Gynandroblastoma of the ovary.

A gynandroblastoma of the ovary in a 17-year-old girl is reported. Primary amenorrhoea, hirsuties and slight clitoral enlargement were associated with the tumour and high levels of circulating testosterone were found. This is the first gynandroblastoma in which Reinke crystalloids have been identified in the Leydig cell component. The criteria for the diagnosis of this tumour and its histogenesis are discussed.     

Gynandroblastoma and Fragile X syndrome. Case report

Gynandroblastoma is a rare ovarian tumor, derived sex cord-stromal, malignant, with low scalable potential. Clinical investigations include endocrinology or gynecological troubles, or pelvic mass syndrome. After pelvic MRI of reference, optimum surgery is the treatment of gynandroblastoma. Fragile X syndrome is the most common inherited cause of mental retardation, and females are more affected. Association of both is totally new.     

Gynandroblastoma: a rare ovarian tumour. Case report

Gynandroblastoma is an extremely rare sex cord-stromal ovarian tumor. Only thirty cases have been published in the literature up to now. Clinical investigations include virilism associated with menstrual irregularity, or amenorrhea. The surgical treatment is salpingo-oophorectomy and lymphadenectomy if malignant spread is suspected.     

Gynandroblastoma with the symptoms of infertility and secondary amenorrhea: a case report

The case of a female patient who failed to get pregnant due to delayed menstruation is reported. Gynecological examination showed that the patient had a male pubic distribution, hypertrophic clitoris, unobstructed vagina and hypertrophic cervices with smooth and medium texture. B ultrasonic examination detected a 42 x 30 mm in size medium echo mass. This mass had irregular shape, smooth surface, relatively clear boundary and hard texture. Examination with paraffin-embedded section indicated that the tumor was composed of supporting cells and to a lesser amount of interstitial components. Some regions had particle-like cell differentiation. These results suggested that the tumor was gynandroblastoma. We found that the increased level of serum testosterone in the patient was the reason for amenorrhea and infertility. The diagnosis and treatment for patients with gynandroblastoma is also discussed.