恩纳乳膏在小儿包皮粘连分离术中的应用

目的 观察表面麻醉剂恩纳乳膏在包皮粘连分离治疗时的镇痛效果.方法 将包皮粘连分离的176例患儿随机分为观察组(86例)和对照组(90例),观察组在阴茎包皮及龟头涂恩纳乳膏后进行粘连分离术,对照组不涂任何药物,直接进行粘连分离术.结果 观察组疼痛感显著低于对照组(P＜0.01).结论 恩纳乳膏可有效减轻或消除包皮粘连分离治疗导致的疼痛.     

恩纳涂抹麻醉包皮环扎切除术65例

我们探讨用恩纳乳膏涂抹麻醉方法，于2000年1-12月对部分需作包皮环切术而且包皮可上翻的病例作包皮无血环扎切除术〔1〕，现报告如下。1资料与方法1.1临床资料本组65例，其中4-6岁10例，-10岁15例，-14岁29例，＞14岁11例。均有1次以上包皮炎病史。恩纳（EMLA）乳膏，瑞典阿斯特拉（ASTRA）药厂生产，每支乳膏总含量为5 g，每克含利多卡因25 mg、丙胺卡因25 mg，以赋型剂乳化为稳定混合剂。采用包皮环扎切术专用器械〔1〕。1.2方法将包皮外翻直到冠状沟，将恩纳涂满包皮内板，将包皮复位，尔后在包皮外板表面阴茎远端2/3涂满恩纳，总用…     

恩纳乳膏用于尿毒症患者血液透析静脉穿刺镇痛

目的观察恩纳乳膏用于尿毒症患者血液透析静脉穿刺的镇痛效果。方法将80例尿毒症维持性血液透析患者随机均分为对照组和恩纳镇痛组各40例，恩纳镇痛组患者穿刺点周围涂恩纳乳膏1g，对照组患者涂红霉素乳膏1g，90min后进行血管穿刺。采用视觉模拟评分法（VAS）评价两组患者痛觉，以及有无肢体抵抗、局部皮肤并发症等。结果恩纳镇痛组患者VAS评分显著低于对照组（P〈0．01），两组患者穿刺时均无明显肢体抵抗，无局部并发症发生。结论恩纳乳膏可减轻尿毒症维持性血液透析患者静脉穿刺时的疼痛，且使用安全、方便。     

恩纳乳膏用于尿毒症患者血液透析静脉穿刺镇痛

目的 观察恩纳乳膏用于尿毒症患者血液透析静脉穿刺的镇痛效果.方法 将80例尿毒症维持性血液透析患者随机均分为对照组和恩纳镇痛组各40例,恩纳镇痛组患者穿刺点周围涂恩纳乳膏1 g,对照组患者涂红霉素乳膏1 g,90 min后进行血管穿刺.采用视觉模拟评分法(VAS)评价两组患者痛觉,以及有无肢体抵抗、局部皮肤并发症等.结果 恩纳镇痛组患者VAS评分显著低于对照组(P<0.01),两组患者穿刺时均无明显肢体抵抗,无局部并发症发生.结论 恩纳乳膏可减轻尿毒症维持性血液透析患者静脉穿刺时的疼痛,且使用安全、方便.     

手法分离治疗小儿包皮内板粘连80例

目的观察纯手法分离治疗小儿包皮内板粘连的临床效果。方法采用纯手法分离治疗小儿包皮内板粘连,并在创面涂上粘膜碘、抗生素软膏（红霉素）,术后每天用生理盐水清洗1～2次,口服抗生素3天,定期复查。结果本组随访6～12个月,阴茎勃起、尿频、尿道口红肿及包皮垢均消失,包皮上翻自如。结论纯手法分离治疗小儿包皮内板粘连效果良好,危险系数小,适宜推广治疗。     

恩纳用于小儿包皮环切术麻醉的可行性

恩纳是一种透皮吸收的乳膏样局部麻醉剂,本研究将恩纳涂抹在小儿阴茎部行包皮环切术,旨在为患儿行该手术探讨一种新的麻醉方法。资料和方法 病例选择 随机选择140例拟采用包皮环切器行包皮环切手术患儿,年龄2-12岁,体重10-45 kg。4 h前进食或饮水、呼吸道感染、高铁血红蛋白血症、体重过低及过度肥胖     

医用透明质酸钠预防小儿包茎环套术后粘连的评价

目的：了解小儿包茎术后包皮粘连的发生及透明质酸预防粘连的效果。方法：2008年12月～2009年1月门诊小儿包茎包皮环套术90例，随机分A、B、C三组，术中分别局部用1％透明质酸、局部用红霉素、空白对照。随访2个月，观察冠状沟处粘连情况。结果：A、B、C三组术中无粘连率分别为10％、6％、10％。粘连面积50％以上三组分别为43％、53％、40％。术后评估，三组术中无粘连者术后粘连率均为0。三组术中有粘连者术后粘连率分别为74．7％（20／27）、78．6％（22／28）、100％（27/27）。总无粘连率分别为33．3％、26．7％、10．0％，透明质酸与红霉素组粘连发生率与空白对照比较，差异有统计学意义（P〈0．05）。结论：透明质酸可减少小儿包茎、包皮环套术后包皮粘连的发生。     

恩纳乳膏应用于手术患者静脉穿刺镇痛的效果观察

目的 评价恩纳乳膏应用于手术患者静脉穿刺的镇痛效果。方法 选择40例择期手术患者，在静脉穿刺前30min使用恩纳乳膏,观察其镇痛效果，生效时间与年龄、性别的关系及对患者产生的心理影响。结果 使用恩纳孔膏后患者对静脉穿刺及手术疼痛的惧怕率显著降低；使用30min、60min无痛率分别为52．5％、80．0％，与20min（10．0％）相比，疼痛程度显著减轻（均P〈0．01）;患者达到完全镇痛的时间小儿、女性显著短于成人、男性（均P〈0．01）。结论 恩纳乳膏应用于手术患者的静脉穿刺，镇痛效果好，并可缓解患者术前的紧张心理。     

湿润烧伤膏在包皮手术粘连创面的临床疗效观察

我院自2006年2月—2007年8月对24例包皮粘连患者行粘连分离加包皮环切术，术后用烧伤湿润膏（美宝，MEBO，汕头市美宝制药有限公司生产，批准文号：Z20000004）纱条代替凡士林纱条外敷切缘，并用MEBO涂抹粘连创面，取得满意效果，现报告如下。     

0.05%地奈德乳膏治疗湿疹皮炎类皮肤病的效果

目的 探究使用0.05%地奈德乳膏治疗湿疹皮炎类皮肤疾病的有效性。方法 选取我院2021年 10月-2022年9月收治的70例湿疹皮炎类患者为研究对象，按照随机数字表法分为对照组与观察组，各 35例。对照组采用1%氢化可的松乳膏治疗，观察组采用0.05%地奈德乳膏治疗，比较两组临床疗效、症状 评分及不良反应发生情况。结果 观察组治疗总有效率高于对照组（P＜0.05）；观察组治疗后EASI及瘙痒 度评分低于对照组（P＜0.05）；观察组不良反应总发生率低于对照组（P＜0.05）。结论 0.05%地奈德乳膏 在湿疹皮炎类皮肤疾病治疗效果较好，可有效缓解症状，且安全性较高。     

杭州健康女性定量骨超声测定原发性骨质疏松

目的 评价杭州健康女性骨超声速度(SOS)值随增龄减少和骨质疏松患病率，建立杭州地区女性骨超声速度值参考数据库。方法 定量超声法测定1208例杭州地区健康女性桡骨远端(RAD)，第3指骨近节(PLX)，第V跖骨(MTR)和胫骨中段(TIB)的超声速度值。结果 RAD、PLX、MTR和TIBSOS峰值(Peak of SOS)均出现在40-45岁，TJB的SOS峰值出现在35—40岁，此后随年龄增长而下降。绝经后妇女在绝经后早期和晚期各有1个SOS快速减少期，前见于桡骨近端，平均年减少率为2．4％，后见于胫骨中段，平均年减少率为1．8％。各部位骨SOS累积减少率随年龄增长而增加，到85岁4部位累积减少为13％-18％。60岁以后骨质疏松性症(OP)检出率为45％-70％，OP检出率以桡骨远端最高，60-70岁平均为67％，第3指骨近端次之约50％，胫骨中段最低为36％；75岁以后分别为70％，65％和45％。结论 全身各部位骨超声速度值到达峰值的年龄不同，峰值也各有差异。绝经后妇女骨超声速度值随年龄增加减少较快，应予激素和补钙治疗，桡骨远端为本地区SOS检测和OP检出的敏感部位。     

Importance of echocardiography in prognosis of surgical outcomes in cholecystitis in elderly patients

The authors propose to use more often echocardiography (EchoCG) in examination of elderly (over 60 years) of age patients with cholecystitis that permits to increase surgical activity to 92.4%. Left ventricular ejection fraction is the most informative. When this fraction is lower than 45% surgery must be recommended on vital indications only. EchoCG was used in 155 patients with cholecystitis, 131 of them were operated. 2 (1.52%) patients died due to acute cardio-vascular insufficiency and pulmonary artery thromboembolism.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

目的 评价脊髓胶质细胞在小鼠骨癌痛形成中的作用.方法 健康雄性C3H/He小鼠40只,周龄8～10周,体重18～22 g,随机分为4组(n=10):假手术组(S组)、骨癌痛组(B组)、PBS组(P组)和米诺环素组(M组).S组跟骨骨髓腔内注射PBS 10 μl;余3组跟骨骨髓腔内注射含2×105个骨纤维肉瘤细胞的PBS 10 μl制备骨癌痛模型,于造模前即刻开始PBS组鞘内注射PBS 5μl,M组鞘内注射米诺环素(用PBS溶解为0.2 mmol/L)5μl,1次/d,连续11 d.于造模前1 d、造模后即刻、3、5、7、9、11 d时测定机械痛阈;于造模后3、7、9、11 d机械痛阈测定结束后测定冷痛阈.痛阈测定结束后处死小鼠,取脊髓组织,测定神经胶质纤维酸性蛋白(GFAP)和CD11b的表达水平.结果 与S组比较,B组和P组造模后3-11 d时、M组造模后3、5 d时机械痛阈升高,B组、P组和M组造模后7～11 d时冷痛阈升高,脊髓CD11b和GFAP表达上调(P<0.05).与B组比较,M组造模后3-11 d时机械痛阈降低,造模后7-11 d时冷痛阈降低,脊髓CD11b和GFAP表达下调(P<0.05).结论 脊髓胶质细胞(星形胶质细胞和小胶质细胞)的激活参与了小鼠骨癌痛的形成.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.