闭合复位经皮克氏针内固定治疗小儿肱骨髁上不稳定型骨折

目的 :小儿肱骨髁上不稳定型骨折并发症多 ,治疗不当经常会产生严重后遗症。该文旨在观察闭合复位后经皮克氏针交叉固定治疗此类骨折的临床疗效。方法 :回顾性临床研究 14例小儿肱骨髁上不稳定型骨折病人经全麻下行闭合复位 ,经皮克氏针交叉内固定治疗效果及并发症的分析。结果 :平均随访 10个月 (6～ 12个月 ) ,所有骨折术后 4周骨痂愈合良好 ,拔除克氏针。术后 8周肘关节功能恢复。 2例暂时性神经麻痹病人术后 12周和 16周神经功能完全恢复。 2例早期肌间膈综合征病人复位固定后症状消失 ,无肘关节畸形和永久性神经血管损伤发生。结论 :闭合复位经皮克氏针交叉内固定是治疗小儿肱骨髁上移位不稳定型骨折的理想的选择方法。     

闭合复位经皮克氏针内固定治疗儿童肱骨髁上骨折

目的 评价闭合复位后经皮克氏针交叉固定治疗此类骨折的临床疗效。方法 回顾性分析18例儿童肱骨髁上不稳定型骨折病人经全麻下行闭合复位，经皮克氏针交叉内固定的治疗效果及并发症的分析。结果 平均随访10个月（6－12个月），所有骨折术后4周骨痂愈合良好，拔除克氏针。术后8周肘关节功能恢复，1例暂时性尺神经麻痹病人术后12周时神经功能完全恢复。2例早期肌间隔综合征病人复位固定后症状消失，无肘关节畸形和永久性神经血管损伤发生。结论 闭合复位经皮克氏针交叉内固定是治疗儿童肱骨髁上移位不稳定型骨折的理想的选择方法。     

儿童Gartland Ⅲ型肱骨髁上骨折两种手术治疗方法对比分析

目的:比较两种手术方法治疗儿童Gartland Ⅲ型肱骨髁上骨折的临床疗效。方法:C臂透视下闭合复位经皮克氏针微创固定及切开复位克氏针内固定手术治疗儿童肱骨髁上骨折38例,从肘关节功能、骨折愈合时间、术后并发症及治疗费用方面对治疗效果进行综合评定比较。结果:C臂透视下闭合复位经皮克氏针微创固定组骨折愈合时间及术后并发症与切开复位克氏针内固定手术组比较差异无统计学意义(P0.05),切开复位克氏针内固定手术组治疗费用多于C臂透视下闭合复位经皮克氏针微创固定组(P0.05)。结论:C臂透视下闭合复位经皮克氏针微创固定治疗儿童Gartland Ⅲ型肱骨髁上骨折治疗效果理想,综合评价优于切开复位克氏针内固定手术,值得在基层医院推广。     

手法复位克氏针固定治疗肱骨髁上骨折治疗体会

目的:探讨移位型儿童肱骨髁上骨折手法复位经皮克氏针固定的疗效并评估相关的危险性。方法:采用手法复位经皮克氏针内固定治疗移位儿童肱骨髁上骨折患儿53例,分析治疗效果及相关危险因素。结果:所有骨折均达到骨性愈合,肘关节功能及外观满意,无严重并发症。结论:手法复位经皮克氏针固定儿童移位肱骨髁上骨折疗效确切,并发症少,是治疗该骨折安全,有效的方法。     

闭合复位经皮交叉克氏针内固定治疗小儿肱骨髁上骨折27例体会

目的采用闭合复位经皮克氏针交叉内固定,治疗小儿肱骨髁上骨折的临床疗效。方法自2007年1月～2008年12月采用闭合复位经皮克氏针交叉内固定术,治疗小儿肱骨髁上骨折27例,所有骨折均为闭合性骨折,无神经血管损伤。患者年龄5～12岁,平均7.8岁。从肘关节的功能和外观两方面进行疗效评价。结果术后随访时间6～10个月,平均8个月。所有骨折均为术后3～5周达到临床愈合,并拔除克氏针,治疗过程中未出现骨折再移位。术后无1例肘内翻等并发症。按Fly-nm评分：优27例,良0例,一般0例,差0例。肘关节伸屈活动丢失是影响治疗结果的主要原因,但这种活动受限会随着时间的延长而有所改善。结论采用闭合复位经皮克氏针交叉内固定治疗儿童肱骨髁上骨折手术创伤小,固定可靠,可以获得良好的肘关节功能和外形,减少并发症。     

手法复位克氏针固定治疗肱骨髁上骨折

目的:探讨移位型儿童肱骨髁上骨折手法复位经皮克氏针固定的疗效并评估相关的危险性。方法:对采用手法复位经皮克氏针内固定治疗的53例移位的儿童肱骨髁上骨折进行回顾,分析治疗效果及相关危险因素。结果:所有骨折均达到骨性愈合,肘关节功能及外观满意,无严重并发症。结论:手法复位经皮克氏针固定儿童移位肱骨髁上骨折疗效确切,并发症少,是治疗该骨折安全、有效的方法。     

闭合复位、经皮克氏针固定治疗儿童肱骨颗上骨折

目的:探讨闭合复位、经皮克氏针固定治疗儿童肱骨髁上骨折的临床疗效。方法:我院自2002年3月～2008年5月采用C型臂X线机透视下手法整复、闭合交叉穿针治疗儿童肱骨颗上骨折20例,按照Jupiter等肘关节评分系统评估肘关节功能。结果:肘关节功能优17例、良2例、可1例。优良率95%。所有病例无Voklmann肌挛缩及骨化性肌炎发生。结论:采用闭合复位经皮克氏针固定疗法治疗儿童髁上骨折,明显减少了并发症的发生,肘关节功能恢复良好,方法简便易于开发。     

闭合复位经皮克氏针内固定治疗儿童肱骨髁上骨折

目的 探讨C型臂X线透视下闭合复位经皮克氏针内固定治疗儿童肱骨髁上骨折的疗效.方法 回顾性分析笔者所在医院2006年7月～2008年7月采用闭合复位经皮克氏针内固定治疗儿童肱骨髁上骨折32例.结果 随访32例,随访时间为12～18个月,平均15个月,优26例,占81%,良6例,占19%.结论 采用闭合复位经皮克氏针内固定治疗儿童肱骨髁上骨折创伤小,费用低,固定可靠,可获得良好的肘关节功能并减少了肘内翻畸形等并发症.     

闭合复位经皮克氏针内固定治疗小儿肱骨髁上下稳定型骨折

目的：小儿肱骨髁上不稳定型骨折并发症多,治疗不当经常会产生严重后遗症。该文旨在观察闭合复位后经皮克氏针交叉固定治疗此类骨折的临床疗效。方法：回顾性临床研究１４例小儿肱骨髁上不稳定型骨折病人经全麻下行闭合复位,经皮克氏针交叉内固定治疗效果及并发症的分析。结果：平均随访１０个月（６～１２个月）,所有骨折术后４周骨闸愈合良好,拔除克氏针,术后８周肘关节功能恢复,２例暂时性神经麻痹病人术后１２周和１６周神     

两种方法治疗儿童肱骨髁上骨折的疗效比较

目的:探讨闭合复位经皮克氏针内固定治疗儿童肱骨髁上骨折与切开复位克氏针内固定治疗儿童肱骨髁上骨折的疗效差异.方法:回顾性分析比较闭合复位经皮克氏针内固定治疗儿童肱骨髁上骨折20例与切开复位克氏针内固定治疗儿童肱骨髁上骨折23例的治疗效果与并发症.结果:43例经5～36个月,平均12.5个月随访,按照Flynn标准两组治疗的优良率差异无显著性,但在患者住院周期、出血量、创伤、费用等方面前者明显优于后者.结论:闭合复位经皮克氏针内固定治疗肱骨髁上骨折恢复快,出血少,创伤小,费用低,固定可靠,值得推广.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.