重组人脑利钠肽对急性心肌梗死伴心衰患者的疗效观察

目的：观察重组人脑利钠肽治疗急性心肌梗死伴心衰患者的疗效及安全性。方法：我院2008年11月～2010年11月共收治急性心肌梗死伴心衰患者64例,随机分成对照组和治疗组各32例,对照组给予常规利尿、扩血管等治疗．治疗组在常规治疗的基础上加用重组人脑利钠肽。结果：治疗组与对照组相比,显效率、有效率差异均有统计学意义（均P〈O．05）,总有效率差异有高度统计学意义（P〈0．01）;治疗组治疗前后LVDD、LVEF、NT—proBNP、hs—CRP水平均显著改善（均P〈O．05）。结论：重组人脑利钠肽治疗急性心肌梗死伴心衰效果显著,可以作为临床治疗的常规用药。     

重组人脑利钠肽治疗急性心肌梗死伴心力衰竭的疗效观察

目的:重组人脑利钠肽治疗急性心肌梗死伴心力衰竭的疗效探讨。方法:选择74例急性心肌梗死患者,按照随机数字表法将患者划分为观察组与对照组各37例,观察组在对照组治疗基础上联合重组人脑利钠肽治疗,对照组采用常规治疗措施,评价两组患者疗效。结果:观察组治疗总有效率35例(94.59%),高于对照组的27例(72.97%),差异有统计学意义(χ~2=17.198,P<0.05)。结论:重组人脑利钠肽治疗急性心肌梗死伴心衰患者可有效改善患者心功能。     

急性心肌梗死合并心力衰竭应用替罗非班及重组人脑利钠肽的临床研究

目的：研究急性心肌梗死合并心力衰竭(AMI-HF)应用替罗非班及重组人脑利钠肽的临床疗效。方法整群选取该院2013年9月—2015年8月确诊并收治的168名AMI-HF患者按照随机数字表法分为研究组和对照组各84人。两组均采用AMI-HF基线治疗。对照组在基线治疗基础上应用尿激酶实施溶栓治疗,研究组在基线治疗基础上应用替罗非班及重组人脑利钠肽治疗。对比两组临床疗效、治疗前后心彩超主要参数变化情况、不良反应。结果研究组总有效率为96.43%,显著优于对照组的83.33%。研究组左室舒张末径、左室收缩末径、左室射血分数治疗后改善幅度显著优于对照组。两组均无明显不良反应发生。结论 AMI-HF应用替罗非班及重组人脑利钠肽疗效确切,可更显著改善患者心功能,安全性好。     

重组人脑利钠肽治疗急性心梗合并急性左心衰竭临床分析

目的观察重组人脑利钠肽治疗急性心肌梗死合并急性左心衰竭的临床效果。方法将64例急性心肌梗死合并急性左心衰竭患者随机分为两组,各32例。对照组进行常规治疗,观察组在常规治疗基础上加用重组人脑利钠肽治疗,两组均连续治疗3-7 d,观察两组治疗后临床症状及体征改善情况,并对两组临床效果进行比较。结果观察组临床总有效率为93.75%,高于对照组的75.00%（P〈0.05）;治疗结束后,两组患者心率、血压值均低于治疗前（P〈0.05）;两组治疗后比较,观察组心率、血压均低于对照组（P〈0.05或P〈0.01）。结论重组人脑利钠肽治疗急性心肌梗死合并急性左心衰竭,临床效果显著。     

重组人脑利钠肽对急性心肌梗死伴心衰患者的临床效果观察

目的探讨重组人脑利钠肽治疗急性心肌梗死伴心衰患者的临床效果。方法对2013年5月~2016年1月期间来我院治疗的急性心肌梗死伴心衰患者110例进行分析,将其按照随机数字表法分为两组,研究组和对照组各55例,两组患者均给予常规治疗,在常规治疗的基础上,研究组使用重组人脑利钠肽治疗,比较两组心功能疗效、LVEF、LVDd、NT-proBNP、hs-CRP。结果与对照组比较,研究组在心功能方面的总有效率更高(P0.05)。治疗后两组LVEF升高,研究组与治疗前比较差异有统计学意义(P0.05);治疗后两组LVDd与治疗前比较差异均无统计学意义(P0.05)。治疗后两组NT-proBNP、hs-CRP水平均明显降低,研究组NT-proBNP、hsCRP水平与对照组比较降低的程度更大(P0.05)。结论急性心肌梗死伴心衰患者采用重组人脑利钠肽治疗疗效确切,可有效缓解患者的临床症状体征,使心功能得到有效改善,可在临床推广应用。     

重组人脑利钠肽对老年慢性心衰急性加重期患者心功能及BNP水平的影响

目的探讨重组人脑利钠肽对老年慢性心衰急性加重期患者心功能及B型脑钠肽(BNP)水平的影响。方法选取2016年3月至2017年1月于本院接受治疗的90例老年慢性心衰急性加重期患者,按照随机数表法分为两组,各45例。对照组给予硝普钠治疗,观察组给予重组人脑利钠肽治疗。比较两组患者治疗前后的心功能及BNP水平。结果与对照组比较,观察组治疗后的HR及LVEDD水平均较低,MAP及LVEF水平均较高,差异具有统计学意义(P<0.05);治疗后,两组患者BNP水平与治疗前比均较高,且观察组治疗后BNP水平低于对照组,差异具有统计学意义(P<0.05)。结论给予老年慢性心衰急性加重期患者重组人脑利钠肽治疗,可有效改善患者心功能及BNP水平,临床效果显著,值得应用推广。     

重组人脑利钠肽治疗急性心肌梗死并左心功能不全疗效观察

目的研究重组人脑利钠肽治疗急性心肌梗死并左心功能不全的临床效果。方法选取河南能源鹤煤总医院2013年5月至2015年8月收治的80例急性心肌梗死并左心功能不全患者,随机分为观察组和对照组,各40例。观察组采用重组人脑利钠肽治疗,对照组采用硝酸甘油治疗。比较两组患者治疗效果与心功能指标变化情况。结果治疗后但观察组患者B型尿钠肽、左心射血分数、左心室内径、收缩压及住院时间均优于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率(92.5%)高于对照组(80.0%),差异有统计学意义(P<0.05)。结论给予急性心肌梗死并左心功能不全患者重组人脑利钠肽治疗,可明显缓解临床症状,利于心功能恢复,值得临床推广。     

重组人脑利钠肽对急性非ST段抬高型心肌梗死合并心力衰竭患者疗效及预后的影响

目的：探讨分析重组人脑利钠肽对急性非ST段抬高型心肌梗死合并心力衰竭患者疗效及预后的影响。方法选择2014年1月—2015年1月在我院进行治疗的70例急性非ST段抬高型心肌梗死合并心力衰竭患者为研究对象，随机分为观察组和对照组，每组各35例。对照组给予常规药物治疗，观察组给予重组人脑利钠肽治疗，对比2组临床疗效和预后。结果观察组治疗总有效率为91.4%，显著高于对照组的62.9%；观察组患者的再住院率、病死率均显著低于对照组，以上差异均具有统计学意义（P<0.05）。结论重组人脑利钠肽能够有效改善急性非ST段抬高型心肌梗死合并心力衰竭患者的临床治疗效果，改善预后，提高生活质量，值得临床推广。     

重组人脑利钠肽治疗急性左心衰可行性及应用价值评述

目的：分析重组人脑利钠肽在治疗急性左心衰的可行性和临床应用价值。方法将84例确诊为急性左心衰竭的患者随机分为对照组和观察组,各41例。对照组采用常规抗心衰治疗,观察组在常规治疗的基础上增加重组人脑利钠肽,对比2组患者的治疗效果和不良反应。结果观察组患者心功能改善总有效率为优于对照组;观察组心率下降水平明显优于对照组;2组患者在治疗前后NT-proBNP水平均较治疗前有所下降,但观察组患者下降水平高于对照组患者;差异均具有统计学意义（P＜0.05）。结论利用重组人脑利钠肽治疗急性左心衰时治疗效果良好,为发生明显不良反应,适宜在临床中使用。     

静脉注射重组人脑利钠肽对急性心肌梗死伴心力衰竭患者的急性血流动力学效应的研究

目的:探讨静脉注射重组人脑利钠肽对急性心肌梗死伴心力衰竭患者的急性血流动力学效应。方法:选取2011年6月至2013年5月我院收治的急性心肌梗死伴心力衰竭患者60例进行分析,按照治疗方法分成观察组和对照组两组,每组30例,观察组采用静脉注射重组人脑利钠肽治疗,对照组采用静脉注射硝酸甘油治疗,观察两组治疗前后血流动力学指标变化。结果:两组治疗后2h、12h心率(HR)、肺小动脉契压(PCWP)和心脏指数(CI)均有显著改善(P0.05),且观察组改善水平明显优于对照组(P0.05);三个指标停药后6h均恢复到治疗前水平。结论:静脉注射重组人脑利钠肽治疗急性心肌梗死伴心力衰竭患者具有较好的急性血流动力学效应,安全可行。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.