共查询到17条相似文献,搜索用时 140 毫秒
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<正>21世纪自然科学领域中,生命科学是发展最为迅速、科研成果最为显著的学科之一。实验动物作为生命科学研究和发展的重要基础和支撑,对医学发展和人类健康的科学研究具有十分重要的意义。动物实验为生命科学研究提供准确、可靠的实验基础数据,善待实验动物,完善实验动物的福利伦理,以及动物实验应符合伦理学原则等问题已引起广泛关注。从伦理学的角度去思考善待实验动物,一方面是生命科学研究的可持续性发展的需要,另一方面也体现了人类社会的文明进步。 相似文献
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实验动物福利工作的好坏,不仅反映实验动物学科建设的成就,而且影响着生物医学研究成果的社会性及公众认可程度。如何保证实验动物的福利,提高实验动物福利水平,正逐步成为社会公众所关注的一个热点〔1〕。 相似文献
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药品临床前大鼠慢性毒性实验是药物非临床安全性研究的重要组成部分,是药物非临床毒理学研究中综合性最强、获得信息最多和对临床指导意义最大的研究。该文结合我国药品非临床前大鼠慢性毒理实验规定及实验室十余个大鼠慢性毒理学实验的经验和教训,分析探讨了实验中动物实验质量的控制问题。认为大鼠实验技术因素的质量控制和值得关注的影响动物实验结果的环境控制、动物福利控制、误差控制决定着大鼠慢性毒理学实验结果的客观性,直接影响药物的安全性评价结果,其标准化问题应引起新药研发人员及管理机构的重视。 相似文献
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The number of animals used in research has increased with the advancement of research and development in medical technology. Every year, millions of experimental animals are used all over the world. The pain, distress and death experienced by the animals during scientific experiments have been a debating issue for a long time. Besides the major concern of ethics, there are few more disadvantages of animal experimentation like requirement of skilled manpower, time consuming protocols and high cost. Various alternatives to animal testing were proposed to overcome the drawbacks associated with animal experiments and avoid the unethical procedures. A strategy of 3 Rs (i.e. reduction, refinement and replacement) is being applied for laboratory use of animals. Different methods and alternative organisms are applied to implement this strategy. These methods provide an alternative means for the drug and chemical testing, up to some levels. A brief account of these alternatives and advantages associated is discussed in this review with examples. An integrated application of these approaches would give an insight into minimum use of animals in scientific experiments. 相似文献
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Rationale The ethical debate concerning the use of animals in biomedical and pharmacological research continues to be replete with misunderstandings
about whether animals have moral standing.
Objectives This article briefly reviews the central ethical positions and their relationship to the basic parameters of research regulation
from an international perspective. The issues associated with the validation of animal models will then be discussed. Finally,
suggestions for empirical ethics research will be presented.
Methods Recent literature reviews were accessed and analyzed.
Results This review summarizes the pertinent ethical and research literature.
Conclusions In summary, regardless of the ethical perspective one favors, there is strong agreement that animals matter morally and that
at a minimum their welfare must be considered. This position is reflected in the structure of national regulatory schemes
that emphasize the three Rs (replacement, reduction, refinement). Researchers should more actively participate in the discussion
by becoming more knowledgeable about the details of the ethical issues. Research with animal models has been problematic in
that it has often focused on attempting to produce global models of psychiatric disorders, which suffer from inherent validity
problems. Researchers must also become more sophisticated about issues of model validation and the nature of the animals they
use. 相似文献
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随着医药研发的全球化发展,国内新药安全评价机构获得药物非临床研究质量管理规范(GLP)和国际实验动物评估和认可管理委员会(AAALACi)双认证的越来越多。实验动物作为药物安全性评价的载体,其生存状态和动物福利将直接影响到试验结果,处理好两种体系下实验动物的饲养管理工作,是保证实验数据准确的必要条件。以天津药物研究院新药评价有限公司通过GLP和AAALACi两种体系认证的实际工作经验为基础,辅以与同行们的交流经验,探讨两种认证体系在实验动物管理工作中的关系,以期通过加强实验动物管理工作来保障新药安全评价工作的顺利进行。 相似文献
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《Fundamental and applied toxicology : official journal of the Society of Toxicology》1984,4(4):508-516
Animal welfare and antivivisection groups have protested against animal research for the last 150 years. However, they have recently (ca. 20 years ago) injected a new element into the debate by pressing for the development and application of alternatives. By this, they mean the development of techniques which could replace or reduce the use of laboratory animals, or the refinement of existing techniques to reduce animal suffering. Animal welfare concerns have focused on toxicology testing in particular. Of course, the state of the art in toxicology has advanced considerably in the last 20 years and some of the changes have resulted in a reduction of the use of animals. Nevertheless, the animal welfare movement seeks a more specific program which will review testing guidelines and support the development of new techniques which will reduce or eliminate animal use. Carcinogen detection, Draize eye irritancy testing, and LD50 testing are three specific areas where the pressure for alternatives development has been strongest. The prospects for alternatives in each of these three are briefly discussed together with one or two comments about possible future trends. 相似文献
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Matfield M 《Nature reviews. Drug discovery》2002,1(2):149-152
The use of animals in research and development has remained a subject of public debate for over a century. Although there is good evidence from opinion surveys that the public accepts the use of animals in research, they are poorly informed about the way in which it is regulated, and are increasingly concerned about laboratory-animal welfare. This article will review how public concerns about animal experimentation developed, the recent activities of animal-rights groups, and the opportunities and challenges facing the scientific community. 相似文献