东方国家人群幽门螺杆菌感染与结直肠肿瘤相关性的meta分析

目的采用meta分析方法对国内外已发表的有关东方国家人群中幽门螺杆菌(Hp)感染与结直肠肿瘤(包括增生性息肉、腺瘤、肠癌)的关系进行综合评价。方法对符合纳入标准的8篇文献用Review manager 5.2软件进行meta分析,选择OR值及95%CI作为meta分析指标。并做出倒漏斗图,对各研究结果进行异质性检验和效应值合并计算。结果纳入总样本量为5 385例,其中Hp阳性组为3 396例,Hp阴性组为1 989例;通过meta分析合并认为结果存在异质性(I2=83%,P0.10)。因存在异质性,对肿瘤的类型(增生性息肉、腺瘤、肠癌)、不同的Hp检测方法进行亚组分析。1Hp感染不增加患增生性息肉、结直肠非进展性腺瘤、肠癌的风险(OR=0.73,95%CI=0.45～1.17;OR=1.35,95%CI=0.98～1.86;OR=1.09,95%CI=0.71～1.68),而增加了患结直肠腺瘤及进展性腺瘤的风险(OR=1.81,95%CI=1.31～2.49;OR=2.02,95%CI=1.38～2.96);2采用血清学抗体检测出的Hp感染可增加患结直肠肿瘤的风险(OR=1.49,95%CI=1.00～2.22);3采用非血清学抗体检测出的Hp感染无明显增加患肿瘤的风险(OR=1.35,95%CI=0.89～2.07)。结论 Hp感染可能增加了结直肠腺瘤及进展性腺瘤的发生风险,但无明显增加患肠癌的风险。     

慢性胃炎患者抗幽门螺杆菌感染治疗后幽门螺杆菌感染情况分析

目的:探讨慢性胃炎患者抗幽门螺杆菌感染治疗后幽门螺杆菌感染情况及炎症因子水平变化。方法:选取2017年12月至2020年12月新泰市第三人民医院内一科收治的97例慢性胃炎患者,男54例,女43例,年龄(41.78±5.64)岁,年龄范围为25～63岁。采用随机数表法将患者随机分为单药治疗组( n＝48)和联...     

上消化道疾病患者幽门螺杆菌感染情况分析

目的:对上消化道疾病的幽门螺杆菌(Hp)感染的检测情况进行临床分析.方法:用14C-尿素呼气试验(14C-UBT)和快速尿素酶试验对l355例上消化道疾病患者进行脚感染检测,并对结果采用χ2检验进行分析.结果:l355例上消化道疾病患者的Hp检出率为57.6%.上消化道疾病的检出率依次为:十二指肠溃疡94.4%(151/160)、胃溃疡71.8%(79/110)、慢性萎缩性胃炎63.1%(123/195)、胃癌60.3%(38/63)、胃食管返流病56.2%(18/32)、慢性浅表性胃炎43.8%(299/683).消化性溃疡、慢性胃炎和胃癌组比较,差异有统计学意义(χ2=129.43,P=O.0000).不同性别、年龄Hp检出率差异无统计学意义(χ2=1.768,P=O.184;χ2=9.2128,P=O.1009).结论:上消化道疾病的Hp感染率较高,且两者关系密切;Hp感染与性别年龄无关.     

多发性硬化患者幽门螺杆菌感染情况分析

目的 探讨幽门螺杆菌(H p)感染与多发性硬化(M S)易感性间的关系.方法 回顾性分析2018年8月至2021年5月于首都医科大学附属北京天坛医院就诊的94例M S患者(M S组)的临床资料与实验室数据.另选取同时期就诊的282例体检健康者作为对照组.分析M S患者与体检健康者H p阳性率的差异,并分析差异是否与性别...     

幽门螺杆菌感染在老年结直肠腺瘤患者中的临床病理学观察

目的 探讨老年结直肠腺瘤患者中幽门螺杆菌(Hp)感染与临床病理学参数的关系.方法 将结直肠腺瘤组纳入老年结直肠腺瘤患者204例,对照组纳入110例,回顾性分析2组临床资料.观察分析Hp感染与结直肠腺瘤临床病理参数间的关系.结果 结直肠腺瘤组Hp感染阳性率为54.9％,高于对照组的42.7％,差异有统计学意义(P＜0.0...     

武汉地区公务员幽门螺杆菌感染情况分析

目的分析武汉地区公务员幽门螺杆菌(helicobacter pylori,Hp)感染情况。方法采用免疫胶体金法检测武汉地区9 790例公务员血清Hp抗体,分析不同性别、年龄人群Hp感染率。结果 Hp阳性率为25.1%,其中男性阳性率(27.6%)高于女性(21.1%)(χ2=52.33,P<0.01);随年龄增长Hp阳性率逐渐增高,在>50～60岁年龄组达到感染高峰,随后略微回落(χ2=152.16,P<0.01);>30～40岁年龄组男、女性Hp阳性率比较差异无统计学意义(P>0.05),余各年龄组男、女性Hp阳性率比较差异均有统计学意义(P<0.05或P<0.01)。结论武汉地区公务员Hp感染率与性别、年龄有密切关系。     

胃溃疡患者幽门螺杆菌感染若干情况的研究

总结了１年内该院胃镜检查４０８２例次中符合研究标准的２１６例胃溃疡（ＧＵ）患者与１０９例胃粘膜无异常者（对照组），对其幽门螺杆菌（ＨＰ）感染进行了若干情况研究，结果显示ＧＵ组ＨＰ感染率为８４７２％，与胃粘膜无异常组ＨＰ感染率４３１２％相比有显著差异（Ｐ＜０．０１），说明ＨＰ在ＧＵ发病中其重要作用。同时发现，随ＧＵ个数增加ＨＰ感染率升高，但无统计学上的显著差异（Ｐ＞０．０５），胃底至幽门各个部位ＧＵ组ＨＰ感染显著高于贲门组（Ｐ＜０．０１），而其他各组之间无显著差异（Ｐ＞０．０５）。此外，对于ＧＵ周边粘膜有或无蒌缩、肠化和／或异型增生者ＨＰ感染率情况比较，两组之间有显著差异（Ｐ＜０．０１）。     

农民上腹不适患者幽门螺杆菌感染分析

我院1992年11月～1994年11月,对有上腹不适症状接受胃镜检查的门诊及住院患者1053例,常规进行了胃粘膜活检,作快速尿素酶试验及组织切片染色检查幽门螺杆菌(Helicobacter Pylori,HP)。将其中535例农民患者(甲组)HP感染情况与518例城镇其他职业患者(乙组)进行了比较,以期探讨这些农民患者HP感染情况。     

大连地区477例人员幽门螺杆菌感染情况分析与对策

目的了解大连地区人群幽门螺杆菌(Helicobacter pylori,Hp)的感染情况,以便实施有效防治举措。方法运用酶联免疫法对477例健康体检者进行血清抗Hp抗体检测,分析Hp在不同性别、不同年龄组及不同职业受检者中的感染情况。结果大连地区部分人群Hp感染率为39.2%,其中男性感染率为42.3%,女性为35.1%,两者间差异有统计学意义(P0.05)。不同年龄组体检者Hp感染率以51~60岁最高(男性55.2%,女性52.5%),男性20岁以下最低(28.6%),女性31~40岁最低(19.6%),部分年龄组之间差异有统计学意义(P0.05)。不同职业组中,男性感染率从高到低依次为教师、行政管理人员、运动员、银行职员,分别为50.0%、47.1%、40.5%、20.0%,女性感染率从高到低依次为教师、行政管理人员、运动员、银行职员,分别为41.0%、35.5%、34.4%、28.8%。结论大连地区人群Hp感染率较高,且随年龄增长有上升趋势,并与所从事职业相关。     

体检人群1200例幽门螺杆菌感染情况调查

胃幽门螺杆菌（H．pylori,Hp）是慢性胃炎、消化性溃疡的主要病原菌,也是引起胃癌的危险因子,世界卫生组织将Hp列为第一类致癌因子,故及时检出、积极治疗非常重要。本文通过对本院体检人群血清Hp抗体检测,分析Hp感染在不同性别、年龄分布的差异及意义。     

幽门螺旋杆菌感染与大肠息肉的相关性

目的:探讨幽门螺旋杆菌感染与大肠息肉发生的相关性。方法:选择南京中医药大学附属中西医结合医院消化科2017年1月至2018年12月期间同时进行电子肠镜及幽门螺旋杆菌检查的住院患者共341例,分为肠息肉组及对照组,比较两组一般资料、幽门螺旋杆菌感染率及大肠息肉的个数、位置、大小、性质等。结果:肠息肉组幽门螺旋杆菌感染阳性率为59.1%,对照组幽门螺旋杆菌感染阳性率22.4%,差异有统计学意义(P<0.05)。肠息肉组中,大肠单发息肉患者幽门螺旋杆菌感染阳性率51.4%,多发息肉幽门螺旋杆菌感染阳性率69.8%,差异具有统计学意义(P<0.05)。幽门螺旋杆菌感染与患者年龄、性别及大肠息肉的位置、大小、性质无明显相关性(P>0.05)。结论:幽门螺旋杆菌感染可增加大肠息肉尤其是多发性大肠息肉的发病风险。     

Helicobacter pylori infection in patients with chronic hives and asthma

Difficulties in treatment of allergic diseases (ADs) are often determined by the fact that the origin of the illness is impossible to establish. Foreign researchers have demonstrated a correlation between Helicobacter pylori (HP) persistence and such conditions as chronic relapsing urticaria (CRLU), Quincke's edema (QO) and respiratory manifestations of allergy (usually bronchial asthma (BA)). HP may participate in the forming of ADs in three possible ways: 1) the bacteria interact with mast cells, and thus are able to initiate mediator liberation; 2) being full antigens, the bacteria themselves are able to cause allergy; 3) the infection process development impairs the barrier function of the alimentary tract mucosa, thus impairing food processing. This creates conditions for allergic food particles to enter bloodstream, which is facilitated by inflammatory lesions of the intestinal tract, protozoal and helminthic invasion, and dysbacteriosis. The aim of the study was to determine how frequently patients with CRU, QO and BA have HP invasion and develop intestinal microflora disbalance, as well as to find out whether there is a correlation between HP infection and alterations in the IgE-system, and establish anti-HP therapy effects, measuring the levels of anti-helicobacter antibody and IgE before and after the treatment. The study revealed HP invasion in 89.2% of patients with chronic ADs; 96.7% of the subjects had disturbances of microbiocenosis; total IgE level correlated with the allergic process activity and anti-helicobacter antibody level; eradicational therapy was more effective when included proton pump inhibitor, clarithromycin and flemoxin than when de-nol, clarithromycin and flemoxin were administered. According to the results of the study, anti-helicobacter therapy allows more effective treatment of patients with relapsing ADs and HP infection.     

558例有消化道症状患儿幽门螺杆菌检测分析

目的 了解唐山地区有消化道症状患儿幽门螺杆菌(Hp)感染状况。方法 对2013年1月至2015年1月,558例有消化道症状的门诊和住院患儿进行空腹¹³C-尿素呼气试验检测,并分析结果。结果 558例儿童Hp阳性率41.4%(231/558),其中男阳性率47.1%(152/323),女阳性率33.6%(79/235),两组比较差异有统计学意义(P＜0.01),3～6岁阳性率28.8%(40/139),7～14岁阳性率45.6%(191/419),两组比较差异有统计学意义(P＜0.01)。结论 唐山地区有消化道症状患儿Hp感染率与性别有关,男性感染率高于女性,且阳性率与年龄因素成正比。     

Helicobacter pylori infection in Finland

Helicobacter pylori causes chronic gastritis worldwide and it is the most important single factor in peptic ulcer disease. Up to half of H. pylori infected individuals develop atrophic gastritis over years and decades. H. pylori infection has also been classified as a class I carcinogen in human gastric cancer. Most infections are obtained in childhood, in Finland mainly before the age of 7 years but the exact transmission routes are not known. The infection shows an age-dependent pattern, the infection being rare among children but gradually becoming more prevalent among older age groups. As new infections are few in adults and the infection only rarely disappears without effective anti-microbial therapy, the occurrence of the infection in the old actually reflects the prevalence of the infection in their childhood. In developed countries, such as Finland, a rapid decline of H. pylori prevalence rate has been demonstrated. In order to speed up this natural decline of the infection, a unique population based 'screen and treat' project was started in Vammala, a semiurban south-western community in Finland. In this survey, young inhabitants were offered diagnosis and treatment for H. pylori.     

Helicobacter pylori infection in Finland

Helicobacter pylori causes chronic gastritis worldwide and it is the most important single factor in peptic ulcer disease. Up to half of H. pylori infected individuals develop atrophic gastritis over years and decades. H. pylori infection has also been classified as a class I carcinogen in human gastric cancer. Most infections are obtained in childhood, in Finland mainly before the age of 7 years but the exact transmission routes are not known. The infection shows an age‐dependent pattern, the infection being rare among children but gradually becoming more prevalent among older age groups. As new infections are few in adults and the infection only rarely disappears without effective antimicrobial therapy, the occurrence of the infection in the old actually reflects the prevalence of the infection in their childhood. In developed countries, such as Finland, a rapid decline of H. pylori prevalence rate has been demonstrated. In order to speed up this natural decline of the infection, a unique population based ‘screen and treat’ project was started in Vammala, a semiurban south‐western community in Finland. In this survey, young inhabitants were offered diagnosis and treatment for H. pylori.