青年与老年良性阵发性位置性眩晕患者临床特征及复发危险因素分析

目的比较青年与老年良性阵发性位置性眩晕患者的临床特点。方法研究对象为北京天坛医院神经内科门诊2010年1月~2014年10月期间接受诊疗的良性阵发性位置性眩晕患者。年龄18~45岁者归入青年组(98例),60岁者归入老年组(197例)。比较两组患者的临床特征,应用多因素Logistic回归分析影响其BPPV复发的危险因素。结果青年组男41例,女57例;老年组男73例,女124例,共纳入295例。两组病例性别比差异无统计学意义(P=0.487)。两组病例梅尼埃病、突发性耳聋、偏头痛、头外伤及以往手术史的病例分布差异均无统计学意义(P0.05),但老年组患者中合并高血压病、高脂血症、糖尿病、冠心病、动脉斑块和脑梗死的比例明显均高于青年组(P0.05)。复位治疗1个月后青年组和老年组BPPV复发率分别为19.3%和29.4%,其差异无统计学意义(P0.05),高血压、糖尿病和脑梗死为影响BPPV复发的独立危险因素。结论老年BPPV患者合并高血压病、高脂血症、糖尿病、冠心病、动脉斑块和脑梗死的比例明显均高于年轻患者,高血压、糖尿病和脑梗死为BPPV复发的独立危险因素。     

口腔颌面部恶性黑色素瘤─—预后因素探讨

本文将我科１９６７年７月～１９９３年７月收治４４例口腔颌面部恶性黑色素瘤进行临床与病理分析，探讨影响预后因素。男３１例，女１３例，年龄２５～７８岁，中位数４６岁。颌面部皮肤恶性黑色素瘤５例，口腔粘膜３９例。对４１例行２～３０年随诊，初治病例３５例中２６例（７４．２％）局部复发。全组病例中２４例（５８．５％）区域淋巴结转移，１６例（３９．０％）远处转移，３５例（８５．４％）死亡。其结果说明口腔颌面部恶性黑色素瘤预后与肿瘤部位、肿瘤的临床与病理分型、病变侵袭深度、淋巴结有无转移、治疗方式有关。     

喉鳞状细胞癌患者预后的多因素分析

目的：探讨影响喉鳞状细胞癌患者预后的主要因素。方法：采用免疫组织化学SP法检测79例喉鳞状细胞癌患者肿瘤组织和10例癌旁正常组织中细胞s期激酶相关蛋白（Skp2）、p27、上皮细胞钙黏素（E-cad）、r连环素（α-cat）的表达,并对可能影响喉鳞状细胞癌患者预后的12项临床病理因素进行单因素和多因素分析。结果：①Skp2在喉鳞状细胞癌和癌旁正常组织中的表达率分别为53,16％和0,p27分别为30．38％和90．00％,E-cad分别为34．18％和100,00％,α-cat分别为40．51％和100,00％,其差异均有统计学意义（P〈0．05或P〈0．01）。②本组患者总的5年生存率为58．75％,Skp2蛋白低表达组的5年生存率（72．18％）显著高于高表达组（44．17％）（P〈0.01）;p27蛋白高表达组的5年生存率（72．98％）显著高于低表达组（51．13％）（P〈O．01）;E-cad及α-cat阳性表达组的5年生存率（分别为63．80％和81．74％）显著高于阴性表达组（分别为50.68％和41．09％）（P〈0．05和P〈0．01）。③单因素分析显示：病理分级,颈淋巴结转移,临床分期,T分期,复发,Skp2、p27、E-cad及α-cat表达对患者预后的影响均有统计学意义（P〈0．05或P〈0．01）;多因素分析显示：复发、Skp2及α-cat表达为影响患者预后的独立因素（P〈0．05或P〈O．01）。④Skp2和p27蛋白表达之间存在着负相关关系（P〈0.01）;p27和α-cat蛋白表达之间、E-cad和α-cat蛋白表达之间存在正相关关系（均P〈0．01）。结论：复发、Skp2及α-cat表达为影响喉鳞状细胞癌患者预后的重要因素。     

青年人头颈癌的预后是个迷吗?

对1962～1984年间116例16～35岁的头颈恶性肿瘤患者进行了回顾性分析。目的是证实在头颈癌病人中,是否青年患者比老年患者的肿瘤恶性程度高,预后更差。年青患者是否逐年增加。116例16～35岁患者为青年组。在同时期治疗的所有头颈恶性肿瘤患者为总体组。将两组患者各按解剖部位分为鼻和鼻窦、喉、鼻咽、舌、咽等组。分别列出青年组和总体组患者的病变部位、性别、组织学、分期、病程、以前的治疗、最后的处理和5年生存率等的情况,并加以对比分析。结果:在青年组各部位肿瘤的男女比例大致相同,为2∶1。总体组中,男女比例喉癌7.3∶1,鼻咽癌4.6∶1,舌癌3.4∶1,咽癌9∶1,两组有显著差异。青     

头颈部肿瘤放射治疗后味觉及唾液障碍的临床研究

[日]伊藤善之….癌临床．1995，41（7）．－749～755该作者对50例接受了放射治疗的头颈部恶性肿瘤病例，以门诊方式进行了调查。结果，味觉完全恢复：鼻咽癌名例（36％），口咽癌4例（5％），恶性淋巴瘤7例（50％），舌癌17例（10％）。舌癌完全恢复率明显高于鼻咽癌、日咽癌及恶性淋巴瘤。唾液恢复：鼻咽癌、口咽癌无一例恢复，恶性淋巴瘤恢复2例（14％），舌癌全部恢复。味觉恢复时期：鼻咽癌、口咽癌2年以后恢复，舌癌全部在1年以内恢复，恶性淋巴癌在l～5年内恢复。唾液分泌恢复时期：舌癌全部在1年内恢复，恶性淋巴瘤2例均在1年以后恢…     

舌癌颈淋巴结转移的处理

选择性颈清扫在舌癌颈部的处理是目前的流行趋势，对于提高舌癌患者生存率的意义是明确的，为探讨临床颈淋巴结阴性（cN0）的病人是否一概需作选择性颈清扫，本文回顾我院1970年～1990年期间外科收治的160例舌活动部鳞状细胞癌病人，分析其颈淋巴结的转移、处理及其转归，结果发现143例颈清扫组中cN087例，术后病理阳性（pN＋）为19例（21．8％）；放疗能降低颈部复发率；对于30例T1N0选择性预清扫3年无瘤生存23例（76.7％）与观察15例中存活10例（66．7％）比较无统计学差异。作者认为对于某些早期cN0病人可以不行颈部清扫，不影响其生存率而提高生活质量。     

喉癌中能动性相关蛋白-1的表达与临床病理特征间的关系

目的 观察能动性相关蛋白-1（motility-related protein-1,MRP-1/CD9）在喉癌组织中的表达水平及与患者临床病理特征间的关系.方法 选取61例喉癌患者手术切除的病理组织标本（喉癌组）、61例癌旁切缘组织标本（对照组,经术后病理证实为非肿瘤组织）,其中喉癌组有33例发生颈淋巴结转移.采用免疫组化SP法检测MRP-1/CD9的表达水平,并结合患者的临床病理资料对其结果进行对比分析.结果 喉癌组中MRP-1/CD9的表达水平低于切缘对照组（P＜0.05）;喉癌原发灶中MRP-1/CD9表达水平高于颈淋巴结转移灶（P＜0.01）;喉癌伴颈淋巴结转移者MRP-1/CD9的表达水平低于不伴颈淋巴结转移者（P＜0.01）,不同临床分期、组织病理分级的患者之间其表达水平差异有显著性.结论 MRP-1/CD9的表达在喉癌的发生、发展及转移过程中具有一定作用,可能作为判断喉癌转移潜能和预后的因素之一,为临床了解患者的病情进展提供一定的理论依据.     

Squamous cell carcinoma of the oral tongue in young patients: a matched-pair analysis

CONCLUSIONS: Young patients with squamous cell carcinoma (SCC) of the oral tongue developed fewer locoregional recurrences. The overall survival and disease-specific survival rates were better in the young patient population. OBJECTIVES: To compare the survival rates of patients under 45 years of age and diagnosed with SCC of the oral tongue with those of patients older than 45 years. PATIENTS AND METHODS: A retrospective review of 20 patients under 45 years of age with SCC of the oral tongue was performed. These patients were matched to an older population by sex and clinical stage. Overall survival, disease-free survival, disease-specific survival, and rates of local, regional and distant metastases were determined for both populations. RESULTS: Stage and treatment modality were similar in the two age groups. There were significant differences in overall survival (p=0.013) and disease-specific survival (p=0.046) favoring young patients. Rates of locoregional recurrence and distant metastasis were higher in the older patients.     

Squamous cell carcinoma of the oral tongue in young patients: a matched-pair analysis

Conclusions. Young patients with squamous cell carcinoma (SCC) of the oral tongue developed fewer locoregional recurrences. The overall survival and disease-specific survival rates were better in the young patient population. Objectives. To compare the survival rates of patients under 45 years of age and diagnosed with SCC of the oral tongue with those of patients older than 45 years. Patients and methods. A retrospective review of 20 patients under 45 years of age with SCC of the oral tongue was performed. These patients were matched to an older population by sex and clinical stage. Overall survival, disease-free survival, disease-specific survival, and rates of local, regional and distant metastases were determined for both populations. Results. Stage and treatment modality were similar in the two age groups. There were significant differences in overall survival (p=0.013) and disease-specific survival (p=0.046) favoring young patients. Rates of locoregional recurrence and distant metastasis were higher in the older patients.     

Clinical outcome of squamous cell carcinoma of the tongue in young patients: a stage-matched comparative analysis

Objectives

The reported incidence of tongue cancer in young patients has recently increased. The aim of this study was to analyze the clinical characteristics of tongue cancer in a young group of patients, and to compare them with those of an older group of tongue cancer patients.

Methods

We retrospectively reviewed the records of 85 patients who were diagnosed with squamous cell carcinoma of the tongue. They were divided into two age groups: over 45 years of age and under 45 years. To compare the prognosis of similarly staged patients in the group, each age group was divided into the early (stage I, II) and advanced stage groups (stage III, IV), and then they were compared. The young group consisted of 23 patients and the older group had 62 patients.

Results

At the early stage, the clinical prognosis of the patients in both age groups was good, and no significant difference was observed. However, at the advanced stage, the overall and regional recurrence rates were significantly higher in the younger age group as compared to that in the old age group (P=0.007, P=0.001, respectively). The disease-specific survival rate of the patients in the young group was significantly lower than that in the old age group (P=0.025).

Conclusion

Tongue cancer in young subjects has significantly different clinical outcomes according to the stage. The clinical outcome of the advanced-stage tongue cancer in young subjects was poorer than that in the older subjects. Regional recurrence seemed to be the main cause of the poor prognosis.     

Management of cervical metastases in advanced squamous cell carcinoma of the base of tongue

OBJECTIVE: To clarify the role of neck dissection following primary radiotherapy for treatment of squamous cell carcinoma of the base of tongue. DESIGN: Case series. SETTING: Academic, tertiary care medical center. PATIENTS OR OTHER PARTICIPANTS: A consecutive series of 45 patients with biopsy-proven squamous cell carcinoma of the base of tongue and cervical metastases treated with primary radiotherapy at The University of California, San Francisco, was examined. Patients with a prior history of neck irradiation, neck dissection, or head and neck cancer within 5 years were excluded. MAIN OUTCOME MEASURES: Overall survival and regional control. RESULTS: Of the 45 patients treated with definitive radiotherapy, 25 (56%) achieved a complete response, 13 (29%) achieved a partial response, 4 (9%) were nonresponders, and 3 (7%) did not complete radiotherapy. Two thirds of the complete responders had N2 or N3 disease; 3 had recurrences in the neck, 1 of which was an isolated neck recurrence. Of the 13 partial responders, 5 had isolated persistence of disease, with 4 undergoing neck dissections. The only long-term survivors among the partial responders were those 4 who underwent a neck dissection. Overall survival was 50% at 3 years and 32% at 5 years. Regional control for complete responders was 84% at 5 years. CONCLUSIONS: The low rate of isolated regional recurrence in patients with a complete response to radiotherapy supports the practice of surveillance alone in such patients. Patients with less than a complete response appear to benefit from prompt surgical salvage.     

中期舌体鳞状细胞癌的预后及诱导化疗在治疗中的价值

目的 探讨诱导化疗在中期舌体鳞癌治疗中的价值,以及影响中期舌体鳞癌预后的因素.方法 回顾性分析1990年1月-1999年12月间首次在中山大学肿瘤防治中心头颈科住院治疗的符合条件的cTNM中期(Ⅱ、Ⅲ期,T2-3NO或T1-3N1)舌体鳞癌患者122例.单纯手术69例,诱导化疗后手术治疗53例,其中顺铂+5-氟尿嘧啶+博来霉素A5(简称PBF方案)诱导化疗17例,博来霉素A5单药诱导化疗36例.Kaplan-Meier法计算累积生存率,Cox比例风险模型进行多因素分析.结果 全组随访时间为7～177个月,平均随访(79.9±49.8)个月(-x±s),死亡45例(包括5例失访),失访率4.1%,存活77例中66例随访5年以上.全组3年、5年生存率分别为79.4%、69.0%,无瘤生存率分别为71.7%、66.3%;单纯手术组的3年、5年生存率分别为82.5%、73.1%,PBF方案组的3年、5年生存率分别为82.4%、70.1%,博来霉素单药诱导化疗后手术的3年、5年生存率分别为72.2%、61.1%,各组间比较差异无统计学意义(χ2=0.42,P=0.8106);单纯手术、PBF诱导化疗后手术、博来霉素诱导化疗后手术组的复发率分别为30.4%、41.2%和38.9%;单因素分析显示诱导化疗未见提高患者生存率、降低局部区域复发率(χ2=1.148,P=0.563)和远处转移率(χ2=2.305,P=0.316);多因素分析显示舌癌复发是影响预后的独立因素.结论 舌癌复发是影响中期舌体鳞癌预后的独立因素.诱导化疗未见提高患者生存率,降低复发率和远处转移率,PBF方案和博来霉素单药方案对舌体鳞癌的诱导化疗疗效差异无统计学意义.     

Squamous-cell carcinoma of the tongue: treatment results and prognosis

OBJECTIVE: The aim of the study was to assess the results of curative treatment of patients with squamous cell carcinoma of the tongue and to evaluate survival and predictive factors of recurrence. PATIENTS AND METHODS: A series of 309 patients with squamous cell carcinoma of the tongue treated with curative intent was studied from January 1988 to December 1999. The percentage of oral tongue cancer was 82.2 and the percentage of cancer of base of the tongue was 17.8. Most patients underwent surgical procedure alone or combined with radiotherapy (92%). We performed 252 neck dissections. Bilateral dissections were performed for cancer of the apex linguae, cancer of the base of the tongue, for patients with N2c neck disease and whenever the primary tumor site crossed the median line. Twenty-five patients (8%) were treated with radiation therapy alone. Mean follow-up was 55 months. The functional results were assessed within a minimum of 10 months postoperative follow-up. RESULTS: In 45.2%, there was histological evidence of node invasion with 53.5% of extracapsular node spread in the neck specimens. Extracapsular node spread did not influence survival or recurrences. Occult cervical metastasis in an elective neck dissection in clinically negative necks was found in about 20% of patients with 47% of extracapsular node spread (41% for cancer of mobile tongue and 80% for those of base of the tongue). About 23% of patients with cancer of base of the tongue staged N0 had histological node invasion in controlateral neck nodes. The postoperative mortality rate was 0.9%. The rate of complications was 17%. The cancer recurred in 41.7% of all cases. Twelve percent of all patients had second primary cancers of the upper aerodigestive tract. The overall survival and non-recurrence rates at 2 and 5 years were higher in cancer of oral tongue than in cancer of base of the tongue. Survival rates were better when neck nodes were clinically or histologically negatives and in early-stage carcinomas. Non-recurrence rates were better when nodes were clinically or histologically negatives and when margins of exeresis were not involved. The functional results were better in oral tongue cancer than in base of the tongue cancer. DISCUSSION: Prognosis (survival and non-recurrence rates and functional results) of squamous cell carcinomas of oral tongue was better than prognosis of those of base of tongue. We recommend an aggressive surgical procedure even in patients with neck classed N0 (with reservations for T1 lesions with small depth of invasion): an ipsilateral supraomohyoid neck dissection for cancer of oral tongue and a bilateral supraomohyoid neck dissection for cancer of base of the tongue, cancer of oral tongue which crosses the median line of the oral cavity and cancer of the apex linguae. Postoperative radiotherapy must be performed when margins are positives and/or when nodes are involved with or without extracapsular spread.     

Radical surgery for lingual cancer

The survival rates of 58 patients treated for squamous carcinoma of the tongue between 1972 and 1985 were evaluated. The overall 5-year survival rate was 41.6%; for stage I it was 61.8%; stage II 59.5%; and stage III, 27.7%. No patient survived for more than 2 years when their tumour was stage IV on presentation. A composite pull-through resection with radical neck dissection gave a 5-year survival rate of 50.7%, which was significantly (P less than 0.01) higher than the 13.8% achieved by other treatments, mainly local tumour excision combined with radiation therapy. The same trend in favour of radical surgery was also seen stage by stage. In 45% of the patients regional neck metastases (palpable in 35% and occult in 10%) were present and predicted a poor prognosis. Among T1-T2 cases the 5-year survival of 58.5% in the N0 group was significantly (P less than 0.01) higher than the 15.1% among those with nodal involvement. The location of the primary tumour did not affect the survival rates.     

Treatment of squamous cell carcinoma of the tongue base: irradiation, surgery, or palliation?

OBJECTIVES: Squamous cell carcinoma of the tongue base has a poor prognosis, and treatment is accompanied by a number of major problems. In view of this, it is important to recognize which patients will benefit from treatment with curative intent and which treatment method to use. METHODS: One hundred sixty-five patients with squamous cell carcinoma of the tongue base were identified on our database. Eighty-two patients were treated by radical irradiation, and 41 by surgery. A further 42 patients were considered unsuitable for curative treatment. RESULTS: The 5-year cause-specific survival rate was 41% for those treated by irradiation, 58% for those treated by surgery, and 9% for untreated patients. There was no difference in the efficacy of treatment methods (p = .5362), but a highly significant difference was seen in survival rate between treated and untreated patients (p = .0028). The decision regarding administration of curative treatment was based on the extent of locoregional involvement at the primary site (p = .0139; odds ratio, 0.43) and in the neck (p = .0078; odds ratio, 0.23). No factors affected the decision to treat by irradiation or surgery. When the observed survival rate was calculated, there was no significant difference in 5-year survival rate between treated and untreated patients (p = .2762). Those with early (T1-2) disease at the primary site had an improved survival rate from 0.5 to 4 years compared with those who were untreated (T3-4; p = .0081; odds ratio, 2.2). In addition, those with early (T1-2) disease had a better survival rate than those with advanced cancers (p = .0139; odds ratio, 2.09). There was, however, no difference in survival rate at 5 years. Those with early disease compared with those with advanced disease were twice as likely to be alive at 2 years; however, all survival advantages had disappeared by 5 years. CONCLUSIONS: In terms of observed survival, treating tongue base squamous cell carcinoma that is locally advanced (T3-4) at presentation offers no survival advantage over palliation alone. Treating early disease (T1-2) doubles the survival rate for up to 4 years, but by 5 years this survival advantage is lost. The present study finds radiotherapy and surgery to be equivalent at controlling this disease.     

More Aggressive Behavior of Squamous Cell Carcinoma of the Anterior Tongue in Young Women

Objective To review the combined experience from two large medical centers in treating young female patients with anterior tongue cancer to determine the clinical course of this unique subset of patients. Study Design Retrospective study. Methods Seventeen female patients less than 40 years of age (group A) and 17 older patients, both male and female, greater than 40 years of age (group B) who had treatment for invasive squamous cell carcinoma of the anterior tongue were studied. The charts were reviewed for the clinical staging, treatment, and outcome of each patient. The disease‐free survival and recurrence rates were compared between the two cohorts. Results The mean disease stage between the groups was II. The survival analysis showed a significant difference between the two groups in recurrences (group A = 65%, group B = 41%;P = .02). Further, of the patients who had recurrence, the young women did so significantly earlier in their disease course than the older patients (group A = 14 mo, group B = 40 mo;P < .05). Although the survival differences did not reach statistical significance (P = .15), the power of the study was low (power = 0.26) resulting in a high‐level type II error. Conclusion These data suggest that young women with squamous cell carcinoma of the anterior tongue have significantly higher rates of recurrent disease and the interval to recurrence is significantly shorter than in older patients. Further investigation is warranted until a statistically significant cohort is accrued; until that time, these patients warrant an aggressive initial treatment and close surveillance for recurrence.