脊柱胸腰段骨折行后路椎弓根螺钉内固定联合植骨手术的临床效果

目的：研究分析脊柱胸腰段骨折行后路椎弓根螺钉内固定联合植骨手术的临床效果。方法整群选取并回顾分析该院2013年7月—2015年12月期间收治的脊柱胸腰段骨折患者71例,根据患者治疗方式的不同而分为观察、对照两组,观察组36例,采取行后路椎弓根螺钉内固定联合植骨手术进行治疗,对照组35例,采用联合外侧植骨方式治疗,术后随访观察3~6个月,对比分析两组患者临床疗效及相关并发症率。结果观察组患者治疗后Worter指数达到0.51±0.28,Cobb 角(9.27±4.27）°,前缘高度(90.12±10.74）%,对照组Worter 指数达到(0.87±0.26）,Cobb 角(17.38±4.36）°,前缘高度(75.34±11.26）%,两组对比差异有统计学意义(t=2.2915,P=0.0279);两组患者对比术后并发症,差异无统计学意义(χ2=2.1626,P=0.1414）。结论脊柱胸腰段骨折行后路椎弓根螺钉内固定联合植骨手术疗效确切,安全可靠,值得临床推广应用。     

脊柱胸腰段骨折行后路椎弓根螺钉固定联合植骨手术的临床效果

目的观察分析脊柱胸腰段骨折行后路椎弓根螺钉固定联合植骨手术的临床效果。方法选取我院2013年5月至2015年10月收治的64例脊柱胸腰段骨折患者为研究对象,随机分为对照组与观察组,各32例。观察组行后路椎弓根螺钉固定联合植骨术治疗,对照组行联合外侧植骨治疗,比较两组治疗效果。结果术后,观察组VAS评分、Worter指数、Cobb角及并发症发生率均显著优于对照组,(P0.05)差异具有统计学意义。结论对脊柱胸腰段骨折患者行后路椎弓根螺钉固定联合植骨术的临床疗效显著,可有效提高患者生活质量,值得临床广泛应用及推广。     

后路减压植骨联合椎弓根螺钉内固定对胸腰段脊柱骨折合并脊髓损伤患者术后生活质量的影响

目的探讨后路减压植骨联合椎弓根螺钉内固定对胸腰段脊柱骨折合并脊髓损伤患者术后生活质量的影响。方法选取胸腰段脊柱骨折合并脊髓损伤患者62例,按照入院时间分组,各31例。对照组行椎弓根螺钉内固定术治疗,观察组在对照组基础上行后路减压植骨术治疗。对比手术前后两组触觉评分、运动觉评分及Oswestry功能障碍指数(ODI)评分。结果术后观察组触觉评分、运动觉评分均高于对照组,ODI评分低于对照组,差异均有统计学意义(P<0.05)。结论后路减压植骨联合椎弓根螺钉内固定治疗胸腰段脊柱骨折合并脊髓损伤,可促进触觉、运动觉及日常生活功能的恢复,提高患者术后生活质量。     

经后路椎弓根螺钉内固定联合伤椎内植骨手术治疗脊柱胸腰段骨折的效果及对疼痛程度的影响

目的探讨经后路椎弓根螺钉内固定联合伤椎内植骨手术治疗脊柱胸腰段骨折的效果及对疼痛程度的影响。方法选取2017年5月至2019年5月新郑市人民医院收治的82例脊柱胸腰段骨折患者,依据双盲法分为对照组和观察组,每组41例。对照组患者接受经后路椎弓根螺钉内固定结合外侧植骨融合术治疗。观察组患者接受经后路椎弓根螺钉内固定联合伤椎内植骨术治疗。比较两组患者手术前后伤椎前缘高度、后缘高度及视觉模拟评分(VAS)。结果术后3个月,两组伤椎前缘高度和后缘高度均高于术前,观察组伤椎前缘高度和后缘高度均高于对照组,差异有统计学意义(均P<0.05)。术后3个月,两组VAS评分均低于术前,观察组VAS评分低于对照组,差异有统计学意义(均P<0.05)。结论经后路椎弓根螺钉内固定联合伤椎内植骨手术治疗脊柱胸腰段骨折可提升骨折复位效果,降低患者疼痛程度。     

胸腰椎骨折内固定术后椎弓根螺钉断裂的原因分析

目的 分析脊柱胸腰段骨折脱位椎弓根螺钉内固定系统术后断裂原因.方法 随访应用后路椎弓根螺钉内固定系统治疗的153 例胸腰椎骨折、脱位患者,了解其椎弓根螺钉内固定系统术后断裂情况.结果 发生断钉18例,其中14例未行任何植骨,断裂部位全部在钉杆连接处1.5 cm之内.结论 置钉技术不当、未植骨融合和术后管理不当是胸腰段骨折脱位椎弓根螺钉内固定系统术后断裂的主要原因.     

探讨不同手术方法治疗胸腰段脊柱骨折的临床效果比较

目的总结分析探讨不同手术方法治疗胸腰段脊柱骨折的临床效果。方法选择2013年1月至2018年12月我院收治的106例胸腰段脊柱骨折患者为研究对象,根据手术方案不同分为观察组和对照组各53例,其中对照组应用椎弓根螺钉内固定方案治疗,观察组应用椎弓根螺钉内固定与椎板间植骨术联合治疗,观察两组Cobb角、椎体前缘及后缘高度、脊髓神经功能恢复状态。结果①两组患者治疗后的Cobb角明显小于治疗前,椎体前后缘高度明显高于治疗前水平,差异显著(P0.05);②观察组治疗后Cobb角(2.3±0.2)°明显小于对照组,椎体前缘高度(92.6±1.7)mm、椎体后缘高度(96.5±2.2)mm均明显高于对照组,且两组差异显著(P0.05);③观察组神经功能恢复有效率54.72%明显高于对照组恢复有效率33.96%差异明显(P0.05)。结论椎弓根螺钉内固定与椎间板植骨术联合应用与胸腰段脊柱骨折治疗中可以获得更好的临床疗效,优于单纯性螺钉内固定治疗方案。     

后路椎弓根钉棒系统固定并植骨治疗脊柱胸腰段椎体骨折

目的:探讨和总结胸腰段椎体骨折应用后路椎弓根钉棒系统复位、内固定并植骨治疗的临床效果。方法:采用脊柱后路正中切口,应用手法及椎弓根钉棒系统对伤椎复位、内固定并植骨融合,重建脊柱稳定性。结果:伤椎平均复位率在95%以上,脊柱损伤局部稳定性得以重建。结论:后路椎弓根钉棒系统复位内固定并植骨治疗脊柱胸腰段椎体骨折具有手术操作简便,固定可靠,符合脊柱稳定的生物力学要求,是脊柱胸腰段椎体骨折非常好的手术治疗方法。     

探讨不同手术方法治疗胸腰段脊柱骨折的临床效果比较

目的研究不同手术方法治疗胸腰段脊柱骨折的临床效果。方法将本院2016年1月至2018年12月收治的72例胸腰段脊柱骨折患者作为此次研究纳入对象,入院随机的分为对比组(n=37例)、探究组(n=35例)。对比组采取椎弓根螺钉内固定术予以治疗,而探究组则采取椎弓根螺钉内固定+椎板间植骨术联合治疗。对两组脊髓神经功能、椎体前缘、后缘高度、Cobb角大小以及生活质量进行比较。结果探究组脊髓神经功能恢复明显优于对比组,数据之间差异较大(P0.05);探究组椎体前缘高度、后缘高度以及Cobb角均优于对比组,组间数据差异显著(P0.05);探究组生活质量评分均比对比组高,数据之间差异显著(P0.05)。结论对胸腰段脊柱骨折采取椎弓根螺钉内固定+椎板间植骨术联合治疗效果较为明显,可有效改善症状,促进脊髓神经功能恢复,对于疾病治疗具有较高临床价值。     

后路椎弓根钉固定结合后外侧植骨融合术选择性治疗胸腰段脊柱爆裂性骨折30例疗效观察

目的:观察后路椎弓根钉固定结合后外侧植骨融合术选择性治疗胸腰段脊柱爆裂性骨折疗效。方法:选择本院于2011年1月-2012年10月收治的胸腰段脊柱爆裂性骨折患者60例作为研究对象,按照数字随机法分为两组,每组30例,对照组采取单纯后路椎弓根钉内固定术治疗,观察组采取后路椎弓根钉内固定结合后外侧植骨融合术,术后两组患者均随访24个月,比较两组患者疗效。结果:观察组手术时间及出血量均多于对照组,观察组末次随访Cobb’s角及患椎楔变角较对照组小(P0.05),稳定效果更好,治疗更加有效。结论:后路椎弓根钉固定结合后外侧植骨融合术选择性治疗胸腰段脊柱爆裂性骨折手术疗效较佳,具有重要临床价值。     

脊柱胸腰段骨折经皮后路微创椎弓根螺钉固定的疗效分析

目的探讨脊柱胸腰段骨折患者采用经皮后路微创椎弓根螺钉固定治疗的疗效。方法选择2012年10月至2016年10月收治的脊柱胸腰段骨折患者44例,随机分为两组,各22例。对照组给予切开后路椎弓根螺钉固定治疗,观察组给予经皮后路微创椎弓根螺钉固定治疗,对比两组治疗效果。结果观察组切口长度、术中出血量和住院时间少于对照组,差异显著(P0.05);观察组术后2d VAS评分低于对照组,差异显著(P0.05);观察组椎体前缘高度比值高于对照组,Cobb角小于对照组,差异显著(P0.05)。结论脊柱胸腰段骨折患者采用经皮后路微创椎弓根螺钉固定治疗可减少术中出血量,缩短切口长度,减轻术后疼痛,缓解伤锥严重程度,促进骨折复位,值得推广。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.