探讨降钙素和低频脉冲电磁场治疗骨质疏松伴腰椎管狭窄的疗效

目的：探讨降钙素和低频脉冲电磁场治疗骨质疏松伴腰椎管狭窄的疗效。方法：选取我院2012年5月至2013年3月中收治的100例骨质疏松伴腰椎管狭窄患者为观察对象,将患者随机分为观察组和对照组,每组各50例,对照组患者单独使用低频电磁场治疗,观察组的患者在此基础配合降钙素进行治疗。两组患者同时采用一定剂量的钙剂和维生素D,观察两组患者治疗前、后第2、4、8周时的视觉模拟痛疼评分情况,并在治疗前后3、6个月的时候测量腰椎及股骨颈。结果：观察组患者的骨密度较对照组更好,差异具有统计学意义（P〈0．05）。结论：降钙素和低频脉冲电磁场治疗骨质疏松伴腰椎管狭窄的疗效较好,安全性较高,具有推广价值。     

降钙素配合低频脉冲电磁场治疗骨质疏松症的临床研究

目的：探讨降钙素配合低频脉冲电磁场治疗骨质疏松症的临床疗效。方法：选取84例原发性骨质疏松患者,随机分为对照组和治疗组,每组42例。两组均给予碳酸钙、维生素D等常规药物治疗。在此基础上对照组肌内注射鲑鱼降钙素,治疗组肌内注射鲑鱼降钙素并配合低频脉冲电磁场治疗。并分别评估治疗前及治疗后3个月、6个月患者的疼痛疗效及检测骨密度。结果：两组患者治疗后疼痛较治疗前均明显减轻,治疗时间越长,疼痛减轻越明显;治疗3个月、6个月后,治疗组骨密度较对照组均有显著提高,其差异有统计学意义（t=3.129,t=6.457;P〈0.05）;两组均未发生严重的不良反应。结论：骨质疏松症患者在常规治疗的基础上肌内注射鲑鱼降钙素并配合低频脉冲电磁场进行治疗,可明显减轻患者的疼痛,并增加骨密度。经统计学分析,该治疗方法疗效确切,不良反应少,具有一定的临床借鉴意义。     

脉冲电磁场生物学效应的作用机制

当今社会电磁辐射已成为一种严重的环境污染因素,并且越来越受到关注。尤其是脉冲电磁场,由于其对生物机体的作用有其本身的特点,对生物机体将产生比连续波更为明显的影响。然而,脉冲电磁场对生物机体有害或有利的机理尚不很清楚。为此,本文依据目前人体电磁模型方面的研究,就脉冲电磁场的生物学效应可能的作用机制,从基因、细胞核、细胞膜及酶活性和细胞转化等方面及其可能的临床应用前景做一概述。使之正确认识脉冲电磁场对生物物机体的双重作用,预防有害作用,利用其有利因素。     

基于脉冲电磁场的骨折愈合刺激仪

本文介绍了基于脉冲电磁场的骨折愈合刺激仪的原理与临床实验研究。采用15H2准脉冲群,5ms脉冲群延时的刺激波形产生0~8×10_(-4)T连续可调的磁场强度。临床应用26例表明,该方法可有效地治疗骨折后骨不连及延迟愈合等疾病。     

复合脉冲电磁场治疗老年妇女绝经后骨质疏松症86例临床分析

近年来．随着社会人口的老龄化．骨质疏松症（osteoporosis，OP）及其并发症是严重危害绝经后中老年妇女身体健康的主要疾病之一．作为一种临床常见病和多发病．治疗上多采用药物疗法．但是采用药物疗法存在着副作用较大、并发症较多的麻烦。我院自2004年起应用复合脉冲电磁场（compoundpulsed elect romagneticfields．C-PEMFs）治疗绝经后老年妇女骨质疏松症患者86例．疗效显著，现报告如下。     

脉冲电磁场对绝经后骨质疏松症疗效的临床研究

目的研究脉冲电磁场在治疗绝经后骨质疏松症方面的疗效。方法将152例绝经后骨质疏松症伴有腰背部疼痛的患者随机分为两组,对照组70例接受口服钙剂、阿法骨化醇和阿仑膦酸钠治疗,治疗组82例在此基础上加用脉冲电磁场治疗,分别于治疗后60、180d观察患者腰背部疼痛改善情况．并在治疗后180d测量患者骨密度。结果治疗组患者在治疗后60d较治疗前疼痛明显缓解（P〈0．01）,两组患者疼痛情况在治疗后180d均较治疗前明显缓解（P〈0．01）。对照组治疗后180d L1-L4骨密度较治疗前明显升高[（0．773±0．129）、（0．842±0．179）、（0．873±0．139）、（0．908±0．183）g／cm^2比（0．751±0．135）、（0．819±0．183）、（0．848±0．146）、（0．883±0．174）g/cm^2],差异有统计学意义（P〈0．01）。治疗组治疗后180d L1-L4骨密度较治疗前也明显升高[（0．791±0．131）、（0．853±0．181）、（0．884±0．137）、（0．918±0．180）g/cm^2比（0．750±0．123）、（0．820±0．176）、（0．850±0．140）、（0．882±0．179）g/cm^2]．差异有统计学意义（P〈0．01）。两组L1～L4骨密度治疗后180d比较差异有统计学意义（P〈0．05）。两组股骨颈区骨密度治疗前后比较差异均无统计学意义（P〉0．05）。结论脉冲电磁场在改善绝经后骨质疏松症患者腰背部疼痛症状方面作用比较明显,俩且也能够提高患者腰椎骨密度。     

脉冲电磁场对绝经后骨质疏松症疗效的临床研究

目的 研究脉冲电磁场在治疗绝经后骨质疏松症方面的疗效.方法 将152例绝经后骨质疏松症伴有腰背部疼痛的患者随机分为两组.对照组70例接受口服钙剂、阿法骨化醇和阿仑膦酸钠治疗,治疗组82例在此基础上加用脉冲电磁场治疗,分别于治疗后60、180 d观察患者腰背部疼痛改善情况,并在治疗后180 d测量患者骨密度.结果 治疗组患者在治疗后60 d较治疗前疼痛明显缓解(P<0.01),两组患者疼痛情况在治疗后180d均较治疗前明显缓解(P<0.01).对照组治疗后180 d L1～L4骨密度较治疗前明显升高[(0.773±0.129)、(0.842±0.179)、(0.873±0.139)、(0.908±O.183)g/cm2(0.751±0.135)、(0.819±0.183)、(0.848±0.146)、(0.883±0.174)g/cm2],差异有统计学意义(P<0.01).治疗组治疗后180 d L1～L4骨密度较治疗前也明显升高[(0.791±0.131)、(0.853±0.181)、(0.884±0.137)、(0.918±0.180)g/cm2比(0.750±0.123)、(0.820±0.176)、(0.850±0.140)、(0.882±0.179)g/cm2],差异有统计学意义(P<0.01).两组L1～L4骨密度治疗后180d比较差异有统计学意义(P<0.05).两组股骨颈区骨密度治疗前后比较差异均无统计学意义(P>0.05).结论 脉冲电磁场在改善绝经后骨质疏松症患者腰背部疼痛症状方面作用比较明显,而且也能够提高患者腰椎骨密度.     

脉冲电磁场对糖尿病大鼠足底血流灌注量的影响

目的：研究脉冲电磁场对糖尿病大鼠足底血流灌注量的影响.方法：成年SD大鼠随机分为3组（8只/组）：正常组（正常成年非糖尿病大鼠）、模型组（糖尿病大鼠,不施加脉冲电磁场照射）以及实验组（糖尿病大鼠,施加脉冲电磁场辐照8 h/d,6周）,以足底血流灌注量为检测指标对各组糖尿病大鼠的微循环进行评估.结果：经过6周的脉冲电磁场照射,发现脉冲电磁场能够显著抑制糖尿病引起的大鼠足底血流灌注量的降低.结论：脉冲电磁场照射能够缓解糖尿病导致的大鼠足底血流灌注量的下降,并且脉冲电磁场对相关疾病导致的微循环障碍可能有积极的治疗作用,但其确切机理还有待更多的实验来加以研究证实.     

长波脉冲电磁场对作业者健康的影响

国内首座长波导航台现场卫生学调查结果表明，发射机房内不同位点电场强度均方根值为０～３．６Ｖ／ｍ，相应的峰值场强为０～２７６．９Ｖ／ｍ，磁场强度仅为１．６×１０－３～２．５×１０－３Ａ／ｍ。作业人员ＷＢＣ减少的发生率明显高于对照组（Ｐ＜０．０１），ＷＢＣ吞噬活力显著降低（Ｐ＜０．０１），若干心血管植物神经功能调节不良的发生率也有增高倾向。     

Studies on antioxidant enzymes in mice exposed to pulsed electromagnetic fields

In this study, 56 female albino mice weighing 30-35 g were used. The animals were divided into a control and an experimental group. The animals in the experimental group were subjected to a pulsed electromagnetic field (PEMF) with a field magnitude of 50 Hz and 2 mT for 8h each day between 0900 and 1700 for 90 days. In both control and experimental groups, blood was sampled at 45, 60, and 90 days in heparinized tubes and erythrocyte malondialdehyde levels, and superoxide dismutase, glutathione peroxidase, catalase, and glucose-6-phosphate dehydrogenase activities were determined. The results revealed that the PEMF applied chronically within the given period and field magnitude does not cause oxidative damage.     

Simulation of pulsed ELF magnetic fields generated by GSM mobile phone handsets for human electromagnetic bioeffects research

Human provocation studies that investigate the effects of Global System for Mobiles (GSM) communication systems on the brain have focused on Radio Frequency (RF) exposure. We wish to further extend such study by investigating the effect of both RF and Extremely Low Frequency (ELF) field exposure, the latter generated by the GSM handset's battery switching. The use of a commercial handset as an exposure source for such investigations is problematic for a number of reasons and therefore a simulated exposure source, capable of producing both RF and ELF components of exposure, is desirable. As a first step in developing such a source, we have quantified and characterized the ELF field from several commercial handsets (the RF characteristics being already well understood). Through experimental measurement we deduce that these fields can be sufficiently simulated by a 9 mm radius loop residing 10 mm beneath the front surface of the handset device and carrying enough current to generate peak fields of 25 microT at the surface of the handset.     

Effects of low-energy electromagnetic fields (pulsed and DC) on membrane signal transduction processes in biological systems

The vertebrate organism possesses a number of internal processes for signaling and communication between cell types. Hormones and neurotransmitters move from one cell type to another and carry chemical "messages" that modulate the metabolic responses of tissues to the environment. Interaction with these signaling systems is a potential mechanism by which very low-energy electromagnetic fields might produce metabolic responses in the body. Hormone and neurotransmitter receptors are specialized protein molecules that use a variety of biochemical activities to pass chemical signals from the outside of a cell across the plasma membrane to the interior of the cell. Since many low-energy electromagnetic fields have too little energy to directly traverse the membrane, it is possible that they may modify the existing signal transduction processes in cell membranes, thus producing both transduction and biochemical amplification of the effects of the field itself. As an example of the kinds of processes that may be involved in these interactions, one metabolic process in which the physiological effects of low-energy electromagnetic fields is well established is the healing of bone fractures. The process of regulation of bone turnover and healing is reviewed in the context of clinical applications of electromagnetic energy to the healing process, especially for persistent nonunion fractures. A hypothetical molecular mechanism is presented that might account for the observed effects of electromagnetic fields on bone cell metabolism in terms of the fields' interference with signal transduction events involved in the hormonal regulation of osteoblast function and differentiation.     

Exposure modeling of high-frequency electromagnetic fields

We developed a geospatial model that calculates ambient high-frequency electromagnetic field (HF-EMF) strengths of stationary transmission installations such as mobile phone base stations and broadcast transmitters with high spatial resolution in the order of 1 m. The model considers the location and transmission patterns of the transmitters, the three-dimensional topography, and shielding effects by buildings. The aim of the present study was to assess the suitability of the model for exposure monitoring and for epidemiological research. We modeled time-averaged HF-EMF strengths for an urban area in the city of Basel as well as for a rural area (Bubendorf). To compare modeling with measurements, we selected 20 outdoor measurement sites in Basel and 18 sites in Bubendorf. We calculated Pearson's correlation coefficients between modeling and measurements. Chance-corrected agreement was evaluated by weighted Cohen's kappa statistics for three exposure categories. Correlation between measurements and modeling of the total HF-EMF strength was 0.67 (95% confidence interval (CI): 0.33-0.86) in the city of Basel and 0.77 (95% CI: 0.46-0.91) in the rural area. In both regions, kappa coefficients between measurements and modeling were 0.63 and 0.77 for the total HF-EMF strengths and for all mobile phone frequency bands. First evaluation of our geospatial model yielded substantial agreement between modeling and measurements. However, before the model can be applied for future epidemiologic research, additional validation studies focusing on indoor values are needed to improve model validity.     

低频磁疗对缓解脑胶质瘤患者瘤周水肿的效果初探

【目的】了解低频脉冲电磁场(low frequency pulsed electromagnetic field,LFPEMF)对治疗脑胶质瘤瘤周水肿的作用,为临床治疗脑胶质瘤瘤周水肿提供一定的理论依据。【方法】将2017年3月至2018年12月期间就诊于首都医科大学附属北京世纪坛医院脑胶质瘤科的脑胶质瘤术后复发伴瘤周水肿患者32例作为研究对象。患者应用低频电磁场治疗10~14 d。治疗前后记录患者脑水肿相关临床症状、美国国立卫生研究院卒中量表(NIHSS)得分、卡氏生活质量评分(KPS)得分、头颅磁共振成像(MRI)脑水肿及肿瘤范围、T淋巴细胞亚群CD4+/CD8+比值、超氧化物歧化酶(SOD)水平等。采用自身前后对照研究方法,应用SPSS 21.0统计软件进行统计学分析。【结果】经低频电磁场治疗后,达临床有效者25人,无效者7人,总有效率为78.13%。使用低频电磁场治疗后患者脑水肿带面积有明显减小(P<0.05),脑肿瘤面积无明显改善(P>0.05)。与低频电磁场治疗前相比,KPS及NIHSS评分明显改善(P<0.05)。【结论】对脑胶质瘤瘤周水肿患者涌泉穴及劳宫穴进行低频脉冲电磁场治疗,可以减轻脑胶质瘤瘤周水肿及临床症状。     

脉冲磁场刺激仪的研制

研制的脉冲磁场刺激仪主要指标是：最大磁感应强度0．01-2T，频率0．2-100Hz，脉冲宽度0．01～1ms。仪器的工作方式分为手控、脚控和自控，可显示刺激强度和刺激次数，并可输出不同波形的触发信号，使检测仪器同步工作。     

数码式音乐电治疗仪的研制

音乐电治疗仪是一种实用性很强的理疗仪器，现有的磁带式音乐电治疗仪存在很多缺陷，本文介绍了一种新型音乐电治疗仪的研制过程及临床应用，利用最新的数码技术提供立体声源，配上电极电针，选择合适的处方音乐，临床效果满意。