神经内科癫痫病临床诊治效果观察

目的：探讨神经内科癫痫病临床诊治效果和有效方法。方法：选取2015年2月至2016年5月在该院接受治疗的神经内科癫痫病患者50例，随机分成两组，对照组患者单纯进行予德巴金药物治疗，观察组患者进行德巴金联合拉莫三嗪药物治疗。结果：加强临床诊治后发现，观察组患者临床治疗有效率明显高于对照组，且观察组患者后期不良反应发生率明显低于对照组，差异存在统计学意义（P＜0.05）。结论：针对神经内科癫痫病患者来说，临床症状变化速度快，必须在准确诊断病情之后采取有效的治疗方法，相对比来看，德巴金联合拉莫三嗪药物治疗效果显著。     

46例癫痫病患者临床治疗效果分析

目的 分析德巴金联合利必通治疗癫痫病患者的临床疗效,探讨德巴金联合利必通在治疗癫痫病中的临床价值.方法 随机抽选2014年1月1日—2015年6月30日在该院就诊并接受治疗的癫痫病患者共计92例,随机分为对照组和观察组,每组46例患者.为对照组患者予以德巴金治疗,对观察组患者提供德巴金联合利必通治疗,观察并比较两组患者经治疗后的疗效.结果 经治疗观察组患者的总有效率为86.06%(40/46),对照组的总有效率为65.22%(30/46),观察组优于对照组,疗效显著.而不良反应方面观察组不良反应发生率26.09%(12/46)对照组不良反应发生率为30.43%(14/46),两组比较差异无统计学意义(P>0.05).结论 德巴金联合利必通对癫痫病的治疗能够获得较好疗效,值得临床推广.     

神经内科癫痫病患者的临床治疗效果

目的探析对神经内科癫痫病患者进行临床治疗的效果。方法选取2015年4月至2016年4月神经内科收治的100例癫病患者作为研究对象,在经得家属同意后将患者随机分为观察组和对照组,每组50例,对照组患者给予单纯的德巴金治疗,观察组患者在对照组基础上加用利必通,对比观察两组的临床治疗效果。结果观察组总有效率明显高于对照组,两组比较差异具有显著性(P0.05)。结论对于神经内科癫病病患者给予德巴金联合利必通治疗能够收到显著的疗效,治疗过程中不良反应少,安全性能高,在临床有推广使用价值。     

神经内科癫痫病的临床诊断及治疗效果探讨

目的:探讨神经内科癫痫病的临床诊断问题,观察疾病的治疗效果。方法:选取本院患者67例作为样本,将其分为治疗组与对照组。两组患者分别采用头颅CT与头颅MRI诊断,对照组给予德巴金治疗,治疗组在给予德巴金的基础上,联合给予利必通治疗。结果:CT与MRI诊断结果对比无统计学差异(p0.05),对照组治疗有效率81.82%,治疗组治疗有效率97.06%。结论:临床可视患者需求,采用CT或MRI诊断癫痫。应将德巴金与利必通联合用于癫痫的治疗中,提高治疗有效率。     

神经内科癫痫病的临床诊断及治疗效果分析

目的研究神经内科癫痫病的临床诊断及治疗效果并作出分析。方法选择本院神经内科癫痫病患者100例为本次研究对象,分为研究组与对照组,并且给予两组神经内科癫痫病患者不同的治疗方法持续治疗三个月;仔细观察两组患者的各项临床表现,研究结束后进行比较分析。结果持续三个月治疗后临床治疗效果比较,研究组神经内科癫痫病患者的治疗总有效率明显优于对照组,P0.05;两组神经内科癫痫病患者的不良反应发生情况比较,对照组神经内科癫痫病患者不良反应发生率明显高于研究组,P0.05。结论神经内科癫痫病患者的临床诊断应结合各方面的具体资料作综合性判断确诊,丙戊酸钠缓释片及拉莫三嗪片联合使用可以提高临床治疗效果,值得临床推广及应用。     

应用尼莫通联合复方丹参和右旋糖酐治疗脑梗塞的临床疗效观察

目的：分析应用尼莫通联合复方丹参和右旋糖酐治疗脑梗塞的临床疗效。方法：选取90例脑梗塞患者作为研究对象,按照数字抽签法将其随机分为研究组与对照组,每组各有患者45例。为研究组患者应用尼莫通联合复方丹参（注射液）和右旋糖酐进行治疗,为对照组患者应用右旋糖酐联合复方丹参进行治疗,然后比较两组患者的治疗效果。结果：研究组患者的治愈率为44.4%,总有效率为91.1%;对照组患者的治愈率为33.3%,总有效率为75.6%。研究组患者治疗的效果明显优于对照组患者（P＜0.05）。治疗后研究组患者神经功能损伤的改善效果评分明显优于对照组患者（P＜0.05）。两组患者在治疗中均未出现严重的不良反应。结论：应用尼莫通联合复方丹参和右旋糖酐治疗脑梗塞具有显著的临床疗效,该疗法可在临床上推广应用。     

神经内科癫痫病的临床诊断及治疗效果探讨

目的:探讨神经内科癫痫病的临床诊断及治疗效果。方法:对我院神经内科2011年2月至2013年4月收治的癫痫病患者进行抽样,按照入院时间将40例患者分为对照组和观察组。对照组采取丙戊酸钠缓释片治疗,观察组采取丙戊酸钠缓释片联合拉莫三嗪治疗。对两组患者治疗前后效果进行对比分析。结果:观察组治愈7例(35%)、显效6例(30%)、好转5例(25%),总有效率90%。对照组治愈4例(20%)、显效4例(20%)、好转6例(30%),总有效率70%。两组治疗有效率差异有统计学意义,P0.05。所有患者未出现严重不良反应。结论:丙戊酸钠缓释片联合拉莫三嗪治疗效果显著。但癫痫病发病类型多,要根据患者病史、临床症状、EEG等综合诊断,针对性的采取治疗方法,提高癫痫病治愈率。     

应用苇苓汤治疗慢性前列腺炎的疗效观察

目的：探讨分析应用苇苓汤治疗慢性前列腺炎的临床疗效。方法：选取2012年6月～2013年6月间我院收治的慢性前列腺炎患者124例作为研究对象，将其随机分为研究组（62例）与对照组（62例），应用前列康片为对照组患者进行治疗，应用前列康片联合苇苓汤为研究组患者进行治疗，观察对比两组患者的临床疗效，并将对比的结果及两组患者的临床资料进行回顾性的分析。结果：研究组患者治疗的总有效率为95.16%，对照组患者治疗的总有效率为79.03%，研究组患者的临床疗效明显优于对照组患者，差异显著（P＜0.05），具有统计学意义。结论：应用苇苓汤治疗慢性前列腺炎的临床疗效显著，值得在临床上推广应用。     

中药熏眼联合玉屏风散对单纯疱疹性病毒性角膜炎血清及泪液相关指标的影响

目的 探讨单纯疱疹性病毒性角膜炎应用中药熏眼联合玉屏风散的治疗效果及对血清及泪液相关指标的影响。方法 选取2016年5月—2017年5月我院收治的单纯疱疹性病毒性角膜炎患者102例，根据治疗方法不同分成2组，对照组应用玉屏风散加减治疗，研究组应用中药熏眼联合玉屏风散加减治疗，对比临床疗效、视力改善情况以及血清、泪液的氧化应激指标以及其他指标。结果 对比临床疗效，研究组疗效显著优于对照组（P＜0.05）；治疗后2组患者视力均有所改善，且研究组显著优于对照组（P＜0.05）；治疗后研究组血清、泪液的MAD、NO、β-MG水平显著低于对照组，而TAC、Zn水平高于对照组（P＜0.05）。结论 应用中药熏眼联合玉屏风散加减的方法治疗单纯疱疹性病毒性角膜炎，有助于改善患者的角膜病变，提高患者视力，值得临床推广。     

中青年肺结核患者与老年肺结核患者病情特点的对比分析

目的：对中青年肺结核患者与老年肺结核患者的病情特点进行对比分析。方法：将2012年1月至2013年5月我院收治146例肺结核患者按照年龄的不同分为对照组（16-59岁）与研究组（60-89岁），比较两组患者痰结核菌检查结果的阳性率、临床症状、治疗结果及发生合并症的情况。结果：两组患者进行痰结核菌检查结果的阳性率与临床症状相比较，差异显著（P<0.01），有统计学意义。研究组患者治疗的有效率明显低于对照组患者，差异显著（P<0.05），有统计学意义。研究组患者的临床病死率明显高于对照组患者，差异显著(P<0.05)，有统计学意义。两组患者发生合并症的几率相比较，差异显著（P<0.05），有统计学意义。结论：在治疗肺结核的过程中，早发现、早诊断、早治疗是提高患者治愈率的重要措施。因此，临床医生在对老年肺结核患者进行抗结核治疗时应采取“早期、联合、适量、规律”的综合措施。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.