脂蛋白A和载脂蛋白A多态性与脑梗死的关系

脂蛋白Ａ和载脂蛋白Ａ多态性与脑梗死的关系２５００３１济南济南军区总医院王和德郭述苏许荣家陈同慧尚明谦关键词脑梗塞；载体蛋白类中国图书资料分类号Ｒ７４３．３２脂蛋白（ＬｐＡ）是脑血管疾病的危险因素之一，但作为ＬｐＡ特殊的载脂蛋白（ａｐｏＡ）的多态性与脑...     

Über A1/A2-Bestimmungen bei Massenblutgruppenuntersuchungen

Ohne ZusammenfassungVortrag auf der Tagung der Deutschen Gesellschaft für gerichtliche und soziale Medizin, Oktober 1956, in Marburg a. d. Lahn.     

维生素A可防肺癌

维生素Ａ可防肺癌马效品编译在所有的癌症中，肺癌是头号杀手。在美国，每年有十几万人死于肺癌。戒烟是减少肺癌发病率的一种必要措施，还有一种有效的措施就是改变人的饮食习惯。新的研究表明，即使是一个吸烟成瘾的人，只要每天饮食中有定量的胡萝卜、菠菜或其它含维生...     

腺苷A2A受体：机体免疫调节的重要分子

腺苷A2A受体是目前已知的四种腺苷受体（A1、A2A、A2B和A3）之一,其在免疫细胞上呈高水平表达,活化后可通过对免疫细胞功能的调控而密切参与炎性反应、免疫耐受等免疫调节。但在不同的病理条件下,A2A受体活化的免疫调节作用方向不同、产生的效应不同。因此,对该受体产生不同免疫调节作用原因及机制进行深入的研究,以有效发挥其保护作用,而避免损伤效应,将为在临床疾病的免疫治疗中合理利用A2A受体调节剂奠定基础。     

STEPS TO A STRONGER SKELETON

Ｅｘｅｒｃｉｓｅａｎｄｄｉｅｔａｒｙｉｎｔａｋｅｏｆｃａｌｃｉｕｍａｒｅｔｗｏｌｉｆｅｓｔｙｌｅｆａｃｔｏｒｓｗｉｔｈｉｎｏｕｒｃｏｎｔｒｏｌｔｈａｔｃａｎｇｒｅａｔｌｙｉｍｐｒｏｖｅｂｏｎｅｈｅａｌｔｈ.Ｔｈｅｏｐｔｉｍａｌｃｈａｒａｃｔｅｒｉｓｔｉｃｓｏｆａｐｈｙｓｉｃａｌａｃｔｉｖｉｔｙｐｒｏｇｒａｍｔｈａｔｔｙｐｉｃａｌｌｙｗｉｌｌｉｎｃｒｅａｓｅｂｏｎｅｍａｓｓａｎｄｔｈｅｒｅｂｙｍｉｎｉｍｉｚｅｆｒａｃ ｔｕｒｅｒｉｓｋａｒｅｓｕｍｍａｒｉｚｅｄｉｎｔｈｅｔａｂｌｅｂｅｌｏｗ .Ｅｘａｍ…     

冠心病与A型性格

美国医学博士弗里曼（Friedman)和罗森曼（Rosenmen)在1959年提出了以时间紧迫感和好胜心过强的主要特征的A型性格（行为）是发生冠心病的一个危险因素^[1]。现代医学模式转化，A型性格作为冠心病的危险因素日益引起人们重视。本文对100名40－60岁职工进行A型性格问卷测试，发现具有A型性格行为者占55％并追踪随访具有A型性格行为者；其中70％者已患冠心病因素。提示A型性格是冠心病发生的主要易患因素。     

A punch drunk jockey?

The case is reported of a retired professional jockey with progressive memory loss. The concern is that he may be suffering from chronic traumatic encephalopathy or the "punch drunk syndrome".     

eIF-5A与hypusine

翻译起始因子eIF-5A在真核细胞内普遍存在，是目前为止惟一发现含独特氨基酸hypLlsine残基的蛋白。hypusine是eIF-5A前体的特定赖氨酸残基(第50位)经亚精胺依赖性的翻译后修饰形成的，每一成熟的eIF-5A仅含一个hypusine残基，eIF-5A的hypusine修饰是其发挥功能、细胞存活和增殖所必需的。本文对eIF-5A的研究历史、现状和hypusine功能的近期进展进行了概述，并进一步分析了eIF-5A的可能功能及hypusine修饰过程作为药物靶标诱导细胞凋亡的应用前景。     

环孢素A与创伤性脑损伤

创伤性脑损伤(traumatic brain injury，TBI)包括创伤部位的直接损伤和创伤后缺血缺氧、钙通道异常和脂质过氧化反应等病理过程所介导的继发性损伤。继发性损伤是决定损害范围和程度的重要因素之一，因此，防止脑创伤后的继发损害具有重要意义，也是脑保护性治疗的目标。近几年研究表明，     

环孢菌素A阻断刀豆蛋白A诱发昆明小鼠肝损害的研究

观察环孢菌素A（Cs A）能否阻断刀豆蛋白A（Con A）诱发小鼠肝损害,将昆明小鼠随机分为5组,Con A自小鼠尾静脉注入制作肝损害实验动物模型,据Con A应用剂量不同而分别称为Con A 10mg/kg组,Con A20 mg/kg组和Con A 40mg/kg组;应用Con A前15h和1h皮下注射Cs A(130mg/kg0,该组称为Cs A组,单独用PBS者为对照组,应用Con A后8h取小鼠血测定ALT与TNF-α,并取肝组织行病理学观察。结果显示,Con A功复制了小鼠特异性肝损害;Cs A组小鼠血浆中ALT与PBS组相比无显著性差异（P＞0.05）,血浆TNF－α亦无增高;病理学观察未发现肝脏内淋巴细胞及其他炎性细胞浸润,提示Cs A可完全阻断Con A诱发小鼠肝损害,抑制淋巴细胞活化和TNF－α的释放是其重要的保护机制。     

False-positive diatom test: A real challenge? A post-mortem study using standardized protocols

The main criticism of the validity of the diatom test for the diagnosis of drowning is based on the potential ante- and post-mortem penetration of diatoms and the finding of diatoms in bodies of non-drowned human beings. However, qualitative and quantitative studies on diatoms in organs of the non-drowned have yielded both conflicting and contradictory results. In the present study, we have analysed under standardised methods the diatom content in several organs of 14 non-drowned human bodies. Overall, only 9 diatoms (6 entire, 3 fragmented) were disclosed in 6 of the 14 non-drowned bodies. Each of these 6 cadavers had only a single “positive” organ. Six diatoms were found in the bone marrow, 2 in the lung, and one in the pleural liquid. No diatoms were recovered from the brain, liver, kidney, or blood samples of any of these 14 bodies. Moreover, in five additional cadavers, whose lungs were injected, prior autopsy, with a 3.5 L solution containing a bi-cellulate diatom culture (Thalassiosira baltica, Thalassiosira levanderi) via tracheostomy, a few diatoms appeared in the pleural cavity and in the blood from the left heart chamber, but none in any other internal organs investigated. The results of the presented study demonstrate that the issue of the false-positive diatom test should not be a logical impediment to the performance of the diatom method. However, strict and standardized protocols aimed at avoiding contamination during sample preparation must be used, appropriate separation values set and taxonomic analysis of all diatoms performed.     

Palonosetron—A Single-Dose Antiemetic Adjunct for Hepatic Artery Radioembolization: A Feasibility Study

Nausea and vomiting may occur in a significant minority of patients following hepatic artery embolization with yttrium-90 spheres (K. T. Sato et al. Radiology 247:507–515, 2008). This encumbers human and economic resources and undercuts the assertion that it is as a well-tolerated outpatient treatment. A single intravenous dose of palonosetron HCl was administered before hepatic artery embolization with yttrium-90 spheres to ameliorate posttreatment nausea and vomiting, in 23 consecutive patients. The patients were discharged the day of procedure on oral antiemetics, steroids, and blockers of gastric acid release. All patients had clinical and laboratory evaluation at 2 weeks after the procedure. The data were gathered and reviewed retrospectively. At 2-week follow-up, none reported significant nausea, vomiting, additional antiemetic use, need for parenteral therapy, hospital readmission, or palonosetron-related side effects. All patients recovered from postembolization symptoms within a week after treatment. In conclusion, this retrospective study suggests that single-dose palonosetron is feasible, safe, and effective for acute and delayed nausea and vomiting in this group of patients. The added cost may be offset by benefits.     

谷氨酸对腺苷A2A受体调节一氧化氮合酶活力的影响

目的探讨谷氨酸是否能够影响腺苷A2A受体对一氧化氮合酶（NOS）活力的调节。方法用1000ng／ml脂多糖（LPS）刺激小胶质细胞，分别加入100nmol／L A2A受体激动剂CGS21680以及不同浓度的谷氨酸（0，1，0，25，0，5mmol／L）干预，观察NOS活力变化。结果LPS诱导NOS活力增高，激活A2A受体可以产生抑制作用；0，25及0．5mmoL／L谷氨酸和A2A受体激动剂同时存在时，NOS活力进一步增高。结论高浓度谷氨酸可逆转腺苷A2A受体激动剂抑制升高NOS活力的作用。