食管腺样囊性癌22例报道并文献复习

目的 食管腺样囊性癌(adenoid cystic carcinoma,ACC)临床上罕见,文献多为个案报道或小样本病例,对本病缺乏系统了解.本研究回顾性分析22例食管ACC患者,分析其临床病理特征及诊疗策略,为临床提供参考.方法 分析河北医科大学第四医院2004-01-01-2013-12-31行根治性手术切除,且术后病理确诊为食管ACC患者的临床病理资料,采用Kaplan-Meier法进行生存分析.结果 食管ACC发病率男性多于女性,男女比例为4.5∶1.发病部位以胸中段最常见,为14例;其次是胸上段和胸下段,各4例.Ⅰ期19例,Ⅱ期2例,Ⅲ期1例.食管ACC的术前内镜诊断率较低,仅为27.3％(6/22),其中11例被误诊为鳞状细胞癌,4例误诊为腺癌,1例误诊为腺鳞癌.全组患者淋巴结转移率为9.1％(2/22),淋巴结转移度为0.9％(2/229),肺转移发生率为27.3％(6/22).全组患者1、3、5年生存率分别为90.9％、81.3％和65.1％,术后综合治疗与单纯手术相比生存率差异均无统计学意义,x2=0.054,P=0.816.结论 食管ACC发病男性多于女性,发病部位以胸中段最为多见,术前内镜诊断确诊率低.食管ACC总体预后较好,淋巴结转移并不常见,治疗失败以肺转移最为多见,术后是否需行综合治疗尚待进一步探索.     

双侧腮腺腺样囊性癌1例并文献复习

腺样囊性癌(adenoid cystic carcinoma,ACC)多发生于颌面部大、小涎腺,其中腭部最为常见,现有文献中腮腺ACC双侧发病率极低,仅有1973年法国报道1例.1 病例资料患者,女性,65岁,2013年7月因左耳后肿物8年余,发现右咽旁肿物半月入本院.无进食肿胀,无耳鸣、听力下降,无闭眼不全、口角歪斜.否认系统性疾病史、家族性疾病史及肿瘤性疾病史.查体见左乳突前下缘可及大小分别为1.0 cm ×1.0 cm、1.5 cm×1.7cm、2.0 cm ×2.0 cm的3个肿物,轻压痛、活动度尚可、界尚清、质地中等.右腮腺区未及明显肿块,咽腔右侧略饱满,软腭活动可,扁桃体无肿大.无面瘫症状,无声嘶.     

食管腺样囊性癌1例

男性，６０岁。进食梗阻感１个月余，于１９９９年９月２４日入院。查体：体温３６．５０C，脉搏７６次／分，血压１３．０１０．０kPa。上消化道造影显示，食管下段约３．０cm长狭窄，其上段扩张。胃镜检查，距贲门４０cm处食管的右侧壁见一肿物，直径约３．０cm，其表面糜烂。取活检病理报告为中分化鳞癌。于１０月９日手术切除下段食管。病理检查切除食管一段，长８cm，直径约４．０cm。距远切端１．０cm处有一肿物，向食管外膜突起，灰白色质地较硬。切面见肿物由粘膜面向腔内突出，颜色灰红与灰白相间，大小３．０cm×２．５cm×１．…     

食管腺样囊性癌二例报告

腺样囊性癌(简称ACC)一般发生在大小涎腺,而发生在食管非常罕见,1954年第一次描述食管ACC,至1990年共有47例报告。我院25年来仅见2例,组织学图象与发生在涎腺的ACC一致,现进行简要的报道并结合文献进行讨论。 病例报道 例1:患者男性,60岁,因吞咽不顺半年来     

乳腺腺样囊性癌（附1例报告并文献复习）

腺样囊性癌多见于涎腺 ,发生在乳腺十分罕见 ,占乳腺癌的不到 1%。我科收稿日期 :1999-11-10作者单位 :泰州市人民医院 ,江苏　泰州2 2 5 3 0 01989年— 1998年间仅发现 1例 ,占同期乳房恶性肿瘤的 0 .34 % ,占同期乳房上皮性恶性肿瘤的 0 .36 %。乳腺腺样囊性癌甚少见 ,但其预后较其他类型乳腺癌为好 ,有必要和其它类型的乳腺癌加以鉴别。现报道我科乳腺腺样囊性癌 1例并做文献复习。1　临床资料患者女性 ,6 1岁 ,发现左乳肿块 3个月 ,乳头无溢液 ,乳房皮肤外观无桔皮样改变 ,触诊 :左乳外上象限近乳晕下方触及 4cm× 3cm大小的肿块 ,呈单…     

乳腺腺样囊性癌一例

<正>腺样囊性癌是一种常发生于涎腺的恶性肿瘤,较少发生在乳腺、前列腺、呼吸道、消化道等处~[1]。乳腺腺样囊性癌是乳腺癌中十分罕见的一种类型,其发病率不足乳腺癌的0.1%~[2]。文献报道其多为三阴性乳腺癌,但与其他类型乳腺癌及唾液腺的腺样囊性癌不同,乳腺腺样囊性癌预后良好~[3]。笔者回顾性分析北京大学深圳医院收治的1例乳腺腺样囊性癌患者,并结合相关文献进行复习。一、临床资料患者,女性,47岁,因发现右乳肿物伴疼痛2年,2013年     

鼻中隔腺样囊性癌一例报告

1病例报告患者,男,60岁。因左鼻塞、嗅觉减退、偶有溢泪6个月,于2010-03-11收入山东大学齐鲁医院桓台分院耳鼻咽喉科。患者6个月前无明显诱因左侧鼻塞,持续加重,伴有嗅觉减退,感冒时症状明显,有时左眼溢泪,无脓血涕,无头疼头晕恶心呕吐。曾用布地奈德鼻喷剂和呋麻滴鼻液等治疗无明显好转。     

乳腺腺样囊性癌3例临床病理分析并文献复习

目的：探讨乳腺腺样囊性癌的病理形态学特点及ER，PR,p53，C-erb-B2的表达与其预后。方法：观查和分析3例乳腺腺样囊性癌的病理形态学特征，免疫组化染色表达并进行文献复习。结果：镜检病变形态与涎腺的腺样囊性癌相似，组织学上分为筛孔型、管状-小梁型和实体型三种类型。3例免疫组化均显示ER（-），PR（-），C-erb-B2（-），除1例p53（＋）外，另2例p53（-）。结论：发于乳腺的腺样囊性癌较罕见，预后良好，需与乳腺的筛状型导管内癌和筛状癌、分泌型癌病变鉴别。     

乳腺腺样囊性癌1例

患者女性,56岁,主因发现左乳肿物20余天于2002年10月23日入院,无疼痛、发热、乳头溢液等不适,肿物位于左乳外上象限,直径约2.5cm,质硬,界不清,腋窝可触及肿大的淋巴结,直径约0.5cm～0.8cm,活动,未融合。X线表现为分叶状肿物,边缘毛糙,符合乳腺癌特点;超声表现为低回声肿物,边界不规则,内部回声不均匀,可探及动脉血流;穿刺发现癌细胞。2002年10月28日行左乳腺癌改良根治术,肿瘤大体表现为质硬、边界不清的肿块,无包膜,切面灰白色,可见大小不等的囊腔,直径约0.1cm～0.5cm,内含清亮的黏液。镜下见2种细胞,一种为小而着色深的肌上皮细胞,另一种…     

A case of adenoid cystic carcinoma of the esophagus

A surgical case of an adenoid cystic carcinoma (ACC) of the esophagus in a 75-year-old man is reported. Histologically, the tumor consisted of an ACC, a squamous cell carcinoma and a small tubular adenocarcinoma. The ACC and the tubular adenocarcinomatous regions in the submucosa and the lamina propria were continuous with the overlying squamous cell carcinoma and atypical squamous epithelium. Immunohistochemically, two types of tumor cells were detected in the ACC. One was found to have EMA-positive epithelial cells whereas the other had actin-positive myoepithelial cells. In the normal esophageal gland, actin-positive cells are found at the periphery of acini and around the layer of epithelial cells in the small duct but they have not been detected in the main duct. These findings suggest that the tumor developed from the small duct and differentiated into two directions: an ACC and a squamous cell carcinoma.     

阴囊部皮肤原发性腺样囊性癌1例报告及文献复习

目的 探讨原发阴囊部皮肤腺样囊性癌的临床病理特点,免疫组化及鉴别诊断要点.方法 报道1例原发阴囊部皮肤腺样囊性癌的临床、病理组织学形态和免疫组化特点,并复习相关文献对以上特点进行分析.结果 皮肤的腺样囊性癌较少见,可发生于除掌跖以外的任何部位,中老年好发,平均发病年龄为59岁.原发阴囊部皮肤腺样囊性癌未见报道,镜下肿瘤组织形成特殊的筛状结构,囊腔内常含有阿辛兰(pH5.2)阳性的透明质酸和硫酸化的酸性黏蛋白,瘤细胞间和小叶间周围可见透明嗜酸性基底膜物质的沉积,PAS染色呈阳性.免疫组化CK7、S-100、EMA、P63阳性表达.结论 阴囊皮肤原发腺样囊性癌相对少见,其具有与涎腺腺样囊性癌相同的镜下特征和免疫组化特点,临床表现呈惰性过程,预后相对较好.     

Primary adenoid cystic carcinoma of the esophagus: report of a case.

A case of primary adenoid cystic carcinoma of the esophagus is reported. A 51-year-old male patient had a tumor in the lower third of the esophagus which was incidentally found during an examination for cholelithiasis, and resected successfully. The tumor exhibited a polypoid appearance covered by normal esophageal epithelium, localized entirely in the submucosal layer, and morphologically identical to adenoid cystic carcinoma in the salivary glands. The patient is still alive and well three and one-half years after surgery. This seems to be a typical case of adenoid cystic carcinoma of the esophagus arising from the submucosal esophageal gland.     

Invasion of the hypoglossal nerve by adenoid cystic carcinoma of the tongue: case report and review of the literature

Adenoid cystic carcinoma (ACC) is a rare but highly aggressive malignancy mainly originating from the salivary glands. ACC is well known for its propensity toward neural invasion (NI). NI is the process of neoplastic invasion in and along nerves. It is a distinct and well-documented phenomenon in ACC; however, it is an underestimated route of metastatic spread. Multiple distant metastases can be established through NI route, and NI is believed to portend a poor prognosis. Despite increasing recognition of NI in many malignancies, the molecular mechanism behind NI is not well established. We present a unique case of hypoglossal nerve invasion by ACC arising from the minor salivary glands in the tongue of a 34-year-old man. We also review and discuss current theories on the pathogenesis and mechanism of NI.     

Primary adenoid cystic carcinoma of the esophagus

A case of primary adenoid cystic carcinoma of the esophagus is reported, and 45 cases are reviewed. The light and electron microscopic appearances are described in a 77-year-old woman. This patient manifested the intraepithelial spread of cancer cells, which suggested that the tumor arose from the mucosal epithelium of the esophagus. The patient died of mediastinal metastasis 11 months after resection. Adenoid cystic carcinoma of the esophagus is a relatively rare lesion, which exhibits a clinically aggressive behavior. Earlier resection and more intensive chemotherapy will be required.     

Low-dose radiotherapy combined with immunotherapy for suboral adenoid cystic carcinoma with bilateral lung metastasis: A case report and literature review

Adenoid cystic carcinoma (ACC) is a type of malignant tumor arising from the salivary glands. The tumor is characterized by a predilection for recurrence and metastasis. At present, there is no effective treatment for ACC complicated with lung metastasis. The present study reported on a case of suboral ACC with bilateral lung metastasis and the clinical features and treatment options were discussed based on a literature review. A 55-year-old female presented with suboral ACC accompanied with bilateral lung metastases. The main symptoms were masses in the right mandible and shortness of breath. Low-dose radiotherapy (LDRT) combined with immunotherapy were administered to control lung metastases. The patient is currently in a stable condition and is receiving immunotherapy. LDRT combined with immunotherapy is a feasible treatment option for such patients. Our experience with this case and the information from the literature review provide insight into the therapeutic approach for this relatively rare entity.     

Adenoid cystic carcinoma of the buccal vestibule: A case report and review of the literature

Minor salivary gland tumors of the buccal vestibule are relatively rare. Adenoid cystic carcinoma is the fifth most common salivary gland malignancy following mucoepidermoid carcinoma, adenocarcinoma not otherwise specified (NOS), acinic cell adenocarcinoma and polymorphous low-grade adenocarcinoma (PLGA). Greater than half of adenoid cystic carcinomas occur in the parotid and submandibular glands. The most common intraoral site is the palate. Adenoid cystic carcinoma tends to have a protracted clinical course with wide infiltration and late distant metastases. We present a case of an adenoid cystic carcinoma of the buccal vestibule in a 59-year-old Caucasian female patient that she had been aware of for 15 years.     

Partial remission of advanced adenoid cystic carcinoma obtained with adriamycin: a case report with a review of the literature.

Adenoid cystic carcinoma is relatively uncommon and often originates from the salivary glands. Although distant metastases develop rather frequently no satisfactory form of therapy has been reported. We achieved a partial remission with adriamycin in a patient with advanced metastases of adenoid cystic carcinoma. This case is described, and a short review of the literature, including papers on the treatment of advanced disease, is also given.